Methotrexate combined with Provigil

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Breast Cancer Other Serious 4/20/2006 Female 148 lb 8/10/2006 Physician United States
Primary
Concomitant
Hyperhidrosis Other Serious 3/1/2006 Female 9/19/2006 Consumer United States
Primary
Concomitant
Drug Ineffective 73 Female 12/28/2006 Consumer United States
Primary
Concomitant
Syncope Other Serious 4/1/2004 Male 2/16/2007 Physician United States
Primary
Concomitant
Syncope Other Serious 4/1/2004 Male 3/14/2007 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 4/23/2005 72 Female 160 lb 3/8/2007 Physician United States
Primary
Concomitant
Syncope Other Serious 4/1/2004 Male 3/27/2007 Consumer United States
Primary
Concomitant
Malaise Other Serious 4/26/2007 57 Female 6/25/2007 Consumer United States
Primary
Concomitant
Mydriasis 5/1/2007 47 Female 101 lb 6/25/2007 Other Health Professional United States
Primary
Concomitant
Swelling Face Other Serious 1/1/2007 Female 191 lb 10/16/2007 United States
Primary
Concomitant
Sinusitis 4/12/2007 Male 243 lb 12/12/2007 Physician United States
Primary
Concomitant
Unevaluable Event Hospitalization 6/27/2007 Female 326 lb 3/31/2008 Other Health Professional United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization Female 103 lb 6/18/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 6/27/2008 Consumer United States
Primary
Secondary
Concomitant
Nausea 1/1/2007 38 Female 170 lb 6/30/2008 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 4/22/2008 Female 103 lb 7/8/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 7/11/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 7/29/2008 Consumer United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased 56 Male 192 lb 7/31/2008 Consumer United States
Primary
Secondary
Concomitant
Ligament Rupture Other Serious 11/1/2007 Female 167 lb 8/12/2008 Other Health Professional United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 9/11/2008 Consumer United States
Primary
Secondary
Concomitant
Ligament Rupture Other Serious 11/1/2007 Female 167 lb 9/26/2008 Other Health Professional United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/17/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 10/23/2008 Consumer United States
Primary
Secondary
Concomitant
Wound Infection Hospitalization Female 10/22/2008 Consumer United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/29/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/5/2008 Consumer United States
Primary
Secondary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 3/3/2008 Other Health Professional United States
Primary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 9/9/2008 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 11/18/2008 Consumer United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/13/2005 Female 146 lb 11/24/2008 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/24/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting 1/1/2008 Female 216 lb 12/2/2008 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/3/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/29/2008 Consumer United States
Primary
Secondary
Concomitant
Death Death 1/26/2009 Female 134 lb 2/12/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Death 1/1/2009 Female 134 lb 2/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hypophagia 11/11/2008 Male 190 lb 3/14/2009 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Death 1/1/2009 Female 134 lb 3/27/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Life Threatening 5/15/2008 66 Female 5/14/2009 United States
Primary
Concomitant
Vomiting Hospitalization 62 Female 6/16/2009 United States
Primary
Concomitant
Vomiting Other Serious 1/1/2007 32 Female 119 lb 6/23/2009 Physician United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2004 53 Female 145 lb 7/14/2009 United States
Primary
Concomitant
Vomiting Hospitalization 62 Female 8/25/2009 Lawyer United States
Primary
Concomitant
No Adverse Event 58 Female 172 lb 9/10/2009 United States
Primary
Concomitant
Vomiting Hospitalization 56 Female 9/17/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Thrombocytopenia Hospitalization Male 11/4/2009 United States
Primary
Concomitant
Vascular Dementia Hospitalization 68 Male 11/17/2009 Lawyer United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2000 Female 11/30/2009 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 53 Female 12/10/2009 United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 3/13/2005 Female 146 lb 1/28/2010 Physician United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 2/16/2010 Physician United States
