Metformin combined with Pioglitazone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Insomnia 1/1/2006 59 Female 10/11/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 12/26/2006 71 Female 150 lb 2/12/2007 Consumer United States
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 9/1/2006 Male 187 lb 4/12/2007 Physician France
Primary
Secondary
Concomitant
Wrong Drug Administered Other Serious 1/1/2006 70 Female 4/23/2007 United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 10/24/2007 40 Male 11/2/2007 Physician United Kingdom
Primary
Concomitant
Drug Ineffective 11/1/2007 Male 3/14/2008 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 5/1/2008 69 Male 7/1/2008 Physician Switzerland
Primary
Concomitant
Tooth Disorder 67 Female 8/22/2008 Consumer Japan
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 6/1/2008 Female 161 lb 9/8/2008 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 9/26/2008 58 Female 207 lb 10/16/2008 Consumer Brazil
Primary
Secondary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/16/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 9/26/2008 58 Female 207 lb 10/28/2008 Physician Brazil
Primary
Secondary
Concomitant
Haemolysis Hospitalization 11/19/2008 Female 1/15/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Other Serious 7/1/2008 Male 248 lb 1/14/2009 Physician United States
Primary
Concomitant
Psoriasis Other Serious 7/24/2008 40 Male 254 lb 1/15/2009 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 2/1/2007 Female 1/13/2009 Consumer United States
Primary
Concomitant
Occult Blood Positive Hospitalization 9/9/2008 64 Female 284 lb 1/13/2009 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Other Serious 9/24/2008 Male 322 lb 1/30/2009 Consumer United Kingdom
Primary
Concomitant
Respiratory Acidosis Other Serious 2/20/2009 Switzerland
Primary
Secondary
Hypoglycaemia Death 2/20/2009 Switzerland
Primary
Secondary
Myocardial Ischaemia Other Serious 75 Male 2/20/2009 Physician United Kingdom
Primary
Concomitant
Pancreatitis Other Serious 7/31/2008 Female 166 lb 2/19/2009 Physician United States
Primary
Concomitant
Myalgia 11/20/2008 Male 2/24/2009 United States
Primary
Concomitant
Myocardial Infarction Other Serious 1/11/2009 Male 269 lb 3/5/2009 Consumer United Kingdom
Primary
Concomitant
Polymyalgia Rheumatica Other Serious 7/29/2006 Female 166 lb 3/5/2009 Physician United States
Primary
Concomitant
Speech Disorder Other Serious 1/7/2009 Male 3/24/2009 Physician United Kingdom
Primary
Concomitant
Myalgia Other Serious 1/1/2006 3/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Macular Oedema Other Serious 3/1/2009 Male 6/2/2009 Physician Israel
Primary
Secondary
Concomitant
Vomiting Other Serious 7/29/2006 Female 166 lb 5/29/2009 Physician United States
Primary
Concomitant
Muscle Disorder Other Serious 67 Male 6/25/2009 Other Health Professional France
Primary
Secondary
Concomitant
Rectal Haemorrhage 1/1/2009 Female 288 lb 7/29/2009 Consumer United States
Primary
Concomitant
Weight Decreased 8/2/2008 Male 8/21/2009 United States
Primary
Concomitant
Flushing Male 8/21/2009 United States
Primary
Secondary
Concomitant
Flushing 9/1/2008 Male 250 lb 8/21/2009 Consumer United States
Primary
Concomitant
Urticaria 9/14/2008 Male 8/21/2009 Consumer United States
Primary
Concomitant
Dizziness 11/14/2008 Male 200 lb 8/22/2009 Consumer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 48 Female 9/25/2009 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2007 Male 170 lb 9/30/2009 Consumer United States
Primary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 8/1/2009 Male 222 lb 10/20/2009 Physician United States
Primary
Concomitant
High Density Lipoprotein Decreased Other Serious Male 11/5/2009 Other Health Professional Canada
Primary
Concomitant
Oedema Peripheral Other Serious 11/6/2009 France
Primary
Secondary
Completed Suicide Death 66 Female 12/30/2009 Physician United States
Primary
Secondary
Urticaria Other Serious 8/4/2009 50 Female 243 lb 12/31/2009 United Kingdom
Primary
Concomitant
Pancreatitis Other Serious 1/1/2007 Female 200 lb 1/26/2010 Physician United States
Primary
Concomitant
Cholecystitis Acute Hospitalization 11/16/2009 Female 2/17/2010 Physician India
Primary
Concomitant
Blood Glucose Increased Other Serious 1/1/2010 Male 214 lb 3/11/2010 Consumer United States
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 Male 174 lb 3/22/2010 United States
Primary
Secondary
Concomitant
Myalgia Other Serious 72 Female 213 lb 4/21/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Life Threatening 1/1/2010 66 Female 4/22/2010 Physician United Kingdom
Primary
Concomitant
Myalgia Other Serious 6/1/2006 72 Female 214 lb 4/22/2010 Germany
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 10/29/2007 60 Male 4/26/2010 Lawyer United States
Primary
Concomitant
Myalgia Other Serious 72 Female 213 lb 4/23/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Dizziness Other Serious 3/25/2010 62 Male 227 lb 4/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Paraesthesia Oral Other Serious 3/18/2010 69 Male 4/28/2010 Physician United Kingdom
