Metformin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Somnolence Hospitalization 8/13/2000 Female 1/3/2006 Australia
Primary
Concomitant
Adverse Event Other Serious 11/11/2005 68 Female 1/10/2006 Physician Sweden
Primary
Concomitant
Skin Graft Infection Other Serious 9/15/2005 Male 192 lb 1/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 12/25/2005 57 Male 235 lb 1/13/2006 Other Health Professional United States
Primary
Concomitant
Prostate Examination Abnormal Hospitalization 10/1/2005 Male 253 lb 1/17/2006 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Hospitalization 4/29/2001 55 Female 148 lb 1/20/2006 Lawyer United States
Primary
Concomitant
Renal Failure Required Intervention 8/25/2005 61 Male 11/15/2005 Other Health Professional United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 3/19/2002 41 Female 150 lb 3/1/2006 Physician United States
Primary
Concomitant
Septic Shock Other Serious 8/3/2005 68 Female 3/9/2006 Physician Sweden
Primary
Concomitant
Weight Decreased 10/1/2005 60 Female 200 lb 1/20/2006 Consumer United States
Primary
Concomitant
Vomiting Other Serious 1/1/2001 41 Female 150 lb 3/27/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 9/29/1999 70 Male 209 lb 3/29/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 3/24/2006 Other Health Professional United States
Primary
Concomitant
Optic Neuritis Retrobulbar Hospitalization 55 Male 4/7/2006 United States
Primary
Concomitant
Death Other Serious Female 185 lb 4/10/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2003 57 Male 5/9/2006 Australia
Primary
Concomitant
Tremor Hospitalization 1/1/2005 85 Female 5/10/2006 Consumer United States
Primary
Concomitant
Scar Hospitalization 11/8/2005 64 Female 5/19/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Candidiasis Hospitalization 9/16/2005 Female 178 lb 5/25/2006 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 1/1/2005 64 Female 207 lb 5/31/2006 Physician United States
Primary
Concomitant
Cardiac Failure Congestive Other Serious Female 185 lb 6/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Septic Shock Other Serious 11/11/2005 68 Female 6/15/2006 Physician Sweden
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 10/1/2003 Female 294 lb 6/15/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Mass Required Intervention 1/18/2006 61 Female 200 lb 6/16/2006 Physician United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization Male 225 lb 6/23/2006 Other Health Professional Canada
Primary
Concomitant
Weight Decreased 7/1/2005 57 Female 156 lb 4/17/2006 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/30/2006 Physician United States
Primary
Secondary
Concomitant
Tooth Disorder Required Intervention 5/1/2006 Male 143 lb 7/7/2006 Pharmacist United States
Primary
Secondary
Concomitant
Confusional State Other Serious Female 185 lb 7/12/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 1/1/2006 Female 7/17/2006 Consumer United States
Primary
Concomitant
Coronary Artery Disease Hospitalization 12/1/2005 Female 7/31/2006 Physician United States
Primary
Concomitant
Vaginal Cancer Other Serious 7/1/2006 Female 155 lb 8/7/2006 Other Health Professional United States
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 2/13/2006 Female 185 lb 8/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Femur Fracture Other Serious 3/25/2006 Male 168 lb 8/14/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 6/2/2005 Female 185 lb 8/23/2006 Consumer United States
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 2/13/2006 Female 185 lb 8/28/2006 Other Health Professional United Kingdom
Primary
Concomitant
Coronary Artery Disease Hospitalization Male 225 lb 10/6/2006 Other Health Professional Canada
