Metformin combined with Tramadol

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Decreased Hospitalization 10/24/2005 58 Male 203 lb 12/1/2005 Pharmacist United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 6/23/2003 Female 2/5/2009 Lawyer United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 6/23/2003 Female 3/6/2009 Lawyer United States
Primary
Concomitant
Death Death 5/13/2009 Male 5/21/2009 Physician United States
Primary
Secondary
Concomitant
Death Death 5/13/2009 Male 6/30/2009 Physician United States
Primary
Secondary
Concomitant
Wheelchair User Disability 3/1/2009 Male 7/9/2009 United States
Primary
Concomitant
Pulmonary Embolism Other Serious 11/12/2008 Female 7/29/2009 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2005 Female 436 lb 7/29/2009 Consumer United States
Primary
Concomitant
Tardive Dyskinesia Other Serious 1/1/1999 39 Male 258 lb 7/30/2009 United States
Primary
Secondary
Concomitant
Hand Deformity Other Serious 4/1/2009 Male 7/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 3/18/2008 56 Female 258 lb 7/22/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 3/18/2008 56 Female 258 lb 8/6/2009 Lawyer United States
Primary
Concomitant
Suicidal Ideation Other Serious 6/16/2009 Female 220 lb 8/17/2009 Consumer United States
Primary
Concomitant
Vomiting 8/13/2008 Male 240 lb 8/21/2009 Consumer United States
Primary
Concomitant
Insomnia 9/28/2008 Male 8/21/2009 United States
Primary
Concomitant
Blood Glucose Increased Male 8/22/2009 United States
Primary
Concomitant
Dizziness 11/14/2008 Male 200 lb 8/22/2009 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 10/1/2009 Male 226 lb 11/23/2009 Consumer United States
Primary
Concomitant
Pain In Extremity Other Serious 1/1/2007 Female 180 lb 12/30/2009 Consumer United States
Primary
Secondary
Concomitant
Epistaxis 9/9/2009 64 Male 1/5/2010 Other Health Professional United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 10/1/2009 Male 226 lb 1/5/2010 Consumer United States
Primary
Concomitant
Myalgia Disability 1/9/2009 69 Female 225 lb 1/6/2010 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2007 Male 155 lb 1/15/2010 Physician United States
Primary
Concomitant
Throat Irritation 10/23/2009 Female 275 lb 1/30/2010 United States
Primary
Concomitant
Productive Cough Other Serious 9/1/2009 Female 240 lb 1/30/2010 United States
Primary
Concomitant
Benign Intracranial Hypertension Other Serious 11/10/2009 Male 337 lb 2/12/2010 Physician United Kingdom
Primary
Concomitant
Chromaturia Other Serious 80 Female 2/21/2010 Physician United States
Primary
Concomitant
Cystoscopy Other Serious 80 Female 3/18/2010 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 3/15/2010 Male 267 lb 3/26/2010 Pharmacist United States
Primary
Concomitant
Spinal Cord Injury Disability 12/1/2009 Male 4/7/2010 Physician Australia
Primary
Concomitant
Cystoscopy Other Serious 80 Female 5/4/2010 Physician United States
Primary
Concomitant
Blood Glucose Increased Other Serious 4/18/2010 50 Female 223 lb 5/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
Panic Attack Other Serious 2/1/2010 50 Female 256 lb 5/19/2010 Physician United States
Primary
Concomitant
Blood Glucose Increased Other Serious 4/18/2010 50 Female 223 lb 5/26/2010 Other Health Professional United Kingdom
Primary
Concomitant
Testicular Swelling Hospitalization 3/1/2010 73 Male 236 lb 6/17/2010 Consumer United States
Primary
Concomitant
Trismus Other Serious 1/1/2008 61 Male 130 lb 6/17/2010 Consumer United States
Primary
Concomitant
Blood Glucose Increased Other Serious 4/18/2010 50 Female 223 lb 6/21/2010 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Female Other Serious 1/1/2006 73 Female 6/23/2010 Lawyer United States
