Methotrexate combined with Mirtazapine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Proteinuria Other Serious 1/1/2006 Female 137 lb 5/2/2006 Other Health Professional United Kingdom
Primary
Concomitant
Wound Infection Hospitalization 2/1/2003 33 Female 117 lb 5/4/2006 Physician Germany
Primary
Secondary
Concomitant
Sepsis Death 2/7/2006 59 Male 5/3/2006 Pharmacist United States
Primary
Concomitant
Somnolence Hospitalization 6/6/2006 53 Male 6/21/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 6/24/2006 70 Female 112 lb 10/24/2006 Pharmacist United States
Primary
Secondary
Concomitant
Nephrotic Syndrome Other Serious 1/1/2006 44 Female 141 lb 1/19/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Disability 9/1/2006 65 Female 5/24/2007 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Disability 9/1/2006 65 Female 5/26/2007 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Disability 9/1/2006 65 Female 5/28/2007 United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Disability 9/1/2006 65 Female 5/31/2007 United Kingdom
Primary
Concomitant
Mental Disorder Hospitalization 9/1/2006 58 Male 7/3/2007 Physician Sweden
Primary
Secondary
Concomitant
Pneumonia Hospitalization 10/23/2006 87 Male 7/20/2007 Physician Sweden
Primary
Secondary
Concomitant
Suicidal Ideation Hospitalization 7/1/2005 Female 156 lb 1/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 9/27/2004 67 Male 2/8/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 9/27/2004 67 Male 2/15/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening Female 2/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Surgery Hospitalization 9/27/2004 29 Male 2/26/2008 Germany
Primary
Secondary
Concomitant
Septic Shock Hospitalization 11/28/2005 Female 3/7/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 1/15/2008 Female 187 lb 4/24/2008 Physician United Kingdom
Primary
Concomitant
Pelvic Fracture Other Serious 1/1/2008 Female 5/12/2008 Consumer United States
Primary
Concomitant
Injection Site Irritation Female 145 lb 6/12/2008 Consumer United States
Primary
Concomitant
Urinary Tract Disorder Other Serious 2/1/2008 37 Female 181 lb 7/8/2008 Physician United Kingdom
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 1/15/2008 Female 187 lb 7/16/2008 Physician United Kingdom
Primary
Concomitant
Syncope Other Serious 6/13/2008 50 Female 146 lb 9/18/2008 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Infection Hospitalization 7/1/2008 Female 326 lb 9/25/2008 Consumer United States
Primary
Concomitant
Cardiac Arrest Death 5/25/2008 Male 143 lb 11/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Cardiac Arrest Death 5/25/2008 Male 143 lb 11/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Other Serious 6/1/2008 Female 126 lb 12/1/2008 Other Health Professional United Kingdom
Primary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 12/10/2008 Physician United States
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 6/1/2008 Female 126 lb 3/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 3/26/2009 Physician United States
Primary
Secondary
Concomitant
Systemic Candida Other Serious 11/27/2008 55 Male 2/23/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/6/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
Tongue Disorder 3/1/2009 Female 4/23/2009 Consumer
Primary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 5/1/2009 Physician United States
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 6/1/2008 Female 126 lb 5/19/2009 Other Health Professional United Kingdom
Primary
Concomitant
Psoriasis Other Serious 10/13/2007 44 Male 6/17/2009 Physician Canada
Primary
Concomitant
Haematemesis Hospitalization 2/11/2009 Male 174 lb 7/9/2009 United Kingdom
Primary
Concomitant
