Methotrexate combined with Nitroglycerin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Renal Artery Stent Placement Hospitalization 4/1/2005 Female 1/3/2006 Physician United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 9/1/2005 Female 3/1/2006 Physician United States
Primary
Concomitant
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Death 1/1/2005 Female 3/29/2006 Physician United States
Primary
Concomitant
Urinary Retention 57 Female 4/28/2006 Consumer United States
Primary
Secondary
Concomitant
Sepsis Death 2/7/2006 59 Male 5/3/2006 Pharmacist United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 9/1/2005 Male 5/26/2006 Physician United States
Primary
Concomitant
Arteriosclerosis Coronary Artery Hospitalization 2/27/2006 Female 5/26/2006 Physician United States
Primary
Concomitant
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 5/31/2006 Physician United Kingdom
Primary
Concomitant
Sleep Disorder Disability 4/6/2006 65 Female 97 lb 6/7/2006 Pharmacist United Kingdom
Primary
Concomitant
Somnolence Hospitalization 6/6/2006 53 Male 6/21/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 8/1/2005 Female 7/10/2006 Physician United States
Primary
Concomitant
Lymphocytic Lymphoma Other Serious 5/17/2005 Male 164 lb 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 5/1/2005 63 Female 157 lb 11/28/2006 Physician United States
Primary
Concomitant
Osteonecrosis Required Intervention 8/2/2006 54 Female 202 lb 1/12/2007 Other Health Professional United States
Primary
Concomitant
Oesophageal Adenocarcinoma Death Male 1/25/2007 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 119 lb 3/20/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Coronary Artery Occlusion Life Threatening 1/12/2007 72 Female 226 lb 3/21/2007 Other Health Professional United States
Primary
Concomitant
Respiratory Arrest Death 11/22/2006 77 Female 3/26/2007 Physician United States
Primary
Secondary
Concomitant
Delirium Other Serious 3/13/2007 70 Male 169 lb 3/28/2007 Pharmacist United States
Primary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 5/18/2007 Consumer United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 1/4/2006 79 Female 150 lb 5/23/2007 Other Health Professional United States
Primary
Concomitant
Lower Limb Fracture Other Serious 5/17/2007 Female 5/25/2007 Physician United States
Primary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 6/13/2007 Consumer United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 46 Female 7/11/2007 Consumer United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 Female 331 lb 7/23/2007 Consumer United States
Primary
Secondary
Concomitant
Somnolence 3/1/2007 Female 300 lb 8/29/2007 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 5/3/2007 Female 331 lb 9/11/2007 Consumer United States
Primary
Secondary
Concomitant
Rheumatoid Lung Hospitalization 8/1/2007 82 Female 154 lb 10/4/2007 Consumer United States
Primary
Concomitant
Haemoglobin Decreased Other Serious 4/1/2007 71 Female 10/16/2007 Physician Canada
Primary
Concomitant
Interacting
Haemoglobin Decreased Other Serious 4/1/2007 71 Female 10/18/2007 Physician Canada
Primary
Concomitant
Interacting
Meningitis Aseptic Hospitalization 62 Male 10/25/2007
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 10/5/2007 68 Male 11/6/2007 Consumer United States
Primary
Concomitant
Spinal Laminectomy Other Serious 1/1/1999 Male 180 lb 11/14/2007 Consumer United States
Primary
Concomitant
Urosepsis Other Serious 10/1/2007 Female 11/20/2007 Other Health Professional Canada
Primary
Concomitant
Shock Hospitalization 10/21/2007 Male 84 lb 11/13/2007 United States
Primary
Secondary
Concomitant
Tenosynovitis Other Serious 62 Male 11/28/2007 Pharmacist Canada
Primary
Concomitant
Septic Shock Hospitalization 10/21/2007 Male 84 lb 11/27/2007 United States
Primary
Secondary
Concomitant
Prostate Cancer Other Serious 1/1/2007 Male 267 lb 12/6/2007 Physician United States
Primary
Concomitant
Foreign Body Trauma Other Serious 1/1/2007 Female 12/12/2007 Pharmacist United States
Primary
Secondary
Concomitant
Osteoarthritis Other Serious 12/1/2007 Female 2/6/2008 Physician United States
Primary
Concomitant
Vestibular Disorder Other Serious 1/1/2005 Female 2/15/2008 Other Health Professional Canada
Primary
Concomitant
Shock Hospitalization 10/21/2007 Male 84 lb 2/20/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 3/27/2008 Physician Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 5/12/2008 Physician Canada
Primary
Secondary
Concomitant
Vomiting Other Serious 5/8/2008 Male 153 lb 6/19/2008 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 12/23/2002 Female 6/24/2008 Physician United States
Primary
Secondary
Concomitant
Death Other Serious 80 Female 163 lb 6/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Muscle Spasms 5/1/2008 58 Female 240 lb 6/30/2008 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 2/1/2008 Female 142 lb 7/3/2008 Consumer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 8/13/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/7/2008 60 Female 8/14/2008 Other Health Professional Canada
