Methotrexate combined with Metronidazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Hospitalization 2/1/2006 Male 168 lb 3/28/2006 Physician Germany
Primary
Concomitant
Tachyarrhythmia Hospitalization 1/1/2006 Male 150 lb 4/7/2006 Physician Germany
Primary
Concomitant
Muscle Spasms Hospitalization 11/17/1999 41 Female 154 lb 4/10/2006 Lawyer United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 4/18/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 5/5/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 5/5/2006 Physician Germany
Primary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 5/8/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 5/8/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 5/8/2006 Physician Germany
Primary
Concomitant
Hypertension Required Intervention 1/1/2005 55 Male 192 lb 2/7/2006 Physician United States
Primary
Concomitant
Respiratory Failure Death 2/26/2006 Female 101 lb 5/23/2006 Physician Germany
Primary
Concomitant
Right Ventricular Failure Death 2/26/2006 Female 101 lb 6/7/2006 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 Female 168 lb 6/7/2006 Physician Germany
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 1/1/2006 Male 150 lb 6/7/2006 Physician Germany
Primary
Concomitant
Weight Increased Hospitalization 1/1/2006 Male 132 lb 6/7/2006 Physician Germany
Primary
Concomitant
Malignant Anorectal Neoplasm Other Serious 7/11/2005 Female 8/16/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Rectal Cancer Other Serious 7/13/2005 51 Female 8/7/2006 Other Health Professional Brazil
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 10/14/2006 11 Female 60 lb 11/30/2006 Physician Canada
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 10/14/2006 11 Female 60 lb 1/4/2007 Physician Canada
Primary
Concomitant
Crohn's Disease Hospitalization 10/11/2006 Female 1/16/2007 Other Health Professional United States
Primary
Concomitant
Skin Lesion Other Serious 0 Male 2/15/2007 Other Health Professional Turkey
Primary
Secondary
Concomitant
Pancytopenia Death 3/10/2007 37 Female 165 lb 3/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 10/9/2006 Male 71 lb 3/27/2007 Physician United Kingdom
Primary
Concomitant
Nephritis Interstitial Other Serious 56 5/1/2007 Consumer Australia
Primary
Concomitant
Viral Pharyngitis Other Serious 8/26/2005 19 Male 5/11/2007 Poland
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 1/1/2004 41 Female 6/25/2007
Primary
Secondary
Concomitant
Cerebellar Syndrome Death 5/21/2007 17 Male 7/24/2007 Other Health Professional France
Primary
Secondary
Concomitant
Cerebellar Syndrome Death 5/21/2007 16 Male 8/21/2007 Other Health Professional France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 2/4/2006 80 Male 8/31/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Stenosis Other Serious 3 Female 9/7/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Rheumatoid Lung Hospitalization 8/1/2007 82 Female 154 lb 10/4/2007 Consumer United States
Primary
Concomitant
Pericarditis Fungal Other Serious 11/11/2005 3 Female 10/23/2007
Primary
Secondary
Concomitant
Tibia Fracture Hospitalization 3/1/2004 Female 11/2/2007 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 10/14/2006 11 Female 60 lb 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
Neutropenia Other Serious 11/26/2007 67 Female 12/27/2007
Primary
Concomitant
Septic Shock Death 12/31/2007 65 Male 239 lb 1/16/2008 Physician United States
Primary
Secondary
Concomitant
Sepsis Death 12/31/2007 65 Male 239 lb 1/31/2008 Physician United States
Primary
Secondary
Concomitant
Hypoaesthesia 7/15/2008 Female 209 lb 9/12/2008 United States
Primary
