Metformin combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Adverse Event Other Serious 11/11/2005 68 Female 1/10/2006 Physician Sweden
Primary
Concomitant
Skin Graft Infection Other Serious 9/15/2005 Male 192 lb 1/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pleural Disorder Other Serious 9/21/2005 57 Male 216 lb 1/10/2006 Netherlands
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 9/1/2005 65 Female 130 lb 1/13/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Vitreous Floaters Disability 7/18/2005 61 Female 198 lb 1/23/2006 Physician Germany
Primary
Concomitant
Sepsis Hospitalization 9/1/2005 65 Female 1/20/2006 Switzerland
Primary
Secondary
Concomitant
Pleural Disorder Other Serious 9/21/2005 57 Male 216 lb 1/10/2006 Netherlands
Primary
Secondary
Concomitant
Septic Shock Other Serious 6/1/2005 55 Female 1/23/2006 Physician Sweden
Primary
Concomitant
Vomiting Other Serious 12/12/2005 78 Male 151 lb 12/30/2005 Pharmacist United States
Primary
Concomitant
Peripheral Coldness Disability 52 Female 2/6/2006 Physician Austria
Primary
Concomitant
Lactic Acidosis Required Intervention 11/14/2005 57 Male 286 lb 1/24/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 10/24/2005 58 Male 203 lb 12/1/2005 Pharmacist United States
Primary
Concomitant
Radiculopathy Hospitalization 11/1/2003 Male 231 lb 2/15/2006 Physician New Zealand
Primary
Concomitant
Somnolence Other Serious 1/24/2006 61 Female 2/14/2006 United States
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 9/1/2005 65 Female 2/7/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Dysgeusia 12/3/2005 76 Female 130 lb 1/5/2006 Consumer United States
Primary
Concomitant
Renal Cyst Hospitalization 2/14/2005 63 Male 185 lb 2/17/2006 Poland
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/1/2003 67 Female 2/27/2006 Physician United States
Primary
Concomitant
Flatulence 12/1/2005 65 Male 2/27/2006 Consumer United States
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 1/23/2006 74 2/28/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Prescribed Overdose Death 10/28/2005 78 Male 2/24/2006 Canada
Primary
Concomitant
Vomiting Life Threatening 2/13/2006 2/27/2006 Physician United Kingdom
Primary
Concomitant
Speech Disorder Life Threatening 2/28/2006 Male 162 lb 3/2/2006 Other Health Professional United States
Primary
Concomitant
Necrosis Hospitalization 2/20/2006 65 Female 152 lb 3/8/2006 Physician Austria
Primary
Secondary
Concomitant
Prescribed Overdose Death 10/28/2005 78 Male 2/28/2006 Canada
Primary
Concomitant
Septic Shock Other Serious 8/3/2005 68 Female 3/9/2006 Physician Sweden
Primary
Concomitant
Pulmonary Oedema Other Serious 1/20/2006 48 Female 77 lb 3/14/2006 Consumer United Kingdom
Primary
Concomitant
Cerebrovascular Accident Hospitalization 8/10/2005 71 Male 250 lb 12/27/2005 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 6/27/2005 76 Female 3/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/1/2005 65 Female 3/14/2006 Switzerland
Primary
Secondary
Concomitant
Amenorrhoea Other Serious 37 Female 139 lb 3/22/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 2/20/2006 65 Female 152 lb 3/14/2006 Other Health Professional Austria
Primary
Secondary
Concomitant
Portal Hypertensive Gastropathy Hospitalization 1/1/2006 62 Female 3/29/2006 Consumer Denmark
Primary
Concomitant
Cardiomyopathy Hospitalization 3/17/2006 45 Male 192 lb 3/31/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 3/28/2006 United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 8/30/2004 70 Male 4/5/2006 Physician Australia
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/1/2003 67 Female 190 lb 4/6/2006 Physician United States
Primary