Primary
Secondary
Concomitant
Impaired Gastric Emptying Hospitalization 3/17/2010 41 Male 273 lb 7/21/2010 Physician Denmark
Primary
Concomitant
Somnolence Other Serious 7/9/2010 56 Male 201 lb 7/30/2010 Consumer United States
Primary
Concomitant
Muscle Spasms 3/1/2010 73 Female 8/16/2010 Consumer United States
Primary
Concomitant
Renal Injury Other Serious 1/1/2009 50 Female 205 lb 8/13/2010 Physician United States
Primary
Concomitant
Suicide Attempt Other Serious 1/1/2008 53 Female 9/8/2010 Lawyer United States
Primary
Concomitant
Tendonitis Female 9/14/2010 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious Male 249 lb 9/14/2010 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 8/24/2010 77 Female 143 lb 9/15/2010 Physician Portugal
Primary
Secondary
Concomitant
Medication Residue 1/1/2009 58 Female 9/15/2010 Other Health Professional United States
Primary
Concomitant
Parkinson's Disease Other Serious 1/1/2008 66 Male 190 lb 9/16/2010 Physician United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 10/1/2009 49 Male 226 lb 9/16/2010 Consumer United States
Primary
Concomitant
Panic Attack Other Serious 2/1/2010 50 Female 256 lb 9/16/2010 Physician United States
Primary
Concomitant
Vomiting 8/27/2009 78 Female 140 lb 9/16/2010 Consumer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 49 Male 9/17/2010 Pharmacist United States
Primary
Secondary
Concomitant
Muscle Atrophy 55 Female 172 lb 9/20/2010 United States
Primary
Concomitant
Mood Swings 52 Female 9/20/2010 United States
Primary
Concomitant
Vomiting 1/1/2004 64 Female 140 lb 9/20/2010 United States
Primary
Concomitant
Type 2 Diabetes Mellitus 1/1/2008 42 Female 201 lb 9/20/2010 United States
Primary
Concomitant
Weight Increased Other Serious 3/23/2001 53 Male 219 lb 9/21/2010 United States
Primary
Concomitant
Pruritus Other Serious 2/12/2008 31 Female 208 lb 9/22/2010 Physician United States
Primary
Concomitant
Cardiac Failure Congestive Death 53 Female 9/23/2010 Consumer Australia
Primary
Secondary
International Normalised Ratio Decreased Other Serious 7/1/2010 82 Female 165 lb 9/29/2010 Consumer United States
Primary
Concomitant
Mental Impairment Other Serious 4/1/2010 50 Female 301 lb 10/6/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Life Threatening 3/10/2010 78 Female 10/5/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Paraesthesia Other Serious 1/1/2008 54 Male 257 lb 10/20/2010 Consumer United States
Primary
Secondary
Concomitant
Blood Glucose Increased Female 288 lb 10/29/2010 Other Health Professional United States
Primary
Concomitant
Wheezing Hospitalization 9/28/2005 74 Female 11/11/2010 United States
Primary
Concomitant
Paraesthesia Other Serious 1/1/2008 54 Male 265 lb 12/1/2010 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/1/2007 66 Male 252 lb 12/9/2010 Physician United States
Primary
Concomitant
Pancreatic Carcinoma Other Serious 7/6/2010 61 Male 254 lb 12/8/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 12/14/2010 Physician United States
Primary
Concomitant
Death Death 12/15/2010 Physician Spain
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 10/1/2009 49 Male 226 lb 1/5/2010 Consumer United States
Primary
Concomitant
Panic Attack Other Serious 2/1/2010 50 Female 256 lb 5/19/2010 Physician United States
Primary
Concomitant
Nervous System Disorder Other Serious Female 12/15/2010 Consumer United States
Primary
Concomitant
Prostatic Operation Hospitalization 11/1/2010 72 Male 12/16/2010 Consumer United States
Primary
Concomitant
Somnolence Other Serious 8/1/2010 80 Female 240 lb 12/17/2010 Consumer United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2010 54 Female 132 lb 12/17/2010 Other Health Professional Brazil