Primary
Secondary
Concomitant
Cholecystitis Hospitalization 1/24/2010 Female 2/18/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 2/23/2010 Physician United States
Primary
Secondary
Concomitant
Vascular Dementia Hospitalization 68 Male 2/5/2010 United States
Primary
Concomitant
Vascular Dementia Hospitalization 68 Male 2/5/2010 United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 3/4/2010 Physician United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 3/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 3/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 Female 138 lb 3/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 4/14/2010 United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 53 Female 4/15/2010 United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 5/5/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 5/19/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 5/21/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 6/9/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 7/7/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 7/23/2010 United States
Primary
Secondary
Concomitant
Somnolence Other Serious 9/8/2009 42 Female 250 lb 5/18/2010 United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 8/20/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 8/24/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 8/27/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 9/6/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 9/29/2010 United States
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 10/27/2010 United States
Primary
Secondary
Concomitant
Tremor Hospitalization 8/1/2010 41 Female 220 lb 11/9/2010 Other Health Professional United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 11/12/2010 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2010 38 Female 279 lb 11/24/2010 Consumer United States
Primary
Concomitant
Urticaria Other Serious 10/19/2010 46 Female 11/25/2010 Physician United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 4/1/1997 55 Female 138 lb 12/7/2010 United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 11/1/2005 60 Female 245 lb 12/23/2010 United States
Primary
Secondary
Concomitant
Blood Creatine Abnormal Other Serious 10/19/2010 46 Female 1/12/2011 Physician United States
Primary
Concomitant
Stress Fracture Hospitalization 4/27/2000 58 Female 138 lb 1/12/2011 United States
Primary
Secondary
Concomitant
Spleen Disorder Other Serious 11/1/2005 60 Female 245 lb 1/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Hypogammaglobulinaemia Hospitalization 4/27/2000 58 Female 138 lb 1/18/2011 United States
Primary
Secondary
Concomitant
Pain Female 160 lb 1/29/2011 Other Health Professional United States
Primary
Concomitant
Injection Site Pain 4/1/2010 60 Female 129 lb 1/29/2011 Consumer United States
Primary
Concomitant
Oral Herpes 1/1/2010 72 Female 151 lb 1/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Rhinorrhoea 9/2/2010 66 Female 1/29/2011 Consumer United States
Primary
Concomitant
Myalgia Hospitalization 11/1/2005 60 Female 245 lb 2/1/2011 United States
Primary
Secondary
Concomitant
Tendon Disorder Other Serious 11/1/2005 60 Female 245 lb 3/24/2011 United States
Primary
Secondary
Concomitant
Stress Fracture Other Serious 4/27/2000 58 Female 138 lb 4/6/2011 Physician United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2006 58 Female 179 lb 4/22/2011 Consumer United States
Primary
Secondary
Concomitant
Myalgia Hospitalization 11/1/2005 60 Female 245 lb 5/2/2011 Lawyer United States
Primary
Secondary
Concomitant
Death Death 4/30/2008 50 Female 103 lb 5/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 11/1/2005 60 Female 245 lb 5/26/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Lymphopenia Death 4/30/2008 50 Female 103 lb 6/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrooesophageal Reflux Disease Other Serious 4/27/2000 58 Female 138 lb 6/29/2011 Physician United States
Primary
Secondary
Concomitant
Stress Fracture Hospitalization 4/27/2000 58 Female 138 lb 7/15/2011 United States
Primary
Secondary
Concomitant
Night Sweats Other Serious 11/1/2005 60 Female 245 lb 8/4/2011 Physician United States
Primary
Secondary
Concomitant
Aggression Other Serious 10/13/2006 79 Male 8/12/2011 Physician United States
