Methotrexate combined with Mitoxantrone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tooth Extraction Other Serious 1/1/2005 60 Female 1/17/2006 Physician Australia
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 60 Female 2/28/2006 Physician Australia
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 60 Female 3/21/2006 Physician Australia
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 1/23/2007 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/1/2004 49 Male 2/10/2007 Japan
Primary
Concomitant
Nuclear Magnetic Resonance Imaging Brain Abnormal Other Serious 6/1/2006 66 Female 2/27/2007 Japan
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 3/17/2007 Physician United States
Primary
Secondary
Concomitant
Pancytopenia Other Serious 4/2/2007 Other Health Professional Italy
Primary
Secondary
Inappropriate Antidiuretic Hormone Secretion Hospitalization 66 Female 4/3/2007
Primary
Secondary
Inappropriate Antidiuretic Hormone Secretion Other Serious 66 Female 4/10/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Superior Sagittal Sinus Thrombosis Other Serious 25 Male 151 lb 5/9/2007 Japan
Primary
Secondary
Concomitant
Superior Sagittal Sinus Thrombosis Life Threatening 25 Male 151 lb 6/19/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Cerebellar Syndrome Hospitalization 5/21/2007 Male 8/1/2007 Other Health Professional France
Primary
Secondary
Concomitant
Sepsis Other Serious 70 Female 11/13/2007 Consumer United States
Primary
Secondary
Concomitant
Sepsis Other Serious 70 Female 11/26/2007 Consumer Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/27/2003 44 Female 134 lb 3/6/2008 Physician Spain
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 71 Female 4/8/2008 Other Health Professional Italy
Primary
Secondary
Non-hodgkin's Lymphoma Other Serious 71 Female 4/11/2008 Other Health Professional Italy
Primary
Secondary
Chronic Myeloid Leukaemia Other Serious 71 Female 4/14/2008 Italy
Primary
Secondary
Non-hodgkin's Lymphoma Recurrent Other Serious 71 Female 4/16/2008 Italy
Primary
Secondary
Non-hodgkin's Lymphoma Other Serious 71 Female 4/29/2008 Consumer Japan
Primary
Secondary
Non-hodgkin's Lymphoma Other Serious 1/1/2005 71 Female 4/24/2008 Italy
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 12/1/1995 52 Female 5/5/2008 Consumer Japan
Primary
Secondary
Stomatitis Life Threatening 6/12/2007 52 Female 4/30/2008 Japan
Primary
Concomitant
Bradycardia Other Serious 3/1/2008 7 Male 50 lb 5/2/2008 United Kingdom
Primary
Concomitant
Death Death 73 6/12/2008 Other Health Professional Spain
Primary
Secondary
Leukaemia Other Serious 39 Female 8/5/2008 United States
Primary
Secondary
Guillain-barre Syndrome Other Serious 39 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Coronary Artery Disease Hospitalization 8/9/2008 Female 203 lb 9/26/2008 Physician Ukraine
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 44 Female 9/29/2008 Japan
Primary
Secondary
Chronic Myelomonocytic Leukaemia Other Serious 41 Male 10/21/2008
Primary
Secondary
Non-hodgkin's Lymphoma Recurrent Other Serious 1/1/2005 71 Female 4/18/2008 Italy
Primary
Secondary
Impaired Healing Other Serious 1/10/2007 Female 2/3/2009 Other Health Professional South Africa
Primary
Concomitant
Vomiting Hospitalization 2/3/2009 20 Male 4/28/2009 Consumer France
Primary
Secondary
Renal Failure Acute Other Serious 54 Male 5/11/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization Female 196 lb 5/18/2009 Physician United Kingdom
Primary
Concomitant
Rhabdomyolysis Hospitalization 54 Male 5/18/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization 12/15/2008 Female 196 lb 6/8/2009 Physician United Kingdom
Primary
Concomitant
No Therapeutic Response Death 16 Female 6/15/2009 Other Health Professional China
Primary
Concomitant
Staphylococcal Infection Other Serious 1/1/2008 43 Male 6/29/2009 Physician United Kingdom
Primary
Secondary
Hepatic Function Abnormal Other Serious 65 Male 8/4/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 35 8/4/2009 United Kingdom
Primary
Secondary
Osteomyelitis Other Serious 32 Male 8/4/2009 Physician Puerto Rico
Primary
Secondary
Pneumonia Other Serious 8/1/1997 31 Male 8/12/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Osteomyelitis Other Serious 32 Male 8/18/2009
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 8/19/2009 United Kingdom
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 35 8/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Hemiplegia Other Serious 8/8/2009 Male 9/17/2009 Other Health Professional France
Primary
Secondary
Concomitant
Stenotrophomonas Infection Other Serious 10/5/2006 35 Female 1/25/2010
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 2/1/2009 56 Male 3/25/2010 Other Health Professional Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 11/20/2008 Female 136 lb 3/30/2010 Physician France
