Methotrexate combined with Metoprolol Succinate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Failure Death 7/13/2005 57 Female 159 lb 1/13/2006 Physician Germany
Primary
Concomitant
Varices Oesophageal Hospitalization 12/26/2005 Female 174 lb 1/27/2006 Finland
Primary
Concomitant
Pulmonary Tuberculosis Hospitalization 10/11/2005 64 Female 121 lb 2/6/2006 Physician Germany
Primary
Concomitant
Weight Increased Life Threatening 4/22/2005 Male 254 lb 2/13/2006 United States
Primary
Concomitant
Varices Oesophageal Hospitalization 12/26/2005 Female 174 lb 2/17/2006 Finland
Primary
Concomitant
Varices Oesophageal Hospitalization 12/26/2005 Female 174 lb 3/3/2006 Finland
Primary
Concomitant
Weight Increased Hospitalization 12/26/2005 Female 174 lb 3/29/2006 Finland
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/14/2006 Norway
Primary
Concomitant
Anaemia Hospitalization 4/1/2006 Female 160 lb 4/17/2006 Consumer United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 6/1/2003 66 Female 4/28/2006 Other Health Professional Sweden
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 4/28/2006 Norway
Primary
Concomitant
Sepsis Hospitalization 9/25/2005 Female 108 lb 5/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Carotid Artery Occlusion Other Serious 5/14/2006 Male 156 lb 6/5/2006 Consumer United States
Primary
Concomitant
Cardiomyopathy Life Threatening 4/22/2005 Male 254 lb 6/16/2006 United States
Primary
Concomitant
Therapy Non-responder Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Haemoptysis Hospitalization 3/27/2006 Male 148 lb 7/7/2006 Norway
Primary
Concomitant
Urinary Tract Infection Other Serious 6/2/2005 Female 185 lb 8/23/2006 Consumer United States
Primary
Concomitant
Lipase Increased Other Serious 4/1/2006 68 Female 10/9/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Tricuspid Valve Incompetence Hospitalization 12/23/2003 55 Female 126 lb 10/27/2006 United States
Primary
Concomitant
Rheumatoid Lung Hospitalization 8/22/2006 Female 143 lb 11/17/2006 Belgium
Primary
Concomitant
Brain Stem Infarction Death 11/2/2006 Female 108 lb 11/20/2006 Physician Netherlands
Primary
Concomitant
Hypokalaemia Hospitalization 10/31/2006 Female 11/22/2006 Consumer United States
Primary
Concomitant
Skin Cancer Other Serious 3/1/2006 Female 12/8/2006 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 2/26/2006 Female 12/8/2006 Physician United States
Primary
Concomitant
Lymphocytic Lymphoma Other Serious 5/17/2005 Male 164 lb 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2003 Female 12/13/2006 Physician United States
Primary
Concomitant
Pruritus Generalised 3/22/2006 Female 12/14/2006 Consumer United States
Primary
Concomitant
Viral Infection Hospitalization 12/23/2003 55 Female 126 lb 12/6/2006 Other Health Professional United States
Primary
Concomitant
Sepsis Syndrome Required Intervention 5/31/2006 70 Female 12/15/2006 Pharmacist United States
Primary
Concomitant
Pyrexia Other Serious 9/1/2006 Male 170 lb 12/22/2006 Physician United States
Primary
Concomitant
Ischaemic Cardiomyopathy Hospitalization 1/1/2006 Male 12/22/2006 Physician United States
Primary
Concomitant
Muscle Spasms Other Serious 7/17/2005 Female 150 lb 12/27/2006 Physician United Kingdom
Primary
Concomitant
Rheumatoid Lung Hospitalization 8/7/2006 Female 143 lb 1/2/2007 Belgium
Primary
Concomitant
Lipase Increased Other Serious 4/1/2006 68 Female 1/4/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Bacterial Sepsis Life Threatening 4/27/2006 Male 179 lb 1/10/2007 Netherlands
Primary
Concomitant
