Methotrexate combined with Misoprostol

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Subarachnoid Haemorrhage Other Serious 7/6/2005 Female 150 lb 2/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Disseminated Tuberculosis Other Serious 2/13/2004 Male 4/13/2006 Physician Portugal
Primary
Concomitant
Salivary Gland Mass Other Serious 1/1/2006 Female 240 lb 8/25/2006 Consumer United States
Primary
Concomitant
Thalamic Infarction Hospitalization 11/29/2005 53 Female 159 lb 9/15/2006 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 5/15/2006 55 Male 216 lb 11/20/2006 Other Health Professional United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection 9/6/2006 75 Female 170 lb 12/22/2006 Consumer United States
Primary
Concomitant
Pregnancy Other Serious 27 Female 1/19/2007 Other Health Professional United States
Primary
Concomitant
Pre-eclampsia Other Serious 27 Female 1/25/2007 United States
Primary
Secondary
Microcephaly Other Serious Female 1/25/2007 United States
Primary
Secondary
Neutropenia Other Serious 12/14/2006 60 Female 128 lb 2/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 2/8/2007 Female 4/6/2007 United States
Primary
Concomitant
Post Procedural Complication Congenital Anomaly Male 8/7/2007 Physician United States
Primary
Secondary
Foot Deformity Congenital Anomaly Female 8/7/2007 Physician United States
Primary
Secondary
Weight Gain Poor Congenital Anomaly Female 8/7/2007 Physician United States
Primary
Secondary
Regurgitation Other Serious 7/20/2007 Male 175 lb 8/31/2007 Consumer United States
Primary
Concomitant
Regurgitation Other Serious 7/20/2007 Male 175 lb 10/26/2007 Consumer United States
Primary
Concomitant
Tinnitus Hospitalization 10/21/2005 25 Female 143 lb 11/20/2007 Other Health Professional Austria
Primary
Concomitant
Weight Decreased Hospitalization 5/1/2004 Female 11/1/2007 Physician United States
Primary
Secondary
Concomitant
Paraesthesia 7/15/2007 Female 160 lb 12/14/2007 United States
Primary
Concomitant
Lymphadenopathy 11/1/2007 Female 130 lb 12/15/2007 United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 11/15/2007 Female 165 lb 2/26/2008 Physician United Kingdom
Primary
Concomitant
Cardiac Disorder Hospitalization 8/15/2007 Female 165 lb 2/27/2008 Physician United Kingdom
Primary
Concomitant
Breast Cancer Other Serious 6/4/2007 Female 137 lb 3/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Accidental Exposure 1/4/2008 Female 175 lb 3/15/2008 Other Health Professional United States
Primary
Concomitant
Cardiac Failure Hospitalization 5/16/2008 Male 132 lb 6/6/2008 Japan
Primary
Concomitant
Post Procedural Infection Hospitalization 8/15/2007 Female 165 lb 6/11/2008 Physician United Kingdom
Primary
Concomitant
Swelling Face 3/4/2008 Female 6/12/2008 Other Health Professional United States
Primary
Concomitant
Skin Cancer Other Serious 3/24/2006 65 Male 141 lb 7/2/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vaginal Prolapse Other Serious 3/5/2007 Female 141 lb 7/28/2008 United Kingdom
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/28/2008 Female 99 lb 8/5/2008 Physician Korea, Republic Of
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/28/2008 Female 99 lb 9/15/2008 Physician Korea, Republic Of
Primary
Concomitant
Lymphocytic Infiltration Other Serious 11/1/2007 Female 130 lb 9/17/2008 United States
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 11/1/2007 Female 130 lb 9/22/2008 United States
Primary
Concomitant
Haemophilus Infection Hospitalization 2/12/2009 Female 123 lb 4/1/2009 Japan
Primary
Secondary
Concomitant
Subcutaneous Emphysema Hospitalization 4/3/2009 Male 4/30/2009 Japan
Primary
Secondary
Concomitant
Lung Adenocarcinoma Other Serious 3/13/2009 Male 154 lb 4/30/2009 Canada
Primary
Concomitant
Basal Cell Carcinoma Other Serious 3/24/2006 65 Male 141 lb 5/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Lung Adenocarcinoma Other Serious 3/13/2009 Male 154 lb 5/11/2009 Canada
