Methotrexate combined with Oxycontin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Anaphylactic Shock Required Intervention 2/1/2006 27 Female 160 lb 2/23/2006 United States
Primary
Concomitant
Synovitis Hospitalization 57 Male 2/27/2006 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 61 Male 170 lb 2/28/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Death 1/1/2005 Female 3/29/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/23/2006 Female 4/21/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2002 52 Female 121 lb 4/24/2006 Physician United States
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 6/3/2002 70 Male 130 lb 4/25/2006 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 3/23/2006 Female 5/11/2006 Physician United States
Primary
Secondary
Concomitant
Thrombophlebitis Other Serious 11/4/2005 67 Female 163 lb 5/1/2006 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/23/2006 Female 5/19/2006 Physician United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 12/1/2005 Male 5/25/2006 Physician United States
Primary
Concomitant
Hypoaesthesia Hospitalization 5/3/2006 63 Female 134 lb 6/9/2006 Consumer United States
Primary
Concomitant
Sleep Disorder Disability 4/6/2006 65 Female 97 lb 6/7/2006 Pharmacist United Kingdom
Primary
Concomitant
Walking Aid User Other Serious 5/3/2006 63 Female 132 lb 6/29/2006 Consumer United States
Primary
Concomitant
Chest Discomfort Disability 2/16/2006 43 Female 8/30/2006 Australia
Primary
Secondary
Concomitant
Respiratory Failure Other Serious Female 9/26/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 8/7/2006 48 Female 9/21/2006 Physician United States
Primary
Secondary
Concomitant
Subcorneal Pustular Dermatosis Hospitalization 6/1/2006 Female 11/6/2006 Other Health Professional Norway
Primary
Concomitant
Weight Decreased Other Serious 1/1/2006 Male 153 lb 11/21/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 8/14/2006 Male 160 lb 12/4/2006 Physician United States
Primary
Concomitant
Histoplasmosis Hospitalization 5/1/2006 Female 12/8/2006 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2003 Female 12/13/2006 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2006 Male 153 lb 1/19/2007 Physician United States
Primary
Concomitant
Visual Disturbance Other Serious 7/6/2006 42 Female 1/26/2007 Other Health Professional United States
Primary
Concomitant
Interacting
Embolism Other Serious 1/25/2007 54 Male 164 lb 2/6/2007 Consumer United States
Primary
Concomitant
Heart Rate Abnormal Disability 2/16/2006 43 Female 2/17/2007 Australia
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2006 Male 153 lb 2/20/2007 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 1/1/2004 72 Female 192 lb 11/27/2006 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/30/2005 48 Male 4/2/2007 Pharmacist Japan
Primary
Secondary
Concomitant
Tooth Fracture Hospitalization 1/1/2005 45 Female 140 lb 4/23/2007 Consumer United States
Primary
Concomitant
Injection Site Bruising Other Serious 9/13/2006 Male 151 lb 5/22/2007 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 1/1/2000 21 Female 5/24/2007 Consumer United States
Primary
Secondary
Concomitant
Vascular Dementia Hospitalization 1/1/2007 Female 5/29/2007 Physician United States
Primary
Concomitant
Death Death 6/7/2004 Male 6/11/2007 Physician United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious 5/21/2007 68 Female 152 lb 6/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 1/1/2007 83 Female 7/10/2007 Consumer United States
Primary
Concomitant
Melaena Other Serious 3/2/2007 43 Male 132 lb 9/17/2007 Physician Japan
Primary
Concomitant
Death Death 9/10/2007 Female 9/19/2007 Consumer United States
Primary
Concomitant
Tremor Hospitalization 5/8/2000 52 Female 291 lb 9/24/2007 Physician United States
Primary
Concomitant
Urinary Tract Infection Death 5/1/2007 Female 110 lb 10/23/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/2/2002 Female 10/23/2007 Physician United States
Primary
Concomitant
Procedural Complication Hospitalization 11/8/2007 Female 150 lb 11/28/2007 Consumer United States
Primary
Secondary
Concomitant
Rash Other Serious 9/18/2007 31 Female 12/7/2007 Physician Canada
Primary
Concomitant
Vomiting 12/1/2004 Female 12/12/2007 Physician United States
Primary
Secondary
Concomitant
Weight Decreased 12/22/2006 Male 229 lb 12/15/2007 Physician United States
Primary
Concomitant
Pain In Extremity 1/1/2005 Male 12/15/2007 Physician United States
Primary
Concomitant
Tremor Other Serious 4/10/2002 43 Female 12/18/2007 Physician United States
Primary
Concomitant
Tremor Other Serious 4/10/2002 43 Female 12/27/2007 Physician United States
