Methotrexate combined with Morphine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Post Procedural Complication Death 34 Male 2/7/2006 Physician Japan
Primary
Concomitant
Hemiplegia Death 34 Male 2/16/2006 Physician Japan
Primary
Concomitant
Joint Arthroplasty Hospitalization 5/10/2004 Female 165 lb 2/28/2006 Physician Germany
Primary
Concomitant
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Sedation Hospitalization 6/16/2003 49 Female 231 lb 3/23/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 3/28/2006 Lawyer United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 4/10/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 5/24/2005 83 Female 3/24/2006 Canada
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 5/8/2006 Physician Germany
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2003 57 Male 5/9/2006 Australia
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/11/2006 Male 5/16/2006 Pharmacist United States
Primary
Secondary
Concomitant
Ovarian Cancer Metastatic Life Threatening 3/15/2004 Female 143 lb 5/31/2006 Physician United Kingdom
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 6/7/2006 Physician Germany
Primary
Concomitant
Human Herpesvirus 6 Infection Death 34 Male 5/23/2006 Physician Japan
Primary
Concomitant
Tachycardia Hospitalization 6/13/2006 33 Female 214 lb 6/28/2006 Other Health Professional United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 10/1/2005 Female 7/10/2006 Physician United States
Primary
Concomitant
Mucous Membrane Disorder Hospitalization 8/26/2004 8 Male 51 lb 7/21/2006 Physician Japan
Primary
Concomitant
Lung Adenocarcinoma Hospitalization 12/12/2005 Male 8/1/2006 Physician United States
Primary
Concomitant
Pustular Psoriasis Other Serious 5/31/2006 51 Female 185 lb 8/7/2006 Other Health Professional France
Primary
Concomitant
Sinus Tachycardia Hospitalization 6/13/2006 33 Female 214 lb 8/3/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 6/13/2006 33 Female 214 lb 8/3/2006 Physician United States
Primary
Concomitant
Ovarian Cancer Other Serious 9/9/2004 Female 9/26/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 8/7/2006 48 Female 9/21/2006 Physician United States
Primary
Secondary
Concomitant
Mouth Ulceration Other Serious 7/1/2006 Female 106 lb 9/6/2006 Other Health Professional United States
Primary
Concomitant
Stomatitis Other Serious 7/1/2006 Female 165 lb 10/9/2006 Physician Belgium
Primary
Concomitant
Heart Rate Increased 5/15/2006 55 Female 7/31/2006 Consumer United States
Primary
Concomitant
Skin Infection Hospitalization 5/1/2005 Female 305 lb 10/19/2006 Physician United States
Primary
Concomitant
Urosepsis Hospitalization 8/26/2006 Female 11/10/2006 Physician United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/12/2006 Female 165 lb 12/12/2006 Physician Belgium
Primary
Concomitant
Urosepsis Hospitalization 8/26/2006 Female 12/20/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 11/11/2006 68 Female 2/9/2007 Brazil
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/11/2006 68 Female 2/20/2007 Physician Brazil
Primary
Secondary
Concomitant
Panic Reaction Hospitalization 10/1/2006 Female 3/14/2007 Physician United States
Primary
Concomitant
Pancytopenia Death 3/10/2007 37 Female 165 lb 3/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Palpitations 54 Female 196 lb 3/27/2007 Consumer United States
Primary
Concomitant
Juvenile Arthritis Hospitalization 8/9/2005 Female 4/19/2007 Physician United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2004 46 Female 112 lb 5/8/2007 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2004 46 Female 112 lb 5/10/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 4/30/2007 Female 263 lb 5/22/2007 Consumer Canada
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2004 46 Female 112 lb 5/25/2007 Physician United States
Primary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 121 lb 5/29/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Surgery Other Serious 1/1/2007 Male 168 lb 5/30/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 4/30/2007 Female 263 lb 6/9/2007 Physician Canada
Primary
Concomitant
Palpitations 2/23/2007 54 Female 196 lb 6/25/2007 Consumer United States