Spinal Fracture Life Threatening 3/1/2005 Female 154 lb 1/25/2007 Belgium
Primary
Concomitant
Pulmonary Oedema Hospitalization 1/1/2005 Male 141 lb 2/9/2007 Physician Belgium
Primary
Concomitant
Pulmonary Oedema Hospitalization 1/1/2005 Male 141 lb 2/21/2007 Physician Belgium
Primary
Concomitant
Joint Dislocation Other Serious 2/5/2007 Female 201 lb 3/5/2007 Consumer Canada
Primary
Concomitant
Pancreatitis Hospitalization 11/1/2006 Male 209 lb 3/8/2007 Consumer United States
Primary
Concomitant
Dyspnoea Other Serious Male 206 lb 3/22/2007 Consumer Canada
Primary
Concomitant
Pancytopenia Death 3/10/2007 37 Female 165 lb 3/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 84 Female 3/27/2007 Consumer United States
Primary
Concomitant
Pancytopenia Required Intervention 9/27/2006 64 Female 3/16/2007 Pharmacist United States
Primary
Concomitant
Skin Cancer Other Serious 7/1/2006 Male 4/6/2007 Physician United States
Primary
Concomitant
Monoparesis Hospitalization 11/1/2006 65 Male 4/9/2007 Physician United Kingdom
Primary
Concomitant
Ventricular Dysfunction Other Serious 2/26/2007 Male 173 lb 4/11/2007 Physician United States
Primary
Concomitant
Dyspnoea Other Serious Male 206 lb 4/20/2007 Physician Canada
Primary
Concomitant
Wheezing Hospitalization 1/1/2006 Female 5/14/2007 Physician Norway
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 1/4/2006 79 Female 150 lb 5/23/2007 Other Health Professional United States
Primary
Concomitant
Serum Ferritin Increased Other Serious 12/12/2005 50 Female 141 lb 5/23/2007 Physician United States
Primary
Concomitant
Vomiting Other Serious 4/28/2007 Male 286 lb 5/23/2007 Consumer United States
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 1/15/2007 59 Male 234 lb 5/24/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Disease Progression Other Serious Female 117 lb 6/4/2007 Consumer Canada
Primary
Concomitant
Gastric Ulcer Haemorrhage Hospitalization 1/1/2007 Female 6/13/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Hypersensitivity 5/1/2007 72 Male 185 lb 6/4/2007 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 2/1/2007 Female 6/15/2007 Physician Norway
Primary
Concomitant
Wound Drainage Other Serious 10/27/2006 Female 157 lb 6/20/2007 Physician Germany
Primary
Concomitant
Disease Progression Other Serious Female 117 lb 6/22/2007 Consumer Canada
Primary
Concomitant
Postoperative Wound Infection Hospitalization 205 lb 6/25/2007 Consumer Canada
Primary
Concomitant
Deep Vein Thrombosis Other Serious 6/14/2007 Female 123 lb 6/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Wound Drainage Other Serious 10/27/2006 Female 157 lb 7/12/2007 Germany
Primary
Concomitant
Spinal Fracture Life Threatening 3/1/2005 Female 154 lb 7/13/2007 Belgium
Primary
Concomitant
Weight Decreased Hospitalization 83 Male 225 lb 7/16/2007
Primary
Secondary
Pyrexia Other Serious 5/1/2007 Female 185 lb 8/3/2007 Physician Turkey
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Male 8/6/2007 Physician United States
Primary
Concomitant
Tibia Fracture Hospitalization 4/1/2006 76 Female 8/14/2007 Germany
Primary
Concomitant
Rheumatoid Lung Hospitalization 8/7/2006 Female 143 lb 9/12/2007 Belgium
Primary
Concomitant
Weight Decreased Other Serious 1/1/2004 Male 230 lb 10/5/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 1/23/2007 58 Female 10/23/2007 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2004 Female 10/29/2007 United States
Primary
Secondary
Concomitant
Tibia Fracture Hospitalization 3/1/2004 Female 11/2/2007 Physician United States
Primary
Secondary