Primary
Concomitant
Subcutaneous Emphysema Hospitalization 4/3/2009 Male 5/14/2009 Japan
Primary
Secondary
Concomitant
Subcutaneous Emphysema Hospitalization 4/3/2009 Male 5/27/2009 Japan
Primary
Secondary
Concomitant
Progesterone Receptor Assay Positive Other Serious 2/6/1996 Female 5/28/2009 Lawyer United States
Primary
Secondary
Concomitant
Subcutaneous Emphysema Hospitalization 3/21/2009 Male 6/5/2009 Japan
Primary
Secondary
Concomitant
Injection Site Swelling 4/22/2009 Female 136 lb 6/12/2009 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 7/1/2003 73 Female 4/20/2009 Physician United States
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 4/15/2005 Male 7/24/2009 United Kingdom
Primary
Concomitant
Lung Adenocarcinoma Other Serious 3/13/2009 Male 154 lb 8/6/2009 Canada
Primary
Concomitant
Breast Cancer Other Serious 2/6/1996 Female 8/20/2009 Lawyer United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Disability 6/26/2009 Female 90 lb 8/21/2009 Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 6/26/2009 Female 90 lb 8/26/2009 Japan
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 1/14/2009 Female 132 lb 8/26/2009 Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 2/12/2009 Female 123 lb 9/10/2009 Japan
Primary
Secondary
Concomitant
Visual Impairment Other Serious 6/26/2009 Female 90 lb 9/11/2009 Japan
Primary
Secondary
Concomitant
Incorrect Dose Administered 1/4/2008 Female 175 lb 9/12/2009 Other Health Professional United States
Primary
Concomitant
Suicidal Ideation Other Serious 10/5/2001 64 Female 9/18/2009 Physician Spain
Primary
Concomitant
Suicidal Ideation Other Serious 10/5/2001 64 Female 9/29/2009 Physician Spain
Primary
Concomitant
Haemophilus Infection Hospitalization 2/12/2009 Female 123 lb 10/8/2009 Japan
Primary
Secondary
Concomitant
Haemophilus Infection Hospitalization 2/12/2009 Female 123 lb 10/19/2009 Japan
Primary
Secondary
Concomitant
Agitated Depression Hospitalization 4/1/2009 Female 108 lb 10/30/2009 United Kingdom
Primary
Concomitant
Neoplasm Malignant Other Serious 9/5/2006 71 Female 143 lb 11/25/2009 Other Health Professional United Kingdom
Primary
Concomitant
Neoplasm Malignant Other Serious 8/19/2008 71 Female 143 lb 12/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Tendon Rupture Hospitalization 11/5/2008 Female 103 lb 12/29/2009 Physician Japan
Primary
Secondary
Concomitant
Vertigo Other Serious 10/5/2001 64 Female 1/11/2010 Physician Spain
Primary
Concomitant
Vertigo Other Serious 10/5/2001 64 Female 1/19/2010 Physician Spain
Primary
Concomitant
Neoplasm Malignant Other Serious 8/19/2008 71 Female 143 lb 2/8/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tendon Rupture Hospitalization 11/5/2008 Female 103 lb 2/22/2010 Physician Japan
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 7/25/2009 Female 99 lb 3/12/2010 Japan
Primary
Concomitant
Tonsil Cancer Other Serious 11/15/2009 61 Female 130 lb 3/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Death Death 1/5/2010 70 Male 123 lb 4/1/2010 Physician Japan
Primary
Concomitant
Ileus Hospitalization Female 117 lb 4/9/2010 Japan
Primary
Concomitant
Pneumonia Primary Atypical Hospitalization 3/24/2010 67 Female 115 lb 4/26/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Rectal Ulcer Hospitalization 4/1/2010 82 Female 117 lb 4/29/2010 Physician Japan
Primary
Concomitant
Femur Fracture Hospitalization 7/25/2009 62 Female 99 lb 4/29/2010 Japan
Primary
Concomitant
Rectal Ulcer Hospitalization 4/1/2010 82 Female 117 lb 5/6/2010 Physician Japan
Primary
Concomitant
Metastatic Squamous Cell Carcinoma Other Serious 12/2/2009 61 Female 130 lb 5/7/2010 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Stage Ii Life Threatening 3/9/2009 44 Female 154 lb 5/20/2010 Physician Mexico