Primary
Concomitant
Tremor Other Serious 4/10/2002 43 Female 351 lb 1/21/2008 Physician United States
Primary
Concomitant
Emotional Distress Other Serious 3/1/2008 Female 170 lb 4/10/2008 United States
Primary
Concomitant
Rhinorrhoea Other Serious 8/1/2007 81 Female 181 lb 4/11/2008 Physician United States
Primary
Concomitant
Splenic Injury Other Serious 1/1/2006 Female 5/2/2008 Physician United States
Primary
Concomitant
Retinal Detachment Other Serious 4/1/2007 Male 203 lb 5/2/2008 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization Female 103 lb 6/18/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 6/27/2008 Consumer United States
Primary
Secondary
Concomitant
Nausea 1/1/2007 38 Female 170 lb 6/30/2008 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 4/22/2008 Female 103 lb 7/8/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 7/11/2008 Consumer United States
Primary
Secondary
Concomitant
Spinal Compression Fracture Other Serious 10/19/2006 Male 196 lb 7/18/2008 Canada
Primary
Concomitant
Death Hospitalization 6/8/2008 Male 141 lb 7/18/2008 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/22/2008 Female 103 lb 7/29/2008 Consumer United States
Primary
Secondary
Concomitant
Post Herpetic Neuralgia Hospitalization 8/2/2008 57 Female 137 lb 8/4/2008 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Hospitalization 1/1/2007 63 Male 8/25/2008 Consumer United States
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death 3/21/2008 71 Male 9/8/2008 Physician Japan
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 9/11/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 1/1/2007 63 Male 241 lb 9/17/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/17/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 10/23/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 10/29/2008 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/5/2008 Consumer United States
Primary
Secondary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 3/3/2008 Other Health Professional United States
Primary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 9/9/2008 Physician United States
Primary
Concomitant
Back Pain 7/1/2007 Male 11/17/2008 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 4/30/2008 Female 103 lb 11/18/2008 Consumer United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/13/2005 Female 146 lb 11/24/2008 Physician United States
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 11/24/2008 Consumer United States
Primary
Secondary
Concomitant
Tibia Fracture Hospitalization 10/1/2008 60 Female 11/24/2008 Consumer Canada
Primary
Concomitant
Vasculitis Hospitalization 9/14/2008 60 Female 11/26/2008 Consumer Canada
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/3/2008 Consumer United States
Primary
Secondary
Concomitant
Tremor 6/1/2008 Male 12/13/2008 Consumer United States
Primary
Concomitant
Latex Allergy Female 12/13/2008 Pharmacist United States
Primary
Concomitant
Sneezing 11/28/2007 Female 163 lb 12/15/2008 Physician United States
Primary
Concomitant
Rheumatoid Arthritis 7/1/2007 Male 12/18/2008 Physician United States
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 10/20/2008 74 Female 12/19/2008 Physician Netherlands
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/29/2008 Consumer United States
Primary
Secondary
Concomitant
Loss Of Consciousness Life Threatening 11/13/2008 62 Male 12/22/2008 Japan
Primary
Concomitant
Loss Of Consciousness Life Threatening 11/13/2008 62 Male 12/23/2008 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 1/26/2009 25 Female 159 lb 2/5/2009 Pharmacist Canada
Primary
Secondary
Concomitant
Mental Impairment Other Serious 2/3/2009 65 Male 2/12/2009 Consumer United States
Primary
Secondary
Thrombocytopenia Other Serious 2/11/2009 48 Male 2/26/2009 Physician Sweden
Primary
Concomitant
Macular Degeneration Hospitalization 1/1/2008 Female 134 lb 3/14/2009 Consumer United States
Primary
Concomitant
Incision Site Haemorrhage Other Serious 3/24/2009 Female 122 lb 4/2/2009 Canada
Primary
Concomitant
Vomiting Other Serious 2/9/2000 50 Female 213 lb 4/14/2009 United States
Primary
Concomitant
Sepsis Life Threatening 12/6/2008 Male 4/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Crohn's Disease Other Serious 1/1/2009 52 Female 5/15/2009 Consumer United Kingdom
Primary
Concomitant
Paraesthesia 7/1/2008 Male 237 lb 6/11/2009 United States
Primary
Concomitant
Upper Respiratory Tract Infection 2/28/2009 Female 130 lb 6/11/2009 United States
Primary
Concomitant
Rash 10/1/2008 Female 130 lb 6/12/2009 Consumer United States
Primary
Concomitant