Depression Other Serious 6/15/2009 Female 106 lb 7/22/2009 Other Health Professional Canada
Primary
Concomitant
Rash 9/14/2008 Female 8/21/2009 Consumer United States
Primary
Concomitant
Wheezing Other Serious 5/1/2009 Female 156 lb 8/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Urticaria Other Serious 37 Male 185 lb 8/19/2009
Primary
Concomitant
Urticaria Other Serious 37 Male 9/14/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vitamin D Decreased Hospitalization 8/11/2008 48 Female 212 lb 11/11/2009 Physician United States
Primary
Concomitant
Drug Toxicity Hospitalization 11/2/2009 Female 90 lb 11/20/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Viral Infection Hospitalization 10/17/2009 64 Female 157 lb 1/8/2010 Physician United States
Primary
Concomitant
Death Death Female 2/24/2010 Physician United Kingdom
Primary
Concomitant
Vitamin D Decreased Hospitalization 8/11/2008 48 Female 212 lb 2/26/2010 Physician United States
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization 4/14/2009 51 Female 4/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death Female 4/6/2010 Physician United Kingdom
Primary
Concomitant
Hypokalaemia Other Serious 6/15/2009 56 Female 4/16/2010 United Kingdom
Primary
Concomitant
Drug Toxicity Hospitalization 11/2/2009 50 Female 90 lb 5/7/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 4/12/2010 72 Male 5/21/2010 United Kingdom
Primary
Concomitant
Drug Ineffective For Unapproved Indication Death 45 Male 6/10/2010 Italy
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 4/12/2010 72 Male 6/14/2010 United Kingdom
Primary
Concomitant
Serotonin Syndrome Hospitalization 8/23/2010 23 Female 121 lb 9/6/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Serotonin Syndrome Hospitalization 8/23/2010 23 Female 121 lb 9/24/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 4/12/2010 72 Male 9/24/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pain In Extremity Other Serious 9/3/2010 80 Female 10/12/2010 Other Health Professional Netherlands
Primary
Concomitant
Pulmonary Embolism Hospitalization Female 11/3/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Hemiplegia Other Serious 9/9/2010 73 Male 157 lb 12/3/2010 Physician Australia
Primary
Secondary
Concomitant
Foot Fracture Other Serious 11/1/2010 51 Female 104 lb 12/17/2010 Other Health Professional Canada
Primary
Concomitant
Breast Cancer Other Serious 12/20/2010 Consumer United States
Primary
Concomitant
Pruritus 6/1/2010 45 Female 135 lb 1/29/2011 Consumer United States
Primary
Concomitant
Cough 9/26/2010 59 Male 1/30/2011 Consumer United States
Primary
Concomitant
Fracture Hospitalization 68 Female 3/25/2011 Consumer Canada
Primary
Concomitant
Abdominal Pain Hospitalization 12/4/2008 35 Male 5/13/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Wound Infection Hospitalization 6/14/2010 56 Male 231 lb 5/16/2011 Other Health Professional Germany
Primary
Concomitant
Interacting
Cardiac Failure Congestive Other Serious Female 115 lb 5/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Acetabulum Fracture Hospitalization 1/27/2011 67 Female 201 lb 5/24/2011 Consumer Canada
Primary
Concomitant
Impaired Healing Hospitalization 6/14/2010 56 Male 231 lb 5/13/2011 Physician Germany
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization Male 6/15/2011 Physician United States
Primary
Concomitant
Treatment Failure Life Threatening 4/22/2011 59 Female 7/1/2011 Other Health Professional France
Primary
Secondary
Concomitant
Colitis Hospitalization 2/27/2011 54 Female 7/15/2011 Physician Canada
Primary
Concomitant
Depression Other Serious 4/1/2011 59 Female 7/14/2011 Other Health Professional France
Primary
Concomitant