Primary
Concomitant
Renal Impairment Hospitalization Female 6/26/2007 Consumer Canada
Primary
Concomitant
Pulmonary Congestion Other Serious 1/1/2004 46 Female 112 lb 6/29/2007 Physician United States
Primary
Concomitant
Pulmonary Congestion Other Serious 1/1/2004 46 Female 112 lb 7/3/2007 Physician United States
Primary
Concomitant
Non-hodgkin's Lymphoma Life Threatening 3/16/2007 Female 7/5/2007 Physician United States
Primary
Concomitant
Urinary Retention Hospitalization 1/1/2007 84 Female 6/29/2007 Physician Canada
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 7/12/2007 Physician Germany
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Life Threatening 3/16/2007 Female 7/17/2007 Physician United States
Primary
Concomitant
Pulmonary Congestion Other Serious 1/1/2004 46 Female 112 lb 7/24/2007 Physician United States
Primary
Concomitant
Pulmonary Congestion Other Serious 1/1/2004 46 Female 112 lb 8/2/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Tuberculosis Other Serious 12/27/1999 46 Female 112 lb 8/7/2007 Physician United States
Primary
Concomitant
Urinary Retention Hospitalization 1/1/2007 84 Female 8/13/2007 Physician Canada
Primary
Concomitant
Urinary Retention Hospitalization 1/1/2007 84 Female 8/29/2007 Physician Canada
Primary
Concomitant
Thrombocytopenia Other Serious 20 Male 9/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Head Injury Other Serious 8/1/2007 84 Female 9/14/2007 Consumer Canada
Primary
Concomitant
Urinary Retention Hospitalization 5/1/2007 84 Female 9/13/2007 Physician Canada
Primary
Concomitant
Systemic Lupus Erythematosus Death Male 9/20/2007 Consumer United States
Primary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/27/1999 46 Female 112 lb 9/27/2007 Physician United States
Primary
Concomitant
Renal Failure Life Threatening 8/16/2007 Male 9/27/2007 Australia
Primary
Concomitant
Subdural Haematoma Other Serious 8/1/2007 84 Female 10/9/2007 Consumer Canada
Primary
Concomitant
Procedural Site Reaction Other Serious 20 Male 10/23/2007 Physician United States
Primary
Concomitant
Tuberculosis Other Serious 12/27/1999 46 Female 112 lb 11/1/2007 Physician United States
Primary
Concomitant
Platelet Count Decreased Hospitalization 20 Male 11/14/2007
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/9/2007 Male 11/30/2007 Australia
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Injection Site Pruritus 9/17/2007 Male 208 lb 12/14/2007 United States
Primary
Concomitant
Tremor Other Serious 1/1/2003 Female 130 lb 12/17/2007 Physician United States
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Hospitalization 6/1/1998 53 Female 143 lb 12/20/2007 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 7/5/2007 Male 12/20/2007 Australia
Primary
Concomitant
Syncope Other Serious 11/1/2007 Female 204 lb 12/27/2007 Physician United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 1/1/2007 9 Male 1/16/2008 Sweden
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Hospitalization 6/1/1998 53 Female 143 lb 2/4/2008 Physician United States
Primary
Concomitant
Shock Hospitalization 11/19/2007 Female 37 lb 1/28/2008 United States
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 21 Male 2/21/2008 France
Primary
Secondary
Concomitant
Urticaria Other Serious 1/31/2008 Female 3/28/2008 Consumer United States
Primary
Secondary
Concomitant
Lymphoma Other Serious 68 Female 4/25/2008 Other Health Professional United States
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 33 Female 202 lb 4/30/2008 Physician United Kingdom
Primary
Concomitant
Non-hodgkin's Lymphoma Other Serious 1/1/2008 Female 98 lb 5/15/2008 Other Health Professional United States
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Tricuspid Valve Disease Other Serious 3/20/2008 60 Male 197 lb 5/15/2008 Physician United States
Primary
Secondary
Concomitant
Bone Erosion Hospitalization Male 6/2/2008 Canada
Primary
Concomitant
Rash Other Serious 4/6/2008 Male 168 lb 6/4/2008 United States
Primary
Concomitant
Tuberculosis Other Serious 12/27/1999 46 Female 112 lb 6/5/2008 Physician United States
Primary
Concomitant
Bone Erosion Hospitalization Male 6/17/2008 Canada
Primary
Concomitant
