Methotrexate combined with Phenytoin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Skin Cancer Other Serious 1/1/2005 Female 154 lb 1/3/2006 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Death Male 2/10/2006 United Kingdom
Primary
Concomitant
Vomiting Other Serious 1/11/2006 Female 2/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Hyponatraemia Other Serious 65 Female 4/6/2006 Other Health Professional United States
Primary
Concomitant
Gait Disturbance Disability 2/1/2006 Female 4/27/2006 Other Health Professional Ireland
Primary
Concomitant
Lethargy Other Serious 65 Female 4/21/2006 United States
Primary
Concomitant
Urine Output Increased Hospitalization 65 Female 6/9/2006 Physician United States
Primary
Concomitant
Urine Ketone Body Present Other Serious 12/1/2005 Female 12/26/2006 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Other Serious 2/1/2005 48 Male 1/27/2007 Other Health Professional Sweden
Primary
Concomitant
Acute Graft Versus Host Disease Hospitalization 10/20/2006 46 Male 3/26/2007 Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 11/10/2006 45 Female 4/4/2007 Japan
Primary
Secondary
Concomitant
Varicella Hospitalization 12/20/2006 52 Male 4/19/2007 Japan
Primary
Secondary
Concomitant
Vomiting Death 12/20/2006 52 Male 5/7/2007 Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Death 4/29/2007 21 Female 6/14/2007 Japan
Primary
Concomitant
Vomiting Death 12/20/2006 52 Male 6/20/2007 Japan
Primary
Secondary
Concomitant
Transplant Failure 2/5/2007 47 Male 7/13/2007 Japan
Primary
Concomitant
Vomiting Life Threatening 1/28/2007 34 Female 7/16/2007 Japan
Primary
Concomitant
Staphylococcal Sepsis Life Threatening 4/13/2007 49 Male 7/16/2007 Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 12/6/2006 50 Female 7/16/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Prostatic Specific Antigen Increased Other Serious 6/1/2007 Male 180 lb 7/23/2007 Physician United States
Primary
Concomitant
Syncope Other Serious 2/1/2005 Male 8/13/2007 Other Health Professional Sweden
Primary
Concomitant
Vomiting Death 5/5/2007 21 Female 9/4/2007 Other Health Professional Japan
Primary
Concomitant
Stomatitis Other Serious 12/15/2006 6 Female 9/20/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 4 Female 10/10/2007
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 13 Male 10/10/2007
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 28 Male 10/23/2007
Primary
Concomitant
Vomiting Life Threatening 1/28/2007 34 Female 10/22/2007 Japan
Primary
Concomitant
Thrombotic Microangiopathy Life Threatening 4/13/2007 49 Male 10/22/2007 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 12/6/2006 50 Female 10/22/2007 Japan
Primary
Secondary
Concomitant
Vomiting Life Threatening 4/19/2007 18 Female 11/16/2007 Japan
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 6/24/2007 14 Female 11/16/2007 Japan
Primary
Concomitant
Streptococcal Sepsis Other Serious 5/3/2007 54 Female 11/16/2007 Japan
Primary
Concomitant
Death Other Serious Female 12/3/2007 Other Health Professional United Kingdom
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 11/1/2006 53 Male 12/19/2007 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 4/25/2007 64 Male 1/3/2008 Japan
Primary
Secondary
Concomitant
Prostate Cancer Other Serious 11/15/2007 Male 165 lb 1/18/2008 Physician United Kingdom
Primary
Concomitant
Infection Death 2/19/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Other Serious Female 225 lb 2/21/2008 Other Health Professional United Kingdom
Primary
Concomitant
Adenocarcinoma Death 2/21/2008 Canada
Primary
Secondary
Concomitant
Sepsis Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Sepsis Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Sepsis Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Other Serious 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Graft Versus Host Disease Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Death 2/21/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Infection Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Arrhythmia Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Encephalopathy Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 2/22/2008 Canada
