Metformin Hydrochloride combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombosis Hospitalization 1/20/2001 Male 1/3/2006 France
Primary
Concomitant
Syncope Other Serious 7/26/2005 Male 2/3/2006 Puerto Rico
Primary
Concomitant
Pleural Effusion Other Serious 7/26/2005 Male 215 lb 2/16/2006 Puerto Rico
Primary
Concomitant
Psychotic Disorder Hospitalization 6/1/2005 59 Male 262 lb 2/28/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 1/19/2006 59 Male 262 lb 3/10/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/26/2005 Male 215 lb 4/7/2006 Puerto Rico
Primary
Concomitant
Supraventricular Extrasystoles Hospitalization 10/11/2002 84 Male 4/28/2006 Norway
Primary
Secondary
Concomitant
Urinary Tract Infection Required Intervention 3/16/2006 74 Male 5/9/2006 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Decreased Required Intervention 3/2/2006 54 Male 552 lb 3/23/2006 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral 74 8/1/2006 Consumer United States
Primary
Concomitant
White Blood Cell Count Increased Death 2/16/2006 70 Female 7/27/2006 Physician Japan
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 7/24/2006 77 Male 134 lb 8/8/2006 Physician Canada
Primary
Concomitant
Renal Impairment Hospitalization 74 Male 8/17/2006 Consumer France
Primary
Concomitant
Somnolence Death 71 Male 170 lb 7/24/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 9/6/2004 Male 214 lb 9/7/2006 Australia
Primary
Concomitant
Malnutrition Hospitalization 1/1/2006 67 Male 132 lb 9/14/2006 Physician Canada
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 8/7/2006 77 Male 236 lb 10/10/2006 Pharmacist United States
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 7/24/2006 77 Male 134 lb 12/21/2006 Physician Canada
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/25/2007 43 Male 210 lb 3/15/2007 Consumer United States
Primary
Concomitant
Somnolence Hospitalization 75 Female 3/20/2007 Norway
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/25/2007 43 Male 210 lb 3/28/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 85 Female 4/25/2007 Sweden
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 2/25/2007 43 Male 210 lb 5/8/2007 Consumer United States
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 3/4/2006 56 Female 120 lb 12/13/2006 Pharmacist United States
Primary
Concomitant
Renal Impairment Hospitalization 6/29/2004 68 Female 8/10/2007 Australia
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 6/29/2004 68 Female 8/11/2007 Australia
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 3/9/2007 77 Female 282 lb 10/24/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 1/1/2006 83 Male 11/20/2007 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
Interacting
Renal Failure Acute Hospitalization 11/22/2007 81 Male 12/28/2007 United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 9/15/2007 74 Female 157 lb 1/23/2008 Other Health Professional France
Primary
Secondary
Concomitant
Renal Failure Disability 1/23/2008 61 Male 2/21/2008 Consumer Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/8/2008 69 Male 181 lb 4/2/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 75 Female 6/30/2008 Other Health Professional Sweden
Primary
Concomitant
Visual Impairment Hospitalization 62 Female 8/27/2008 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 7/16/2008 85 Female 9/12/2008 Other Health Professional Sweden
Primary
Secondary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/17/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombosis Hospitalization 7/1/2007 Female 229 lb 10/14/2008 Consumer United States
Primary
Concomitant
Influenza Like Illness Hospitalization 1/1/2008 Male 10/20/2008 Consumer United States
Primary
Concomitant
