Methotrexate combined with Oncaspar

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Disseminated Intravascular Coagulation Other Serious 12/21/2005 Female 42 lb 12/27/2005 United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/22/2005 Female 138 lb 1/23/2006 United States
Primary
Secondary
Death Death 3/13/2006 62 Male 3/29/2006 Other Health Professional United States
Primary
Concomitant
Transverse Sinus Thrombosis Hospitalization 12/9/2005 Female 43 lb 4/4/2006 Physician United States
Primary
Concomitant
Anaphylactic Reaction Other Serious 8/26/2005 7 Female 53 lb 3/30/2006 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 16 Male 6/6/2006 Physician United States
Primary
Concomitant
Type Iv Hypersensitivity Reaction Required Intervention 6/14/2006 12 Female 104 lb 8/8/2006 Physician United States
Primary
Concomitant
Vomiting Life Threatening 8/15/2006 18 Female 124 lb 8/16/2006 Other Health Professional United States
Primary
Concomitant
Type Iv Hypersensitivity Reaction Required Intervention 7/20/2006 19 Male 146 lb 8/8/2006 Physician United States
Primary
Concomitant
Type Iv Hypersensitivity Reaction Required Intervention 6/14/2006 12 Female 104 lb 8/8/2006 Physician United States
Primary
Concomitant
Urticaria Required Intervention 7/20/2006 19 Male 146 lb 8/16/2006 Physician United States
Primary
Concomitant
Urticaria Generalised Life Threatening 7/24/2006 3 Female 33 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Skin Depigmentation Other Serious 7/25/2006 12 Female 75 lb 10/31/2006 Physician United Kingdom
Primary
Concomitant
Pleural Effusion Life Threatening 6/13/2006 61 Male 134 lb 11/23/2006 Physician Germany
Primary
Secondary
Concomitant
Systemic Inflammatory Response Syndrome Hospitalization 12/26/2002 1 Male 26 lb 12/22/2006 United States
Primary
Secondary
Urticaria Other Serious 7/24/2006 3 Female 33 lb 3/27/2007 Pharmacist United States
Primary
Concomitant
Vomiting Life Threatening 9/6/2006 3 Male 33 lb 3/27/2007 Pharmacist United States
Primary
Concomitant
Hypersensitivity Required Intervention 6/14/2006 12 Female 104 lb 3/27/2007 Other Health Professional United States
Primary
Concomitant
Hyperammonaemia Hospitalization 8/24/2006 3 Female 36 lb 3/27/2007 Pharmacist United States
Primary
Concomitant
Hyperglycaemia Other Serious 2/17/2006 9 Female 3/27/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiomyopathy Hospitalization 4/17/2007 8 Male 57 lb 6/5/2007
Primary
Secondary
Transient Ischaemic Attack Other Serious 7/6/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Required Intervention 4/13/2007 3 Female 37 lb 5/6/2008 Pharmacist United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Hospitalization 12/10/2008 26 Female 143 lb 1/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urticaria Other Serious 12/11/2008 2/13/2009 Other Health Professional France
Primary
Secondary
Concomitant
Superior Sagittal Sinus Thrombosis Hospitalization 2/25/2009 29 Female 3/17/2009 Physician United States
Primary
Concomitant
Laboratory Test Abnormal Other Serious 3/2/2009 13 Female 176 lb 3/18/2009 Physician United States
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 11/11/2008 1 Male 24 lb 3/24/2009 Physician
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Other Serious 3/4/2009 23 Male 116 lb 3/24/2009 Physician United States
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 3/2/2009 13 Female 176 lb 3/31/2009 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Life Threatening 2/24/2009 29 Female 112 lb 4/13/2009 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 3/2/2009 13 Female 176 lb 4/21/2009 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 9/3/2008 1 Female 15 lb 4/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Viral Infection Hospitalization 8/27/2008 0 Female 15 lb 4/28/2009 Physician United States
Primary
Secondary
Concomitant