Primary
Concomitant
Vaginal Cancer Other Serious 7/1/2006 Female 155 lb 10/9/2006 Other Health Professional United States
Primary
Concomitant
Arthropathy Other Serious Female 149 lb 10/9/2006 Consumer Canada
Primary
Concomitant
Respiratory Rate Increased Other Serious 10/23/2006 46 Female 11/13/2006 Other Health Professional Thailand
Primary
Concomitant
Non-small Cell Lung Cancer Stage Iii Other Serious 8/31/2006 Female 150 lb 11/16/2006 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Infection Hospitalization 3/1/2006 Female 160 lb 11/16/2006 Consumer United States
Primary
Concomitant
Bladder Cancer Other Serious 11/1/2006 Female 182 lb 11/20/2006 Physician United States
Primary
Concomitant
Hypokalaemia Hospitalization 10/31/2006 Female 11/22/2006 Consumer United States
Primary
Concomitant
Gastric Ulcer Other Serious 10/20/2006 Female 181 lb 12/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 9/12/2006 65 Female 114 lb 12/5/2006 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 1/1/2005 64 Female 207 lb 12/5/2006 Physician United States
Primary
Concomitant
Skin Cancer Other Serious 3/1/2006 Female 12/8/2006 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 2/26/2006 Female 12/8/2006 Physician United States
Primary
Concomitant
Coronary Artery Disease Hospitalization 12/1/2005 Female 12/11/2006 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 2/20/2006 Male 230 lb 12/11/2006 Physician United States
Primary
Concomitant
Heart Rate Decreased Hospitalization 9/1/2006 Female 217 lb 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Neutropenia 10/26/2005 Male 350 lb 12/14/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Ureteral Neoplasm Other Serious 11/1/2006 Female 182 lb 12/18/2006 Physician United States
Primary
Concomitant
Injection Site Pain 5/1/2006 Female 12/20/2006 Pharmacist United States
Primary
Concomitant
Trigeminal Neuralgia Other Serious 1/1/2003 Female 2/12/2007 Consumer Germany
Primary
Secondary
Concomitant
Weight Increased 9/8/2006 70 Male 216 lb 10/16/2006 Consumer United States
Primary
Concomitant
Papilloedema Hospitalization 1/1/2006 220 lb 2/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 12/12/2005 63 Male 273 lb 3/30/2007 Other Health Professional France
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 3/27/2006 Female 130 lb 4/11/2007 Consumer United Kingdom
Primary
Concomitant
Motor Neurone Disease Other Serious Male 187 lb 4/16/2007 Physician United Kingdom
Primary
Concomitant
Trigeminal Neuralgia Other Serious 1/1/2003 Female 6/1/2007 Consumer Germany
Primary
Secondary
Concomitant
Mental Disorder Hospitalization 9/1/2006 58 Male 7/3/2007 Physician Sweden
Primary
Secondary
Concomitant
Somnolence 3/1/2007 Female 300 lb 8/29/2007 Physician United States
Primary
Secondary
Concomitant
Thalassaemia Other Serious Male 9/27/2007 Belgium
Primary
Concomitant
Feeling Hot 72 Female 119 lb 9/20/2007 Consumer United States
Primary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 9/28/2007 Physician Germany
Primary
Concomitant
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 9/28/2007 Physician United States
Primary
Concomitant
Weight Decreased 8/26/2005 54 Female 12/15/2006 Physician United States
Primary
Concomitant
Regurgitation Other Serious 7/20/2007 Male 175 lb 10/26/2007 Consumer United States
Primary
Concomitant
Rhinitis Other Serious 10/3/2007 50 Female 143 lb 10/26/2007 Brazil
Primary
Secondary
Concomitant
Rhinitis Other Serious 10/3/2007 50 Female 143 lb 11/2/2007 Brazil
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 9/1/2007 Male 11/12/2007 Consumer Germany
Primary
Concomitant
