Metformin combined with Pregabalin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Therapeutic Agent Toxicity Hospitalization 11/20/2005 60 Male 4/11/2006 Physician United Kingdom
Primary
Concomitant
Rash Generalised Life Threatening 8/7/2006 Female 11/16/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 12/15/2006 66 Male 219 lb 4/3/2007 Physician United Kingdom
Primary
Concomitant
Jaundice Hospitalization Male 7/3/2007 Physician France
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 8/7/2007 57 Male 257 lb 10/25/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Smear Cervix Abnormal 3/10/2007 Female 178 lb 3/15/2008 Physician United States
Primary
Concomitant
Death Death 3/15/2008 61 Female 3/25/2008 Netherlands
Primary
Secondary
Concomitant
Death Death 3/15/2008 61 Female 3/26/2008 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 50 Female 6/13/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 50 Female 6/18/2008 Physician United States
Primary
Secondary
Concomitant
Syncope Life Threatening 6/1/2008 66 Male 7/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 47 Male 7/15/2008 Other Health Professional Canada
Primary
Concomitant
Interacting
Renal Failure Acute Hospitalization 7/4/2008 73 Female 8/5/2008 Physician France
Primary
Concomitant
Pulmonary Embolism Death 5/12/2008 55 Female 254 lb 8/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/4/2008 73 Female 134 lb 9/3/2008 Physician France
Primary
Secondary
Concomitant
Arthralgia Hospitalization 4/14/2008 Male 228 lb 1/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 3/8/2009 Male 143 lb 4/13/2009 Physician India
Primary
Concomitant
Syncope Life Threatening 6/1/2008 66 Male 4/21/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/1/2009 75 Male 5/29/2009 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 6/14/2009 49 Male 7/21/2009 Other Health Professional France
Primary
Secondary
Concomitant
Hypovolaemia Hospitalization 6/18/2009 83 Male 7/30/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting 8/13/2008 Male 240 lb 8/21/2009 Consumer United States
Primary
Concomitant
Nausea 10/1/2008 Female 200 lb 8/22/2009 United States
Primary
Concomitant
Hyperhidrosis 10/15/2008 Female 8/22/2009 United States
Primary
Concomitant
Renal Failure Acute Other Serious 75 10/5/2009
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 6/14/2009 49 Male 10/29/2009 Other Health Professional France
Primary
Secondary
Concomitant
Syncope Life Threatening 6/1/2008 66 Male 11/2/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 6/7/2008 66 Male 11/4/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 6/7/2008 66 Male 11/4/2009 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 10/18/2009 66 Male 12/29/2009 Pharmacist United States
Primary
Concomitant
Completed Suicide Death 1/1/2008 56 Male 1/15/2010 Physician United States
Primary
Secondary
Completed Suicide Death 12/1/2009 56 Male 2/1/2010 Physician United States
Primary
Secondary
Syncope Life Threatening 6/1/2008 66 Male 3/3/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Atrioventricular Block Complete Life Threatening 4/1/2010 84 Female 112 lb 6/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Atrioventricular Block Complete Life Threatening 4/1/2010 84 Female 112 lb 6/17/2010 Other Health Professional United Kingdom
Primary
Concomitant
Atrioventricular Block Complete Life Threatening 4/1/2010 84 Female 112 lb 6/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 65 Male 7/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 65 Male 7/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Hospitalization 7/1/2010 79 Male 7/29/2010 United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 79 Male 8/2/2010 Other Health Professional
Primary
Secondary
Concomitant
Somnolence Hospitalization 7/1/2010 79 Male 8/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 7/1/2010 79 Male 8/25/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wound Hospitalization 7/8/2010 79 Male 8/20/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 79 Male 8/17/2010 Other Health Professional
Primary
Secondary
Concomitant
International Normalised Ratio Increased Life Threatening 7/19/2010 89 Female 9/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Neutropenia Other Serious 5/21/2010 48 Male 9/7/2010 Physician Spain
Primary
Secondary
Concomitant
Somnolence Hospitalization 7/11/2001 79 Male 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Poikilocytosis Hospitalization 8/11/2010 37 Male 9/13/2010 Consumer United Kingdom
Primary
Concomitant
Wound Hospitalization 79 Male 9/8/2010
Primary
Secondary
Concomitant