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 2/22/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Prostate Cancer Other Serious 11/15/2007 Male 165 lb 3/1/2008 Physician United Kingdom
Primary
Concomitant
Gastrooesophageal Reflux Disease Hospitalization 6/1/2007 59 Female 3/6/2008 Consumer Australia
Primary
Concomitant
Haemoglobin Decreased Death 6 Male 3/10/2008
Primary
Secondary
Concomitant
Vomiting Life Threatening 4/19/2007 16 Female 3/6/2008 Japan
Primary
Concomitant
Viraemia Other Serious 5/23/2007 31 Male 3/6/2008 Japan
Primary
Secondary
Concomitant
Sacroiliitis Other Serious 11/9/2007 42 Male 3/14/2008 Physician Finland
Primary
Concomitant
Somnolence 12/21/2007 Female 172 lb 3/14/2008 Consumer United States
Primary
Concomitant
Ventricular Extrasystoles Life Threatening 10/7/2007 57 Male 4/30/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 6/12/2007 52 Female 4/30/2008 Japan
Primary
Concomitant
Vomiting Life Threatening 5/28/2007 25 Male 4/30/2008 Japan
Primary
Concomitant
Weight Increased Life Threatening 2/6/2007 55 Female 4/30/2008 Japan
Primary
Concomitant
Malaise Hospitalization 4/19/2008 Female 167 lb 5/7/2008 Consumer United States
Primary
Concomitant
Tumour Flare Life Threatening 10/30/2007 34 Male 5/15/2008 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 2/6/2007 55 Female 5/15/2008 Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/1989 17 Female 5/21/2008 Other Health Professional Norway
Primary
Concomitant
Renal Failure Acute Other Serious 5/29/2008 Iceland
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 6/2/2008 Iceland
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 5 Female 5/30/2008 Other Health Professional Iran (Islamic Republic Of)
Primary
Concomitant
Vomiting Life Threatening 10/21/2007 42 Male 6/6/2008 Japan
Primary
Concomitant
Injection Site Pain 12/1/2007 Female 240 lb 6/12/2008 United States
Primary
Concomitant
Cellulitis 4/10/2008 Female 248 lb 6/12/2008 United States
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 7/1/2007 50 Male 6/19/2008 Japan
Primary
Concomitant
Infection Death 6/26/2008 Spain
Primary
Secondary
Concomitant
Vomiting Life Threatening 9/24/2007 58 Male 6/27/2008 Other Health Professional Japan
Primary
Concomitant
Vomiting Hospitalization 3/22/2007 64 Male 6/30/2008 Physician Japan
Primary
Concomitant
Vomiting 2/9/2008 16 Male 7/2/2008 Japan
Primary
Concomitant
Pneumonia Hospitalization 7/28/2007 47 Male 7/8/2008 Japan
Primary
Concomitant
Stomatitis Hospitalization 12/28/2007 2 Female 7/11/2008 Japan
Primary
Concomitant
Stomatitis Hospitalization 8/31/2007 60 Male 7/10/2008 Japan
Primary
Concomitant
Stomatitis Hospitalization 4/15/2008 16 Male 7/17/2008 Other Health Professional Japan
Primary
Concomitant
Transplant Rejection 12/27/2006 13 Female 7/18/2008 Japan
Primary
Concomitant
Stomatitis 2/21/2008 6 Female 7/18/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting 11/30/2007 9 Male 8/14/2008 Other Health Professional Japan
Primary
Concomitant
Stomatitis 5/23/2007 29 Female 8/14/2008 Japan
Primary
Concomitant
Stomatitis Hospitalization 5/27/2007 53 Female 8/22/2008 Japan
Primary
Concomitant
Stomatitis Disability 4/15/2008 Female 8/25/2008 Japan
Primary
Concomitant
Vomiting Hospitalization 3/6/2008 16 Male 9/3/2008 Japan
Primary
Concomitant
Transplant Failure Life Threatening 5/23/2007 55 Female 9/8/2008 Japan
Primary
Concomitant
Rheumatoid Arthritis 6/1/2008 Female 176 lb 9/13/2008 Consumer United States
Primary
Concomitant
Pneumonia Life Threatening 5/18/2007 65 Female 9/10/2008 Japan
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 3/14/2007 35 Female 9/10/2008 Japan
Primary
Concomitant
Stomatitis Life Threatening 10/13/2007 53 Male 9/11/2008 Other Health Professional Japan
Primary
Concomitant
Vomiting Life Threatening 5/23/2007 31 Male 9/16/2008 Japan
Primary
Secondary
