Metformin combined with Morphine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Toe Amputation Hospitalization 9/1/2005 Female 220 lb 1/13/2006 United States
Primary
Concomitant
Hyperglycaemia Death 82 Male 2/9/2006 Canada
Primary
Secondary
Concomitant
Renal Failure Life Threatening 12/22/2005 60 Male 4/4/2006 Physician South Africa
Primary
Concomitant
Hypoglycaemia Death 82 Male 4/24/2006 Canada
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2003 57 Male 5/9/2006 Australia
Primary
Concomitant
Lethargy Hospitalization 4/23/2006 77 Male 208 lb 5/15/2006 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Life Threatening 5/15/2006 69 Female 6/22/2006 Physician Hong Kong
Primary
Concomitant
Thrombocytopenia Life Threatening 5/15/2006 69 Female 7/14/2006 Physician Hong Kong
Primary
Concomitant
Rash 5/29/2005 67 Female 7/21/2006 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/1/2006 50 Female 238 lb 7/12/2006 Consumer United States
Primary
Concomitant
Weight Fluctuation Hospitalization 9/9/2006 67 Male 251 lb 11/2/2006 Physician United States
Primary
Concomitant
Pain In Extremity Life Threatening 1/26/2006 69 Male 12/1/2006 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious Male 146 lb 2/19/2007 United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 3/7/2007 53 Female 327 lb 3/29/2007 Pharmacist United States
Primary
Secondary
Concomitant
Nervous System Disorder Other Serious 6/10/2007 Male 201 lb 9/7/2007 Physician United States
Primary
Secondary
Concomitant
Death Death 9/26/2007 Male 181 lb 11/5/2007 Physician United States
Primary
Concomitant
Oesophagitis Hospitalization 12/26/2007 Male 6/19/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/10/2008 67 Female 7/14/2008 Physician France
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/4/2008 73 Female 8/5/2008 Physician France
Primary
Concomitant
Wound Treatment Other Serious 5/1/2004 Male 297 lb 8/21/2008 United States
Primary
Concomitant
Wound Treatment Other Serious 5/1/2004 Male 297 lb 8/21/2008 United States
Primary
Concomitant
Renal Failure Acute Hospitalization 7/4/2008 73 Female 134 lb 9/3/2008 Physician France
Primary
Secondary
Concomitant
Vomiting Required Intervention 8/22/2008 Female 241 lb 9/3/2008 Physician United States
Primary
Concomitant
Oesophagitis Hospitalization 12/26/2007 Male 10/16/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 5/12/2007 Male 210 lb 1/14/2009 Physician United States
Primary
Concomitant
Sepsis Other Serious 5/12/2007 Male 210 lb 2/20/2009 Physician United States
Primary
Concomitant
Sepsis Other Serious 5/12/2007 Male 210 lb 3/5/2009 Physician United States
Primary
Concomitant
Lung Neoplasm Malignant Death 1/29/2009 Male 150 lb 3/27/2009 Consumer Brazil
Primary
Concomitant
Weight Decreased Hospitalization 12/1/2008 Male 462 lb 8/11/2009 Consumer United States
Primary
Concomitant
Speech Disorder Disability 53 8/28/2009 Consumer Canada
Primary
Concomitant
Vomiting Hospitalization 5/13/2008 Male 10/22/2009 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 11/3/2009 Female 190 lb 11/5/2009 United States
Primary
Concomitant
Speech Disorder Disability 53 Female 11/24/2009 Consumer Canada
Primary
Concomitant
Flushing 10/1/2009 Female 225 lb 11/25/2009 United States
Primary
Concomitant
Osteomyelitis Other Serious 1/1/2006 Female 200 lb 12/18/2009 Other Health Professional United States
Primary
Concomitant
Peripheral Ischaemia Other Serious 1/1/2007 68 Female 254 lb 12/29/2009 Lawyer United States
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 1/1/2007 Female 180 lb 12/30/2009 Consumer United States
Primary
Secondary
Concomitant
Death Death Male 2/3/2010 Consumer United States
Primary
Concomitant