Somnolence Hospitalization 7/8/2010 79 Male 9/16/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Atrioventricular Block Complete Life Threatening 4/1/2010 84 Female 112 lb 9/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 65 Male 9/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Other Serious 8/3/2010 41 Male 9/23/2010 Pharmacist United Kingdom
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 8/11/2010 37 Male 9/27/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rash Erythematous Other Serious 9/13/2010 60 Female 220 lb 9/30/2010 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Hospitalization 7/11/2001 79 Male 10/7/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 11/1/2007 58 Male 137 lb 10/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/8/2010 79 Male 10/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/8/2010 79 Male 10/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/8/2010 79 Male 10/11/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 7/8/2010 79 Male 10/12/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 7/1/2010 79 Male 10/12/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Bacterial Other Serious 1/1/2008 70 Male 196 lb 11/29/2010 Physician United States
Primary
Secondary
Concomitant
Escherichia Infection Hospitalization 10/17/2010 78 Female 148 lb 12/3/2010 Consumer United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 12/15/2006 66 Male 219 lb 12/13/2010 Physician United Kingdom
Primary
Concomitant
Drug Ineffective 11/4/2009 12/13/2010 Consumer United States
Primary
Concomitant
Drug Ineffective 11/4/2009 12/13/2010 Consumer United States
Primary
Concomitant
Death Death 12/15/2010 Physician Spain
Primary
Secondary
Concomitant
Atrioventricular Block First Degree Life Threatening 4/1/2010 84 Female 112 lb 6/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Other Serious 65 Male 7/14/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 12/15/2006 66 Male 219 lb 12/16/2010 Other Health Professional United Kingdom
Primary
Concomitant
Abdominal Pain 12/22/2010 Consumer United States
Primary
Concomitant
Cellulitis Hospitalization 10/27/2010 59 Male 357 lb 12/22/2010 Physician United Kingdom
Primary
Concomitant
Death Death 12/23/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 11/19/2010 56 Male 234 lb 12/28/2010 Physician Australia
Primary
Secondary
Concomitant
Injection Site Nodule 8/21/2010 50 Female 1/29/2011 Consumer United States
Primary
Concomitant
Bradycardia Hospitalization 1/7/2011 84 Male 173 lb 2/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Bradycardia Hospitalization 1/7/2011 84 Male 173 lb 2/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Polyneuropathy Hospitalization 7/23/2010 77 Male 238 lb 2/14/2011 Physician Germany
Primary
Concomitant
Generalised Erythema Hospitalization 61 Male 273 lb 3/15/2011 Other Health Professional United Kingdom
Primary
Concomitant
Dysarthria Hospitalization 7/31/2010 77 Male 238 lb 3/7/2011 Other Health Professional Germany
Primary
Concomitant
Blood Amylase Increased Hospitalization 9/8/2010 58 Female 3/25/2011 Other Health Professional France
Primary
Secondary
Concomitant
Confusional State Other Serious 11/1/2007 58 Male 137 lb 4/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Balance Disorder Hospitalization Male 8/18/2011 Consumer Canada
Primary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 1/1/2011 Female 8/29/2011 Physician France
Primary
Secondary
Concomitant
Blood Urea Increased Other Serious Male 195 lb 11/25/2011 Other Health Professional United Kingdom
Primary
Concomitant
Adverse Event Hospitalization 11/1/2011 60 Male 12/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Viral Pericarditis Hospitalization 2/20/2011 62 Male 234 lb 6/7/2012 Physician France
Primary
Secondary
Concomitant
Diabetes Mellitus Other Serious 7/1/2012 51 Female 8/9/2012 Consumer Argentina
Primary
Concomitant
Transient Ischaemic Attack Other Serious 11/19/2010 57 Male 234 lb 1/21/2013 Physician Au
Primary
Concomitant
Acute Sinusitis Hospitalization 10/10/2011 58 Female 203 lb 10/2/2012 Physician Us
Primary
Concomitant
Myocardial Infarction Death 5/18/2012 56 Female 150 lb 10/30/2012 Physician Mx
Primary
Secondary
Concomitant
Myocardial Infarction Death 5/18/2012 56 Female 150 lb 11/1/2012 Physician Mx
Primary
Secondary
Concomitant
Gastroenteritis Hospitalization Female 137 lb 10/8/2012 Physician Es
Primary
Concomitant
Diverticulum Hospitalization 5/5/2012 57 Female 6/7/2013 Physician Country Not Specified
Primary
Concomitant
Pain Other Serious 2012 Female 150 lb 9/12/2012 Physician Us
Primary
Secondary
Concomitant
Fatigue Other Serious 7/2012 51 Female 3/4/2013 Consumer Ar
Primary
Concomitant
Renal Failure Acute Death 7/31/2012 73 Male 10/12/2012 Other Health Professional Gb
Primary
Concomitant
Urinary Tract Infection Hospitalization 8/31/2012 57 Female 146 lb 9/11/2012 Consumer Cl
Primary
Concomitant
Sudden Death Death 61 Female 319 lb 9/18/2012 Other Health Professional Gb
