Metformin Hydrochloride combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Varices Oesophageal Hospitalization 5/22/2000 Male 1/3/2006 Australia
Primary
Concomitant
Hyponatraemia Hospitalization 10/1/2005 80 Female 148 lb 1/9/2006 Other Health Professional France
Primary
Secondary
Concomitant
Myalgia Death 1/1/2004 77 Male 192 lb 2/7/2006 Physician Canada
Primary
Concomitant
Ventricular Asystole Death 7/15/2004 68 Female 128 lb 2/9/2006 Physician Brazil
Primary
Concomitant
Ventricular Failure Required Intervention 12/1/2005 Female 2/8/2006 Physician Netherlands
Primary
Concomitant
Pyrexia Hospitalization 3/31/2006 Female 5/26/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/31/2006 Female 6/7/2006 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/31/2006 Female 159 lb 7/27/2006 Physician Japan
Primary
Secondary
Concomitant
Suicidal Ideation Other Serious 7/17/2006 47 Female 8/10/2006 Consumer United States
Primary
Concomitant
Renal Impairment Hospitalization 74 Male 8/17/2006 Consumer France
Primary
Concomitant
Breast Cancer In Situ Hospitalization 12/7/2005 Female 12/13/2006 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/26/2006 36 Female 117 lb 1/11/2007 Physician Ireland
Primary
Concomitant
Visual Acuity Reduced Other Serious 58 Female 280 lb 1/25/2007 Other Health Professional Poland
Primary
Concomitant
Pruritus Generalised Disability 3/20/2007 Male 9/14/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pruritus Generalised Disability 3/20/2007 Male 9/18/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Pruritus Generalised Disability 3/20/2007 Male 9/27/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 3/9/2007 77 Female 282 lb 10/24/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Muscle Haemorrhage Hospitalization 9/17/2007 Male 11/16/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Meningitis Death 11/10/2006 66 Female 11/20/2007 Physician Germany
Primary
Secondary
Concomitant
Cardiovascular Disorder Hospitalization 10/15/2007 66 Female 11/21/2007 Physician Russian Federation
Primary
Concomitant
Malaise Other Serious 11/7/2007 Female 170 lb 11/21/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious 4/26/2006 Female 117 lb 12/28/2007 Physician Ireland
Primary
Concomitant
Hyponatraemia 1/1/2004 64 Female 145 lb 2/20/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 1/14/2008 68 Male 157 lb 3/6/2008
Primary
Concomitant
Vomiting Life Threatening 1/14/2008 68 Male 3/12/2008 Other Health Professional United Kingdom
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 7/16/2008 85 Female 9/12/2008 Other Health Professional Sweden
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 9/1/2008 Female 214 lb 10/21/2008 United States
Primary
Concomitant
Lethargy Other Serious 5/16/2006 76 Female 10/22/2008 United Kingdom
Primary
Secondary
Concomitant
Product Quality Issue 3/18/2008 66 Male 10/30/2008 Consumer United States
Primary
Concomitant
Death Death 12/25/2008 1/9/2009 Physician Malaysia
Primary
Concomitant
Death Death 12/25/2008 Male 1/26/2009 Physician Malaysia
Primary
Concomitant
Pulmonary Arterial Hypertension Death 10/3/2008 1/30/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/26/2008 61 Female 4/13/2009 Physician Spain
Primary
Secondary
Concomitant
Social Avoidant Behaviour Death Male 5/22/2009 Lawyer United States
Primary
Concomitant
Weight Decreased Other Serious 76 Male 5/26/2009 Lawyer United States
Primary
Concomitant
Subdural Haematoma Life Threatening 4/1/2009 73 Female 5/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Death Death 5/27/2009 Male 240 lb 6/3/2009 Physician United States
Primary
Concomitant
Shock Life Threatening 3/6/2008 Male 6/5/2009 Other Health Professional France
Primary
Secondary
Concomitant
Dysphonia Hospitalization 1/1/2006 71 Male 228 lb 6/8/2009 Other Health Professional United States
