Metformin combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Productive Cough 5/10/2005 66 Female 12/7/2005 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 9/8/2004 Female 3/3/2006 Physician Germany
Primary
Secondary
Concomitant
Uterine Leiomyoma Hospitalization 5/1/2005 Female 210 lb 3/17/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 9/8/2004 Female 3/28/2006 Physician Germany
Primary
Concomitant
Weight Decreased 11/22/2005 60 Male 311 lb 1/20/2006 Consumer United States
Primary
Concomitant
Death Death 1/19/2005 64 Male 143 lb 3/23/2006 Other Health Professional Netherlands
Primary
Concomitant
Fluid Retention Hospitalization 3/28/2001 53 Male 280 lb 4/11/2006 Lawyer United States
Primary
Concomitant
Circulatory Collapse Hospitalization 1/18/2006 67 Male 165 lb 4/13/2006 Physician Germany
Primary
Concomitant
Neck Pain Death 2/16/2006 82 Male 205 lb 4/4/2006 Consumer United States
Primary
Concomitant
Varicose Vein Operation Hospitalization 1/1/2000 53 Male 351 lb 5/5/2006 Lawyer United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2004 65 Female 176 lb 5/5/2006 Physician United States
Primary
Concomitant
Wound Infection Hospitalization 12/20/2000 58 Female 192 lb 5/8/2006 Physician United States
Primary
Concomitant
Varicose Vein Operation Hospitalization 1/1/2000 53 Male 351 lb 5/9/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Fungal Life Threatening 5/19/2005 Male 172 lb 5/9/2006 Physician Portugal
Primary
Concomitant
Ventricular Hypertrophy Other Serious 11/22/2005 71 Male 194 lb 5/9/2006 Physician Belgium
Primary
Concomitant
Synovial Cyst Hospitalization 10/30/2000 53 Male 280 lb 5/16/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/23/2006 67 Male 163 lb 5/22/2006 Physician Germany
Primary
Concomitant
Somnolence Hospitalization 1/1/2005 Male 5/24/2006 Consumer United States
Primary
Concomitant
Rhabdomyolysis Death 4/2/2006 69 Female 6/5/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urticaria Generalised Hospitalization 2/20/2005 54 Female 130 lb 5/25/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Death 4/2/2006 69 Female 5/30/2006 United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Death 4/2/2006 69 Female 6/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Injection Site Bruising 1/1/2006 67 Female 249 lb 4/17/2006 Consumer United States
Primary
Concomitant
Lethargy Hospitalization 5/16/2006 76 Female 6/27/2006 United Kingdom
Primary
Secondary
Concomitant
Lethargy Hospitalization 5/16/2006 76 Female 7/6/2006 United Kingdom
Primary
Secondary
Concomitant
Skin Exfoliation Hospitalization 1/27/2006 76 Female 209 lb 7/7/2006 Other Health Professional France
Primary
Secondary
Concomitant
Overdose Hospitalization 4/8/2006 87 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Muscle Spasms 68 Female 7/21/2006 Consumer United States
Primary
Secondary
Concomitant
Pharyngeal Oedema Other Serious 92 Female 7/17/2006 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 74 Male 7/21/2006 Other Health Professional Denmark
Primary
Concomitant
Rhabdomyolysis Death 4/9/2006 69 Female 8/18/2006 Other Health Professional Denmark
Primary
Concomitant
Ventricular Arrhythmia Hospitalization 80 Female 10/5/2006 Netherlands
Primary
Secondary
Concomitant
Weight Fluctuation Hospitalization 9/9/2006 67 Male 251 lb 11/2/2006 Physician United States
Primary
Concomitant
Drug Administration Error Male 11/13/2006 Consumer United States
Primary
Concomitant
Malaise Life Threatening 9/8/2006 67 Female 165 lb 11/7/2006 France
Primary
Concomitant
Malaise Hospitalization 5/28/2006 94 Female 11/21/2006 Physician France
Primary
Secondary
Concomitant
Rhabdomyolysis Death 4/2/2006 69 Female 1/22/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Visual Acuity Reduced Disability 9/3/2006 Female 1/25/2007 Consumer United States
Primary
Concomitant
Weight Increased 1/29/2006 64 Male 249 lb 10/16/2006 Consumer United States
Primary
Secondary
Concomitant
Post Procedural Complication Hospitalization 1/1/2006 62 Female 198 lb 3/19/2007 Consumer United States
Primary
Concomitant
Cardiac Failure Congestive Other Serious 52 Female 3/30/2007 Other Health Professional France
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 5/29/2007 37 Male 292 lb 6/18/2007 Pharmacist United States
Primary
Concomitant
Somnolence 3/1/2007 Female 300 lb 8/29/2007 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2007 62 Male 223 lb 9/4/2007 Physician United States
Primary
Secondary
Concomitant
Dizziness 12/11/2006 77 Female 114 lb 8/16/2007 Physician United States
Primary
Concomitant
Fractured Sacrum Other Serious 70 Female 214 lb 9/26/2007 Physician Australia