Concomitant
Vomiting Life Threatening 2/13/2006 57 Male 3/29/2006 Physician United Kingdom
Primary
Concomitant
Blood Glucose Increased 9/29/2005 63 Male 198 lb 1/20/2006 Consumer United States
Primary
Concomitant
Optic Neuritis Retrobulbar Hospitalization 55 Male 4/7/2006 United States
Primary
Concomitant
Renal Impairment Life Threatening 2/13/2006 57 Male 3/29/2006 Physician United Kingdom
Primary
Concomitant
Thirst Life Threatening 2/28/2006 Male 162 lb 4/7/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 2/17/2006 75 Male 223 lb 4/5/2006 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 4/7/2006 United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 72 Male 170 lb 4/10/2006 Physician United States
Primary
Secondary
Concomitant
Neck Pain Death 2/16/2006 82 Male 205 lb 4/4/2006 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 7/19/2005 61 Female 151 lb 2/8/2006 Pharmacist United States
Primary
Secondary
Concomitant
Hypernatraemia Other Serious 1/1/2006 69 Male 196 lb 4/19/2006 Physician France
Primary
Concomitant
Respiratory Arrest Hospitalization 4/11/2005 27 Male 243 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Osteonecrosis Other Serious 6/1/2004 Female 4/28/2006 Physician Sweden
Primary
Concomitant
Renal Cyst Hospitalization 2/14/2005 63 Male 185 lb 4/25/2006 Poland
Primary
Secondary
Concomitant
Skin Exfoliation Disability 8/24/2004 72 Female 188 lb 5/3/2006 Physician Brazil
Primary
Secondary
Concomitant
Chest Pain Hospitalization 3/30/2006 5/3/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Death 87 Male 5/3/2006 Pharmacist Canada
Primary
Concomitant
Myocardial Infarction Death 87 Male 5/3/2006 Pharmacist Canada
Primary
Concomitant
Renal Failure Acute Other Serious 2/17/2006 75 Male 223 lb 5/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious 1/1/2006 69 Female 196 lb 5/1/2006 Physician France
Primary
Concomitant
Sepsis Hospitalization 9/1/2005 65 Female 5/1/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Myocardial Infarction Death 87 Male 5/5/2006 Consumer Canada
Primary
Concomitant
Myocardial Infarction Death 87 Male 5/5/2006 Consumer Canada
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 7/8/2002 70 Male 196 lb 5/10/2006 Physician United States
Primary
Concomitant
Fall Hospitalization 2/21/2006 74 Male 5/8/2006 United States
Primary
Secondary
Concomitant
Varicella Hospitalization 8/29/2000 62 Female 5/11/2006 Consumer Denmark
Primary
Concomitant
Syncope Life Threatening 4/2/2006 Female 331 lb 5/11/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 2/20/2006 65 Female 152 lb 5/12/2006 Physician Austria
Primary
Secondary
Concomitant
Oedema Other Serious 3/13/2006 80 Male 162 lb 5/17/2006 Physician Canada
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 5/11/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Swollen Tongue Other Serious 1/22/2006 Male 5/16/2006 Pharmacist United States
Primary
Concomitant
Lethargy Hospitalization 4/23/2006 77 Male 208 lb 5/15/2006 Pharmacist United States
Primary
Concomitant
Posturing Life Threatening 3/21/2006 Male 5/17/2006 Pharmacist United States
Primary
Concomitant
Troponin Increased Hospitalization 2/5/2006 Male 5/22/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 2/20/2006 65 Female 152 lb 5/17/2006 Physician Austria
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 224 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
Varicella Hospitalization 8/29/2000 62 Female 5/25/2006 Consumer Denmark
Primary
Concomitant
Depressed Mood Other Serious 1/1/2006 65 Female 5/25/2006 Consumer United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 5/21/2006 77 Male 211 lb 5/25/2006 Pharmacist United States
Primary
Concomitant