Primary
Concomitant
Speech Disorder Hospitalization 3/14/2009 78 Female 6/5/2009 France
Primary
Secondary
Concomitant
Coronary Artery Disease Death 5/27/2009 Male 240 lb 6/10/2009 Physician United States
Primary
Concomitant
Paralysis Hospitalization 5/1/2006 41 Male 365 lb 6/15/2009 Other Health Professional United States
Primary
Concomitant
Headache Hospitalization 2/25/2009 58 Male 6/15/2009 Physician Italy
Primary
Concomitant
Left Ventricular Failure Death 5/12/2009 69 Male 6/15/2009 Other Health Professional United Kingdom
Primary
Concomitant
Malaise Life Threatening 6/2/2008 83 Male 6/29/2009 Physician Australia
Primary
Secondary
Concomitant
Throat Irritation Other Serious 9/16/2009 77 Male 170 lb 9/30/2009 Consumer United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 54 Male 281 lb 9/22/2009 United States
Primary
Concomitant
Vasculitis Other Serious 7/7/2009 75 Male 9/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Stress Hospitalization 61 Female 180 lb 9/28/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 9/23/2009 United States
Primary
Concomitant
Tricuspid Valve Disease Hospitalization 6/5/2007 44 Male 213 lb 9/25/2009 United States
Primary
Concomitant
Therapeutic Agent Toxicity Other Serious 46 Female 223 lb 9/25/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 50 Male 354 lb 9/22/2009 United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 60 Female 9/29/2009 United States
Primary
Concomitant
Throat Irritation Hospitalization 5/1/2009 66 Female 10/13/2009 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 6/30/2009 78 Female 161 lb 8/31/2009 Pharmacist United States
Primary
Concomitant
Leukocytoclastic Vasculitis Other Serious 76 Female 10/19/2009 Pharmacist United States
Primary
Concomitant
Dehydration Hospitalization 12/10/2008 62 Male 161 lb 11/13/2009 Physician Malaysia
Primary
Concomitant
Dehydration Hospitalization 12/10/2008 62 Male 161 lb 11/24/2009 Physician Malaysia
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 4/26/2006 Female 117 lb 11/30/2009 Physician Ireland
Primary
Concomitant
Syncope Other Serious 12/1/2009 67 Male 170 lb 1/15/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 8/3/2009 70 Female 154 lb 2/3/2010 Pharmacist Germany
Primary
Secondary
Concomitant
Urinary Tract Obstruction Hospitalization 76 Male 1/22/2010 United States
Primary
Concomitant
Lactic Acidosis Life Threatening 9/5/2009 61 Male 198 lb 1/29/2010 Germany
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 7/15/2009 70 Female 2/12/2010 Pharmacist Germany
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 72 Male 256 lb 2/5/2010 United States
Primary
Concomitant
Weight Increased Hospitalization Male 2/5/2010 Lawyer United States
Primary
Concomitant
Weight Increased Hospitalization Male 2/5/2010 Lawyer United States
Primary
Concomitant
Waist Circumference Increased Hospitalization 72 Male 256 lb 2/5/2010 United States
Primary
Concomitant
Haemoglobin Decreased Life Threatening 10/13/2009 Female 3/2/2010 Physician Hungary
Primary
Secondary
Concomitant
Knee Operation Other Serious 58 Male 3/4/2010 Consumer Brazil
Primary
Concomitant
Death Death 2/23/2010 Female 120 lb 3/8/2010 Consumer United States
Primary
Concomitant
Death Death 1/26/2010 81 Male 185 lb 3/5/2010 Other Health Professional United States
Primary
Concomitant
Renal Injury Hospitalization Female 3/22/2010 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2008 Male 179 lb 3/22/2010 Consumer United States
Primary
Concomitant
Urine Albumin/creatinine Ratio Increased Other Serious Male 4/5/2010 Physician United Kingdom
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/12/2009 69 Male 4/26/2010 Physician United Kingdom
Primary
Concomitant
Mixed Hepatocellular Cholangiocarcinoma Life Threatening Male 5/10/2010 Other Health Professional Germany
Primary
Concomitant
