Methotrexate combined with Metoprolol

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pyrexia Other Serious 11/26/2005 66 Female 128 lb 12/30/2005 Switzerland
Primary
Secondary
Concomitant
Hypertension Hospitalization 10/26/2002 60 Male 170 lb 1/17/2006 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 49 Female 1/19/2006 Physician United States
Primary
Concomitant
Ankle Fracture Other Serious 8/1/2005 Female 281 lb 1/24/2006 Physician United States
Primary
Concomitant
Abdominal Abscess Hospitalization 11/8/2004 Female 148 lb 1/25/2006 Netherlands
Primary
Concomitant
Candidiasis Hospitalization 3/22/2005 Female 186 lb 1/26/2006 Physician United States
Primary
Concomitant
Right Ventricular Failure Hospitalization 12/25/2003 78 Male 1/27/2006 United States
Primary
Secondary
Concomitant
Pulmonary Cavitation Other Serious 6/5/2003 Female 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2002 61 Female 2/21/2006 Physician United States
Primary
Concomitant
Hypotension Hospitalization 10/26/2002 60 Male 170 lb 2/22/2006 Physician United States
Primary
Concomitant
Death Death Female 2/24/2006 Physician United States
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 3/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2002 66 Male 201 lb 3/14/2006 Lawyer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2002 61 Female 170 lb 3/30/2006 Physician United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2002 66 Male 201 lb 4/6/2006 Lawyer United States
Primary
Concomitant
Gastric Ulcer Perforation Other Serious Female 185 lb 4/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 4/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Hospitalization 9/18/2005 58 Male 4/13/2006 Physician Germany
Primary
Concomitant
Hypercholesterolaemia Hospitalization 10/26/2002 60 Male 170 lb 4/17/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 5/1/2004 76 Male 168 lb 4/19/2006 Lawyer United States
Primary
Concomitant
Hospitalisation Hospitalization Female 170 lb 5/12/2006 Consumer Canada
Primary
Concomitant
Cerebrovascular Accident Hospitalization 1/1/1999 60 Female 201 lb 5/15/2006 Lawyer United States
Primary
Concomitant
Respiratory Arrest Death 2/28/2006 68 Female 6/6/2006 Physician United States
Primary
Concomitant
Hypertensive Crisis Hospitalization 3/1/2006 61 Female 8/1/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Thyroid Neoplasm Life Threatening 4/21/2006 Female 167 lb 8/4/2006 Other Health Professional Canada
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 73 Male 201 lb 8/18/2006 United States
Primary
Concomitant
Throat Tightness Other Serious 1/1/2004 Male 270 lb 8/18/2006 Consumer United States
Primary
Concomitant
Hypoglycaemia Other Serious 7/28/2006 69 Female 158 lb 9/15/2006 Consumer United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 5/29/2006 Female 142 lb 9/20/2006 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/1/2006 Male 170 lb 11/21/2006 Physician United States
Primary
Concomitant
Sinusitis Other Serious 8/3/2005 Female 155 lb 1/27/2007 Physician United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 83 Male 4/9/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 83 Male 225 lb 4/13/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 5/20/2005 82 Male 225 lb 5/7/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 5/20/2005 82 Male 225 lb 5/9/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 5/20/2005 82 Male 225 lb 5/14/2007 Pharmacist Norway
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 4/1/2007 71 Female 10/16/2007 Physician Canada
Primary
Concomitant
Interacting
Haemoglobin Decreased Other Serious 4/1/2007 71 Female 10/18/2007 Physician Canada