Insomnia 2/14/2006 47 Female 204 lb 4/3/2006 Consumer United States
Primary
Concomitant
Pleural Effusion Hospitalization 4/19/2006 Male 6/1/2006 Physician United States
Primary
Secondary
Concomitant
Lethargy Other Serious 4/24/2006 72 Male 6/1/2006 Consumer United Kingdom
Primary
Concomitant
Wound Infection Hospitalization 62 Male 223 lb 4/19/2006 Pharmacist United States
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 2/7/2006 58 Male 196 lb 6/1/2006 United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/12/2005 57 Female 6/5/2006 Physician Netherlands
Primary
Secondary
Concomitant
Swelling Other Serious 11/1/2005 Male 200 lb 4/20/2006 Consumer United States
Primary
Concomitant
Blood Potassium Increased Other Serious 3/24/2005 65 Male 4/7/2006 Pharmacist United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 9/21/2004 72 Male 170 lb 6/7/2006 United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 11/11/2005 68 Female 6/15/2006 Physician Sweden
Primary
Secondary
Concomitant
White Blood Cells Urine Positive Hospitalization 5/2/2006 71 Female 185 lb 6/12/2006 Physician Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 9/14/2004 72 Male 170 lb 6/21/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 5/15/2006 69 Female 6/22/2006 Physician Hong Kong
Primary
Concomitant
Psychotic Disorder Other Serious 8/30/2004 70 Male 6/28/2006 Physician Australia
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 3/1/2005 45 Female 280 lb 6/30/2006 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/30/2006 Physician United States
Primary
Secondary
Concomitant
Rash Pruritic Other Serious 1/18/2005 Male 2/23/2006 Pharmacist United States
Primary
Secondary
Concomitant
Rash Hospitalization 5/15/2006 70 Male 6/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Coronary Artery Disease Hospitalization 3/27/2006 60 Male 220 lb 6/28/2006 Netherlands
Primary
Secondary
Concomitant
Pain Hospitalization 72 Male 6/30/2006 United States
Primary
Secondary
Concomitant
Angioneurotic Oedema Life Threatening 6/9/2006 72 Female 144 lb 6/14/2006 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Life Threatening 5/15/2006 69 Female 7/14/2006 Physician Hong Kong
Primary
Concomitant
Influenza Like Illness 12/1/2005 70 Male 7/21/2006 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 8/1/2005 78 Male 7/21/2006 Consumer United States
Primary
Concomitant
Myocardial Infarction Life Threatening 10/8/2005 75 Male 183 lb 6/30/2006 Physician United States
Primary
Concomitant
Sudden Death Death 6/3/2006 75 Female 132 lb 7/18/2006 Physician Netherlands
Primary
Concomitant
Syncope Other Serious 3/1/2000 Male 8/3/2006 Physician United Kingdom
Primary
Concomitant
Coronary Artery Disease Hospitalization 3/27/2006 60 Male 220 lb 7/27/2006 Netherlands
Primary
Secondary
Concomitant
Hypoglycaemia Life Threatening 6/3/2006 81 Female 7/28/2006 United Kingdom
Primary
Secondary
Concomitant
Headache 3/1/2006 59 Male 200 lb 7/12/2006 Consumer United States
Primary
Concomitant
Swelling Face Life Threatening 6/4/2006 55 Male 8/10/2006
Primary
Concomitant
Bone Marrow Disorder Hospitalization 7/5/2006 79 Male 8/11/2006 Other Health Professional France
Primary
Concomitant
Pruritus Life Threatening 6/4/2006 55 Male 8/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Oedema Peripheral Other Serious 2/17/2006 57 Female 231 lb 8/17/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Neoplasm Progression Life Threatening 6/2/2006 Male 8/23/2006
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 71 Female 8/18/2006 Denmark
Primary
Concomitant
Skin Ulcer Life Threatening 4/2/2006 Female 331 lb 8/24/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 9/1/2004 72 Male 170 lb 8/22/2006 Physician United States