Concomitant
Vomiting 8/1/2008 Female 210 lb 9/13/2008 Consumer United States
Primary
Concomitant
Sepsis Other Serious 1/1/2006 Female 134 lb 9/19/2008 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 9/29/2008 Korea, Republic Of
Primary
Secondary
Concomitant
Visual Impairment Other Serious 4/21/2008 Male 36 lb 11/4/2008 Pharmacist Brazil
Primary
Concomitant
Urinary Tract Infection 12/6/2006 Female 134 lb 11/26/2008 Physician United States
Primary
Concomitant
Insomnia Required Intervention 8/23/2008 42 Male 370 lb 12/2/2008 Physician United Kingdom
Primary
Concomitant
Oedema Peripheral 8/1/2008 Female 140 lb 12/12/2008 United States
Primary
Concomitant
Rheumatoid Arthritis 6/1/2008 Female 12/12/2008 Physician United States
Primary
Concomitant
Staphylococcal Infection Death 67 4/30/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Required Intervention 67 5/1/2009 Germany
Primary
Secondary
Concomitant
Apnoea Other Serious 9/10/2008 48 Female 7/22/2009 Consumer United Kingdom
Primary
Concomitant
Crohn's Disease Hospitalization 7/13/2009 Male 92 lb 7/24/2009 Other Health Professional United States
Primary
Concomitant
Crohn's Disease Hospitalization 7/13/2009 Male 92 lb 8/7/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 62 Female 8/25/2009 Lawyer United States
Primary
Concomitant
Dysuria Other Serious 8/27/2009 Male 158 lb 9/4/2009 Canada
Primary
Concomitant
Incorrect Dose Administered 7/4/2007 Female 106 lb 9/11/2009 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 16 Female 9/15/2009
Primary
Secondary
Concomitant
Hemiplegia Other Serious 8/8/2009 Male 9/17/2009 Other Health Professional France
Primary
Secondary
Concomitant
Colitis Hospitalization 8/31/2009 Female 62 lb 9/23/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 56 Female 9/17/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
Histoplasmosis Disseminated Hospitalization 10/3/2009 Male 199 lb 10/19/2009 Physician Canada
Primary
Concomitant
Weight Decreased Life Threatening 10/1/2007 Male 10/27/2009 Physician United States
Primary
Secondary
Concomitant
Endometrial Cancer Metastatic Other Serious Female 261 lb 10/30/2009 Physician United States
Primary
Secondary
Concomitant
Hemiplegia Other Serious 8/11/2009 16 Male 11/6/2009 Other Health Professional France
Primary
Secondary
Concomitant
Pharyngeal Disorder Other Serious 19 Female 11/6/2009 United States
Primary
Concomitant
Pharyngeal Disorder Other Serious 19 Female 11/9/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Histoplasmosis Disseminated Hospitalization 10/3/2009 Male 199 lb 11/20/2009 Physician Canada
Primary
Concomitant
Histoplasmosis Disseminated Hospitalization 10/3/2009 Male 199 lb 11/25/2009 Physician Canada
Primary
Concomitant
Urinary Tract Infection 12/6/2006 Female 134 lb 12/1/2009 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 53 Female 12/10/2009 United States
Primary
Concomitant
Crohn's Disease Hospitalization 9/17/2009 Male 95 lb 12/23/2009 Other Health Professional United States
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10/17/2009 62 Female 142 lb 1/21/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Crohn's Disease Hospitalization 1/6/2010 Female 89 lb 1/22/2010 Other Health Professional United States
Primary
Concomitant
Nausea 3/1/2009 Female 163 lb 1/30/2010 United States
Primary
Concomitant
Hepatitis Other Serious 1/25/2010 Female 123 lb 2/8/2010 Physician France
Primary
Secondary
Concomitant
Renal Mass Other Serious 10/12/2009 Female 161 lb 2/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Tooth Loss Other Serious 10/1/2005 15 Female 2/18/2010
Primary
Secondary