Primary
Concomitant
Interacting
Pericarditis Other Serious 46 Female 11/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Lung Neoplasm Malignant Other Serious Female 143 lb 12/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Vulvovaginal Mycotic Infection Hospitalization 10/1/2005 Female 206 lb 12/6/2007 Physician United States
Primary
Concomitant
Thrombocytopenia Disability 8/5/2007 68 Female 234 lb 12/4/2007 Pharmacist United States
Primary
Concomitant
Foreign Body Trauma Other Serious 1/1/2007 Female 12/12/2007 Pharmacist United States
Primary
Secondary
Concomitant
Adverse Event 1/1/2007 Male 220 lb 12/14/2007 Consumer United States
Primary
Concomitant
Temperature Intolerance 6/1/2007 Female 271 lb 12/14/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 9/1/2007 Female 200 lb 12/14/2007 Consumer United States
Primary
Concomitant
Injection Site Pain Female 220 lb 12/14/2007 Consumer United States
Primary
Concomitant
Underdose 1/1/2004 Male 241 lb 12/15/2007 Consumer United States
Primary
Concomitant
Urticaria 10/2/2007 65 Female 158 lb 12/17/2007 United States
Primary
Concomitant
Wound Drainage Other Serious 10/27/2006 Female 157 lb 12/28/2007 Germany
Primary
Concomitant
Abdominal Wall Abscess Hospitalization 3/29/2007 Female 134 lb 12/28/2007 United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 60 Female 1/25/2008 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Other Serious Female 5/1/2008 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 59 Female 5/28/2008 Other Health Professional United States
Primary
Concomitant
Rash Erythematous 3/16/2008 Female 212 lb 6/12/2008 Physician United States
Primary
Concomitant
Underdose 2/1/2008 Male 198 lb 6/12/2008 Consumer United States
Primary
Concomitant
Swelling Other Serious 1/1/2007 Female 155 lb 6/12/2008 Consumer United States
Primary
Concomitant
Oedema Peripheral 1/1/2008 Male 160 lb 6/12/2008 United States
Primary
Concomitant
Injection Site Pain 3/12/2008 Female 145 lb 6/13/2008 Consumer United States
Primary
Concomitant
Urticaria 5/11/2008 Female 140 lb 6/13/2008 Consumer United States
Primary
Concomitant
Tachycardia Hospitalization 11/1/2001 Male 6/16/2008 Other Health Professional Austria
Primary
Concomitant
Vomiting Other Serious 5/8/2008 Male 153 lb 6/19/2008 Other Health Professional United States
Primary
Concomitant
Blood Pressure Decreased Other Serious 82 Female 236 lb 6/25/2008 Consumer United States
Primary
Concomitant
Prostate Cancer Other Serious 5/12/2008 Male 182 lb 7/7/2008 Consumer United States
Primary
Concomitant
Tumour Lysis Syndrome Hospitalization 1/1/2008 Female 126 lb 12/2/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 2/1/2008 Female 114 lb 12/2/2008 Physician United States
Primary
Secondary
Concomitant
Injection Site Pain 5/1/2008 Female 115 lb 12/12/2008 Consumer United States
Primary
Concomitant
Injection Site Pain 9/3/2008 Female 123 lb 12/12/2008 United States
Primary
Concomitant
Swollen Tongue 5/1/2008 Female 151 lb 12/12/2008 Physician United States
Primary
Concomitant
Drug Ineffective 10/13/2008 Male 202 lb 12/12/2008 Physician United States
Primary
Concomitant
Wound 9/1/2008 Female 200 lb 12/12/2008 United States
Primary
Concomitant
Incorrect Dose Administered 10/31/2008 Female 150 lb 12/12/2008 Consumer United States
Primary
Concomitant
Injection Site Irritation 11/18/2008 Male 178 lb 12/12/2008 Other Health Professional United States
Primary
Concomitant
Gynaecomastia 4/1/2008 Male 150 lb 12/13/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased 8/2/2006 Female 195 lb 12/15/2008 Physician United States
Primary
Concomitant