Primary
Concomitant
Pituitary Tumour Other Serious 2012 51 Female 9/19/2012 Consumer Ar
Primary
Concomitant
Insomnia Hospitalization 10/2012 40 Female 231 lb 12/27/2012 Physician Us
Primary
Concomitant
Necrotising Fasciitis Disability 1/2012 75 Male 196 lb 1/28/2013 Physician Ie
Primary
Concomitant
Intervertebral Discitis Other Serious 11/14/2012 66 Female 150 lb 1/8/2013 Physician Mx
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/2012 47 Male 4/16/2013 Other Health Professional Ie
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 2011 71 Female 1/8/2013 Physician Us
Primary
Secondary
Toxicity To Various Agents Death 71 Female 1/9/2013 Physician Us
Primary
Secondary
Toxicity To Various Agents Death 71 Female 1/21/2013 Physician Us
Primary
Secondary
Electrocardiogram Qt Prolonged Other Serious NotSpecified 3/29/2013 Pharmacist Us
Primary
Secondary
Concomitant
Death Death 71 Female 1/28/2013 Physician Us
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 70 Male 8/1/2013 Pharmacist Gb
Primary
Concomitant
Completed Suicide Death 71 Female 1/28/2013 Other Health Professional Us
Primary
Secondary
Subdural Haematoma Death 12/31/2012 59 Male 218 lb 5/28/2013 Physician Gb
Primary
Secondary
Concomitant
Gait Disturbance 67 Female 165 lb 4/29/2013 Consumer Us
Primary
Concomitant
Subdural Haematoma Hospitalization 12/31/2012 58 Male 218 lb 9/26/2013 Physician Gb
Primary
Secondary
Concomitant
Subdural Haematoma Death 12/31/2012 58 Male 218 lb 10/3/2013 Physician Gb
Primary
Secondary
Concomitant
Poisoning Death 2011 71 Female 2/1/2013 Physician Us
Primary
Secondary
Poisoning Deliberate Death 71 Female 2/1/2013 Physician Us
Primary
Secondary
Tendon Injury Hospitalization 9/22/2012 69 Male 147 lb 4/3/2013 Consumer Us
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/2011 48 Female 210 lb 9/8/2012 Us
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/2011 48 Female 210 lb 9/9/2013 Us
Primary
Secondary
Concomitant
Tearfulness Other Serious 3/26/2013 36 Female 4/15/2013 Other Health Professional Gb
Primary
Concomitant
Vomiting Other Serious 3/26/2013 36 Female 4/15/2013 Consumer Gb
Primary
Concomitant
Tearfulness Other Serious 3/26/2013 36 Female 4/17/2013 Consumer Gb
Primary
Concomitant
Acute Coronary Syndrome Other Serious 3/13/2013 64 Female 4/30/2013 Other Health Professional Pt
Primary
Concomitant
Tearfulness Other Serious 3/26/2013 36 Female 4/24/2013 Consumer Gb
Primary
Concomitant
Ovarian Enlargement Hospitalization 12/2012 37 Female 5/2/2013 Physician Us
Primary
Concomitant
Pulmonary Oedema Hospitalization 4/24/2013 64 Female 166 lb 7/1/2013 Consumer Gb
Primary
Secondary
Concomitant
Sleep Apnoea Syndrome Hospitalization 1/2007 54 Female 200 lb 3/12/2013 Us
Primary
Secondary
Concomitant
Plasma Cell Myeloma Death 7/27/2013 82 Male 8/23/2013 Other Health Professional Ca
Primary
Concomitant
Swelling Face Other Serious 7/29/2013 61 Male 324 lb 8/19/2013 Physician Jp
Primary
Concomitant
Tachycardia Hospitalization 49 Male 8/12/2012 Physician De
Primary
Concomitant
Treatment Failure Hospitalization 3/6/2012 63 Male 9/17/2013 Other Health Professional Gb
Primary
Concomitant
Treatment Failure Other Serious 3/6/2012 63 Male 9/17/2013 Consumer Gb
Primary
Concomitant
Thrombocytopenia Hospitalization 5/1/2009 56 Male 12/6/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Renal Failure Hospitalization 5/1/2009 56 Male 12/3/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Subdural Haematoma Death 12/31/2012 59 Male 218 lb 9/24/2013 Physician Gb
Primary
Secondary
Concomitant
Neuropathy Peripheral Disability 3/2013 60 Male 238 lb 10/4/2013 Physician Gb
Primary
Concomitant
Pyrexia Death 9/5/2013 64 Male 187 lb 10/9/2013 Us
Primary
Secondary
Concomitant
Ocular Hyperaemia 9/27/2013 52 Female 128 lb 10/15/2013 Consumer Co
Primary
Concomitant
Tongue Disorder Other Serious 75 Female 205 lb 10/30/2013 Pharmacist Ca
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 9/3/2013 53 Male 181 lb 10/18/2013 Physician De
Primary
Concomitant
Syncope Other Serious 8/31/2013 76 Female 10/18/2013 Physician Gb
Primary
Concomitant
Syncope Life Threatening 8/31/2013 76 Female 10/11/2013 Other Health Professional Gb
Primary
Concomitant
Pneumonitis Hospitalization 9/5/2013 64 Male 187 lb 11/27/2013 Physician Us
Primary
Secondary
Concomitant
Syncope Hospitalization 8/31/2013 76 Female 10/23/2013 Physician Gb
Primary
Concomitant
Syncope Life Threatening 8/31/2013 76 Female 10/24/2013 Physician Gb
Primary
Concomitant
Pneumonitis Death 9/5/2013 64 Male 187 lb 12/3/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Syncope Life Threatening 8/31/2013 76 Female 10/25/2013 Consumer Gb
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/4/2012 21 Female 2/7/2013 Other Health Professional Gb
Primary
Concomitant

Drug Data