Primary
Concomitant
Disseminated Tuberculosis Hospitalization 4/22/2010 67 Female 115 lb 5/21/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Disseminated Tuberculosis Hospitalization 4/22/2010 67 Female 115 lb 5/27/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pneumonia Primary Atypical Hospitalization 3/24/2010 67 Female 115 lb 6/14/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Disseminated Tuberculosis Hospitalization 4/22/2010 67 Female 115 lb 6/18/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Lung Disorder Hospitalization 12/15/2009 72 Female 6/17/2010 Physician United States
Primary
Concomitant
Septic Shock Hospitalization 4/22/2010 67 Female 115 lb 7/7/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Pneumonia Primary Atypical Hospitalization 3/24/2010 67 Female 115 lb 7/7/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Septic Shock Hospitalization 4/22/2010 67 Female 115 lb 7/16/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 7/1/2003 73 Female 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 7/1/2003 73 Female 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 12/15/2009 72 Female 7/30/2010 Physician United States
Primary
Concomitant
Hydrocele Hospitalization 7/20/2010 71 Male 116 lb 8/2/2010 Physician Japan
Primary
Secondary
Concomitant
Polyp Death 8/26/2002 68 Female 82 lb 8/4/2010 Other Health Professional Denmark
Primary
Concomitant
Hydrocele Hospitalization 7/20/2010 71 Male 116 lb 9/7/2010 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Hospitalization 12/15/2009 72 Female 10/7/2010 Physician United States
Primary
Concomitant
Hydrocele Hospitalization 1/1/2010 70 Male 116 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Depression Hospitalization 6/15/2009 68 Female 11/13/2010 Consumer United Kingdom
Primary
Concomitant
Peritonitis Hospitalization 10/27/2007 50 Female 194 lb 11/30/2010 Physician France
Primary
Secondary
Concomitant
Skin Infection Hospitalization 6/7/2010 67 Female 95 lb 12/10/2010 Physician Japan
Primary
Concomitant
Hydrocele Hospitalization 1/1/2010 70 Male 116 lb 12/16/2010 Physician Japan
Primary
Secondary
Concomitant
Sinusitis 5/27/2010 12/22/2010 Consumer United States
Primary
Concomitant
Wound Dehiscence Other Serious 7/1/2003 73 Female 10/28/2010 Physician United States
Primary
Secondary
Concomitant
Thyroiditis Subacute Hospitalization 11/13/2010 52 Female 1/28/2011 Physician Japan
Primary
Concomitant
Fall Hospitalization 7/24/2010 69 Female 110 lb 1/30/2011 Physician United States
Primary
Concomitant
Thyroiditis Subacute Hospitalization 11/13/2010 50 Female 2/22/2011 Physician Japan
Primary
Concomitant
Impaired Driving Ability Other Serious 3/7/2011 66 Female 180 lb 3/15/2011 Consumer United States
Primary
Concomitant
Visual Impairment Other Serious 3/7/2011 66 Female 180 lb 3/21/2011 Consumer United States
Primary
Concomitant
Lymphadenopathy Hospitalization 10/5/2010 51 Female 119 lb 4/21/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombosis Other Serious 12/1/2010 78 Female 5/11/2011 Consumer United States
Primary
Concomitant
Vasoconstriction Other Serious 5/1/2011 80 Female 6/23/2011 Physician Japan
Primary
Concomitant
Oedema Peripheral Other Serious 5/1/2011 80 Female 7/1/2011 Physician Japan
Primary
Concomitant
Cellulitis Other Serious 5/1/2011 80 Female 7/15/2011 Physician Japan
Primary
Secondary
Concomitant
Maternal Exposure During Pregnancy Other Serious 23 7/25/2011 Physician United States
Primary
Secondary
Pain Death 5/1/2011 80 Female 7/26/2011 Physician Japan
Primary
Secondary
Concomitant
Gastric Cancer Other Serious 6/24/2011 72 Male 116 lb 7/27/2011 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/12/2011 Male 171 lb 8/5/2011 Other Health Professional Canada
Primary
Concomitant
Vasoconstriction Death 5/1/2011 80 Female 8/5/2011 Physician Japan
Primary
Secondary
Concomitant