Tooth Abscess Life Threatening 9/30/2008 72 Male 10/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 9/29/2008 Female 198 lb 10/23/2008 United States
Primary
Secondary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Walking Disability Other Serious 1/1/2003 Male 172 lb 10/30/2008 Consumer United States
Primary
Secondary
Concomitant
Flushing Male 2/24/2009 United States
Primary
Secondary
Concomitant
Splenic Marginal Zone Lymphoma Hospitalization 75 Male 2/23/2009 Other Health Professional France
Primary
Concomitant
Total Lung Capacity Decreased Other Serious 1/1/2008 Male 203 lb 3/31/2009 Physician United States
Primary
Concomitant
Haemoptysis Other Serious 3/28/2009 4/10/2009 Pharmacist Canada
Primary
Concomitant
Vomiting Other Serious 1/1/2004 40 Female 166 lb 5/14/2009 United States
Primary
Concomitant
Haemoptysis Other Serious 3/28/2009 64 5/21/2009 Pharmacist Canada
Primary
Concomitant
Peripheral Ischaemia 9/1/2008 78 Male 171 lb 5/15/2009 Other Health Professional United States
Primary
Concomitant
Haemoptysis Other Serious 3/28/2009 64 6/1/2009 Pharmacist Canada
Primary
Concomitant
Subdural Haematoma Life Threatening 4/1/2009 73 Female 5/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Interaction Hospitalization 83 Male 6/5/2009 Taiwan, Province Of China
Primary
Concomitant
Interacting
Death Death 5/27/2009 Male 240 lb 6/3/2009 Physician United States
Primary
Concomitant
Coronary Artery Disease Death 5/27/2009 Male 240 lb 6/10/2009 Physician United States
Primary
Concomitant
Dizziness Male 8/21/2009 United States
Primary
Concomitant
Hepatic Function Abnormal Other Serious 3/14/2009 61 Female 10/1/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Stress Hospitalization 61 Female 180 lb 9/28/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/23/2009 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 4/23/2007 54 Female 258 lb 9/24/2009 United States
Primary
Concomitant
Throat Irritation Hospitalization 5/1/2009 66 Female 10/13/2009 Consumer United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 8/30/2009 41 Female 198 lb 10/13/2009 Other Health Professional Singapore
Primary
Concomitant
Pain Hospitalization 1/1/2007 Male 365 lb 10/6/2009 Consumer United States
Primary
Concomitant
Diarrhoea 9/1/2009 Female 10/16/2009 Physician United States
Primary
Concomitant
Vomiting Death 9/1/2008 73 Female 1/29/2010 Other Health Professional United Kingdom
Primary
Concomitant
Catheterisation Cardiac Hospitalization Female 235 lb 2/18/2010 Consumer United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 72 Male 256 lb 2/5/2010 United States
Primary
Concomitant
Wheezing Hospitalization 79 Male 2/5/2010 United States
Primary
Concomitant
Weight Increased Hospitalization Male 2/5/2010 Lawyer United States
Primary
Concomitant
Haemoglobin Decreased Life Threatening 10/13/2009 Female 3/2/2010 Physician Hungary
Primary
Secondary
Concomitant
Procedural Pain Other Serious 9/17/2007 45 Female 214 lb 3/3/2010 Other Health Professional United States
Primary
Concomitant
Visual Impairment Other Serious 1/1/1993 Female 3/9/2010 Consumer United States
Primary
Concomitant
Renal Disorder Other Serious 11/1/2006 Male 250 lb 3/17/2010 Physician United States
Primary
Concomitant
Subdural Haematoma Other Serious 87 Female 3/22/2010 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 1/1/2008 Male 179 lb 3/22/2010 Consumer United States
Primary
Concomitant
Prostate Cancer Other Serious 12/22/2009 76 Male 3/17/2010 United States
Primary
Concomitant
Pyrexia Hospitalization 5/31/2008 54 Male 202 lb 3/29/2010 Physician South Africa
Primary
Secondary
Concomitant
Tachycardia Other Serious 11/1/2007 71 Female 4/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Eosinophilic Cellulitis Hospitalization 6/1/2006 51 Male 4/29/2010 Other Health Professional France