Primary
Concomitant
Toe Amputation Hospitalization 3/24/2010 59 Male 4/30/2010 Physician Germany
Primary
Secondary
Concomitant
Myalgia Other Serious 6/1/2006 72 Female 213 lb 5/5/2010 United Kingdom
Primary
Secondary
Concomitant
Blood Glucose Increased Life Threatening 5/20/2010 52 Male 6/3/2010 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 3/31/2010 62 Male 6/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myalgia Other Serious 6/1/2006 72 Female 214 lb 6/11/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Myalgia Other Serious 72 Female 212 lb 6/5/2010 United Kingdom
Primary
Secondary
Concomitant
Myalgia Other Serious 72 Female 213 lb 6/17/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Thyroid Neoplasm Other Serious Female 6/17/2010 Other Health Professional United States
Primary
Concomitant
Thyroid Neoplasm Other Serious Female 7/9/2010 Other Health Professional United States
Primary
Concomitant
Myalgia Other Serious 6/1/2006 72 Female 214 lb 8/17/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 4/1/2006 64 Male 8/23/2010 Other Health Professional United States
Primary
Concomitant
Spinal Cord Injury Cervical Life Threatening 10/30/2009 66 Male 229 lb 8/27/2010 Physician United States
Primary
Secondary
Concomitant
Intestinal Dilatation Hospitalization 7/21/2010 72 Male 8/30/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatitis Other Serious 2/1/2010 56 Male 8/31/2010 Other Health Professional United Kingdom
Primary
Secondary
Hepatitis Other Serious 2/1/2010 56 Male 9/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Hepatitis Other Serious 2/1/2010 56 Male 9/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Hepatitis Other Serious 2/1/2010 56 Male 8/24/2010 Pharmacist United Kingdom
Primary
Secondary
Intestinal Dilatation Hospitalization 7/21/2010 72 Male 9/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 9/3/2010 United States
Primary
Secondary
Concomitant
Dehydration Hospitalization 8/11/2010 42 Female 272 lb 9/9/2010 Consumer United States
Primary
Concomitant
Tremor Other Serious 1/1/2001 67 Female 9/17/2010 Consumer United States
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 65 Female 9/20/2010 United States
Primary
Concomitant
Intestinal Dilatation Hospitalization 7/21/2010 72 Male 9/21/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Pancreatic Carcinoma Other Serious 10/1/2009 43 Male 185 lb 9/20/2010 Other Health Professional United Kingdom
Primary
Concomitant
Lung Cancer Metastatic Death Female 9/23/2010 Other Health Professional Canada
Primary
Concomitant
Left Ventricular Dysfunction Other Serious 7/20/2010 60 Female 9/27/2010 Pharmacist United Kingdom
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 9/30/2010 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/1/2008 46 Female 309 lb 10/4/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 4/1/2006 64 Male 10/11/2010 United States
Primary
Concomitant
Renal Tubular Acidosis Life Threatening 9/7/2010 88 Male 163 lb 10/11/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Tubular Acidosis Life Threatening 9/7/2010 88 Male 163 lb 10/11/2010 Other Health Professional United Kingdom
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 10/14/2010 United States
Primary
Secondary
Concomitant
Renal Tubular Necrosis Other Serious 4/28/2008 58 Female 170 lb 10/20/2010 Physician United States
Primary
Concomitant
Dehydration Hospitalization 8/11/2010 42 Female 272 lb 10/20/2010 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 9/15/2010 63 Female 337 lb 10/26/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/7/2005 58 Male 174 lb 10/27/2010 United States
Primary
Secondary
Concomitant
Renal Tubular Acidosis Life Threatening 9/7/2010 88 Male 163 lb 11/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Renal Tubular Acidosis Life Threatening 9/7/2010 88 Male 163 lb 11/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Renal Tubular Acidosis Life Threatening 9/7/2010 88 Male 163 lb 11/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Confusional State Hospitalization 7/21/2009 65 Male 255 lb 11/12/2010 Consumer United States
Primary
Secondary
Concomitant
Renal Tubular Acidosis Life Threatening 9/7/2010 88 Male 11/2/2010 United Kingdom
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 10/22/2010 67 Male 165 lb 11/16/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/15/2010 63 Female 337 lb 11/18/2010 Physician Japan
Primary
Concomitant
Cellulitis Staphylococcal Hospitalization 10/27/2010 59 Male 357 lb 11/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 4/1/2006 64 Male 11/24/2010 Other Health Professional United States
Primary
Concomitant
Multiple Drug Overdose Death 63 Female 265 lb 11/29/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Bacterial Other Serious 1/1/2008 70 Male 196 lb 11/29/2010 Physician United States
Primary
Secondary
Concomitant