Concomitant
Stomatitis Life Threatening 12/27/2006 13 Female 9/23/2008 Japan
Primary
Concomitant
Sepsis Other Serious 2/12/2008 Canada
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
T-cell Lymphoma Recurrent 1/21/2008 33 Male 10/16/2008 Japan
Primary
Concomitant
Liver Function Test Abnormal Death 8/30/2006 46 Male 10/20/2008 Japan
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Serotonin Syndrome Other Serious 46 Female 12/4/2008
Primary
Secondary
Concomitant
Vomiting Life Threatening 9/24/2007 58 Male 12/9/2008 Japan
Primary
Secondary
Concomitant
Nasopharyngitis 10/21/2008 Female 182 lb 12/12/2008 United States
Primary
Concomitant
Vomiting Life Threatening 9/15/2007 58 Male 1/27/2009 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/1989 Female 2/3/2009 Other Health Professional Norway
Primary
Concomitant
Stomatitis Disability 10/11/2007 58 Female 2/6/2009 Japan
Primary
Concomitant
Myocardial Infarction Other Serious 11/15/2008 Male 5/27/2009 Consumer United Kingdom
Primary
Concomitant
Nausea Other Serious 10/27/2008 58 Female 106 lb 6/9/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 10/8/2008 65 Male 132 lb 8/6/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/16/2009 Female 110 lb 9/1/2009 Japan
Primary
Concomitant
Pneumonia Hospitalization 7/16/2009 Female 110 lb 9/3/2009 Japan
Primary
Concomitant
Nausea Other Serious 10/29/2008 58 Female 106 lb 9/8/2009 Physician Japan
Primary
Secondary
Concomitant
Cellulitis 4/10/2008 Female 248 lb 9/12/2009 United States
Primary
Concomitant
Nausea Other Serious 10/29/2008 58 Female 106 lb 9/15/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 10/9/2009 Iceland
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 12/17/2009 89 Male 185 lb 12/21/2009 Pharmacist United States
Primary
Secondary
Concomitant
Hyperammonaemic Encephalopathy Life Threatening 1 Male 2/24/2010
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 3 Male 24 lb 5/31/2010 Physician Turkey
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Cholecystitis Acute Other Serious 8/26/2010 47 Female 9/2/2010 Other Health Professional Argentina
Primary
Secondary
Concomitant
Vertigo Hospitalization 1/1/2000 Female 9/10/2010 Physician Sweden
Primary
Concomitant
Interacting
Vertigo Hospitalization 1/1/2000 Female 10/13/2010 Physician Sweden
Primary
Concomitant
Interacting
Thermal Burn Other Serious 6/1/2010 38 Male 250 lb 12/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 8 Female 12/6/2010 Physician Thailand
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 8 Male 12/6/2010 Physician Thailand
Primary
Concomitant
Vomiting Other Serious 6 Male 12/6/2010 Physician Thailand
Primary
Concomitant
Enteritis Other Serious 5 Male 12/6/2010 Physician Thailand
Primary
Concomitant
Pneumonia Hospitalization 6/1/2010 62 Female 1/29/2011 Physician United States
Primary
Concomitant
Depression Other Serious 6/1/2010 38 Male 250 lb 2/7/2011 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 43 Female 2/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 66 Female 2/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 38 Male 2/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 72 Male 2/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Disease Progression Death 70 Male 2/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 76 Female 2/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 29 Female 2/18/2011 Physician Brazil
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 52 Female 2/22/2011 Physician Brazil
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Death 56 Female 2/22/2011 Physician Brazil
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Recurrent Other Serious 48 Female 2/22/2011 Physician Brazil
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 4/15/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Recurrent Death 38 Male 4/15/2011 Other Health Professional France
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 56 Female 4/15/2011 Other Health Professional France
Primary
Concomitant

Drug Data