Methotrexate combined with Neoral

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pneumonia Hospitalization 7/5/2005 58 Male 1/20/2006 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 8/5/2002 8 Male 2/7/2006 Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 6/1/2005 8 Male 104 lb 2/10/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/1/2004 Female 2/22/2006 Physician United States
Primary
Concomitant
Tonic Convulsion Other Serious 6/1/2005 8 Male 104 lb 2/17/2006 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization 1/1/1999 37 Female 148 lb 2/28/2006 Physician United States
Primary
Concomitant
Wound Dehiscence Hospitalization 63 Male 3/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 14 Male 3/4/2006 Japan
Primary
Concomitant
Weight Decreased Other Serious 15 Male 3/4/2006 Japan
Primary
Concomitant
Graft Versus Host Disease Other Serious 1/1/2005 49 Female 3/4/2006 Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 12/28/2004 75 Male 3/6/2006 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 7/1/2005 14 Male 3/21/2006 Japan
Primary
Secondary
Cytomegalovirus Viraemia Life Threatening 4/21/2004 1 Male 18 lb 3/23/2006 Physician Japan
Primary
Secondary
Concomitant
Trichosporon Infection Other Serious 1/1/2004 30 Male 3/29/2006 Japan
Primary
Secondary
Concomitant
Wound Dehiscence Life Threatening 63 Male 3/24/2006 Consumer United Kingdom
Primary
Secondary
Tuberculosis Other Serious 8/1/2003 71 Male 117 lb 4/20/2006 Physician France
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 3/13/2006 47 Female 104 lb 7/26/2006 Physician Japan
Primary
Concomitant
Renal Neoplasm Hospitalization 3/1/2006 67 Female 8/4/2006 Physician Belgium
Primary
Concomitant
Weight Decreased Hospitalization 12/30/2004 75 Male 8/2/2006 Physician France
Primary
Secondary
Concomitant
Myositis Hospitalization 4/19/2006 46 Male 198 lb 8/22/2006 France
Primary
Secondary
Concomitant
Tachycardia Other Serious 8/24/2006 Female 9/1/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 1/1/2002 32 Female 9/5/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Oesophageal Carcinoma Death 8/17/2006 Male 174 lb 9/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 51 Male 9/21/2006 France
Primary
Secondary
Concomitant
Serum Ferritin Increased Other Serious 4 Female 10/23/2006 Japan
Primary
Secondary
Concomitant
Malignant Melanoma Life Threatening 6/1/2006 60 Female 128 lb 10/31/2006 Physician Greece
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 1/1/2006 64 Female 11/1/2006 Japan
Primary
Concomitant
Renal Impairment Other Serious 5/1/2004 58 Male 11/3/2006 Japan
Primary
Concomitant
Malignant Melanoma Other Serious 6/1/2006 60 Female 128 lb 11/7/2006 Other Health Professional Greece
Primary
Secondary
Concomitant
Rheumatoid Arthritis Death 7/10/2006 Male 174 lb 11/7/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Hospitalization 4/19/2006 46 Male 198 lb 11/2/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Tongue Neoplasm Malignant Stage Unspecified Other Serious 10/1/2006 Male 141 lb 12/7/2006 Physician Canada
Primary
Concomitant
Malignant Melanoma Life Threatening 6/1/2006 60 Female 128 lb 12/19/2006 Physician Greece
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 4/19/2006 46 Male 198 lb 12/11/2006 Physician France
Primary
Secondary
Concomitant
Mucous Stools Other Serious 4 Female 1/3/2007 Japan
Primary
Concomitant
Thrombophlebitis Other Serious 1/1/2003 34 Female 1/5/2007 Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/1/2004 49 Male 2/10/2007 Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 2/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 2/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 86 lb 2/23/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/12/2001 23 Female 2/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 4/25/2003 46 Male 128 lb 3/5/2007 Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 8/5/2002 8 Male 3/23/2007 Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 6/1/2005 Male 104 lb 3/27/2007 Japan
Primary
Secondary
Concomitant
Rash Other Serious 4/25/2003 46 Male 128 lb 4/3/2007 Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 8/5/2002 8 Male 4/3/2007 Japan
Primary
Secondary
Concomitant
Viral Pharyngitis Other Serious 8/26/2005 19 Male 5/11/2007 Poland
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Viral Dna Test Positive Other Serious 7/11/2004 15 Male 73 lb 6/22/2007 Japan
Primary
Secondary
Concomitant
Glioblastoma Multiforme Other Serious 5/15/2006 Male 179 lb 8/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 6/1/2007 54 Female 8/31/2007 Pharmacist Netherlands