Primary
Secondary
Concomitant
Myocardial Ischaemia Death 1/11/2008 Female 163 lb 8/15/2008 United Kingdom
Primary
Concomitant
Upper Limb Fracture Hospitalization 5/26/2008 Female 99 lb 9/3/2008 United Kingdom
Primary
Concomitant
Injection Site Swelling 5/1/2008 Female 9/12/2008 Consumer United States
Primary
Concomitant
Joint Swelling 5/1/2008 Female 156 lb 9/12/2008 United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/1/2007 Male 202 lb 9/18/2008 Physician United States
Primary
Concomitant
Muscle Spasms 5/15/2008 58 Female 240 lb 9/25/2008 Other Health Professional United States
Primary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 143 lb 11/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Visual Acuity Reduced 12/17/2007 Female 12/11/2008 Consumer United States
Primary
Concomitant
Pyrexia 10/12/2008 Female 12/12/2008 Consumer United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious 80 Female 163 lb 1/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Synovial Cyst Other Serious 6/20/2008 Female 211 lb 1/27/2009 Canada
Primary
Concomitant
Respiratory Disorder Other Serious 12/9/2008 Female 154 lb 1/30/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2008 Male 185 lb 2/9/2009 Physician United States
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2008 Male 185 lb 2/20/2009 Physician United States
Primary
Concomitant
Dyspepsia Hospitalization 10/27/2008 68 Female 2/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection 10/25/2008 Female 3/14/2009 United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 1/1/2008 61 Male 5/5/2009 Other Health Professional United Kingdom
Primary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 1/27/2009 35 Female 345 lb 5/21/2009 Physician United States
Primary
Concomitant
Necrosis Other Serious 7/10/2007 Female 159 lb 7/17/2009 United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 68 Female 8/10/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 68 Female 8/13/2009 Consumer United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 68 Female 8/23/2009 Lawyer United States
Primary
Concomitant
Unevaluable Event Death Male 8/28/2009 United States
Primary
Concomitant
Unevaluable Event Death Male 8/31/2009 United States
Primary
Concomitant
Throat Irritation Hospitalization 4/1/2009 Male 214 lb 9/11/2009 Consumer United States
Primary
Secondary
Concomitant
Throat Irritation Hospitalization 4/1/2009 Male 214 lb 9/14/2009 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/1/2005 Male 9/18/2009 United States
Primary
Concomitant
Drug Dose Omission 6/16/2009 Male 237 lb 9/19/2009 United States
Primary
Concomitant
Urinary Tract Infection 7/31/2009 Female 180 lb 9/19/2009 Physician
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/27/2008 93 Female 9/15/2009 United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 68 Female 9/17/2009 United States
Primary
Concomitant
Renal Failure Hospitalization 1/1/2008 71 Female 179 lb 9/29/2009 Lawyer United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/27/2008 93 Female 9/24/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Death Male 9/22/2009 United States
Primary
Concomitant
Oesophageal Perforation Other Serious 4/1/2009 Female 185 lb 10/16/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 61 Male 10/22/2009 United States
Primary
Concomitant
Renal Failure Death Male 11/16/2009 United Kingdom
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/27/2008 93 Female 11/17/2009 United States
Primary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 1/27/2009 35 Female 345 lb 12/1/2009 Physician United States
Primary
Concomitant
Osteonecrosis Disability 12/1/2007 57 Female 11/25/2009 United States
Primary
Concomitant
Upper Limb Fracture Other Serious 1/1/2004 Female 1/8/2010 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 2/24/2009 Female 1/21/2010 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 2/24/2009 Female 1/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 74 Female 1/20/2010 United States
Primary
Concomitant
Drug Effect Decreased 11/1/2008 Female 144 lb 1/29/2010 Physician United States
Primary
Concomitant
Sputum Discoloured Other Serious 1/1/2008 Female 180 lb 2/26/2010 United States
Primary
Concomitant
Vulvovaginal Pain Hospitalization 2/16/2010 Female 3/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Scab Hospitalization 2/16/2010 Female 3/9/2010 Japan
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 74 Female 3/5/2010 Lawyer United States
Primary
Concomitant
Scab Hospitalization 2/16/2010 Female 3/22/2010 Japan
Primary
Secondary
Concomitant
Lung Neoplasm Other Serious 6/1/2009 66 Female 255 lb 4/6/2010 Physician United States
Primary
Concomitant
Heart Rate Increased Other Serious 4/1/2010 57 Female 245 lb 4/13/2010 Consumer United States
Primary
Concomitant
Lung Neoplasm Other Serious 6/1/2009 66 Female 255 lb 4/30/2010 Physician United States