Joint Swelling Other Serious 6/15/2007 Female 20 lb 1/21/2008 United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 2/20/2008 Female 110 lb 3/3/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Increased 9/22/2006 Female 180 lb 3/14/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting 11/1/2007 Female 224 lb 3/14/2008 Consumer United States
Primary
Concomitant
Smear Cervix Abnormal 3/10/2007 Female 178 lb 3/15/2008 Physician United States
Primary
Concomitant
Drug Ineffective 10/1/2007 Female 171 lb 3/15/2008 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 8/1/2007 Female 172 lb 3/15/2008 United States
Primary
Concomitant
Mental Impairment 2/16/2008 3/15/2008 United States
Primary
Concomitant
Procedural Complication 2/25/2008 Female 190 lb 3/15/2008 Consumer United States
Primary
Concomitant
Oedema Peripheral 1/1/2008 Female 135 lb 3/15/2008 Consumer United States
Primary
Concomitant
Red Blood Cell Sedimentation Rate Increased Other Serious 2/1/2008 Female 122 lb 3/24/2008 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 3/3/2008 Female 231 lb 6/13/2008 Other Health Professional United Kingdom
Primary
Concomitant
Bone Disorder Other Serious 5/19/2008 Female 139 lb 6/16/2008 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 159 lb 6/16/2008 Physician United States
Primary
Secondary
Concomitant
Sensory Disturbance Other Serious 5/1/2008 Female 6/20/2008 Physician United States
Primary
Concomitant
Pain In Extremity 62 Male 6/23/2008 United States
Primary
Concomitant
White Blood Cell Count Decreased Disability 1/1/2008 69 Female 6/26/2008 Physician United States
Primary
Concomitant
Pain Hospitalization 7/13/2007 77 Female 7/3/2008 Physician Belgium
Primary
Concomitant
Hypotension Hospitalization 6/12/2008 64 Male 7/8/2008 Pharmacist United States
Primary
Secondary
Renal Disorder Other Serious Female 178 lb 7/16/2008 Physician United States
Primary
Concomitant
Heart Rate Increased 1/1/1999 53 Female 7/24/2008 Consumer United States
Primary
Concomitant
Squamous Cell Carcinoma Other Serious 9/21/2007 Female 104 lb 8/25/2008 Physician Brazil
Primary
Concomitant
Foot Deformity Other Serious Female 9/8/2008 Brazil
Primary
Concomitant
Synovitis Other Serious 10/1/2008 67 Male 203 lb 12/19/2008 Other Health Professional United Kingdom
Primary
Concomitant
Renal Mass Other Serious 11/26/2008 Female 12/24/2008 Consumer United Kingdom
Primary
Concomitant
Wound Infection Other Serious 10/30/2008 Male 183 lb 12/29/2008 Canada
Primary
Secondary
Concomitant
Tinnitus Other Serious 12/10/2008 Female 147 lb 1/14/2009 Physician United States
Primary
Concomitant
Neuropathy Peripheral Other Serious Male 242 lb 1/15/2009 Consumer United States
Primary
Concomitant
Syncope Other Serious 12/21/2008 73 Male 165 lb 1/5/2009 Other Health Professional United States
Primary
Concomitant
Immune System Disorder Hospitalization Female 1/21/2009 Brazil
Primary
Concomitant
Tuberculosis Other Serious 1/1/2007 Female 1/22/2009 Physician Brazil
Primary
Secondary
Concomitant
Renal Failure Death 1/1/2009 Female 1/22/2009 Physician United States
Primary
Concomitant
Subdural Haematoma Hospitalization 7/26/2008 Female 2/4/2009 Germany
Primary
Secondary
Concomitant
Breast Cancer Male Hospitalization 11/1/2008 2/6/2009 Other Health Professional Sweden
Primary
Concomitant
Vomiting Hospitalization 10/14/2008 2/16/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 1/25/2009 Female 294 lb 2/24/2009 Other Health Professional Canada
Primary
Concomitant
Osteomyelitis Hospitalization 10/1/2008 Female 194 lb 2/24/2009 Other Health Professional Canada
Primary
Concomitant
Weight Increased Other Serious 1/1/2005 Female 3/25/2009 Consumer United States
Primary
Concomitant
Surgery Other Serious 1/1/2007 Female 180 lb 3/23/2009 Consumer United States
