Metformin combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Blood Creatinine Increased 2/16/2005 69 218 lb 1/6/2006 Pharmacist United States
Primary
Concomitant
Blood Creatinine Increased 2/16/2005 69 218 lb 1/6/2006 Pharmacist United States
Primary
Concomitant
Visual Disturbance Hospitalization 6/1/2005 Male 263 lb 3/1/2006 Physician United States
Primary
Secondary
Concomitant
Visual Disturbance 11/8/2005 65 Male 340 lb 1/20/2006 Other Health Professional United States
Primary
Concomitant
Injection Site Haemorrhage 11/25/2005 64 Male 1/20/2006 Consumer United States
Primary
Concomitant
Respiratory Disorder Other Serious 75 Female 180 lb 4/7/2006 United States
Primary
Secondary
Concomitant
Depression Hospitalization 11/20/2001 82 Male 134 lb 4/20/2006 Physician United States
Primary
Concomitant
Neck Pain Death 2/16/2006 82 Male 205 lb 4/4/2006 Consumer United States
Primary
Concomitant
Pain In Extremity Required Intervention 10/14/2004 Male 288 lb 3/29/2006 Other Health Professional United States
Primary
Concomitant
Weight Increased 1/7/2006 65 Male 230 lb 2/20/2006 United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Other Serious 3/22/2006 81 Male 162 lb 5/8/2006
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2003 57 Male 5/9/2006 Australia
Primary
Concomitant
International Normalised Ratio Increased Other Serious 3/22/2006 81 Male 162 lb 5/9/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Death 78 Female 5/9/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Oedema Other Serious 3/13/2006 80 Male 162 lb 5/17/2006 Physician Canada
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 5/21/2006 77 Male 211 lb 5/25/2006 Pharmacist United States
Primary
Concomitant
Wound Infection Hospitalization 62 Male 223 lb 4/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Urticaria Generalised Hospitalization 2/20/2005 54 Female 130 lb 5/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Stomach Discomfort Hospitalization 1/1/2005 87 Male 134 lb 5/31/2006 United States
Primary
Concomitant
Cellulitis Hospitalization 12/27/2005 61 Male 359 lb 6/15/2006 Physician Canada
Primary
Concomitant
Pneumonia Life Threatening 1/30/2006 78 Female 6/14/2006 Canada
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Life Threatening 1/30/2006 78 Female 6/19/2006 Canada
Primary
Secondary
Concomitant
Somnolence 1/1/2006 76 Female 200 lb 4/17/2006 Consumer United States
Primary
Concomitant
Medication Residue 75 Male 7/21/2006 Consumer United States
Primary
Concomitant
Diarrhoea 3/1/2006 Female 7/21/2006 Consumer United States
Primary
Secondary
Concomitant
Macular Oedema Other Serious 4/12/2006 Male 7/18/2006 Pharmacist United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/23/2006 59 Male Pharmacist United States
Primary
Secondary
Concomitant
Haematuria Hospitalization 5/19/2006 77 Male Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 74 Male 7/21/2006 Other Health Professional Denmark
Primary
Concomitant
Vomiting Life Threatening 7/15/2006 55 Male 350 lb 7/24/2006 Physician United States
Primary
Concomitant
Insomnia 3/1/2006 64 Female 280 lb 7/12/2006 Consumer United States
Primary
Concomitant
Dyspnoea Hospitalization 6/30/2006 79 Male 167 lb 7/31/2006 Other Health Professional United States
Primary
Concomitant
Pain In Extremity Other Serious 7/1/2006 Male 200 lb 8/25/2006 United States
Primary
Concomitant
Drug Administration Error Male 11/13/2006 Consumer United States
Primary
Concomitant
Fatigue 62 Male 11/13/2006 Consumer United States
Primary
Concomitant
Tooth Extraction Other Serious 9/11/2006 59 Male 11/15/2006 United States
Primary
Concomitant