Primary
Secondary
Concomitant
Transplant Rejection Other Serious 2/1/2009 56 Male 3/31/2010 Other Health Professional Japan
Primary
Concomitant
Toxic Encephalopathy Other Serious 11/20/2008 4/20/2010 Physician France
Primary
Secondary
Concomitant
Toxic Encephalopathy Other Serious 11/20/2008 5/11/2010 Physician France
Primary
Secondary
Concomitant
Drug Ineffective For Unapproved Indication Death 45 Male 6/10/2010 Italy
Primary
Concomitant
Stem Cell Transplant Other Serious 2/1/2004 23 Female 7/15/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Hepatitis B Other Serious 57 Female 9/9/2010 Other Health Professional Turkey
Primary
Secondary
Acute Myeloid Leukaemia Death Male 9/20/2010 Other Health Professional Spain
Primary
Secondary
Myelodysplastic Syndrome Other Serious Male 9/20/2010 Other Health Professional Spain
Primary
Secondary
Myelodysplastic Syndrome Death Female 9/20/2010 Other Health Professional Spain
Primary
Secondary
Myelodysplastic Syndrome Other Serious Female 9/20/2010 Physician Spain
Primary
Secondary
Acute Myeloid Leukaemia Death Female 9/20/2010 Other Health Professional Spain
Primary
Secondary
Drug Toxicity Other Serious Female 9/21/2010 Other Health Professional Spain
Primary
Secondary
Myelodysplastic Syndrome Other Serious Female 9/22/2010 Other Health Professional Spain
Primary
Secondary
Acute Myeloid Leukaemia Other Serious Male 9/22/2010 Other Health Professional Spain
Primary
Secondary
Hepatitis B Surface Antigen Positive Required Intervention 57 Female 9/17/2010 Other Health Professional Turkey
Primary
Secondary
Concomitant
Hepatitis B Other Serious 57 Female 9/28/2010 Physician Turkey
Primary
Secondary
Urinary Retention Other Serious 1/29/2009 65 Female 119 lb 9/28/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Hepatitis B Hospitalization 1/1/2010 57 Female 10/15/2010 Other Health Professional Turkey
Primary
Secondary
Tachycardia Other Serious 8/30/2010 13 Female 97 lb 10/29/2010 Other Health Professional France
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/1/2008 27 Male 11/21/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Therapeutic Response Decreased Hospitalization 5/1/2008 27 Male 11/30/2010
Primary
Secondary
Thrombotic Microangiopathy Other Serious 9 Female 12/28/2010 Physician Japan
Primary
Concomitant
Bronchiectasis Hospitalization 35 Male 3/30/2011 Other Health Professional Japan
Primary
Concomitant
Amino Acid Level Increased Other Serious 20 Male 4/21/2011 Other Health Professional France
Primary
Secondary
Hyperammonaemia Other Serious 15 Male 4/21/2011 Physician France
Primary
Secondary
Neutropenia Other Serious 54 Male 5/2/2011 Other Health Professional United Kingdom
Primary
Secondary
Sepsis Other Serious 4/4/2011 14 Female 139 lb 6/10/2011 Physician France
Primary
Secondary
Abscess Other Serious 63 Female 6/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pneumonia Death 8/11/2011 Other Health Professional China
Primary
Secondary
Disseminated Intravascular Coagulation Other Serious 1 Female 8/19/2011 Other Health Professional Japan
Primary
Secondary
Jaundice Other Serious 1 Female 8/19/2011 Other Health Professional Japan
Primary
Secondary
Lymphohistiocytosis Death 1 Female 8/22/2011 Physician Japan
Primary
Secondary
Lymphohistiocytosis Death 1 Female 8/22/2011 Physician Japan
Primary
Secondary
Acute Respiratory Distress Syndrome Death 1 Female 8/22/2011 Physician Japan
Primary
Secondary
Shock Hospitalization 1 Female 8/26/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Lung Induration Death 1 Female 8/31/2011 Other Health Professional Japan
Primary
Secondary
Blood Lactate Dehydrogenase Increased Death 1 8/30/2011 Japan
Primary
Secondary
Pneumonia Death 4 Male 9/7/2011 Other Health Professional China
Primary
Secondary
Osteonecrosis Of Jaw Other Serious 63 Female 9/6/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Leukaemia Recurrent Other Serious 54 Male 9/30/2011 Other Health Professional United Kingdom
Primary
Secondary
Ileus Other Serious 1 Female 10/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Bile Output Abnormal Death 1 Female 10/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cardiac Cirrhosis Death 51 Female 11/9/2011 Other Health Professional Israel
Primary
Secondary
Concomitant
Hepatic Failure Death Female 11/17/2011 Physician Israel
Primary
Secondary
Concomitant
Cardiac Cirrhosis Other Serious 51 Female 11/20/2011 Other Health Professional Israel
Primary
Secondary
Hepatic Failure Death 51 Female 11/18/2011 Israel
Primary
Secondary
Concomitant
Hepatic Failure Death 51 Female 12/1/2011 Other Health Professional Israel
Primary
Secondary
Congestive Cardiomyopathy Hospitalization 50 Female 12/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiac Failure Congestive Other Serious Female 1/30/2012 Other Health Professional United States
Primary
Secondary