Pulmonary Haemorrhage Hospitalization 7/29/2009 Male 185 lb 3/15/2010 Physician Poland
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Hospitalization 8/5/2009 Male 185 lb 3/31/2010 Physician Poland
Primary
Secondary
Concomitant
Weight Increased Hospitalization 53 Female 4/15/2010 United States
Primary
Concomitant
Fistula Hospitalization 5/1/2010 57 Male 193 lb 5/14/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/1/2009 38 Female 123 lb 5/28/2010 Netherlands
Primary
Concomitant
Vaginal Lesion Hospitalization 4/14/2010 3 Female 43 lb 6/17/2010 United States
Primary
Secondary
Concomitant
Fistula Hospitalization 5/1/2010 57 Male 193 lb 6/21/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 1/1/2009 61 Female 6/15/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/4/2010 3 Female 43 lb 6/21/2010 United States
Primary
Secondary
Concomitant
Enterocutaneous Fistula Hospitalization 5/1/2010 57 Male 193 lb 7/2/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/8/2010 9 Male 60 lb 7/2/2010 Physician United States
Primary
Concomitant
Vomiting Hospitalization 9/1/2009 38 Female 123 lb 7/9/2010 Physician Netherlands
Primary
Concomitant
Vomiting Hospitalization 9/1/2009 38 Female 123 lb 7/21/2010 Physician Netherlands
Primary
Concomitant
Perirectal Abscess Hospitalization 7/7/2010 17 Male 132 lb 7/26/2010 Physician United States
Primary
Concomitant
Pyrexia Other Serious 1/9/2009 58 Female 97 lb 7/28/2010 Physician Japan
Primary
Concomitant
Suicidal Ideation Other Serious 3/1/2008 55 Female 8/23/2010 Lawyer United States
Primary
Concomitant
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/1/2009 38 Female 123 lb 8/25/2010 Physician Netherlands
Primary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 59 Female 132 lb 9/1/2010 Physician Germany
Primary
Secondary
Concomitant
Vertigo Hospitalization 1/1/2000 Female 9/10/2010 Physician Sweden
Primary
Concomitant
Interacting
Crohn's Disease Hospitalization 9/1/2009 38 Female 123 lb 9/17/2010 Physician Netherlands
Primary
Concomitant
Drug Interaction Hospitalization 6/19/2010 38 Male 9/24/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Swelling Face Hospitalization 8/18/2010 58 Female 110 lb 10/5/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Vertigo Hospitalization 1/1/2000 Female 10/13/2010 Physician Sweden
Primary
Concomitant
Interacting
Respiratory Failure Life Threatening 7/27/2010 60 Female 254 lb 10/6/2010 Other Health Professional
Primary
Secondary
Respiratory Failure Life Threatening 7/27/2010 60 Female 10/8/2010 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 9/27/2010 52 Female 110 lb 10/29/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Injection Site Reaction 4/5/2010 12/21/2010 Consumer United States
Primary
Concomitant
Sinusitis 4/1/2010 12/21/2010 Other Health Professional United States
Primary
Concomitant
Appendicitis Hospitalization 12/7/2010 53 Female 132 lb 1/20/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Injection Site Pain 10/1/2010 26 Male 1/30/2011 Consumer United States
Primary
Concomitant
Angioedema Other Serious 1/1/2011 24 Female 2/11/2011 Consumer Canada
Primary
Concomitant
Pseudomembranous Colitis Hospitalization 12/28/2010 15 Female 101 lb 2/15/2011 Other Health Professional United States
Primary
Concomitant
Enterocutaneous Fistula Hospitalization 5/1/2010 57 Male 193 lb 2/16/2011 Physician United States
Primary
Secondary
Concomitant
Appendicitis Hospitalization 12/7/2010 53 Female 132 lb 2/16/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Malnutrition Hospitalization 1/8/2010 9 Male 60 lb 3/21/2011 Physician United States
Primary
Concomitant
Colitis Hospitalization 8/31/2009 8 Female 62 lb 3/21/2011 Other Health Professional United States