Wrong Drug Administered Hospitalization 4/28/2009 Male 213 lb 5/12/2009 United States
Primary
Secondary
Concomitant
Eye Pruritus Life Threatening 4/21/2009 27 Male 166 lb 5/21/2009 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 4/28/2009 Male 213 lb 5/26/2009 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/20/2009 Male 144 lb 5/26/2009 United States
Primary
Secondary
Vomiting Hospitalization 5/26/2009 Female 152 lb 5/28/2009 Pharmacist United States
Primary
Concomitant
Pseudomonas Infection Hospitalization 5/15/2009 Male 38 lb 5/29/2009 United States
Primary
Secondary
Vomiting Hospitalization 6/14/2009 Male 35 lb 6/15/2009 United States
Primary
Secondary
Sepsis Hospitalization 5/9/2009 Female 144 lb 6/15/2009 United States
Primary
Secondary
Septic Shock Hospitalization 4/12/2009 Female 50 lb 6/15/2009 United States
Primary
Secondary
Staphylococcal Infection Other Serious 3/2/2009 13 Female 176 lb 6/29/2009 Physician United States
Primary
Secondary
Sepsis Hospitalization 5/9/2009 Female 144 lb 6/26/2009 United States
Primary
Secondary
Hepatotoxicity Other Serious 5/1/2009 24 Female 203 lb 8/6/2009 Pharmacist United States
Primary
Concomitant
Pyrexia Hospitalization 4/28/2009 Male 213 lb 8/10/2009 United States
Primary
Secondary
Concomitant
Pneumomediastinum Hospitalization 7/30/2009 Female 153 lb 8/7/2009 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 7/28/2009 Female 30 lb 8/14/2009 United States
Primary
Secondary
Shock Hospitalization 7/30/2009 15 Female 153 lb 8/14/2009 Physician United States
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 8/10/2009 Male 79 lb 8/11/2009 United States
Primary
Secondary
Rash Hospitalization 8/16/2009 Female 75 lb 8/17/2009 United States
Primary
Secondary
Pyrexia Hospitalization 8/5/2009 Female 46 lb 8/19/2009 United States
Primary
Secondary
Vomiting Hospitalization 8/17/2009 Male 170 lb 8/20/2009 United States
Primary
Secondary
Prothrombin Time Prolonged Hospitalization 7/30/2009 Female 153 lb 8/21/2009 United States
Primary
Secondary
Embolism Hospitalization 8/2/2009 15 Male 104 lb 8/27/2009 Other Health Professional United States
Primary
Secondary
Vomiting Hospitalization 8/10/2009 Male 79 lb 8/26/2009 United States
Primary
Secondary
Concomitant
Hyperglycaemia 6/4/2009 Male 170 lb 8/27/2009 United States
Primary
Secondary
Pyrexia Hospitalization 4/28/2009 Male 213 lb 8/26/2009 United States
Primary
Secondary
Concomitant
Shock Hospitalization 7/30/2009 15 Female 153 lb 9/1/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/13/2009 Male 170 lb 8/31/2009 United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 9/8/2009 Male 58 lb 9/18/2009 United States
Primary
Secondary
Low Density Lipoprotein Increased Hospitalization 7/10/2009 Female 33 lb 9/22/2009 United States
Primary
Secondary
Viral Infection Hospitalization 9/17/2009 Male 57 lb 9/22/2009 United States
Primary
Secondary
Mucosal Inflammation Hospitalization 5/26/2009 Female 139 lb 9/14/2009 United States
Primary
Secondary
Hyperglycaemia Hospitalization 9/23/2009 Male 28 lb 9/23/2009 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 9/17/2009 Male 57 lb 9/23/2009 United States
Primary
Secondary
Vomiting 9/23/2009 Female 24 lb 9/24/2009 United States
Primary
Secondary
Lipase Increased Other Serious 7/10/2009 3 Female 33 lb 9/29/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting 8/5/2009 Female 30 lb 9/30/2009 United States
Primary
Secondary
Blood Bilirubin Increased 9/21/2009 Male 47 lb 10/6/2009 United States
Primary
Secondary
Vomiting 9/23/2009 Female 24 lb 9/30/2009 United States
Primary
Secondary
Concomitant
Pneumomediastinum Hospitalization 7/30/2009 15 Female 153 lb 10/7/2009 Physician United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 9/8/2009 Male 58 lb 10/7/2009 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 9/17/2009 Male 57 lb 10/8/2009 United States
Primary
Secondary