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Required Intervention 7/11/2007 73 Female 7/13/2007 United States
Primary
Concomitant
Hypersensitivity Hospitalization 8/7/2007 57 Male 257 lb 10/25/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Hyperglycaemia 49 Male 10/25/2007 Consumer United States
Primary
Concomitant
Dyspnoea Hospitalization 1/1/2006 Female 10/24/2007 Consumer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 5/21/2007 76 Female 12/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 12/12/2007 59 Male 1/4/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Urine Output Decreased Other Serious 11/13/2004 84 Male 165 lb 1/19/2008 United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 301 lb 1/16/2008 Consumer United States
Primary
Concomitant
Pneumonia 12/1/2007 Female 351 lb 3/15/2008 United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 2/7/2008 Female 3/27/2008 Physician United States
Primary
Concomitant
Uterine Cervix Stenosis Other Serious 11/1/2007 60 Female 6/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Fall Other Serious 4/3/2008 57 Male 260 lb 5/30/2008 Consumer United States
Primary
Concomitant
Rhabdomyolysis Death 4/2/2006 69 Female 7/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 5/8/2008 51 Female 7/7/2008 Physician Canada
Primary
Concomitant
Pain Hospitalization 7/13/2007 77 Female 7/3/2008 Physician Belgium
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 4/30/2008 Female 320 lb 7/11/2008 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/1/2007 Female 7/11/2008 Physician United Kingdom
Primary
Concomitant
Panic Attack 53 Female 7/24/2008 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/4/2008 73 Female 8/5/2008 Physician France
Primary
Concomitant
Sudden Death Death 5/8/2008 51 Female 8/13/2008 Physician Canada
Primary
Concomitant
Sepsis Hospitalization 3/1/2008 70 Male 131 lb 8/26/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/4/2008 73 Female 134 lb 9/3/2008 Physician France
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 3/12/2008 66 Female 146 lb 9/9/2008 Consumer United States
Primary
Concomitant
Post Procedural Swelling Other Serious 5/28/2008 59 Male 196 lb 9/2/2008 United States
Primary
Concomitant
Photopsia Other Serious Male 160 lb 10/16/2008 Consumer United States
Primary
Concomitant
Left Ventricular Dysfunction Other Serious 2/1/2008 60 Male 269 lb 1/16/2009 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 12/18/2008 Female 193 lb 1/16/2009 Physician United States
Primary
Concomitant
Product Quality Issue Hospitalization 1/1/2005 Male 280 lb 1/16/2009 Consumer United States
Primary
Concomitant
Renal Failure Death 1/1/2009 Female 1/22/2009 Physician United States
Primary
Concomitant
Visual Field Defect Other Serious 1/23/2009 Other Health Professional France
Primary
Concomitant
Lung Disorder Life Threatening 12/28/2008 Male 2/26/2009 Other Health Professional France
Primary
Concomitant
Visual Acuity Reduced Hospitalization 1/1/2006 Female 160 lb 3/5/2009 Consumer United States
Primary
Concomitant
Laceration Hospitalization 7/1/2008 67 Male 176 lb 3/9/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/15/2008 61 Male 305 lb 3/12/2009 Other Health Professional Sweden
Primary
Concomitant
Renal Failure Hospitalization 11/15/2008 61 Male 305 lb 3/17/2009 Sweden
Primary
Concomitant
Vomiting Other Serious 2/1/2009 Male 3/23/2009 Consumer United States
Primary
Concomitant
Unevaluable Event Death 71 Male 5/28/2009 United States
Primary
Concomitant
Therapy Regimen Changed Hospitalization 6/1/2009 68 7/7/2009 Physician Hungary
Primary
Concomitant
Interacting
Therapeutic Agent Toxicity Hospitalization 5/7/2009 78 7/10/2009 Other Health Professional Spain
Primary
Secondary
Left Ventricular Failure Other Serious 6/5/2009 67 7/24/2009 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 67 Female 7/28/2009 Pharmacist United States
Primary
Concomitant
Weight Decreased Other Serious 76 Male 7/22/2009 Lawyer United States
Primary
Concomitant
Renal Failure Acute Life Threatening 7/7/2009 77 Male 7/29/2009 Physician Germany
Primary
Concomitant
Left Ventricular Failure Other Serious 6/23/2009 67 8/3/2009 Other Health Professional United Kingdom
Primary
Concomitant
Therapy Regimen Changed Hospitalization 6/1/2009 68 8/3/2009 Physician Hungary
Primary
Concomitant
Interacting
Anaphylactic Reaction Life Threatening 7/1/2009 53 Female 8/7/2009 Physician United States
Primary
Secondary
Concomitant
Left Ventricular Failure Other Serious 6/23/2009 67 8/7/2009 Other Health Professional United Kingdom
Primary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/12/2009 Portugal
Primary
Concomitant