Pneumonia Hospitalization 11/1/2006 58 Male 188 lb 11/10/2006 Pharmacist United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 9/11/2006 59 Male 11/23/2006 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 54 Female 12/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Weight Increased 1/1/2005 83 Male 12/8/2006 Consumer United States
Primary
Secondary
Concomitant
Cardiac Hypertrophy Death 11/15/2006 51 Female 252 lb 12/11/2006 Physician United Kingdom
Primary
Concomitant
Insomnia 1/1/2006 59 Female 10/11/2006 Consumer United States
Primary
Concomitant
Hypnopompic Hallucination Other Serious 12/1/2006 70 Female 1/18/2007 Consumer United States
Primary
Secondary
Concomitant
Thrombophlebitis Superficial Hospitalization 9/8/2006 66 Female 167 lb 1/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Post Procedural Complication Hospitalization 1/1/2006 62 Female 198 lb 3/19/2007 Consumer United States
Primary
Concomitant
Cardiac Failure Congestive Other Serious 52 Female 3/30/2007 Other Health Professional France
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Hospitalization 3/20/2007 64 Male 163 lb 3/28/2007 Pharmacist United States
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 5/29/2007 37 Male 292 lb 6/18/2007 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 6/9/2007 81 Female 7/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Type 2 Diabetes Mellitus Other Serious 1/1/2003 32 Female 237 lb 7/12/2007 Other Health Professional United States
Primary
Concomitant
Intestinal Haemorrhage Hospitalization Male 54 lb 8/23/2007 Pharmacist United States
Primary
Concomitant
Pancreatic Disorder Hospitalization 7/1/2007 60 Female 9/21/2007 Physician Czech Republic
Primary
Concomitant
Treatment Noncompliance 6/8/2006 69 Male 10/25/2007 Consumer United States
Primary
Concomitant
Pancreatic Disorder Hospitalization 7/1/2007 Female 10/24/2007 Physician Czech Republic
Primary
Concomitant
Regurgitation Other Serious 7/20/2007 Male 175 lb 10/26/2007 Consumer United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 7/28/2007 64 Male 229 lb 11/5/2007 Pharmacist United States
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization Female 162 lb 1/21/2008 Physician United Kingdom
Primary
Concomitant
Interacting
Skeletal Injury Hospitalization 12/28/2007 51 Male 256 lb 3/17/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Migraine Hospitalization 3/1/2008 Female 6/17/2008 Physician United States
Primary
Concomitant
Gingival Bleeding Other Serious 2/14/2008 Female 155 lb 6/20/2008 Physician United States
Primary
Concomitant
Malaise Other Serious 4/1/2008 62 Female 160 lb 6/17/2008 United States
Primary
Concomitant
Weight Decreased Other Serious 5/29/2008 71 Female 7/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Heart Rate Increased Other Serious 5/1/2008 83 Female 135 lb 5/1/2008 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 5/29/2008 71 Female 7/7/2008 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 5/3/2008 Female 7/23/2008 Other Health Professional Sweden
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Hospitalization 3/6/2008 68 Male 212 lb 7/7/2008 Pharmacist United States
Primary
Concomitant
Pulmonary Hypertension Hospitalization 6/1/2002 63 Male 269 lb 8/22/2008 Consumer United States
Primary
Concomitant
Palpitations Other Serious 1/1/2008 63 Female 297 lb 8/22/2008 United States
Primary
Concomitant
Tremor Life Threatening 6/1/2008 Male 198 lb 9/9/2008 Consumer United States
Primary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tooth Infection Hospitalization 9/25/2008 72 Male 10/13/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/16/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/12/2008 Female 1/15/2009 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Life Threatening 10/1/2008 63 Male 205 lb 1/16/2009 Consumer United States