Renal Impairment Other Serious 5/20/2009 19 Female 10/12/2009 Pharmacist New Zealand
Primary
Concomitant
Low Density Lipoprotein Increased Other Serious 7/10/2009 3 Female 33 lb 10/19/2009 Physician United States
Primary
Secondary
Concomitant
Syncope Hospitalization 7/26/2009 Female 153 lb 10/23/2009 United States
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 8/10/2009 Male 79 lb 10/22/2009 United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 7/26/2009 Female 153 lb 11/12/2009 United States
Primary
Secondary
Blood Bilirubin Abnormal Hospitalization 10/22/2009 Male 28 lb 11/23/2009 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 10/4/2009 Female 49 lb 12/3/2009 United States
Primary
Secondary
Cholecystitis Hospitalization 11/11/2009 Male 67 lb 12/2/2009 United States
Primary
Secondary
Unresponsive To Stimuli Hospitalization 11/20/2009 Female 49 lb 12/3/2009 United States
Primary
Secondary
Renal Failure Hospitalization 12/8/2009 Male 146 lb 12/10/2009 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 12/8/2009 Male 146 lb 12/16/2009 United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 5/26/2009 Female 139 lb 12/18/2009 United States
Primary
Secondary
Venous Thrombosis Hospitalization 10/4/2009 Female 49 lb 12/21/2009 United States
Primary
Secondary
Systemic Candida Hospitalization 10/4/2009 11 Female 81 lb 12/22/2009 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 12/7/2009 17 Male 146 lb 12/23/2009 Physician United States
Primary
Secondary
Concomitant
Screaming Hospitalization 10/4/2009 11 Female 81 lb 1/19/2010 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Toxicity Other Serious 17 Female 1/29/2010 Physician United States
Primary
Concomitant
Hypertriglyceridaemia Other Serious 7/10/2009 3 Female 33 lb 1/29/2010 Physician United States
Primary
Secondary
Concomitant
Withdrawal Of Life Support Death 12/28/2009 11 Male 79 lb 2/17/2010 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 12/7/2009 17 Male 146 lb 2/5/2010 Physician United States
Primary
Secondary
Concomitant
Superior Sagittal Sinus Thrombosis Life Threatening 1/7/2010 11 Male 79 lb 3/8/2010 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization 12/7/2009 17 Male 146 lb 3/11/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/14/2010 9 Male 95 lb 3/26/2010 Physician United States
Primary
Secondary
Concomitant
Wheezing Life Threatening 1/20/2009 16 Female 109 lb 3/25/2010 Physician United States
Primary
Concomitant
Shock Hospitalization 7/30/2009 15 Female 153 lb 4/7/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/14/2010 9 Male 95 lb 4/22/2010 Physician United States
Primary
Secondary
Concomitant
Paraesthesia Other Serious 13 Male 88 lb 5/3/2010 Other Health Professional Canada
Primary
Concomitant
Thrombocytopenia Other Serious 4/21/2010 42 Female 5/5/2010 Physician United States
Primary
Secondary
Thrombocytopenia Other Serious 4/21/2010 42 Female 5/13/2010 Physician United States
Primary
Secondary
Weight Decreased Hospitalization 3/14/2010 9 Male 95 lb 5/21/2010 Physician United States
Primary
Secondary
Concomitant
Staphylococcus Test Positive Hospitalization 5/29/2010 14 Female 104 lb 6/8/2010 Pharmacist United States
Primary
Secondary
Ocular Icterus Hospitalization 5/28/2010 16 Male 227 lb 6/15/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/14/2010 9 Male 95 lb 6/22/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/12/2010 32 Male 216 lb 7/21/2010 United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 3/2/2009 13 Female 144 lb 7/30/2010 Physician United States
Primary
Secondary
International Normalised Ratio Increased Hospitalization 5/28/2010 16 Male 227 lb 8/3/2010 Physician United States
Primary
Secondary
Concomitant
Viith Nerve Paralysis Hospitalization 21 Male 8/10/2010 Other Health Professional United States
Primary
Secondary
Neutrophil Count Abnormal 6/19/2009 18 Male 143 lb 8/12/2010 Physician United States
Primary
Secondary