Primary
Concomitant
Vomiting Other Serious 59 Female 4/27/2010 United States
Primary
Concomitant
Speech Disorder Other Serious 12/1/2009 73 Female 198 lb 5/11/2010 Physician Brazil
Primary
Concomitant
Chest Pain Other Serious 3/12/2009 69 Male 5/12/2009 United States
Primary
Concomitant
Rash Macular 3/1/2010 79 Male 185 lb 5/13/2010 Consumer United States
Primary
Concomitant
Loss Of Consciousness Other Serious 2/12/2010 60 Male 190 lb 5/19/2010 Other Health Professional Australia
Primary
Concomitant
Fatigue Other Serious 8/1/2009 89 Male 5/21/2010 Physician Canada
Primary
Secondary
Concomitant
Nausea Other Serious 12/1/2008 64 Male 5/21/2010 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 74 Male 5/27/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Interacting
Syncope Other Serious 4/15/2009 54 Male 6/4/2010 Other Health Professional France
Primary
Secondary
Concomitant
Paraesthesia 1/1/2009 65 Male 145 lb 6/29/2010 Pharmacist United States
Primary
Concomitant
Prostate Cancer Other Serious 12/22/2009 76 Male 236 lb 6/23/2010 United States
Primary
Secondary
Concomitant
Paraesthesia 1/1/2008 76 Male 241 lb 8/3/2010 Consumer United States
Primary
Concomitant
Insomnia Male 175 lb 8/6/2010 Physician United States
Primary
Concomitant
Cold Sweat 1/1/2010 58 Male 280 lb 9/14/2010 Consumer United States
Primary
Concomitant
Tetany Other Serious 5/1/2010 46 Female 304 lb 9/17/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tetany Other Serious 5/1/2010 46 Female 304 lb 9/20/2010 Physician United Kingdom
Primary
Concomitant
Tetany Other Serious 5/1/2010 46 Female 9/16/2010 United Kingdom
Primary
Concomitant
Tachycardia Other Serious 11/1/2007 71 Female 192 lb 11/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 3/9/2007 77 Female 282 lb 12/3/2010 Other Health Professional Australia
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 12/18/2010 48 Female 2/9/2011 Other Health Professional Finland
Primary
Concomitant
Off Label Use Hospitalization 12/18/2010 48 Female 2/18/2011 Other Health Professional Finland
Primary
Secondary
Concomitant
Blindness Other Serious 1/1/2008 52 Male 256 lb 4/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 10/7/2010 Male 220 lb 5/3/2011 Physician United Kingdom
Primary
Concomitant
Cataract Hospitalization 7/1/2010 76 Male 6/9/2011 Consumer United States
Primary
Concomitant
Feeling Abnormal Other Serious 3/24/2011 Female 6/13/2011 Consumer United States
Primary
Concomitant
Ischaemic Stroke Hospitalization 2/9/2011 80 Female 132 lb 8/22/2011 Physician Argentina
Primary
Concomitant
Pain Hospitalization 8/1/2011 63 Male 325 lb 8/24/2011 Consumer United States
Primary
Concomitant
Microangiopathic Haemolytic Anaemia Hospitalization 8/3/2010 57 Male 222 lb 8/26/2011 Physician United States
Primary
Secondary
Concomitant
Blood Sodium Decreased Hospitalization 8/15/2011 76 Male 8/30/2011 Consumer United States
Primary
Concomitant
Inappropriate Schedule Of Drug Administration Hospitalization 12/18/2010 48 Female 9/21/2011 Other Health Professional Finland
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 6/11/2011 79 Male 174 lb 9/12/2011 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Hospitalization 3/10/2010 63 Female 223 lb 10/7/2011 United States
Primary
Secondary
Concomitant
Pain Hospitalization Female 10/10/2011 Consumer United States
Primary
Concomitant
Electrolyte Imbalance Hospitalization 6/9/2011 Female 187 lb 10/10/2011 Physician Denmark
Primary
Concomitant
Cerebrovascular Accident Death 8/3/2010 57 Male 223 lb 10/10/2011 Consumer United States
Primary
Secondary
Concomitant
Nervousness Hospitalization 8/25/2007 63 Male 280 lb 10/10/2011 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Enterococcal Disability 6/9/2011 65 Female 200 lb 10/10/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Death 8/3/2010 57 Male 222 lb 10/3/2011 Consumer United States