Emphysema Hospitalization 2/18/2010 Male 165 lb 3/11/2010 Physician United States
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 4/2/2008 53 Male 209 lb 3/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wheelchair User Other Serious 1/1/2004 Male 174 lb 3/22/2010 United States
Primary
Secondary
Concomitant
Upper Limb Fracture Other Serious 9/1/2009 77 Female 4/8/2010 Consumer Canada
Primary
Secondary
Concomitant
Toe Amputation Hospitalization 65 Male 4/22/2010 Consumer United States
Primary
Concomitant
Dyspnoea Hospitalization 2/18/2010 66 Male 165 lb 4/23/2010 Physician United States
Primary
Secondary
Concomitant
Muscle Injury Other Serious 2/17/2010 54 Female 4/30/2010 Consumer United States
Primary
Concomitant
Tooth Erosion Hospitalization 1/1/2009 71 Male 240 lb 5/5/2010 Consumer United States
Primary
Concomitant
Weight Decreased Other Serious 1/20/2003 61 Female 203 lb 6/11/2010 Other Health Professional United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 10/1/2007 68 Male 159 lb 6/17/2010 Lawyer United States
Primary
Concomitant
Thrombocytopenia Other Serious 65 Male 6/17/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 4/26/2010 65 Male 6/17/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Toe Amputation Hospitalization 65 Male 6/18/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 4/23/2008 54 Male 209 lb 6/18/2010 Lawyer United States
Primary
Concomitant
Toxic Encephalopathy Hospitalization 3/10/2010 57 Female 149 lb 7/19/2010 Physician Canada
Primary
Secondary
Concomitant
Lymphadenopathy Other Serious 5/24/2008 51 Male 230 lb 7/22/2010 Consumer United States
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 8/5/2010 68 Male 183 lb 8/16/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 4/18/2008 54 Male 209 lb 8/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 65 Male 8/27/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Vision Blurred 3/1/2010 58 8/29/2010 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 4/26/2010 65 Male 8/30/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Pneumothorax Life Threatening 8/21/2010 62 Male 187 lb 8/31/2010 Physician Australia
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 9/3/2010 United States
Primary
Secondary
Concomitant
Speech Disorder Disability 53 Female 9/16/2010 Consumer Canada
Primary
Concomitant
Osteomyelitis Other Serious 1/1/2006 45 Female 200 lb 9/16/2010 Other Health Professional United States
Primary
Concomitant
Diabetic Ketoacidosis Other Serious Male 215 lb 9/17/2010 United States
Primary
Concomitant
Somnolence Female 246 lb 9/20/2010 United States
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 8/5/2010 68 Male 183 lb 9/22/2010 Physician United States
Primary
Concomitant
International Normalised Ratio Decreased Other Serious 7/1/2010 82 Female 165 lb 9/29/2010 Consumer United States
Primary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 9/30/2010 United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 1/1/2008 53 Female 218 lb 9/30/2010 Other Health Professional United States
Primary
Concomitant
Hypersensitivity Other Serious 4/2/2008 53 Male 209 lb 10/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 8/1/2010 63 Male 180 lb 10/4/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 4/8/2008 68 Male 10/6/2010 Other Health Professional United States
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 8/5/2010 68 Male 183 lb 10/12/2010 Physician United States
Primary
Concomitant
Sepsis Other Serious 1/1/2007 49 Male 10/13/2010 Consumer United States
Primary
Secondary
Concomitant
Wheelchair User Other Serious 1/1/2004 57 Male 174 lb 10/14/2010 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/7/2005 58 Male 174 lb 10/27/2010 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/19/2010 52 Male 11/1/2010 Pharmacist United States