Asthenia Hospitalization 5/1/2011 32 Male 130 lb 7/18/2011 Consumer United States
Primary
Concomitant
Colitis Hospitalization 2/27/2011 54 Female 8/5/2011 Physician Canada
Primary
Concomitant
Cardio-respiratory Arrest Life Threatening 7/19/2011 80 Male 8/24/2011 Pharmacist France
Primary
Secondary
Concomitant
Spondyloarthropathy Hospitalization 3/1/2011 56 Female 8/25/2011 Physician Germany
Primary
Concomitant
Deep Vein Thrombosis Other Serious 2/27/2011 54 Female 8/25/2011 Physician Canada
Primary
Concomitant
Cardio-respiratory Arrest Life Threatening 7/19/2011 80 Male 8/26/2011 Physician France
Primary
Secondary
Concomitant
Disease Recurrence Life Threatening 7/19/2011 80 Male 8/29/2011 Other Health Professional France
Primary
Secondary
Concomitant
Spinal Osteoarthritis Hospitalization 3/16/2010 71 Female 163 lb 9/2/2011 Physician Germany
Primary
Concomitant
Myoclonus Life Threatening 7/19/2011 80 Male 9/5/2011 Other Health Professional France
Primary
Secondary
Concomitant
Epilepsy Hospitalization 7/19/2011 79 Male 8/24/2011 Other Health Professional France
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/19/2011 79 Male 8/25/2011 Other Health Professional France
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 5/19/2011 Female 9/27/2011 Physician United States
Primary
Concomitant
Renal Failure Chronic Hospitalization Female 10/26/2011 Consumer United States
Primary
Concomitant
Sinus Disorder 12/12/2010 61 Female 175 lb 10/28/2011 Consumer United States
Primary
Concomitant
Jc Virus Infection Other Serious 9/1/2008 72 Female 11/21/2011 Physician United States
Primary
Secondary
Abdominal Pain Hospitalization 11/1/2010 72 Male 184 lb 11/30/2011 Physician Germany
Primary
Secondary
Concomitant
Meniscus Lesion Congenital Anomaly 7/22/2011 57 Female 11/30/2011 Physician Germany
Primary
Concomitant
Meniscus Lesion Congenital Anomaly 7/22/2011 57 Female 12/1/2011 Physician Germany
Primary
Concomitant
General Physical Health Deterioration Other Serious 6/1/2010 64 Female 12/1/2011 Physician Germany
Primary
Concomitant
Metastatic Neoplasm Death 11/1/2010 72 Male 184 lb 12/8/2011 Physician Germany
Primary
Secondary
Concomitant
Intervertebral Disc Displacement Hospitalization 3/16/2010 71 Female 163 lb 12/27/2011 Physician Germany
Primary
Concomitant
Lower Respiratory Tract Infection Hospitalization 7/31/2011 81 Female 12/27/2011 Physician United Kingdom
Primary
Concomitant
Pain Other Serious 5/1/2011 32 Male 130 lb 1/10/2012 Consumer United States
Primary
Concomitant
Abdominal Distension 1/1/2011 60 Male 91 lb 1/27/2012 Consumer United States
Primary
Concomitant
Pruritus 3/1/2011 51 Female 1/27/2012 Consumer United States
Primary
Concomitant
Decreased Interest 10/1/2010 72 Female 175 lb 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 7/1/2011 54 Female 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 7/14/2011 45 Female 1/28/2012 Consumer United States
Primary
Concomitant
Arthralgia 1/30/2011 59 Male 1/29/2012 Consumer United States
Primary
Concomitant
Pain Hospitalization 2/2/2010 38 Female 245 lb 1/31/2012 Lawyer United States
Primary
Concomitant
Lymphadenectomy Life Threatening 6/1/2010 64 Female 2/3/2012 Physician Germany
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 5/19/2011 65 Female 8/22/2011 Physician United States
Primary
Concomitant
Psoriasis Other Serious 50 Male 3/13/2012 Consumer United Kingdom
Primary
Concomitant
Psoriasis Other Serious 12/4/2010 32 Male 3/29/2012 Other Health Professional Germany
Primary
Concomitant
Ecchymosis Other Serious 12/4/2010 32 Male 3/26/2012 Physician Germany
Primary
Concomitant
Hypoaesthesia Other Serious 16 Female 106 lb 4/2/2012 Pharmacist Canada
Primary
Concomitant
Drug Dependence Other Serious 50 Male 4/3/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Death Death Male 131 lb 4/16/2012 Physician United States