Scoliosis Hospitalization 12/7/2009 17 Male 146 lb 8/12/2010 Physician United States
Primary
Secondary
Concomitant
Ocular Icterus Other Serious 5/28/2010 16 Male 227 lb 8/18/2010 Physician United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 5/28/2010 16 Male 227 lb 8/18/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/19/2009 16 Female 153 lb 9/2/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/6/2010 45 Male 9/14/2010 Physician Canada
Primary
Secondary
Concomitant
Scoliosis Hospitalization 12/7/2009 17 Male 146 lb 10/1/2010 Physician United States
Primary
Secondary
Concomitant
Low Density Lipoprotein Increased Other Serious 7/10/2009 3 Female 33 lb 10/13/2010 Physician United States
Primary
Secondary
Concomitant
Blood Glucose Increased Hospitalization 9/17/2010 20 Female 95 lb 10/15/2010 United States
Primary
Secondary
Weight Decreased Hospitalization 3/14/2010 9 Male 95 lb 10/19/2010 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 10/14/2010 32 Male 10/25/2010 Physician United States
Primary
Secondary
Concomitant
Intracranial Venous Sinus Thrombosis Hospitalization 5/26/2010 31 Male 10/25/2010 Physician United States
Primary
Secondary
Pneumomediastinum Hospitalization 7/30/2009 15 Female 153 lb 10/26/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10/17/2010 23 Female 228 lb 10/20/2010 Physician United States
Primary
Concomitant
Pneumothorax Hospitalization 11/5/2010 39 Male 223 lb 11/16/2010 United States
Primary
Secondary
Pneumomediastinum Hospitalization 7/30/2009 15 Female 153 lb 11/11/2010 Physician United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 5/28/2010 16 Male 227 lb 11/11/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10/17/2010 23 Female 228 lb 11/16/2010 Physician United States
Primary
Concomitant
Cerebral Venous Thrombosis Other Serious 8/26/2005 10 Male 79 lb 11/15/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/14/2010 11/19/2010 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/18/2010 9 Male 69 lb 11/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wrong Drug Administered Hospitalization 10/19/2010 15 Male 304 lb 11/24/2010 Physician United States
Primary
Secondary
Concomitant
Blood Bilirubin Increased 11/3/2010 20 Female 94 lb 12/15/2010 United States
Primary
Secondary
Vomiting Other Serious 10/17/2010 23 Female 228 lb 12/9/2010 Physician United States
Primary
Secondary
Dialysis Hospitalization 12/31/2010 14 Male 107 lb 1/5/2011 Other Health Professional Canada
Primary
Secondary
Proteinuria Hospitalization 11/22/2010 13 Female 98 lb 1/20/2011 Physician United States
Primary
Secondary
Concomitant
Hyperbilirubinaemia Hospitalization 12/3/2010 11 Male 117 lb 1/25/2011 United States
Primary
Secondary
Blood Glucose Increased 11/26/2010 20 Female 120 lb 1/26/2011
Primary
Secondary
International Normalised Ratio Decreased Hospitalization 11/2/2010 16 Male 126 lb 2/3/2011 United States
Primary
Secondary
Venous Stenosis Hospitalization 2/2/2011 8 Female 71 lb 2/4/2011 United States
Primary
Secondary
Proteinuria Hospitalization 11/22/2010 13 Female 98 lb 2/8/2011 Physician United States
Primary
Secondary
Concomitant
Hepatic Steatosis Hospitalization 5/28/2010 16 Male 227 lb 2/15/2011 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/22/2010 13 Female 98 lb 2/15/2011 Physician United States
Primary
Secondary
Concomitant
Pulmonary Infarction Hospitalization 8/6/2010 45 Male 2/22/2011 Physician Canada
Primary
Secondary
Hyperbilirubinaemia Hospitalization 2/3/2011 16 Male 124 lb 2/28/2011 Physician United States
Primary
Secondary
Concomitant
Platelet Count Decreased Death 3/3/2011 14 Female 90 lb 3/16/2011 Physician United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization 12/20/2010 15 Female 143 lb 3/21/2011 Physician United States
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 2/2/2011 8 Female 71 lb 3/22/2011 United States
Primary
Secondary

Drug Data