Primary
Concomitant
Wound Dehiscence Other Serious 10/1/2007 68 Male 159 lb 11/9/2010 Lawyer United States
Primary
Concomitant
Suicide Attempt Other Serious 10/1/2007 30 Female 11/18/2010 Lawyer United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 6/1/2010 55 Male 289 lb 11/24/2010 Consumer United States
Primary
Concomitant
Fatigue 1/1/2010 68 Female 200 lb 11/26/2010 Consumer United States
Primary
Concomitant
Toxic Encephalopathy Hospitalization 2/6/2010 57 Female 149 lb 11/26/2010 Physician Canada
Primary
Secondary
Concomitant
Wheezing Hospitalization 9/28/2005 74 Female 11/11/2010 United States
Primary
Concomitant
Weight Increased 8/29/2010 11/30/2010 Consumer United States
Primary
Concomitant
Weight Increased Other Serious 6/1/2006 47 Female 12/7/2010 Other Health Professional United States
Primary
Concomitant
Pain Other Serious Male 12/9/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 5/13/2008 61 Female 200 lb 12/8/2010 Physician United States
Primary
Concomitant
Pain Other Serious 1/1/2010 62 Male 177 lb 12/13/2010 Consumer United States
Primary
Concomitant
Speech Disorder Disability 53 Female 11/24/2009 Consumer Canada
Primary
Concomitant
Osteomyelitis Other Serious 1/1/2006 45 Female 200 lb 12/18/2009 Other Health Professional United States
Primary
Concomitant
Cerebrovascular Accident Other Serious 11/25/2010 85 Female 186 lb 12/22/2010 Physician Argentina
Primary
Concomitant
Tuberculin Test Positive 12/22/2010 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/7/2005 58 Male 174 lb 12/24/2010 United States
Primary
Secondary
Concomitant
Metabolic Syndrome Hospitalization 6/1/2006 47 Female 1/26/2011 Physician United States
Primary
Concomitant
Arterial Disorder Other Serious 8/1/2008 75 Male 2/3/2011 Other Health Professional United States
Primary
Concomitant
Pyrexia Hospitalization 9/15/2010 2/15/2011 Physician France
Primary
Secondary
Concomitant
Intervertebral Disc Degeneration Hospitalization 5/7/2005 58 Male 174 lb 2/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Ear Infection Other Serious 12/1/2010 2/23/2011 Other Health Professional Canada
Primary
Concomitant
Myocardial Infarction Hospitalization 53 Male 2/23/2011 Physician United States
Primary
Concomitant
Skin Burning Sensation 46 Female 2/28/2011 Consumer United States
Primary
Concomitant
Blister Other Serious Male 3/1/2011 United States
Primary
Concomitant
Osteomyelitis Hospitalization 12/21/2006 62 Male 333 lb 3/3/2011 Physician United States
Primary
Concomitant
Akathisia Other Serious 1/1/1984 32 Female 115 lb 2/28/2011 Lawyer United States
Primary
Concomitant
Cellulitis Other Serious 7/30/2009 64 Male 101 lb 3/15/2011 Consumer United States
Primary
Secondary
Concomitant
Cardiomyopathy Hospitalization 2/20/2008 48 Female 180 lb 3/17/2011 United States
Primary
Concomitant
Pain In Extremity Other Serious 6/7/2010 51 Female 148 lb 4/1/2011 Consumer United States
Primary
Secondary
Concomitant
Herpes Simplex Serology Positive Other Serious 5/7/2005 58 Male 174 lb 4/5/2011 Lawyer United States
Primary
Secondary
Concomitant
Hunger Death Male 4/6/2011 Consumer Canada
Primary
Concomitant
Acute Sinusitis Hospitalization 6/1/2006 47 Female 4/6/2011 Lawyer United States
Primary
Concomitant
Stress Other Serious 7/6/2007 75 Male 145 lb 4/19/2011 Lawyer United States
Primary
Concomitant
Agitation Other Serious 62 Male 194 lb 4/27/2011 Pharmacist Canada
Primary
Concomitant
Diabetes Mellitus 47 Female 210 lb 4/28/2011 Consumer United States
Primary
Concomitant
Constipation Hospitalization 1/1/2008 15 Female 220 lb 5/2/2011 Consumer United States
Primary
Concomitant