Feeling Hot Death 5/1/2011 80 Female 8/8/2011 Physician Japan
Primary
Secondary
Concomitant
Mucosal Haemorrhage Hospitalization 16 Female 93 lb 8/9/2011 Physician Mexico
Primary
Concomitant
Vomiting Hospitalization 16 Female 93 lb 8/9/2011 Physician Mexico
Primary
Concomitant
Myocardial Ischaemia Congenital Anomaly Male 2 lb 8/5/2011 Physician United States
Primary
Concomitant
Arthritis Life Threatening 6/8/2011 69 Female 114 lb 8/22/2011 Physician Japan
Primary
Secondary
Concomitant
Foetal Growth Restriction Death 31 Male 8/24/2011 Physician United States
Primary
Secondary
Congenital Anomaly Other Serious 31 Male 8/30/2011 Physician United States
Primary
Secondary
Respiratory Failure Death Male 8/29/2011 United States
Primary
Secondary
Alanine Aminotransferase Increased Other Serious 6/8/2011 69 Female 114 lb 9/14/2011 Physician Japan
Primary
Secondary
Concomitant
Incorrect Dose Administered Other Serious 5/1/2011 80 Female 9/16/2011 Physician Japan
Primary
Secondary
Concomitant
Premature Labour Other Serious 31 Female 9/22/2011 Physician United States
Primary
Secondary
Foetal Growth Restriction Other Serious 0 Male 2 lb 9/22/2011 Other Health Professional United States
Primary
Secondary
Appendicectomy Other Serious 11/5/2010 41 Female 194 lb 11/3/2011 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 5/31/2011 83 Male 138 lb 11/17/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/31/2011 83 Male 138 lb 11/18/2011 Physician Japan
Primary
Secondary
Concomitant
Gastric Cancer Other Serious 6/21/2011 72 Male 116 lb 11/30/2011 Japan
Primary
Secondary
Concomitant
Condition Aggravated Life Threatening 5/31/2011 83 Male 138 lb 12/1/2011 Physician Japan
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/12/2012 30 Male 143 lb 1/30/2012 Physician United States
Primary
Concomitant
Injection Site Pain Female 196 lb 1/28/2012 Consumer United States
Primary
Concomitant
Ovarian Cyst 7/1/2011 42 Female 188 lb 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 4/1/2011 44 Female 1/29/2012 Consumer United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/12/2012 30 Male 143 lb 1/31/2012 Physician United States
Primary
Concomitant
Oropharyngeal Pain 9/8/2011 44 Male 1/28/2012 Consumer United States
Primary
Concomitant
Gastrooesophageal Reflux Disease Other Serious 1/12/2012 30 Male 143 lb 2/1/2012 Physician United States
Primary
Concomitant
Large Intestine Carcinoma Hospitalization 9/14/2011 68 Female 97 lb 2/2/2012 Japan
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/12/2012 30 Male 143 lb 2/10/2012 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 1/12/2012 30 Male 143 lb 2/15/2012 Physician United States
Primary
Concomitant
Colitis Other Serious 1/1/2012 48 Male 169 lb 2/29/2012 Other Health Professional Canada
Primary
Concomitant
Large Intestine Carcinoma Hospitalization 9/14/2011 68 Female 97 lb 3/15/2012 Physician Japan
Primary
Secondary
Concomitant
Hepatic Neoplasm Malignant Life Threatening 58 Female 117 lb 3/23/2012 Other Health Professional Canada
Primary
Concomitant
Erysipelas Other Serious 11/29/2011 45 Female 119 lb 4/9/2012 Physician Japan
Primary
Secondary
Concomitant
Hip Dysplasia Congenital Anomaly Female 6/7/2012 Physician United States
Primary
Concomitant
Congenital Spinal Cord Anomaly Congenital Anomaly Female 6/7/2012 Physician United States
Primary
Concomitant
Limb Deformity Congenital Anomaly Female 6/8/2012 Physician United States
Primary
Concomitant
Induced Abortion Failed Other Serious 28 Female 6/8/2012 Other Health Professional United States
Primary
Secondary
Skin Ulcer Hospitalization 4/7/2010 63 Female 6/8/2012 Physician Japan
Primary
Concomitant
Skin Ulcer Hospitalization 4/7/2010 63 Female 6/21/2012 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Other Serious 11/29/2011 45 Female 119 lb 6/21/2012 Physician Japan
Primary
Secondary
Concomitant

Drug Data