Primary
Concomitant
Cardiomegaly Hospitalization 11/1/2005 60 Female 245 lb 8/16/2011 United States
Primary
Secondary
Concomitant
Enteritis Other Serious 4/27/2000 58 Female 138 lb 8/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 1/1/2007 49 Female 180 lb 10/6/2011 Physician United States
Primary
Secondary
Concomitant
Convulsion Hospitalization Female 10/7/2011 Physician United States
Primary
Secondary
Concomitant
Biopsy Lip Other Serious 1/1/2007 49 Female 180 lb 10/7/2011 Physician United States
Primary
Secondary
Concomitant
Dry Eye Other Serious Female 10/11/2011 Physician United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 9/1/2011 65 Female 10/13/2011 Consumer United States
Primary
Concomitant
Respiratory Distress Hospitalization Female 10/14/2011 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection 5/1/2011 72 Female 142 lb 11/1/2011 Other Health Professional United States
Primary
Concomitant
Pain Other Serious 8/10/2009 29 Female 151 lb 11/11/2011 Other Health Professional United States
Primary
Concomitant
Psychological Trauma Other Serious 8/10/2009 29 Female 151 lb 11/11/2011 Other Health Professional United States
Primary
Concomitant
Spinal Cord Compression Hospitalization Female 11/17/2011 Lawyer United States
Primary
Secondary
Concomitant
Bone Lesion Death Female 12/1/2011 Lawyer United States
Primary
Secondary
Concomitant
Bacteraemia Other Serious 6/21/2007 50 Female 103 lb 1/11/2012 United States
Primary
Secondary
Concomitant
Bone Lesion Other Serious Female 1/27/2012 Lawyer United States
Primary
Secondary
Concomitant
Injection Site Pain 11/1/2010 61 Male 1/27/2012 Consumer United States
Primary
Concomitant
Lymph Node Pain Other Serious 3/1/2011 39 Female 1/28/2012 Other Health Professional United States
Primary
Concomitant
Sinusitis 6/24/2011 66 Female 1/28/2012 Consumer United States
Primary
Concomitant
Skin Papilloma Hospitalization Female 1/31/2012 Physician United States
Primary
Secondary
Concomitant
Osteoporosis 9/13/2011 53 Female 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 9/9/2011 53 Female 1/28/2012 Consumer United States
Primary
Concomitant
Pain 68 Female 1/28/2012 Consumer United States
Primary
Concomitant
Abasia 8/15/2011 65 Male 245 lb 3/23/2012 Physician United States
Primary
Concomitant
Muscular Weakness Other Serious 65 Male 247 lb 3/20/2012 Physician United States
Primary
Secondary
Concomitant
Wegener's Granulomatosis 11/1/2011 47 Male 225 lb 4/2/2012 Consumer United States
Primary
Concomitant
Micturition Urgency Other Serious 1/1/2010 53 Female 128 lb 4/24/2012 Physician United States
Primary
Concomitant
Walking Aid User Other Serious Male 174 lb 5/22/2012 Consumer United States
Primary
Concomitant
Lumbar Radiculopathy Hospitalization 8/10/2010 51 Female 5/23/2012 Physician United States
Primary
Secondary
Concomitant
International Normalised Ratio Decreased Hospitalization 8/10/2009 29 Female 160 lb 6/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Pain Other Serious 1/1/2009 45 Female 216 lb 6/14/2012 Consumer United States
Primary
Concomitant
Oropharyngeal Cancer Stage Unspecified Hospitalization 4/30/2008 50 Female 103 lb 6/22/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Throat Cancer Other Serious 11/1/2005 60 Female 245 lb 8/1/2012 Physician United States
Primary
Secondary
Concomitant
Sinus Tachycardia Other Serious 11/1/2005 60 Female 245 lb 8/9/2012 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Congestion 11/2010 62 Male 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Skin Exfoliation Hospitalization 8/2012 54 Male 185 lb 8/29/2012 Physician Us
Primary
Concomitant
Skin Exfoliation Hospitalization 8/2012 54 Male 185 lb 8/28/2012 Physician Us
Primary
Secondary
Concomitant
Pain 2010 51 Female 145 lb 9/3/2012 Consumer Us
Primary
Concomitant
Post Procedural Swelling Other Serious 2012 52 Female 145 lb 9/4/2012 Consumer Us
Primary
Concomitant
Injection Site Rash 4/15/2012 35 Female 145 lb 10/23/2012 Consumer Us
Primary
Concomitant
Injection Site Pruritus 6/20/2012 36 Female 153 lb 10/26/2012 Consumer Us
Primary
Concomitant
Injection Site Mass 4/15/2012 30 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Pain 3/3/2012 60 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Tooth Fracture 11/2011 60 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Wound Female 10/29/2012 Physician Us
Primary
Concomitant
Wheezing Other Serious 11/2005 Female 245 lb 10/19/2012 Consumer Us
Primary
Secondary
Concomitant

Drug Data