Ulcer Other Serious 53 Male 5/2/2011 Physician United States
Primary
Secondary
Concomitant
Angina Pectoris Other Serious 3/28/2006 Female 5/5/2011 United States
Primary
Concomitant
Depression Other Serious 4/22/2006 77 Female 160 lb 5/4/2011 Lawyer United States
Primary
Concomitant
Injury Hospitalization 1/19/2007 64 Male 201 lb 5/4/2011 Other Health Professional United States
Primary
Concomitant
Injury Other Serious 1/1/2010 27 Female 323 lb 5/6/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Back Pain Hospitalization 3/1/2000 39 Male 5/9/2011 Physician United States
Primary
Concomitant
Feeling Abnormal Other Serious 5/1/2011 73 Female 146 lb 6/22/2011 Consumer Brazil
Primary
Concomitant
Interacting
Blood Glucose Increased Other Serious 6/17/2011 64 Female 155 lb 7/4/2011 Consumer United States
Primary
Concomitant
Weight Increased Death 67 Male 7/7/2011 Consumer United States
Primary
Concomitant
Neuromuscular Block Prolonged Other Serious 74 Female 7/21/2011 Pharmacist India
Primary
Concomitant
Interacting
Stress Other Serious 7/24/2007 56 Male 245 lb 7/22/2011 Lawyer United States
Primary
Secondary
Concomitant
Blood Glucose Increased Other Serious 6/17/2011 64 Female 155 lb 7/29/2011 Physician United States
Primary
Concomitant
Hallucination Hospitalization 4/1/2011 84 Male 8/16/2011 Physician Sweden
Primary
Secondary
Concomitant
Pulmonary Mass Hospitalization 2/1/2011 73 Male 8/18/2011 Consumer United States
Primary
Concomitant
Impaired Healing Other Serious Female 8/19/2011 Lawyer United States
Primary
Concomitant
Interstitial Lung Disease Hospitalization 67 Female 9/9/2011 Physician United Kingdom
Primary
Concomitant
Initial Insomnia 52 Female 200 lb 9/22/2011 Consumer United States
Primary
Concomitant
Osteomyelitis Other Serious Female 11/23/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Abnormal Dreams 11/26/2011 59 Female 152 lb 11/28/2011 Consumer United States
Primary
Concomitant
Anxiety Other Serious 11/1/2007 49 Male 11/30/2011 Lawyer United States
Primary
Concomitant
Renal Impairment Hospitalization 11/1/2011 59 Male 2/2/2012 Physician United States
Primary
Concomitant
Nerve Compression Other Serious 1/1/2011 60 Female 150 lb 2/28/2012 Consumer United States
Primary
Secondary
Concomitant
Muscle Spasms Disability 6/1/2006 47 Female 3/14/2012 Consumer United States
Primary
Concomitant
Toxicity To Various Agents Other Serious Female 3/14/2012 United Kingdom
Primary
Concomitant
Pain Other Serious 1/1/2011 60 Female 150 lb 4/13/2012 Physician United States
Primary
Secondary
Concomitant
Hypertension Hospitalization 5/14/2012 54 Female 146 lb 5/25/2012 Physician United States
Primary
Concomitant
Drug Ineffective 5/1/2012 52 Female 250 lb 6/5/2012 Consumer United States
Primary
Concomitant
Back Disorder Other Serious 1/1/2011 51 Female 193 lb 7/19/2012 Consumer United States
Primary
Concomitant
Back Disorder Other Serious 1/1/2011 52 Female 193 lb 8/21/2012 Consumer United States
Primary
Concomitant
Off Label Use Hospitalization 2009 48 Male 240 lb 9/24/2012 Us
Primary
Secondary
Concomitant
Pancreatic Carcinoma Hospitalization 2/16/2012 59 Female 157 lb 10/22/2012 Physician Br
Primary
Concomitant
Pulmonary Embolism Hospitalization 45 Female 8/28/2012 Consumer Us
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/1/2012 68 Female 160 lb 8/30/2012 Us
Primary
Concomitant
Multi-organ Failure Life Threatening 7/19/2012 50 Male 236 lb 11/9/2012 Physician Ca
Primary
Concomitant
Thrombocytopenia Other Serious 6/2012 Male 227 lb 9/10/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 27 Female 9/17/2012 Other Health Professional Us
Primary
Concomitant
Intestinal Obstruction Hospitalization 8/28/2012 65 Female 139 lb 1/21/2013 Physician Fr
Primary
Concomitant

Drug Data