Primary
Concomitant
Drug Ineffective 1/1/2010 68 Female 126 lb 12/21/2010 Consumer United States
Primary
Concomitant
Eye Pain Other Serious 12/16/2010 59 Female 130 lb 12/21/2010 Consumer United States
Primary
Concomitant
Pancreatic Carcinoma Other Serious 7/6/2010 61 Male 254 lb 12/21/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/1/2010 68 Female 240 lb 12/22/2010 Consumer United States
Primary
Concomitant
Death Death 12/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Psoriatic Arthropathy 12/23/2010 Physician United States
Primary
Concomitant
Haematuria 9/13/2010 12/23/2010 Physician United States
Primary
Concomitant
Convulsion Other Serious 12/19/2010 45 Male 12/30/2010 Physician United States
Primary
Concomitant
Muscular Weakness Hospitalization 1/1/2009 40 Female 311 lb 1/3/2011 Physician United States
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 56 Female 1/14/2011 Physician United States
Primary
Secondary
Drug Ineffective Death 1/1/2010 68 Female 126 lb 1/13/2011 Consumer United States
Primary
Concomitant
Pancreatitis Chronic Hospitalization 11/21/2010 30 Female 146 lb 1/20/2011 Physician United States
Primary
Concomitant
Toxicity To Various Agents Death 1/1/2009 56 Female 1/24/2011 Physician United States
Primary
Secondary
Malaise Other Serious 1/1/2008 54 Male 265 lb 2/14/2011 Consumer United States
Primary
Secondary
Concomitant
Panic Attack Other Serious 1/1/2008 54 Male 257 lb 2/14/2011 United States
Primary
Secondary
Concomitant
Influenza Virus Test Positive Hospitalization 9/30/2008 69 Male 161 lb 1/31/2011 Physician Netherlands
Primary
Secondary
Concomitant
Hypoaesthesia Other Serious 1/1/2008 54 Male 257 lb 2/17/2011 Consumer United States
Primary
Secondary
Concomitant
Multiple Drug Overdose Intentional Death 1/1/2009 56 Female 2/7/2011 Physician United States
Primary
Secondary
Blood Sodium Decreased Hospitalization 3/10/2010 78 Female 2/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Panic Attack Other Serious 1/1/2008 54 Male 257 lb 3/2/2011 Consumer United States
Primary
Secondary
Concomitant
Osteomyelitis Hospitalization 12/21/2006 62 Male 333 lb 3/3/2011 Physician United States
Primary
Concomitant
Pharyngeal Oedema Hospitalization 2/24/2011 77 Female 140 lb 3/3/2011 Consumer United States
Primary
Concomitant
Erythema Other Serious 2/1/2011 74 Male 160 lb 3/8/2011 Other Health Professional United States
Primary
Concomitant
Cough 10/1/2010 71 Male 3/10/2011 Consumer United States
Primary
Concomitant
Depression Other Serious 3/20/2009 53 Female 3/10/2011 Lawyer United States
Primary
Concomitant
Intentional Drug Misuse Hospitalization 1/1/2009 62 Male 210 lb 3/11/2011 Consumer United States
Primary
Secondary
Concomitant
Akathisia Other Serious 1/1/1984 32 Female 115 lb 2/28/2011 Lawyer United States
Primary
Concomitant
Fanconi Syndrome Hospitalization 2/1/2011 38 Female 155 lb 3/15/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 59 Male 183 lb 4/6/2011 Other Health Professional United States
Primary
Concomitant
Pulmonary Hypertension Hospitalization 53 Female 145 lb 4/6/2011 Physician United States
Primary
Concomitant
Rash Macular Other Serious 6/15/2010 64 Female 260 lb 3/7/2011 United States
Primary
Secondary
Concomitant
Product Formulation Issue Other Serious 6/16/2010 64 Female 260 lb 3/7/2011 Pharmacist United States
Primary
Concomitant
Pain Other Serious Female 4/8/2011 Consumer United States
Primary
Concomitant
Abasia Other Serious 10/1/2009 70 Male 235 lb 4/11/2011 Consumer United States
Primary
Secondary
Concomitant
Dyspepsia 3/8/2011 80 Male 4/14/2011 Consumer United States
Primary
Concomitant
Pleuritic Pain Hospitalization 3/1/2009 20 Female 175 lb 4/14/2011 Lawyer United States
Primary
Secondary