Primary
Secondary
Concomitant
Palpitations Other Serious 9/1/2011 65 Male 168 lb 10/12/2011 Consumer Australia
Primary
Concomitant
Blood Disorder Hospitalization 2/1/2011 82 Male 240 lb 10/13/2011 Physician Israel
Primary
Concomitant
Microangiopathic Haemolytic Anaemia Hospitalization 8/3/2010 57 Male 223 lb 10/13/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Areflexia Other Serious 58 Male 10/14/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Depressed Level Of Consciousness Hospitalization 58 Male 10/16/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Unresponsive To Stimuli Hospitalization 58 Male 10/16/2011 Other Health Professional United States
Primary
Concomitant
Interacting
Orthostatic Hypotension Hospitalization 4/21/2011 65 Male 236 lb 10/17/2011 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 51 Female 10/17/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 68 Male 11/7/2011 Other Health Professional United States
Primary
Concomitant
Pancreatitis Hospitalization 8/16/2011 12/5/2011 Physician Finland
Primary
Concomitant
Pancreatitis Hospitalization 8/16/2011 12/13/2011 Physician Finland
Primary
Concomitant
Abdominal Pain Hospitalization 11/8/2011 30 Female 198 lb 12/13/2011 Physician Brazil
Primary
Secondary
Concomitant
Diverticulum Intestinal Hospitalization 12/9/2005 82 Male 181 lb 12/14/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cystitis Other Serious 11/22/2011 72 Female 176 lb 12/22/2011 Consumer Brazil
Primary
Concomitant
Lactic Acidosis Other Serious 68 Male 12/20/2011 Other Health Professional United States
Primary
Concomitant
Haemoglobin Decreased Hospitalization 9/29/2011 76 Male 1/18/2012 Consumer Germany
Primary
Secondary
Concomitant
Pathological Fracture Other Serious Female 1/25/2012 Physician United States
Primary
Secondary
Concomitant
Renal Failure Life Threatening 5/12/2011 74 Male 189 lb 1/25/2012 Physician United States
Primary
Secondary
Concomitant
Vomiting 12/1/2011 64 Female 144 lb 1/27/2012 Other Health Professional United States
Primary
Concomitant
Skin Ulcer Disability 11/4/2011 85 Female 2/8/2012 Other Health Professional Denmark
Primary
Concomitant
Faeces Pale Death 5/19/2011 57 Male 2/9/2012 Other Health Professional Japan
Primary
Concomitant
Cardiac Failure Hospitalization 1/1/2012 85 Male 2/27/2012 Other Health Professional Japan
Primary
Concomitant
International Normalised Ratio Increased Other Serious 43 Female 3/2/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 3/1/2007 73 Male 172 lb 3/8/2012 Consumer United States
Primary
Secondary
Concomitant
Syncope Hospitalization 3/27/2011 72 Female 3/9/2012 United States
Primary
Concomitant
Blood Calcium Increased Hospitalization 2/20/2012 85 Female 3/9/2012 Physician United Kingdom
Primary
Secondary
Concomitant
Hallucination Other Serious 2/22/2012 75 Male 3/19/2012 Physician United Kingdom
Primary
Secondary
Hallucination Other Serious 75 Male 3/19/2012 Other Health Professional United Kingdom
Primary
Secondary
Nausea Hospitalization 3/6/2012 64 Female 205 lb 4/12/2012 Other Health Professional United Kingdom
Primary
Concomitant
Hypotension Hospitalization 10/7/2011 83 Male 4/13/2012 Other Health Professional Italy
Primary
Concomitant
Hallucination Other Serious 2/22/2012 75 Male 4/18/2012 Other Health Professional Denmark
Primary
Secondary
Hallucination Other Serious 2/22/2012 75 Male 4/30/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Hallucination Other Serious 2/22/2012 75 Male 4/30/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant
Hallucination Other Serious 2/22/2012 75 Male 5/16/2012 Other Health Professional Denmark
Primary
Secondary
Concomitant

Drug Data