Primary
Secondary
Concomitant
Cough Other Serious 74 Female 140 lb 8/23/2006 United Kingdom
Primary
Concomitant
Lactic Acidosis Hospitalization 77 Male 8/23/2006 United Kingdom
Primary
Concomitant
Cough Other Serious 74 Female 140 lb 8/23/2006 Other Health Professional United Kingdom
Primary
Concomitant
Neoplasm Progression Life Threatening 6/2/2006 Male 8/30/2006
Primary
Secondary
Concomitant
Pallor Hospitalization 57 Male 8/28/2006 Other Health Professional United Kingdom
Primary
Concomitant
Therapeutic Response Delayed Life Threatening 3/27/2006 63 Male 174 lb 8/24/2006 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 64 Female 9/7/2006 Denmark
Primary
Concomitant
Knee Arthroplasty Hospitalization 8/24/2006 76 Female 9/1/2006 Pharmacist United States
Primary
Concomitant
Acute Leukaemia Hospitalization 7/5/2006 79 Male 9/15/2006 Other Health Professional France
Primary
Concomitant
Tumour Invasion Life Threatening 6/2/2006 Male 9/25/2006
Primary
Concomitant
Neutropenia Hospitalization 2/8/2006 59 Male 225 lb 9/26/2006 Physician United States
Primary
Secondary
Concomitant
Blood Lactic Acid Increased Other Serious 7/11/2006 63 Male 250 lb 7/13/2006 Pharmacist United States
Primary
Concomitant
Hyponatraemia Hospitalization 9/6/2006 52 Male 10/24/2006 Austria
Primary
Secondary
Concomitant
Ventricular Hypokinesia Other Serious 11/25/2005 67 Male 159 lb 10/25/2006 United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 9/21/2006 78 Male 212 lb 11/2/2006 Physician United States
Primary
Concomitant
Respiratory Rate Increased Other Serious 10/23/2006 46 Female 11/13/2006 Other Health Professional Thailand
Primary
Concomitant
Rash Erythematous Other Serious 10/6/2006 62 Female 198 lb 11/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rash Erythematous Disability 10/6/2006 62 Female 198 lb 11/17/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 6/8/2006 78 Female 187 lb 11/13/2006 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Required Intervention 9/1/2006 60 Female 182 lb 11/6/2006 Physician United States
Primary
Secondary
Concomitant
Guillain-barre Syndrome Hospitalization 9/4/2006 Male 206 lb 11/27/2006 Pharmacist Canada
Primary
Concomitant
Pain In Extremity Other Serious 74 Female 11/23/2006 Consumer Brazil
Primary
Concomitant
Weight Decreased Other Serious 10/2/2006 70 Male 11/30/2006 Physician United States
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Hospitalization 10/6/2006 66 Male 375 lb 11/30/2006 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 54 Female 12/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Pancreatitis Hospitalization 8/12/2006 59 Male 293 lb 12/5/2006 Physician United Kingdom
Primary
Concomitant
Syncope Hospitalization 59 Male 12/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Other Serious 10/2/2006 70 Male 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Multiple Sclerosis 3/2/2006 Female 12/14/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/8/2006 59 Male 225 lb 12/18/2006 Physician United States
Primary
Secondary
Concomitant
Cardiac Hypertrophy Death 11/15/2006 51 Female 252 lb 12/11/2006 Physician United Kingdom
Primary
Concomitant
Insomnia 1/1/2006 59 Female 10/11/2006 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 10/1/2006 69 Female 260 lb 1/9/2007 United States
Primary
Concomitant
Oedema Life Threatening 6/16/2006 61 Male 1/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Aplasia Pure Red Cell Other Serious 1/25/2007 Male 211 lb 3/23/2007 Physician United States
Primary
Concomitant
Procedural Pain Other Serious 11/25/2006 74 Female 259 lb 3/30/2007 Consumer United Kingdom
Primary
Concomitant

Drug Data