Concomitant
Pleuritic Pain Hospitalization 3/1/2009 20 Female 175 lb 4/14/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Erectile Dysfunction Other Serious 50 Male 4/5/2011 United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 2/1/2011 85 Female 4/26/2011 Consumer United States
Primary
Concomitant
Erectile Dysfunction Other Serious 1/1/2011 50 Male 4/27/2011 Other Health Professional United Kingdom
Primary
Concomitant
Neurological Symptom Other Serious 45 Male 4/27/2011 Physician United States
Primary
Concomitant
Back Pain Hospitalization 8/23/2010 63 Female 144 lb 4/28/2011 Physician United Kingdom
Primary
Concomitant
Mental Disorder Hospitalization 5/1/2009 51 Female 5/5/2011 Lawyer United States
Primary
Concomitant
Emotional Distress Other Serious 1/1/2007 52 Male 7/19/2011 Lawyer United States
Primary
Concomitant
Suicidal Ideation Other Serious 9/22/2007 42 Female 7/28/2011 Lawyer United States
Primary
Concomitant
Mental Disorder Other Serious 1/1/2008 42 Male 8/10/2011 Lawyer United States
Primary
Concomitant
Irritability Other Serious 6/1/2011 51 Female 154 lb 8/12/2011 Physician Colombia
Primary
Concomitant
Blood Thyroid Stimulating Hormone Decreased Other Serious 12/10/2010 50 Female 146 lb 9/7/2011 Pharmacist Brazil
Primary
Concomitant
Suicidal Ideation Other Serious 6/1/2011 51 Female 154 lb 9/21/2011 Physician Colombia
Primary
Concomitant
Weight Decreased 1/1/2011 69 Male 181 lb 10/14/2011 Consumer United States
Primary
Concomitant
Anxiety Other Serious 1/1/2008 53 Female 11/10/2011 Lawyer United States
Primary
Concomitant
Rhinorrhoea 1/18/2012 36 Female 224 lb 1/24/2012 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 12/1/2011 64 Female 180 lb 1/26/2012 Consumer United States
Primary
Secondary
Concomitant
Cold-stimulus Headache Other Serious Female 180 lb 1/27/2012 Consumer United States
Primary
Secondary
Concomitant
Fibromyalgia Other Serious Female 284 lb 2/28/2012 Other Health Professional United States
Primary
Concomitant
Disorientation Male 220 lb 3/2/2012 Consumer United States
Primary
Secondary
Concomitant
Pruritus 1/18/2012 36 Female 225 lb 3/2/2012 Consumer United States
Primary
Concomitant
Headache Male 258 lb 3/28/2012 Physician United States
Primary
Secondary
Concomitant
Headache Male 258 lb 4/10/2012 Physician United States
Primary
Secondary
Concomitant
Blood Pressure Decreased 3/13/2012 50 Female 168 lb 4/13/2012 Consumer United States
Primary
Concomitant
Disorientation Male 220 lb 4/24/2012 Consumer United States
Primary
Secondary
Concomitant
Myalgia Other Serious Female 4/25/2012 Consumer United States
Primary
Concomitant
Back Pain 4/25/2012 Consumer United States
Primary
Concomitant
Myalgia Other Serious Female 4/26/2012 Consumer United States
Primary
Concomitant
Hypersensitivity Male 258 lb 5/3/2012 Physician United States
Primary
Secondary
Concomitant
Hyperuricaemia Other Serious 61 Female 5/24/2012 Other Health Professional Belgium
Primary
Secondary
Concomitant
Back Pain 5/25/2012 Physician United States
Primary
Concomitant
Hearing Impaired 1/1/2012 59 Male 234 lb 6/8/2012 Consumer United States
Primary
Concomitant
Pain In Extremity Other Serious 8/1/2010 59 Female 140 lb 6/8/2012 Consumer United States
Primary
Concomitant
Pain Other Serious Female 6/11/2012 Consumer United States
Primary
Concomitant
Dizziness 1/7/2012 58 Male 6/18/2012 Physician United States
Primary
Concomitant
Glycosylated Haemoglobin Increased 1/1/2012 59 Male 234 lb 6/25/2012 Other Health Professional United States
Primary
Concomitant
Pain Other Serious 1/1/2011 70 Female 271 lb 6/29/2012 Consumer United States
Primary
Concomitant
Weight Decreased 1/1/2012 71 Female 270 lb 6/29/2012 Consumer United States
Primary
Concomitant

Drug Data