Primary
Concomitant
Sinusitis Other Serious 1/1/2009 Male 3/27/2009 Consumer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 2/11/2002 Female 198 lb 3/27/2009 Physician Spain
Primary
Concomitant
Oral Pain Hospitalization 6/1/2009 Female 160 lb 7/27/2009 Canada
Primary
Concomitant
Weight Increased Other Serious 9/30/2008 54 Male 7/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Hospitalization 4/23/2008 68 Female 179 lb 7/24/2009 Physician Germany
Primary
Concomitant
Alveolitis Allergic Hospitalization 4/18/2009 Female 183 lb 7/29/2009 New Zealand
Primary
Secondary
Concomitant
Polypectomy Other Serious 6/1/2009 57 Female 280 lb 7/30/2009 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection Hospitalization 10/13/2008 Female 254 lb 8/18/2009 Physician United States
Primary
Secondary
Concomitant
Tinnitus Disability 7/20/2009 56 Male 165 lb 8/20/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Alveolitis Allergic Hospitalization 4/18/2009 Female 183 lb 8/20/2009 New Zealand
Primary
Secondary
Concomitant
Skin Burning Sensation Female 8/22/2009 United States
Primary
Concomitant
Pruritus 12/1/2008 Female 8/22/2009 United States
Primary
Concomitant
Wound Dehiscence Hospitalization 4/2/2009 68 Female 179 lb 9/18/2009 Physician Germany
Primary
Concomitant
Pneumonia Hospitalization 10/11/2008 Male 10/1/2009 Consumer United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious Female 220 lb 10/5/2009 Brazil
Primary
Concomitant
Venous Insufficiency Hospitalization 82 Male 10/23/2009 Lawyer United States
Primary
Concomitant
Skin Burning Sensation 10/28/2009 Female 190 lb 11/25/2009 Consumer United States
Primary
Concomitant
Pain Other Serious 11/18/2009 Female 140 lb 12/14/2009 Canada
Primary
Concomitant
Hypertension Other Serious 64 Female 150 lb 12/29/2009 Other Health Professional United Kingdom
Primary
Concomitant
Paraesthesia Other Serious 11/18/2009 Female 140 lb 12/29/2009 Canada
Primary
Concomitant
Viral Infection Hospitalization 10/17/2009 64 Female 157 lb 1/8/2010 Physician United States
Primary
Concomitant
Tremor Other Serious 12/31/2009 Male 194 lb 1/15/2010 Other Health Professional United States
Primary
Concomitant
Benign Prostatic Hyperplasia Hospitalization 11/1/2008 Male 198 lb 1/22/2010 Germany
Primary
Concomitant
Visual Acuity Reduced Other Serious 8/1/2009 Female 220 lb 1/25/2010 Brazil
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 12/7/2009 Female 1/28/2010 Physician United Kingdom
Primary
Concomitant
Wisdom Teeth Removal Other Serious 7/1/2009 Female 154 lb 1/28/2010 Brazil
Primary
Concomitant
Vomiting Hospitalization 4/17/2009 Female 159 lb 1/29/2010 Other Health Professional Canada
Primary
Concomitant
Rash 9/5/2009 Female 220 lb 1/29/2010 United States
Primary
Concomitant
Drug Effect Decreased 11/1/2008 Female 144 lb 1/29/2010 Physician United States
Primary
Concomitant
Pain In Jaw 8/19/2009 Male 235 lb 1/29/2010 Consumer United States
Primary
Concomitant
Musculoskeletal Stiffness 1/29/2010 Pharmacist United States
Primary
Concomitant
Drug Dose Omission 9/24/2009 Female 198 lb 1/29/2010 Consumer United States
Primary
Concomitant
Pain In Extremity 9/10/2009 Female 225 lb 1/29/2010 United States
Primary
Concomitant
Vitamin D Deficiency 8/1/2009 Female 1/29/2010 Pharmacist United States
Primary
Secondary
Concomitant
Muscle Spasms Female 175 lb 1/30/2010 Consumer United States
Primary
Concomitant
Neuropathy Peripheral Other Serious 3/1/2009 Female 240 lb 1/30/2010 United States
Primary
Secondary
Concomitant
Throat Irritation 10/23/2009 Female 275 lb 1/30/2010 United States
Primary
Concomitant
Palpitations 7/1/2009 Female 140 lb 1/30/2010 Physician United States
Primary
Concomitant

Drug Data