Primary
Concomitant
Anal Abscess Hospitalization 10/11/2006 15 Female 3/22/2011 Physician United States
Primary
Concomitant
Anal Fistula Hospitalization 7/7/2010 17 Male 132 lb 3/22/2011 Physician United States
Primary
Concomitant
Crohn's Disease Hospitalization 1/6/2010 15 Female 89 lb 3/22/2011 Physician United States
Primary
Concomitant
Diverticulitis Hospitalization 7/19/2010 60 Female 254 lb 4/15/2011 Other Health Professional Switzerland
Primary
Secondary
Cholecystectomy Other Serious 1/1/2007 26 Female 216 lb 5/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Fatigue 1/1/2011 68 Female 93 lb 5/11/2011 Consumer United States
Primary
Concomitant
Fungal Skin Infection Death 1/1/2011 8 Male 64 lb 7/22/2011 Physician United States
Primary
Concomitant
Crohn's Disease Hospitalization 1/8/2010 9 Male 60 lb 8/11/2011 Physician United States
Primary
Concomitant
Pseudomembranous Colitis Hospitalization 12/28/2010 15 Female 101 lb 8/11/2011 Other Health Professional United States
Primary
Concomitant
Anal Abscess Hospitalization 10/11/2006 15 Female 8/12/2011 Physician United States
Primary
Concomitant
Skin Hyperpigmentation Death 6/20/2011 11 Female 77 lb 8/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Biliary Dyskinesia Other Serious 1/1/2007 26 Female 216 lb 8/19/2011 Physician United States
Primary
Secondary
Concomitant
Anal Abscess Other Serious 10/11/2006 15 Female 9/1/2011 Physician United States
Primary
Concomitant
Henoch-schonlein Purpura Hospitalization 25 Female 9/9/2011 Physician Korea, Republic Of
Primary
Concomitant
Crohn's Disease Hospitalization 9/3/2011 15 Female 82 lb 9/23/2011 Physician United States
Primary
Concomitant
Renal Failure Life Threatening 5/16/2011 8 Female 49 lb 9/29/2011 Pharmacist United Kingdom
Primary
Concomitant
Abdominal Abscess Hospitalization 8/24/2011 15 Male 105 lb 9/29/2011 Physician United States
Primary
Concomitant
Crohn's Disease Hospitalization 9/3/2011 15 Female 82 lb 9/30/2011 Physician United States
Primary
Concomitant
Pulmonary Hypertension Other Serious 1/1/2011 8 Female 49 lb 10/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 9/16/2011 11 Male 67 lb 10/7/2011 Physician United States
Primary
Concomitant
Methylobacterium Infection Other Serious 8 Female 49 lb 10/6/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 8/7/2011 62 Female 180 lb 10/14/2011 Consumer Canada
Primary
Concomitant
Crohn's Disease Hospitalization 9/16/2011 11 Male 67 lb 10/19/2011 Physician United States
Primary
Concomitant
Pulmonary Hypertension Other Serious 1/1/2011 8 Female 49 lb 10/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haemorrhoids Other Serious 10/31/2007 35 Female 116 lb 10/19/2011 Consumer United States
Primary
Concomitant
Crohn's Disease Hospitalization 9/3/2011 15 Female 82 lb 10/27/2011 Physician United States
Primary
Concomitant
Headache Other Serious 6/20/2011 11 Female 77 lb 10/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Other Serious 8/23/2011 13 Male 92 lb 11/3/2011 Pharmacist Brazil
Primary
Secondary
Concomitant
Interacting
Headache Hospitalization 6/1/2011 22 Female 11/10/2011 Physician United States
Primary
Secondary
Fall Hospitalization 9/9/2011 16 Male 109 lb 11/17/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Enteritis Infectious Hospitalization 8/7/2011 62 Female 180 lb 11/28/2011 Canada
Primary
Concomitant
Neurotoxicity Hospitalization 9/9/2011 16 Male 109 lb 12/2/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 5/19/2005 46 Female 120 lb 12/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/1/2011 Female 75 lb 12/15/2011 Physician United States
Primary
Concomitant

Drug Data