Legionella Infection Hospitalization 7/1/2008 Female 12/16/2008 Germany
Primary
Concomitant
White Blood Cell Count Increased Death 6/25/2008 Female 12/23/2008 Physician New Zealand
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 10/22/2008 Male 187 lb 1/16/2009 United States
Primary
Concomitant
Atrial Fibrillation Other Serious 7/4/2007 68 Male 1/23/2009 Physician Sweden
Primary
Concomitant
Rhabdomyolysis Other Serious 5/1/2008 1/23/2009 France
Primary
Concomitant
Interacting
Gamma-glutamyltransferase Increased Hospitalization 1/12/2006 Female 1/30/2009 Germany
Primary
Concomitant
Tooth Infection Other Serious 12/1/2008 Male 153 lb 2/25/2009 United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 12/1/2008 Female 185 lb 2/27/2009 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Hospitalization 2/19/2009 68 Female 141 lb 3/3/2009 Consumer United States
Primary
Concomitant
Unevaluable Event Other Serious 2/1/2009 Male 181 lb 3/9/2009 Canada
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 4/18/2007 Female 213 lb 4/3/2009 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization Female 112 lb 4/3/2009 Canada
Primary
Concomitant
Interacting
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/6/2009 Physician United States
Primary
Secondary
Concomitant
Sarcoidosis Other Serious 1/21/2008 Female 158 lb 4/28/2009 Other Health Professional Canada
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 59 Female 5/5/2009 Other Health Professional United States
Primary
Concomitant
Dizziness Other Serious 4/2/2009 Female 130 lb 5/6/2009 Physician United States
Primary
Concomitant
Memory Impairment Other Serious 4/1/2009 Female 124 lb 5/6/2009 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 4/3/2009 Male 5/15/2009 Physician Australia
Primary
Secondary
Concomitant
Pneumonia Hospitalization 4/10/2009 Male 176 lb 5/20/2009 Physician Australia
Primary
Secondary
Concomitant
Atrial Fibrillation Other Serious 1/1/2009 Male 240 lb 5/26/2009 Consumer United States
Primary
Concomitant
Uterine Dilation And Curettage Other Serious 4/27/2009 Female 185 lb 5/27/2009 Canada
Primary
Concomitant
Weight Decreased Other Serious 1/1/1999 59 Female 6/9/2009 Other Health Professional United States
Primary
Concomitant
Pyelonephritis Chronic Other Serious 6/2/2009 67 Female 173 lb 6/22/2009 Consumer Lithuania
Primary
Concomitant
Cerebrovascular Accident Other Serious 7/4/2009 52 Female 176 lb 8/10/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Coronary Artery Occlusion Other Serious 6/9/2009 Male 191 lb 8/11/2009 Canada
Primary
Concomitant
Peripheral Ischaemia Hospitalization 6/23/2009 Female 168 lb 8/11/2009 United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 2/8/2006 64 Female 8/5/2009 United States
Primary
Concomitant
Lymphoma Hospitalization 7/12/2009 Female 128 lb 8/14/2009 Physician Canada
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 68 Female 8/10/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 68 Female 8/13/2009 Consumer United States
Primary
Concomitant
Retinal Haemorrhage Hospitalization 12/1/2008 Female 130 lb 8/19/2009 Physician United States
Primary
Concomitant
Disease Recurrence Hospitalization 3/4/2009 Male 243 lb 8/20/2009 Consumer United States
Primary
Concomitant
Paraesthesia Male 8/22/2009 United States
Primary
Concomitant
Pruritus 12/1/2008 Female 8/22/2009 United States
Primary
Concomitant
Flushing 6/18/2009 Female 161 lb 8/23/2009 United States
Primary
Concomitant
Diarrhoea 7/26/2009 82 Female 181 lb 8/25/2009 Consumer United States
Primary
Concomitant
Congestive Cardiomyopathy Other Serious 6/28/2009 Male 8/26/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Scar Other Serious 8/1/2006 Female 8/28/2009 Physician United States