Concomitant
Pleurisy Hospitalization 8/7/2006 Female 143 lb 12/14/2007 Belgium
Primary
Concomitant
Wound Infection Staphylococcal 8/31/2007 Female 140 lb 12/14/2007 United States
Primary
Concomitant
Arthralgia Female 201 lb 12/14/2007 Consumer United States
Primary
Concomitant
Injection Site Irritation 6/1/2007 Female 165 lb 12/14/2007 Consumer United States
Primary
Concomitant
Accidental Exposure 9/20/2007 Female 150 lb 12/14/2007 Consumer United States
Primary
Concomitant
Urinary Tract Infection 9/13/2007 Female 147 lb 12/14/2007 Physician United States
Primary
Concomitant
Urinary Tract Infection 9/19/2007 Female 160 lb 12/14/2007 United States
Primary
Concomitant
Injury 9/24/2007 Female 152 lb 12/14/2007 Consumer United States
Primary
Concomitant
Contusion 10/4/2007 Male 229 lb 12/14/2007 United States
Primary
Concomitant
Paraesthesia 8/1/2007 Female 12/14/2007 Consumer United States
Primary
Concomitant
Contusion 10/1/2007 Female 12/14/2007 Consumer United States
Primary
Concomitant
Middle Insomnia 10/15/2007 Female 135 lb 12/14/2007 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2007 Male 194 lb 1/7/2008 Other Health Professional United States
Primary
Concomitant
Injection Site Pain Hospitalization 8/2/2007 Male 220 lb 1/18/2008 Consumer United States
Primary
Concomitant
Weight Decreased Life Threatening 2/14/2007 Female 2/1/2008 Physician Norway
Primary
Concomitant
Vomiting Other Serious 11/1/2004 Female 2/8/2008 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2004 Female 2/8/2008 Germany
Primary
Secondary
Concomitant
Tibia Fracture Hospitalization 4/1/2006 76 Female 2/8/2008 Germany
Primary
Secondary
Concomitant
Pain 12/1/2007 Female 135 lb 3/15/2008 Consumer United States
Primary
Concomitant
Accidental Exposure 1/31/2008 Female 180 lb 3/15/2008 United States
Primary
Concomitant
Skin Lesion 2/6/2008 Female 155 lb 3/15/2008 United States
Primary
Concomitant
Myocardial Infarction Other Serious 2/3/2008 Female 150 lb 3/15/2008 Consumer United States
Primary
Concomitant
Accidental Needle Stick Female 3/15/2008 Consumer United States
Primary
Concomitant
Throat Irritation 1/1/2008 Male 208 lb 3/15/2008 United States
Primary
Concomitant
Urticaria Other Serious 1/31/2008 Female 3/28/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/1/2004 Female 4/2/2008 Germany
Primary
Secondary
Concomitant
Lymphoma Other Serious 68 Female 4/25/2008 Other Health Professional United States
Primary
Concomitant
Non-hodgkin's Lymphoma Other Serious 1/1/2008 Female 98 lb 5/15/2008 Other Health Professional United States
Primary
Concomitant
Thrombosis Hospitalization 6/1/2008 63 Male 6/4/2008 Consumer Canada
Primary
Concomitant
Pain 2/27/2008 Female 110 lb 6/12/2008 United States
Primary
Concomitant
Injection Site Reaction 1/1/2008 Female 6/12/2008 United States
Primary
Concomitant
Swelling Face 3/4/2008 Female 6/12/2008 Other Health Professional United States
Primary
Concomitant
Injection Site Pain 6/1/2007 Male 210 lb 6/12/2008 United States
Primary
Concomitant
Procedural Complication 4/5/2008 Male 200 lb 6/12/2008 Consumer United States
Primary
Concomitant
Drug Ineffective 3/23/2008 Female 287 lb 6/12/2008 United States
Primary
Concomitant
Procedural Complication 4/17/2008 Male 165 lb 6/12/2008 Consumer United States
Primary
Concomitant
Accidental Exposure 4/18/2008 Female 249 lb 6/12/2008 Consumer United States
Primary
Concomitant
Myalgia 4/1/2008 Female 6/13/2008 United States
Primary
Concomitant
Sensation Of Foreign Body 1/1/2006 Female 200 lb 6/13/2008 United States
Primary
Concomitant