Multiple Drug Overdose Death 63 Female 265 lb 12/14/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Tubular Acidosis Life Threatening 9/7/2010 88 Male 163 lb 12/2/2010 Other Health Professional
Primary
Secondary
Concomitant
Drug Ineffective 1/1/2010 68 Female 126 lb 12/21/2010 Consumer United States
Primary
Concomitant
Cellulitis Hospitalization 10/27/2010 59 Male 357 lb 12/22/2010 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/7/2005 58 Male 174 lb 12/24/2010 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/10/2010 12/24/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Serotonin Syndrome Death 63 Female 265 lb 12/16/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Oral Pain Hospitalization 9/1/2010 53 Female 348 lb 9/20/2010 Pharmacist United States
Primary
Concomitant
Drug Ineffective Death 1/1/2010 68 Female 126 lb 1/13/2011 Consumer United States
Primary
Concomitant
Dyspnoea Other Serious 1/1/2007 65 Male 1/17/2011 United States
Primary
Concomitant
Dyspnoea Hospitalization 1/1/2007 65 Male 1/27/2011 Other Health Professional United States
Primary
Concomitant
Intervertebral Disc Degeneration Hospitalization 5/7/2005 58 Male 174 lb 2/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Malaise Other Serious 1/31/2011 66 Male 209 lb 2/18/2011 Other Health Professional United Kingdom
Primary
Concomitant
Diarrhoea Other Serious Female 107 lb 2/22/2011 Physician United States
Primary
Concomitant
Infection Hospitalization 8/1/2010 49 Male 2/22/2011 Belgium
Primary
Concomitant
Herpes Simplex Serology Positive Other Serious 5/7/2005 58 Male 174 lb 4/5/2011 Lawyer United States
Primary
Secondary
Concomitant
Palpitations Other Serious Female 4/6/2011 Consumer United Kingdom
Primary
Concomitant
Portal Vein Thrombosis Hospitalization 6/24/2010 73 Male 128 lb 4/13/2011 Physician India
Primary
Secondary
Concomitant
Nausea Hospitalization 3/3/2011 46 Female 238 lb 4/12/2011 Physician United States
Primary
Concomitant
Hypoglycaemia Other Serious 3/22/2011 64 Female 273 lb 4/19/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 6/1/2010 60 Female 322 lb 4/20/2011 Other Health Professional United States
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 3/22/2011 64 Female 4/15/2011 United Kingdom
Primary
Secondary
Concomitant
Fluid Overload Hospitalization 7/2/2010 59 Female 4/27/2011 Consumer United States
Primary
Secondary
Off Label Use Other Serious 4/28/2008 58 Female 170 lb 5/5/2011 Consumer United States
Primary
Concomitant
Drug Ineffective Other Serious 77 Male 9/1/2011 Other Health Professional France
Primary
Concomitant
Oedema Peripheral Other Serious 1/1/2009 63 Female 209 lb 9/9/2011 Lawyer United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/1/2009 63 Female 209 lb 9/7/2011 Consumer United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 67 Female 9/9/2011 Physician United Kingdom
Primary
Concomitant
Insomnia Other Serious 8/23/2011 37 Female 344 lb 9/12/2011 Other Health Professional United Kingdom
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2011 37 Female 344 lb 9/19/2011 Other Health Professional United Kingdom
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2011 37 Female 344 lb 9/27/2011 Other Health Professional United Kingdom
Primary
Concomitant
Faeces Discoloured Hospitalization 4/1/2010 79 Female 12/9/2011 Other Health Professional France
Primary
Concomitant
Faeces Discoloured Hospitalization 4/1/2010 79 Female 12/22/2011 Other Health Professional France
Primary
Concomitant
Adverse Event Hospitalization 11/1/2011 60 Male 12/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Injection Site Abscess Other Serious 12/27/2011 Physician United States
Primary
Concomitant
Pancreatitis Acute Other Serious 10/29/2011 48 Male 238 lb 1/8/2012 Other Health Professional United Kingdom
Primary
Concomitant
Myositis Disability 1/18/2012 56 Female 172 lb 3/7/2012 Other Health Professional
Primary
Concomitant
Rhabdomyolysis Hospitalization 75 Male 5/3/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Death Death 77 Female 5/10/2012 Physician United Kingdom
Primary
Concomitant
Drug Interaction Hospitalization 75 Male 5/29/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Completed Suicide Death 66 Female 6/6/2012 Physician United States
Primary
Secondary
Electrocardiogram T Wave Inversion Hospitalization 5/26/2012 52 Male 279 lb 6/15/2012 Consumer United Kingdom
Primary
Concomitant
Drug Interaction Hospitalization 75 Male 6/19/2012 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Myocardial Infarction Death 77 Female 6/26/2012 Physician United Kingdom
Primary
Concomitant
Gastrointestinal Perforation Other Serious 2/10/2012 63 Female 107 lb 12/7/2012 Physician Kr
Primary
Secondary
Concomitant
Weight Decreased Other Serious 5/28/2012 51 Male 8/30/2012 Consumer Es
Primary
Concomitant
Weight Decreased Hospitalization Male 11/12/2012 Physician Ca
Primary
Concomitant
Fluorescent In Situ Hybridisation Other Serious 61 Male 8/31/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Other Serious 56 Male 212 lb 9/23/2012 Physician Gb
Primary
Concomitant

Drug Data