Speech Disorder Disability 53 8/28/2009 Consumer Canada
Primary
Concomitant
Stress Other Serious 1/1/2003 Male 212 lb 9/11/2009 Consumer United States
Primary
Secondary
Concomitant
Wound Infection Hospitalization 63 Male 9/11/2009 United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 54 Male 281 lb 9/14/2009 United States
Primary
Concomitant
Pulmonary Hypertension Hospitalization 6/5/2007 44 Male 213 lb 9/18/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/17/2009 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 10/10/2009 United States
Primary
Concomitant
Death Death 9/25/2009 Female 10/20/2009 Consumer United States
Primary
Concomitant
Heart Rate Increased Other Serious 1/1/2008 59 Female 240 lb 10/21/2009 Consumer United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 54 Male 281 lb 10/22/2009 United States
Primary
Concomitant
Viral Upper Respiratory Tract Infection Other Serious 46 Female 223 lb 10/22/2009 Lawyer United States
Primary
Concomitant
Hyperkalaemia Hospitalization 6/1/2009 68 10/30/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Upper Respiratory Tract Infection Other Serious 46 Female 223 lb 10/27/2009 Lawyer United States
Primary
Concomitant
Speech Disorder Disability 53 Female 11/24/2009 Consumer Canada
Primary
Concomitant
Intervertebral Disc Protrusion Other Serious 8/27/2009 Female 220 lb 11/25/2009 Consumer United States
Primary
Concomitant
Vitreous Floaters Hospitalization 62 Female 12/11/2009 Lawyer United States
Primary
Concomitant
Cardiomyopathy Other Serious 68 Male 12/11/2009 United States
Primary
Concomitant
Pain 6/1/2009 Female 158 lb 12/31/2009 Consumer United States
Primary
Concomitant
Stress Other Serious 1/1/2008 Female 165 lb 12/28/2009 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 68 Male 1/4/2010 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious Female 1/5/2010 Pharmacist United States
Primary
Concomitant
Red Blood Cell Count Decreased Hospitalization 10/18/2009 Female 214 lb 1/7/2010 Consumer France
Primary
Concomitant
Ventricular Hypokinesia Other Serious 62 Male 229 lb 1/22/2010 United States
Primary
Concomitant
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 2/11/2010 Pharmacist Germany
Primary
Secondary
Concomitant
Urinary Tract Obstruction Hospitalization 76 Male 2/19/2010 United States
Primary
Concomitant
Weight Increased Other Serious Female 280 lb 3/9/2010 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious Female 4/8/2010 United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/7/2007 49 Male 4/7/2010 United States
Primary
Concomitant
Diverticulitis Hospitalization 2/17/2010 60 Male 139 lb 4/21/2010 Physician Denmark
Primary
Concomitant
Toe Amputation Hospitalization 65 Male 4/22/2010 Consumer United States
Primary
Concomitant
Vomiting Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Renal Failure Acute Life Threatening 8/3/2009 70 Female 154 lb 4/22/2010 Pharmacist Germany
Primary
Concomitant
Interacting
Blood Bilirubin Increased Other Serious 3/29/2010 57 Male 4/23/2010 China
Primary
Concomitant
Thrombocytopenia Other Serious 5/21/2009 71 Male 143 lb 4/26/2010 Korea, Republic Of
Primary
Concomitant
Oxygen Saturation Decreased Hospitalization 4/15/2010 68 Female 4/26/2010 Consumer United States
Primary
Concomitant
Body Temperature Decreased Other Serious 5/12/2009 69 Male 198 lb 4/30/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Other Serious 3/4/2010 66 Male 5/6/2010 Other Health Professional United Kingdom
Primary
Concomitant
Headache Disability 62 Male 350 lb 5/7/2010 United States
Primary
Secondary
Concomitant
Linear Iga Disease Hospitalization 4/6/2010 87 Female 6/2/2010 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Headache Hospitalization 5/24/2010 67 Female 6/2/2010 Consumer United States
Primary
Concomitant
Linear Iga Disease Hospitalization 4/6/2010 87 Female 6/4/2010 Consumer Switzerland
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious Female 247 lb 6/11/2010 Physician United Kingdom
Primary
Concomitant
Muscle Spasms Female 230 lb 6/16/2010 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 65 Male 6/17/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Acute Myocardial Infarction Life Threatening 5/1/2007 64 Female 6/17/2010 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 4/26/2010 65 Male 6/17/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Toe Amputation Hospitalization 65 Male 6/18/2010 Consumer United States
Primary
Concomitant
Tremor 12/1/2007 35 Male 249 lb 6/21/2010 Other Health Professional United States
Primary
Concomitant
Tongue Discolouration Hospitalization 5/3/2010 74 Female 121 lb 6/30/2010 Consumer United States
Primary
Concomitant

Drug Data