Drug Dose Omission 5/1/2009 Female 136 lb 6/12/2009 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 62 Female 6/16/2009 United States
Primary
Concomitant
Endocarditis Bacterial Life Threatening 3/15/2009 58 Female 108 lb 6/24/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vaginal Haemorrhage Other Serious Female 157 lb 7/16/2009 Canada
Primary
Concomitant
Post Procedural Complication Other Serious 6/15/2008 Female 143 lb 7/27/2009 Other Health Professional United Kingdom
Primary
Concomitant
Histoplasmosis Disseminated Other Serious 5/7/2008 Male 226 lb 8/13/2009 Physician United States
Primary
Concomitant
Post Procedural Complication Other Serious 6/15/2008 Female 143 lb 8/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Life Threatening 3/15/2009 58 Female 108 lb 8/28/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization 62 Female 8/25/2009 Lawyer United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 67 Male 157 lb 9/1/2009 United States
Primary
Concomitant
Vomiting Death 3/2/2008 69 Female 9/8/2009 United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 3/2/2009 58 Female 108 lb 9/18/2009 Physician United Kingdom
Primary
Concomitant
Ventricular Tachycardia Hospitalization 66 Male 160 lb 9/15/2009 United States
Primary
Concomitant
Vomiting Hospitalization 56 Female 9/17/2009 United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 66 Male 160 lb 9/21/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
Pain Other Serious Female 164 lb 10/1/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 10/14/2009 Canada
Primary
Concomitant
Oesophageal Perforation Other Serious 4/1/2009 Female 185 lb 10/16/2009 United States
Primary
Concomitant
Vomiting Death 3/2/2008 78 Female 10/17/2009 United States
Primary
Concomitant
Road Traffic Accident Other Serious 3/1/2005 44 Female 351 lb 10/21/2009 Consumer United States
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 10/27/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 11/4/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 9/1/2009 Female 155 lb 11/4/2009 Canada
Primary
Concomitant
Ventricular Tachycardia Hospitalization 66 Male 11/4/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Tooth Fracture Other Serious 1/1/2007 Female 155 lb 11/19/2009 Canada
Primary
Concomitant
Pancreatitis Hospitalization 2/1/2009 Female 11/20/2009 Physician Sweden
Primary
Concomitant
Vomiting Other Serious 2/9/2000 50 Female 213 lb 11/26/2009 United States
Primary
Concomitant
Diffuse Large B-cell Lymphoma Other Serious 9/29/2009 Male 11/30/2009 Physician United States
Primary
Concomitant
Pancreatitis Hospitalization 2/1/2009 Female 12/1/2009 Physician Sweden
Primary
Concomitant
Tooth Fracture Other Serious 1/1/2007 Female 155 lb 12/8/2009 Canada
Primary
Concomitant
Ventricular Tachycardia Hospitalization 66 Male 160 lb 12/1/2009 Lawyer United States
Primary
Concomitant
Pain Other Serious 11/18/2009 Female 140 lb 12/14/2009 Canada
Primary
Concomitant
Weight Increased Hospitalization 53 Female 12/10/2009 United States
Primary
Concomitant
Paraesthesia Other Serious 11/18/2009 Female 140 lb 12/29/2009 Canada
Primary
Concomitant
Tooth Fracture Other Serious 1/1/2007 Female 155 lb 12/29/2009 Canada
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 4/30/2008 Female 103 lb 12/31/2009 Consumer United States
Primary
Secondary
Concomitant
Tachycardia Foetal Other Serious 11/11/2009 Male 3 lb 1/11/2010 Physician United States
Primary
Concomitant
Premature Labour Other Serious 1/1/2009 Female 215 lb 1/11/2010 Physician United States
Primary
Concomitant
Tachycardia Foetal Other Serious 11/19/2009 Male 3 lb 1/14/2010 Physician United States
Primary
Secondary
Concomitant
Premature Labour Other Serious 1/1/2009 Female 215 lb 1/14/2010 Physician United States
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 3/13/2005 Female 146 lb 1/28/2010 Physician United States
Primary
Concomitant
Sinusitis 6/1/2009 Female 174 lb 1/30/2010 United States
Primary
Concomitant
Psoriasis 5/1/2009 130 lb 1/30/2010 United States
Primary
Concomitant
Myocardial Ischaemia Hospitalization 5/3/2006 Female 2/4/2010 Australia
Primary
Concomitant
Polyarthritis Hospitalization 12/1/2009 Female 2/8/2010 Other Health Professional United States
Primary
Concomitant
Syncope Hospitalization 5/1/2009 Male 2/12/2010 United States
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 9/11/2009 56 Female 2/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 7/2/2009 Female 88 lb 2/22/2010 Physician France
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 7/2/2009 Female 88 lb 2/25/2010 Physician France
Primary
Secondary
Concomitant

Drug Data