Thrombosis In Device Hospitalization 3/1/2005 62 Male 6/20/2008 Pharmacist United States
Primary
Secondary
Concomitant
Wound Secretion Other Serious 10/27/2006 Female 157 lb 8/6/2008 Germany
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 5/26/2008 Female 8/6/2008 Physician United States
Primary
Secondary
Concomitant
Haematochezia Life Threatening 5/6/2006 Male 179 lb 8/6/2008 Netherlands
Primary
Concomitant
Knee Arthroplasty Hospitalization 11/19/2007 Female 128 lb 8/7/2008 Physician Canada
Primary
Concomitant
Rheumatoid Arthritis Other Serious 1/1/2003 Male 8/12/2008 Physician United States
Primary
Concomitant
Insomnia 6/4/2008 Female 150 lb 9/12/2008 Consumer United States
Primary
Concomitant
Pain In Extremity 5/1/2008 Female 170 lb 9/12/2008 Consumer United States
Primary
Concomitant
Pain 6/27/2008 Male 210 lb 9/12/2008 Consumer United States
Primary
Concomitant
Restrictive Pulmonary Disease 9/1/2007 Female 275 lb 9/13/2008 United States
Primary
Concomitant
Sepsis Death 9/26/2008 Female 10/27/2008 Other Health Professional Norway
Primary
Concomitant
Sepsis Other Serious 1/1/2008 Female 11/14/2008 Netherlands
Primary
Concomitant
Nerve Compression Hospitalization 1/1/2008 Male 215 lb 11/14/2008 Consumer United States
Primary
Concomitant
Medical Device Complication Other Serious 7/1/2008 Female 172 lb 11/21/2008 Consumer United States
Primary
Concomitant
Sepsis Other Serious 1/1/2008 Female 12/4/2008 Netherlands
Primary
Concomitant
Serotonin Syndrome Other Serious 73 Female 12/4/2008
Primary
Secondary
Dry Skin 1/1/2005 Female 12/12/2008 Consumer United States
Primary
Concomitant
Procedural Complication 8/30/2008 Male 300 lb 12/12/2008 Consumer United States
Primary
Concomitant
Pneumonia 1/1/2006 Female 125 lb 12/12/2008 United States
Primary
Concomitant
Productive Cough Male 210 lb 12/12/2008 United States
Primary
Concomitant
Injection Site Irritation 4/1/2008 Male 245 lb 12/12/2008 United States
Primary
Concomitant
Localised Infection 9/4/2008 Female 160 lb 12/12/2008 United States
Primary
Concomitant
Upper Respiratory Tract Infection 9/19/2008 Female 195 lb 12/12/2008 United States
Primary
Concomitant
Wheezing 9/5/2008 Female 214 lb 12/12/2008 United States
Primary
Concomitant
Swelling 9/1/2008 Female 200 lb 12/12/2008 Consumer United States
Primary
Concomitant
Product Quality Issue 9/17/2008 Male 225 lb 12/12/2008 United States
Primary
Concomitant
Myalgia 4/1/2008 Female 12/12/2008 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process 11/3/2008 Female 150 lb 12/12/2008 Other Health Professional United States
Primary
Concomitant
Thrombosis 8/1/2008 Female 145 lb 12/12/2008 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 7/1/2008 Female 189 lb 12/12/2008 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/1/2008 Female 2/3/2009 Brazil
Primary
Concomitant
Rectal Polyp Hospitalization 1/30/2009 Male 3/4/2009 Consumer United States
Primary
Concomitant
Skin Lesion 11/1/2008 Male 195 lb 3/14/2009 Consumer United States
Primary
Concomitant
Pain In Extremity 11/1/2008 Female 3/14/2009 Consumer United States
Primary
Concomitant
Pleural Effusion Female 287 lb 3/20/2009 United States
Primary
Concomitant
Tinnitus Other Serious 2/1/2009 Male 181 lb 4/22/2009 Canada
Primary
Concomitant
Thrombosis Other Serious 6/1/2008 63 Male 4/20/2009 Consumer Canada
Primary
Concomitant
Respiratory Failure Hospitalization 5/28/2008 Female 5/22/2009 Physician United States
Primary
Secondary
Concomitant
Uterine Dilation And Curettage Other Serious 4/27/2009 Female 185 lb 6/10/2009 Canada
Primary
Concomitant

Drug Data