Primary
Concomitant
Gastrooesophageal Reflux Disease 76 Female 5/3/2010 Consumer United States
Primary
Concomitant
Palpitations 3/6/2009 76 Female 144 lb 5/3/2010 Consumer United States
Primary
Secondary
Concomitant
Drug Level Increased 76 Female 5/28/2010 Consumer United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2010 76 Female 6/3/2010 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2010 76 Female 6/23/2010 Consumer United States
Primary
Secondary
Concomitant
Sjogren's Syndrome Other Serious Female 6/25/2010 Consumer United States
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 4/1/2010 68 Female 180 lb 6/25/2010 Consumer Canada
Primary
Concomitant
Coronary Artery Bypass Life Threatening 5/12/2010 74 Male 184 lb 6/28/2010 Physician United States
Primary
Concomitant
Staphylococcal Infection Life Threatening 5/12/2010 80 Male 184 lb 6/29/2010 Physician United States
Primary
Concomitant
Coronary Artery Disease Life Threatening 5/13/2010 80 Male 184 lb 7/6/2010 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2008 87 Female 133 lb 7/21/2010 Physician United States
Primary
Concomitant
Rhabdomyolysis Other Serious 2/9/2009 57 Female 154 lb 7/23/2010 Physician United States
Primary
Concomitant
Coronary Artery Disease Life Threatening 5/13/2010 74 Male 184 lb 7/30/2010 Physician United States
Primary
Concomitant
Staphylococcal Skin Infection Life Threatening 5/13/2010 74 Male 184 lb 8/9/2010 Other Health Professional United States
Primary
Concomitant
Synovitis Other Serious 5/1/2007 66 Male 8/10/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 4/1/2008 56 Female 154 lb 8/12/2010 Physician United States
Primary
Concomitant
Tinea Versicolour Hospitalization 3/28/2010 82 Male 8/13/2010 Physician United States
Primary
Secondary
Concomitant
Wrong Technique In Drug Usage Process Hospitalization 12/1/2007 80 Female 212 lb 8/23/2010 Consumer United States
Primary
Concomitant
Tooth Disorder Hospitalization 1/1/2007 57 Female 9/8/2010 Other Health Professional United States
Primary
Concomitant
Swollen Tongue Other Serious 9/5/2010 52 Female 120 lb 9/5/2010 United States
Primary
Secondary
Concomitant
Pain 8/1/2009 65 Female 150 lb 9/14/2010 Other Health Professional United States
Primary
Concomitant
Wheezing Other Serious 4/1/2008 56 Female 154 lb 9/16/2010 Physician United States
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 1/1/2010 81 Female 91 lb 9/24/2010 Other Health Professional Canada
Primary
Concomitant
Tooth Disorder Hospitalization 1/1/2007 57 Female 9/30/2010 Other Health Professional United States
Primary
Concomitant
Stent Placement Other Serious 9/1/2010 55 Male 320 lb 10/8/2010 Other Health Professional United States
Primary
Concomitant
Tooth Infection Other Serious 1/1/2007 57 Female 10/14/2010 Other Health Professional United States
Primary
Concomitant
Stent Placement Other Serious 9/1/2010 55 Male 320 lb 11/1/2010 Other Health Professional United States
Primary
Concomitant
Wheezing Other Serious 4/1/2008 56 Female 154 lb 11/1/2010 Physician United States
Primary
Secondary
Concomitant
Wheezing Other Serious 4/1/2008 56 Female 154 lb 11/3/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 7/31/2004 57 Female 181 lb 11/15/2010 Other Health Professional United States
Primary
Concomitant
Arteriosclerosis Coronary Artery Death 11/24/2010 Physician United Kingdom
Primary
Concomitant
Urticaria Other Serious 10/19/2010 46 Female 11/25/2010 Physician United States
Primary
Concomitant
Sensory Loss Death 4/1/2003 Male 231 lb 11/29/2010 Physician New Zealand
Primary
Concomitant
Suicide Attempt Other Serious 6/1/2007 45 Male 12/7/2010 Lawyer United States
Primary
Concomitant
Coronary Artery Disease Life Threatening 5/13/2010 74 Male 184 lb 12/15/2010 Other Health Professional United States
Primary
Concomitant
Coronary Artery Disease Life Threatening 5/13/2010 74 Male 184 lb 12/17/2010 Other Health Professional United States
Primary
Concomitant
Vulvovaginal Candidiasis Other Serious 1/1/2010 48 Female 256 lb 12/17/2010 Consumer United States
Primary
Concomitant
Tardive Dyskinesia Disability 11/29/2010 60 Female 204 lb 12/8/2010 Physician United States
Primary
Concomitant
Dyspepsia Hospitalization 11/17/2010 60 Female 175 lb 1/5/2011 Consumer United States
Primary
Concomitant
Blood Creatine Abnormal Other Serious 10/19/2010 46 Female 1/12/2011 Physician United States
Primary
Concomitant
Latent Tuberculosis Other Serious 2/1/2010 53 Male 200 lb 1/28/2011 United States
Primary
Concomitant
Injection Site Haemorrhage 1/1/2009 59 Female 150 lb 1/29/2011 Consumer United States
Primary
Concomitant
Influenza Like Illness Life Threatening 3/6/2009 76 Female 144 lb 2/8/2011 Consumer United States
Primary
Secondary
Concomitant
Constipation Hospitalization 8/1/2009 71 Female 3/1/2011 Consumer United States
Primary
Concomitant
Interacting
Chronic Obstructive Pulmonary Disease Other Serious 1/1/2005 57 Female 181 lb 3/10/2011 Other Health Professional United States
Primary
Concomitant

Drug Data