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 6/1/2007 54 Female 9/22/2007 Pharmacist Netherlands
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 7/3/2003 1 Male 19 lb 10/17/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/5/2007 46 Female 10/27/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/5/2007 46 Female 10/27/2007 Japan
Primary
Secondary
Concomitant
Peritonitis Other Serious 9/17/2007 71 Male 11/23/2007 Other Health Professional Serbia
Primary
Secondary
Tongue Neoplasm Malignant Stage Unspecified Other Serious 2/1/2007 Female 12/6/2007 Physician United States
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/1/2001 52 Male 12/21/2007 Japan
Primary
Concomitant
Renal Transplant Other Serious 11/1/2005 22 Female 12/21/2007 Japan
Primary
Concomitant
Lymph Node Tuberculosis Hospitalization 5/19/2007 Male 139 lb 1/2/2008 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 60 Female 1/25/2008 Other Health Professional United States
Primary
Concomitant
Glioblastoma Multiforme Other Serious 5/15/2006 Male 179 lb 1/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Nausea Other Serious 9/26/2007 59 Male 121 lb 2/6/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Disorder Hospitalization 8/15/2007 Female 165 lb 2/27/2008 Physician United Kingdom
Primary
Concomitant
Rash Other Serious 12/1/2006 56 Male 3/11/2008 Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 11/1/2005 55 Male 3/13/2008 Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 1/1/2003 11 Male 3/18/2008 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 7/30/2007 Male 141 lb 4/3/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 1/25/2008 Female 132 lb 4/15/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/17/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 59 Female 5/28/2008 Other Health Professional United States
Primary
Concomitant
Post Procedural Infection Hospitalization 8/15/2007 Female 165 lb 6/11/2008 Physician United Kingdom
Primary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 7/15/2008 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 1/25/2008 Female 7/16/2008 Other Health Professional United Kingdom
Primary
Concomitant
Graft Versus Host Disease Other Serious 58 Male 8/28/2008 Other Health Professional Japan
Primary
Secondary
Pneumothorax Other Serious 20 Female 8/28/2008 Other Health Professional Japan
Primary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 1/1/2002 83 Male 10/22/2008 Other Health Professional Japan
Primary
Secondary
Thrombosis Other Serious 1/1/2007 61 Female 10/30/2008 Physician United States
Primary
Concomitant
Pyrexia Other Serious 20 Female 11/19/2008 Other Health Professional Japan
Primary
Concomitant
Engraftment Syndrome Other Serious 10 Female 12/1/2008 Japan
Primary
Secondary
Concomitant
Type 1 Diabetes Mellitus Other Serious 11/21/2005 61 Female 12/8/2008 Physician United States
Primary
Concomitant
Stomatitis Hospitalization 6/18/2007 27 Female 12/17/2008 Japan
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 10/6/2004 Male 143 lb 12/23/2008 Physician Japan
Primary
Secondary
Concomitant
Venous Thrombosis Limb Other Serious 9/28/2004 61 Female 12/18/2008 Physician United States
Primary
Concomitant
Engraftment Syndrome Other Serious 4/1/2008 10 Female 1/15/2009 Japan
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 10/6/2004 Male 143 lb 1/16/2009 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 7/30/2007 Male 141 lb 2/2/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/19/2008 Male 48 lb 2/13/2009 Physician Japan
Primary
Secondary
Concomitant
Sclerema Other Serious 10/1/2004 2/18/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Tubular Disorder Hospitalization 1/1/1997 56 Male 2/20/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2008 10 Female 2/23/2009 Japan
Primary
Secondary
Concomitant
Toxic Encephalopathy Other Serious 1/1/2003 11 Male 3/24/2009 Japan
Primary
Concomitant
Pyrexia Hospitalization 9/1/2008 48 Male 4/1/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Sinusitis Hospitalization 2/26/2008 16 Male 117 lb 4/3/2009 Physician Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 1/1/2003 11 Female 4/4/2009 Japan
Primary
Concomitant
Sinusitis Hospitalization 2/26/2008 16 Male 117 lb 4/6/2009 Physician Japan
Primary
Concomitant
Splenic Neoplasm Malignancy Unspecified Other Serious 11/24/2005 Male 154 lb 4/8/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2008 16 Male 117 lb 4/14/2009 Physician Japan
Primary
Concomitant
Swollen Tongue Other Serious 1/1/2007 16 Male 4/24/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 59 Female 5/5/2009 Other Health Professional United States