Primary
Concomitant
Road Traffic Accident Death 4/11/2009 Male 195 lb 8/31/2009 Canada
Primary
Concomitant
Road Traffic Accident Death 4/11/2009 Male 195 lb 8/31/2009 Canada
Primary
Concomitant
Colitis Ulcerative Other Serious 12/1/2008 57 Female 9/1/2009 Physician Germany
Primary
Concomitant
Dermatitis Other Serious 64 Female 9/2/2009 Other Health Professional United Kingdom
Primary
Concomitant
Uterine Dilation And Curettage Other Serious 4/27/2009 Female 185 lb 9/4/2009 Canada
Primary
Concomitant
Supraventricular Tachycardia Other Serious 56 Male 9/25/2009
Primary
Secondary
Wound Dehiscence Hospitalization 4/2/2009 68 Female 179 lb 9/18/2009 Physician Germany
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 68 Female 9/17/2009 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 12/1/2008 Female 188 lb 9/30/2009 United States
Primary
Concomitant
Pyrexia Hospitalization 7/31/2009 Male 150 lb 10/12/2009 Canada
Primary
Concomitant
Acute Hepatic Failure Life Threatening 9/29/2009 Male 184 lb 10/16/2009 Pharmacist United States
Primary
Concomitant
Pneumonia Hospitalization 8/6/2009 Male 130 lb 10/21/2009 Canada
Primary
Concomitant
Diabetes Mellitus Other Serious 4/1/2009 Female 130 lb 10/23/2009 Consumer United States
Primary
Concomitant
Pain Other Serious 1/1/2008 Female 185 lb 10/26/2009 Other Health Professional United States
Primary
Concomitant
Diffuse Large B-cell Lymphoma Hospitalization 7/12/2009 Female 128 lb 10/30/2009 Physician Canada
Primary
Secondary
Concomitant
Drug Intolerance Hospitalization 6/14/2009 25 Male 11/9/2009 Physician Germany
Primary
Secondary
Concomitant
Rash Other Serious 8/11/2009 Female 131 lb 11/11/2009 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 12/1/2008 Female 188 lb 11/18/2009 United States
Primary
Concomitant
Uterine Leiomyoma Hospitalization 7/12/2009 Female 128 lb 11/20/2009 Physician Canada
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 11/4/2009 74 Female 11/20/2009 Physician United Kingdom
Primary
Concomitant
Mycosis Fungoides Other Serious 6/1/2008 Female 184 lb 11/30/2009 Physician United States
Primary
Secondary
Concomitant
Volvulus Other Serious 11/17/2009 Male 225 lb 12/1/2009 Canada
Primary
Concomitant
Rash Male 200 lb 12/1/2009 Consumer United States
Primary
Concomitant
Hand Deformity Male 12/1/2009 Physician United States
Primary
Concomitant
Haemarthrosis Hospitalization 9/8/2009 54 Female 146 lb 11/30/2009 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/1/2009 Female 130 lb 12/3/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 1/1/2008 Female 11/30/2009 Consumer United States
Primary
Concomitant
Prostate Cancer Other Serious 5/12/2008 Male 182 lb 12/1/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection 12/6/2006 Female 134 lb 12/1/2009 Physician United States
Primary
Concomitant
Rectal Haemorrhage Other Serious 1/1/2008 84 12/1/2009 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 2/1/2009 Female 242 lb 12/8/2009 Physician United States
Primary
Concomitant
Therapeutic Response Decreased 1/1/2006 Female 183 lb 12/9/2009 Physician United States
Primary
Concomitant
Sepsis Death 10/15/2009 66 Male 240 lb 12/11/2009 Physician United States
Primary
Concomitant
Pneumonitis Hospitalization 11/30/2009 Female 187 lb 12/31/2009 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/25/2008 Female 1/6/2010 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/6/2009 Male 130 lb 1/7/2010 Canada
Primary
Concomitant
Pneumonitis Hospitalization 11/30/2009 Female 187 lb 1/8/2010 Physician United States
Primary
Concomitant

Drug Data