Primary
Secondary
Concomitant
Left Ventricular Dysfunction Other Serious 2/1/2008 60 Male 269 lb 1/16/2009 Other Health Professional United States
Primary
Concomitant
Drug Ineffective 66 Female 220 lb 1/13/2009 Consumer United States
Primary
Concomitant
Occult Blood Positive Hospitalization 9/9/2008 64 Female 284 lb 1/13/2009 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Hospitalization 4/1/2004 42 Female 211 lb 1/22/2009 Consumer United States
Primary
Concomitant
Haematuria Hospitalization 12/31/2008 58 Female 1/19/2009 Pharmacist United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 1/18/2009 Female 2/2/2009 Pharmacist Canada
Primary
Concomitant
Thrombosis Hospitalization 12/23/2008 Male 2/4/2009 Consumer United Kingdom
Primary
Concomitant
Syncope Other Serious 12/22/2008 66 Male 200 lb 2/10/2009 Consumer United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 12/23/2008 Male 2/23/2009 Consumer United Kingdom
Primary
Concomitant
Accidental Death Death 1/5/2005 Female 166 lb 2/16/2009 Physician United States
Primary
Concomitant
Epistaxis Other Serious 5/22/2008 58 Male 2/25/2009 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/18/2009 83 Male 155 lb 2/24/2009 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2008 Female 235 lb 3/6/2009 Physician United States
Primary
Concomitant
Renal Impairment Other Serious 51 Female 3/23/2009 Consumer United Kingdom
Primary
Concomitant
Renal Disorder Hospitalization 10/31/2008 79 Male 240 lb 2/26/2009 Pharmacist United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 11/18/2008 74 Male 254 lb 2/26/2009 Pharmacist United States
Primary
Concomitant
Prostate Cancer Other Serious 3/6/2009 5/19/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Normochromic Normocytic Anaemia Hospitalization 1/9/2009 75 Female 207 lb 5/11/2009 Pharmacist United States
Primary
Concomitant
Pain Hospitalization 8/6/2006 50 Female 226 lb 6/10/2009 Pharmacist United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 5/8/2007 36 Female 260 lb 6/29/2009 United States
Primary
Concomitant
Tachycardia Hospitalization 63 Male 7/23/2009 United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/12/2008 Female 7/29/2009 Consumer United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 2/1/2003 30 Female 236 lb 7/28/2009 United States
Primary
Concomitant
Hand Deformity Other Serious 4/1/2009 Male 7/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Hypovolaemia Hospitalization 6/18/2009 83 Male 7/30/2009 Consumer United States
Primary
Secondary
Concomitant
Unevaluable Event Hospitalization 7/1/2007 48 Male 7/28/2009 Consumer United States
Primary
Concomitant
Hyperkalaemia Hospitalization Male 8/3/2009 Physician Canada
Primary
Concomitant
Myalgia Other Serious 1/29/2008 62 Male 8/3/2009 Pharmacist United States
Primary
Concomitant
Interacting
Wound Abscess Other Serious 1/9/2009 Male 8/3/2009 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 11/12/2008 Female 8/4/2009 Consumer United States
Primary
Secondary
Concomitant
Renal Disorder Death 67 Male 8/3/2009 Lawyer United States
Primary
Concomitant
Diabetes Mellitus Other Serious Female 8/18/2009 Consumer United States
Primary
Concomitant
Paraesthesia 7/1/2008 Male 8/21/2009 United States
Primary
Concomitant
Dyspepsia 8/18/2008 Male 8/21/2009 United States
Primary
Concomitant
Nightmare 8/22/2008 Male 8/21/2009 United States
Primary
Concomitant
Blood Glucose Increased 6/30/2008 Male 8/21/2009 United States
Primary
Concomitant
Cardiac Flutter 11/16/2008 Male 8/22/2009 United States
Primary
Concomitant
Ocular Hyperaemia Other Serious 1/1/2006 Female 200 lb 9/14/2009 Consumer United States
Primary