Primary
Secondary
Concomitant
Metastases To Lymph Nodes Hospitalization 2/1/2010 59 Female 4/26/2012 Consumer Germany
Primary
Secondary
Concomitant
Lymphoma Other Serious 2/1/2012 68 Female 126 lb 4/27/2012 Other Health Professional Canada
Primary
Concomitant
Rheumatoid Arthritis Death 6/1/2010 63 Female 4/30/2012 Physician Germany
Primary
Concomitant
Oedema Peripheral 8/14/2010 47 Female 188 lb 5/3/2012 Consumer United States
Primary
Concomitant
Neuropathy Peripheral Other Serious 12 Male 79 lb 5/1/2012 Pharmacist Canada
Primary
Concomitant
Muscle Atrophy Other Serious 4 Male 35 lb 5/1/2012 Pharmacist Canada
Primary
Concomitant
Pleural Mesothelioma Other Serious 3/26/2011 54 Male 190 lb 5/15/2012 Physician Denmark
Primary
Secondary
Concomitant
Arteriosclerosis Death Male 131 lb 5/17/2012 Physician United States
Primary
Secondary
Concomitant
Pleural Mesothelioma Other Serious 3/26/2011 54 Male 190 lb 5/21/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Eosinophilia Hospitalization 4/3/2012 65 Female 6/13/2012 Other Health Professional France
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 7/1/2011 82 Female 6/27/2012 Consumer United States
Primary
Concomitant
Nasopharyngitis Hospitalization 11/1/2011 Male 8/1/2012 Physician Germany
Primary
Concomitant
Arthralgia Other Serious Female 8/3/2012 Other Health Professional Australia
Primary
Concomitant
Cardiac Failure Congestive Hospitalization Female 110 lb 8/3/2012 Other Health Professional Canada
Primary
Secondary
Concomitant
Death Hospitalization Female 110 lb 8/9/2012 Other Health Professional Canada
Primary
Secondary
Concomitant
Sepsis Hospitalization 8/1/2012 50 Female 223 lb 8/10/2012 Physician United States
Primary
Concomitant
Septic Shock Hospitalization 6/25/2012 50 Female 223 lb 8/10/2012 Physician United States
Primary
Concomitant
Pain Other Serious Female 8/14/2012 Other Health Professional Australia
Primary
Concomitant
Rheumatoid Arthritis 1/30/2011 59 Male 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Rheumatoid Arthritis Disability 10/2011 50 Female 3/21/2013 Other Health Professional Co
Primary
Concomitant
Tachycardia Death Female 110 lb 8/31/2012 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Sepsis Hospitalization 8/1/2012 50 Female 223 lb 10/5/2012 Physician Us
Primary
Concomitant
Weight Increased Other Serious 2/10/2010 78 Female 9/6/2012 Physician Us
Primary
Concomitant
Weight Increased Other Serious 2/10/2010 78 Female 83 lb 9/6/2012 Us
Primary
Concomitant
Thirst Other Serious 2/20/2010 78 Female 83 lb 9/6/2012 Physician Us
Primary
Concomitant
International Normalised Ratio Increased Other Serious 10/2012 Male 270 lb 10/25/2012 Consumer Us
Primary
Concomitant
Neutropenic Sepsis Hospitalization 10/18/2012 53 Female 11/5/2012 Other Health Professional Gb
Primary
Concomitant
Drug Ineffective Female 105 lb 11/8/2012 Physician Us
Primary
Concomitant
Sepsis Hospitalization 10/18/2012 53 Female 11/14/2012 Physician Gb
Primary
Concomitant
Renal Impairment Hospitalization 7/25/2012 55 Male 187 lb 12/3/2012 Other Health Professional Gb
Primary
Concomitant
Therapeutic Response Decreased Other Serious 12/3/2012 49 Female 190 lb 1/10/2013 Other Health Professional Ca
Primary
Concomitant
Troponin Increased Other Serious 12/21/2012 Male 172 lb 1/18/2013 Physician Nl
Primary
Secondary
Concomitant
Swelling Face Other Serious Female 1/24/2013 Other Health Professional Gb
Primary
Concomitant
Tremor 67 Female 1/28/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant
Pain 6/15/2012 85 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Viral Infection 10/2012 85 Female 1/31/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant

Drug Data