Primary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 3/12/2009 61 Male 117 lb 5/29/2009 Physician Japan
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 6/28/2008 65 Male 148 lb 6/1/2009 Physician Japan
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 9/26/2008 46 Male 123 lb 6/5/2009 Physician Jordan
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 9/26/2008 46 Male 123 lb 6/8/2009 Physician Jordan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Disability 4/29/2008 58 Male 6/8/2009 Physician Japan
Primary
Secondary
Concomitant
Nausea Other Serious 10/27/2008 58 Female 106 lb 6/9/2009 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/1999 59 Female 6/9/2009 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Death 73 Female 6/12/2009 Other Health Professional Japan
Primary
Concomitant
Urinary Tract Infection Death 73 Female 6/17/2009 Other Health Professional Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 73 Female 6/18/2009 Other Health Professional Japan
Primary
Concomitant
Vomiting Other Serious 7/1/2008 Female 93 lb 7/22/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 7/1/2008 Female 93 lb 8/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/18/2008 26 Female 117 lb 8/5/2009 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 1/1/2008 Female 112 lb 8/11/2009 Canada
Primary
Concomitant
Pneumonia Hospitalization 9/19/2008 Male 48 lb 8/31/2009 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 57 Female 9/4/2009 Other Health Professional Japan
Primary
Concomitant
Nausea Other Serious 10/29/2008 58 Female 106 lb 9/8/2009 Physician Japan
Primary
Secondary
Concomitant
Splenic Neoplasm Malignancy Unspecified Other Serious 6/18/2005 Male 154 lb 9/8/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Other Serious 50 Male 9/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Nausea Other Serious 10/29/2008 58 Female 106 lb 9/15/2009 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/18/2008 26 Female 117 lb 9/15/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 12 Male 9/18/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 12 Male 9/18/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Pregnancy Hospitalization 8/29/2005 25 Female 9/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sinusitis Hospitalization 1/1/2008 16 Male 117 lb 9/28/2009 Physician Japan
Primary
Secondary
Concomitant
Retinal Artery Thrombosis Other Serious 8/4/2009 63 Female 168 lb 9/29/2009 Other Health Professional United Kingdom
Primary
Concomitant
Cholelithiasis Hospitalization 12/25/2007 30 Male 145 lb 10/12/2009 Physician Japan
Primary
Secondary
Concomitant
Nasal Disorder Hospitalization Male 201 lb 10/14/2009 United Kingdom
Primary
Concomitant
Rash Life Threatening 2/27/2009 57 Male 126 lb 10/26/2009 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Surgery Other Serious 1/1/2008 73 Male 10/27/2009 Physician Belgium
Primary
Concomitant
Tooth Abscess Other Serious 1/1/2002 Male 233 lb 11/9/2009 Physician United States
Primary
Concomitant
Non-hodgkin's Lymphoma Death 7/17/2009 Male 174 lb 11/10/2009 United Kingdom
Primary
Concomitant
Sinusitis 11/10/2008 Female 12/2/2009 Consumer United States
Primary
Concomitant
Wound Dehiscence Other Serious 1/1/2002 Male 233 lb 12/17/2009 Physician United States
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 7/30/2007 Male 141 lb 12/23/2009 Physician Japan
Primary
Secondary
Concomitant
Rash Generalised Life Threatening 4/1/2008 55 Male 126 lb 1/22/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 7/1/2008 Female 93 lb 2/5/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 7/30/2007 Male 141 lb 2/25/2010 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 6/8/2008 2 Male 3/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 6/8/2008 2 Male 3/3/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 7/1/2008 Female 93 lb 3/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Alopecia Universalis Other Serious 9/14/2009 23 Female 203 lb 4/19/2010 Physician Greece
Primary
Secondary
Concomitant
Septic Shock Life Threatening 7/7/2008 15 Female 95 lb 5/19/2010 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 2/28/2007 36 Female 5/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/28/2007 36 Female 5/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Psoriasis Hospitalization Male 6/16/2010 Other Health Professional Australia
Primary
Secondary
Concomitant
Colitis Hospitalization 2/15/2010 56 Female 198 lb 6/22/2010 Physician United Kingdom
Primary
Concomitant

Drug Data