Concomitant
Respiratory Distress Life Threatening 72 Male 9/24/2009 United Kingdom
Primary
Secondary
Concomitant
Presyncope Other Serious 61 Female 230 lb 10/2/2009 United States
Primary
Concomitant
Syncope Hospitalization 4/13/2008 67 Male 278 lb 10/8/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Ocular Hyperaemia Other Serious 1/1/2006 Female 200 lb 10/13/2009 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 10/10/2009 United States
Primary
Concomitant
Right Ventricular Failure Hospitalization 5/22/2009 Male 165 lb 10/20/2009 Physician United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 64 Male 10/20/2009 United States
Primary
Concomitant
Rotator Cuff Repair Hospitalization 10/1/2004 52 Male 11/9/2009 Consumer
Primary
Concomitant
Unemployment Hospitalization 72 Male 11/4/2009 United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 11/12/2008 Female 11/24/2009 Consumer United States
Primary
Secondary
Concomitant
Feeling Hot 9/1/2009 345 lb 11/25/2009 United States
Primary
Concomitant
Mental Impairment Other Serious 10/26/2009 72 Female 11/24/2009 United States
Primary
Secondary
Concomitant
Ocular Hyperaemia Other Serious 1/1/2006 Female 200 lb 12/11/2009 Physician United States
Primary
Concomitant
Cardiomyopathy Other Serious 68 Male 12/11/2009 United States
Primary
Concomitant
Nodal Rhythm Hospitalization 10/14/2009 Female 12/29/2009 Consumer Italy
Primary
Concomitant
Myocardial Infarction Death 75 Male 300 lb 12/29/2009 Consumer United States
Primary
Concomitant
Peripheral Ischaemia Other Serious 1/1/2007 68 Female 254 lb 12/29/2009 Lawyer United States
Primary
Secondary
Concomitant
Transitional Cell Carcinoma Other Serious 10/19/2009 62 Male 205 lb 12/29/2009 Other Health Professional United States
Primary
Concomitant
Hyperkalaemia Other Serious 73 Female 331 lb 12/29/2009 Other Health Professional
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2006 Female 191 lb 12/31/2009 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 68 Male 1/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 10/18/2009 58 Male 1/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Large Intestinal Ulcer Hospitalization 11/18/2009 65 Female 1/15/2010 Consumer United States
Primary
Secondary
Concomitant
Pain Death Male 1/11/2010 United States
Primary
Concomitant
Hyperkalaemia Life Threatening 73 Female 331 lb 1/16/2010 United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 12/7/2009 Female 1/28/2010 Physician United Kingdom
Primary
Concomitant
Wound Other Serious 1/1/2010 66 Female 3/10/2010 Consumer Canada
Primary
Concomitant
Vertigo Hospitalization 2/22/2008 59 Female 3/19/2010 Other Health Professional Singapore
Primary
Secondary
Concomitant
Retinal Vein Occlusion Other Serious 9/6/2009 Male 3/19/2010 Other Health Professional Australia
Primary
Concomitant
Somnolence Other Serious 9/1/2009 Female 134 lb 3/26/2010 Consumer United States
Primary
Concomitant
Constipation Hospitalization 62 Male 212 lb 4/6/2010 Consumer United States
Primary
Concomitant
Off Label Use Life Threatening 6/8/2009 57 Female 154 lb 4/8/2010 Physician Denmark
Primary
Concomitant
Interacting
White Blood Cell Count Increased Life Threatening 3/10/2010 78 Female 4/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiac Disorder Death Male 345 lb 4/9/2010 Canada
Primary
Concomitant
Colon Cancer Other Serious 79 Male 4/21/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Life Threatening 1/1/2010 66 Female 4/22/2010 Physician United Kingdom
Primary
Concomitant
Oxygen Saturation Decreased Hospitalization 4/15/2010 68 Female 4/26/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/8/2010 75 Female 4/15/2010 Physician United States
Primary
Concomitant

Drug Data