Urinary Tract Infection Staphylococcal Other Serious 8/2/2007 50 Female 6/23/2008 Physician United Kingdom
Primary
Concomitant
Pharyngolaryngeal Pain Other Serious 4/6/2008 Male 162 lb 6/23/2008 United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 12/23/2002 Female 6/24/2008 Physician United States
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/27/1999 46 Female 112 lb 7/16/2008 Physician United States
Primary
Concomitant
Pemphigoid Other Serious 4/6/2008 Male 162 lb 7/17/2008 United States
Primary
Concomitant
Pemphigoid Other Serious 4/6/2008 Male 162 lb 7/22/2008 United States
Primary
Concomitant
Thrombocytopenia Other Serious 20 Male 7/30/2008 Other Health Professional United States
Primary
Secondary
Urinary Tract Infection Staphylococcal Other Serious 8/2/2007 50 Female 8/7/2008 Physician United Kingdom
Primary
Concomitant
Lung Disorder Death 11/17/2007 Male 86 lb 8/7/2008 United Kingdom
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 8/15/2008 Other Health Professional Brazil
Primary
Concomitant
Wound Other Serious 4/6/2008 Male 162 lb 8/27/2008 United States
Primary
Concomitant
Transverse Sinus Thrombosis Hospitalization 8/28/2008 Male 197 lb 9/3/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 10/1/2005 Female 120 lb 9/12/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Syncope Other Serious 6/13/2008 50 Female 146 lb 9/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Other Serious 1/1/2006 Female 134 lb 9/19/2008 Physician United States
Primary
Concomitant
Tuberculosis Other Serious 12/27/1999 46 Female 112 lb 10/10/2008 Physician United States
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 10/16/2008 Other Health Professional Brazil
Primary
Concomitant
Shock Other Serious 11/30/2007 Male 35 lb 11/3/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Acuity Reduced Other Serious 4/18/2008 Male 57 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Impairment Other Serious 4/21/2008 Male 36 lb 11/4/2008 Pharmacist Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 166 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Diverticulum Other Serious 5/1/2008 Male 206 lb 11/7/2008 Other Health Professional Canada
Primary
Concomitant
Renal Failure Life Threatening 7/5/2007 Male 11/25/2008 Australia
Primary
Concomitant
Urinary Tract Infection 12/6/2006 Female 134 lb 11/26/2008 Physician United States
Primary
Concomitant
Pleural Effusion Other Serious 12/1/2003 Female 143 lb 11/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 6/1/2008 Female 126 lb 12/1/2008 Other Health Professional United Kingdom
Primary
Concomitant
Procedural Complication 1/1/2008 Female 145 lb 12/12/2008 Consumer United States
Primary
Concomitant
Nasopharyngitis 7/2/2007 Male 179 lb 12/13/2008 Consumer United States
Primary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/23/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/23/2008
Primary
Secondary
Concomitant
Diabetes Insipidus Other Serious 43 Female 223 lb 1/12/2009 Physician Germany
Primary
Concomitant
Death Other Serious 70 Male 220 lb 1/27/2009 Other Health Professional United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Death 11/25/2008 Female 163 lb 1/28/2009 Other Health Professional France
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2008 Male 185 lb 2/9/2009 Physician United States
Primary
Concomitant
Somnolence Hospitalization 1/30/2009 Male 166 lb 2/6/2009 United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2008 Male 185 lb 2/20/2009 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 1/30/2009 Male 166 lb 2/17/2009 United States
Primary
Secondary
Concomitant
Vision Blurred 3/25/2008 40 Female 2/27/2009 Consumer United States
Primary
Concomitant
Streptococcal Sepsis Other Serious 6/1/2008 Female 126 lb 3/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Nasal Polyps Other Serious 1/1/2008 Female 160 lb 3/4/2009 Canada
Primary
Concomitant
Skin Toxicity Death 10/29/2008 Female 3/10/2009 Pharmacist France
Primary
Concomitant
Respiratory Failure Other Serious 11/1/2007 3/11/2009 Other Health Professional Canada
Primary
Concomitant
Pain 1/1/2006 Female 220 lb 3/14/2009 Consumer United States
Primary
Concomitant

Drug Data