Rash Hospitalization Female 1/30/2012 Physician United States
Primary
Secondary
Cardiac Failure Congestive Other Serious Female 1/31/2012 Other Health Professional United States
Primary
Secondary
Cardiac Failure Congestive Other Serious Female 1/29/2012 Other Health Professional United States
Primary
Secondary
Cardiac Failure Congestive Other Serious Female 1/29/2012 Other Health Professional United States
Primary
Secondary
Cardiac Failure Congestive Other Serious Female 1/30/2012 Other Health Professional United States
Primary
Secondary
Congestive Cardiomyopathy Other Serious 30 Female 2/5/2012 Other Health Professional United States
Primary
Secondary
Cardiac Failure Congestive Other Serious 50 Female 2/14/2012 Physician United States
Primary
Secondary
Bile Duct Cancer Hospitalization 50 Female 2/28/2012 Physician United States
Primary
Concomitant
Respiratory Tract Haemorrhage Other Serious 47 Female 3/7/2012 Other Health Professional Brazil
Primary
Secondary
Concomitant
Pneumonia Klebsiella Hospitalization 47 Female 152 lb 3/9/2012 Other Health Professional Brazil
Primary
Secondary
Concomitant
Interacting
Small Intestine Carcinoma Metastatic Hospitalization 10/9/2010 3/23/2012 Physician Germany
Primary
Secondary
Concomitant
Fungal Sepsis Other Serious 3/26/2012 Other Health Professional China
Primary
Secondary
Concomitant
Small Intestine Carcinoma Metastatic Hospitalization 10/9/2010 40 Male 190 lb 3/29/2012 Physician Germany
Primary
Secondary
Acute Lymphocytic Leukaemia Hospitalization 3/22/2012 19 Male 187 lb 4/24/2012 Physician France
Primary
Secondary
Concomitant
Sepsis Death 1/8/2010 38 Female 176 lb 5/11/2012 Physician France
Primary
Secondary
Concomitant
Coma Other Serious 11/20/2008 41 Female 136 lb 5/11/2012 Physician France
Primary
Secondary
Concomitant
Cholecystitis Acute Death 5/18/2012 Other Health Professional France
Primary
Concomitant
Blood Bilirubin Increased Death 10/19/2009 5/18/2012 Physician France
Primary
Concomitant
Acute Myeloid Leukaemia Death 49 Male 5/22/2012 United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 25 Male 5/22/2012 United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 52 Female 5/22/2012 United States
Primary
Secondary
Respiratory Tract Haemorrhage Death 47 Female 150 lb 5/30/2012 Other Health Professional Brazil
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 25 Male 6/14/2012 Physician United States
Primary
Secondary
Multi-organ Failure Other Serious 52 Female 6/14/2012 Physician United States
Primary
Secondary
Myeloid Leukaemia Death 49 Male 6/14/2012 Physician United States
Primary
Secondary
Anaemia Death Male 7/17/2012 Other Health Professional United States
Primary
Secondary
Multi-organ Failure Death 52 Female 7/17/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious Male 7/17/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Oesophageal Mass Death 60 Female 7/18/2012 Physician United States
Primary
Secondary
Multi-organ Failure Death 60 Female 7/18/2012 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Death 60 Female 7/18/2012 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Death 60 Female 7/18/2012 Physician United States
Primary
Secondary
Treatment Related Secondary Malignancy Death 60 Male 7/18/2012 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Death 60 Male 7/18/2012 Physician United States
Primary
Secondary
Acute Myeloid Leukaemia Death 60 Male 7/18/2012 Physician United States
Primary
Secondary
Acute Myeloid Leukaemia Death 60 Male 7/18/2012 Physician United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 30 Male 7/18/2012 Physician United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 30 Male 7/18/2012 Physician United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 30 Male 7/18/2012 Physician United States
Primary
Secondary
Multi-organ Failure Death 52 Female 7/23/2012 Physician United States
Primary
Secondary
Petechiae Other Serious 25 Male 7/23/2012 Physician United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 49 Male 7/23/2012 Physician United States
Primary
Secondary
Osteonecrosis Other Serious 8/24/2012 8 Male 49 lb 8/31/2012 Physician Us
Primary
Secondary
Viith Nerve Paralysis Other Serious 8/8/2009 16 Male 9/24/2012 Other Health Professional Fr
Primary
Secondary
Concomitant
Cerebellar Syndrome Other Serious 68 10/25/2012 Other Health Professional Country Not Specified
Primary
Secondary
Thrombocytopenia Hospitalization 11/8/2012 Other Health Professional Nl
Primary
Secondary
Sweat Gland Tumour Other Serious 2002 66 Female 11/29/2012 Other Health Professional Jp
Primary
Secondary
Sweat Gland Tumour Other Serious 2002 66 Female 12/26/2012 Other Health Professional Jp
Primary
Secondary
Sweat Gland Tumour Other Serious 66 Female 12/21/2012 Other Health Professional Jp
Primary
Secondary
Vomiting Other Serious 78 Female 12/26/2012 Physician Ru
Primary
Concomitant

Drug Data