Weight Increased Hospitalization 1/7/2007 49 Male 4/28/2010 United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/13/2009 69 Male 4/30/2010
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/6/2010 55 Female 5/13/2010 Physician United States
Primary
Concomitant
Loss Of Consciousness Hospitalization 12/27/2008 54 Male 216 lb 5/18/2010 Physician Canada
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/7/2007 49 Male 5/11/2010 United States
Primary
Concomitant
Skin Discolouration Hospitalization 5/6/2010 73 Male 170 lb 5/25/2010 Other Health Professional United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 76 Male 5/18/2010 United States
Primary
Concomitant
Transplant Rejection Life Threatening 11/1/2009 53 Female 5/27/2010 Physician United States
Primary
Concomitant
Abdominal Pain Upper 80 Female 181 lb 5/27/2010 Consumer United States
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 12/27/2008 54 Male 216 lb 5/28/2010 Physician Canada
Primary
Secondary
Concomitant
Extrasystoles Female 5/28/2010 Consumer United States
Primary
Concomitant
Pulse Absent Other Serious 4/19/2010 69 Female 6/10/2010 United States
Primary
Secondary
Pruritus Generalised 6/24/2008 41 Female 180 lb 7/22/2010 Consumer United States
Primary
Concomitant
Dehydration Hospitalization 12/10/2008 62 Male 161 lb 10/13/2010 Physician Malaysia
Primary
Concomitant
Gastric Cancer Hospitalization 10/29/2010 76 Male 148 lb 11/10/2010 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 10/1/2010 76 Male 148 lb 11/17/2010 Physician Japan
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 3/9/2007 77 Female 282 lb 12/3/2010 Other Health Professional Australia
Primary
Secondary
Concomitant
Large Intestine Carcinoma Hospitalization 10/1/2010 76 Male 148 lb 12/3/2010 Physician Japan
Primary
Secondary
Concomitant
Ventricular Arrhythmia Hospitalization 83 Female 12/15/2010 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 10/1/2010 86 Female 12/6/2010 Other Health Professional Denmark
Primary
Secondary
Large Intestine Carcinoma Hospitalization 10/1/2010 76 Male 148 lb 12/22/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Death 1/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Large Intestine Carcinoma Hospitalization 10/1/2010 Male 148 lb 1/4/2011 Physician Japan
Primary
Secondary
Concomitant
Death Death 1/17/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Interaction Death 1/17/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 10/1/2010 Male 148 lb 1/26/2011 Physician Japan
Primary
Secondary
Concomitant
Gastric Cancer Hospitalization 8/1/2010 Male 148 lb 3/16/2011 Physician Japan
Primary
Secondary
Concomitant
Rash Macular Hospitalization 9/1/2010 61 Female 3/25/2011 Consumer Canada
Primary
Concomitant
Urinary Tract Infection Hospitalization 9/1/2010 61 Female 4/1/2011 Consumer Canada
Primary
Concomitant
Hyperkalaemia Hospitalization 10/7/2010 Male 220 lb 5/3/2011 Physician United Kingdom
Primary
Concomitant
Emotional Disorder Hospitalization 1/1/2009 69 Male 282 lb 7/21/2011 Consumer Brazil
Primary
Secondary
Concomitant
Dehydration Hospitalization 88 Female 8/10/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Stress Other Serious 4/3/2008 83 Male 180 lb 8/22/2011 Consumer United States
Primary
Concomitant
Hiccups Other Serious 9/21/2010 48 Female 9/20/2011 Other Health Professional France
Primary
Secondary
Upper Gastrointestinal Haemorrhage Other Serious 7/22/2011 72 Male 121 lb 9/22/2011 Physician United States
Primary
Secondary
Concomitant
Portal Vein Thrombosis Hospitalization 7/9/2011 60 Male 10/7/2011 Physician Sweden
Primary
Concomitant
Hypoglycaemia Other Serious 2/1/2010 67 Male 223 lb 10/7/2011 Physician Germany
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 3/7/2011 64 Male 195 lb 10/10/2011 Physician United States
Primary
Concomitant
Interacting
Liver Disorder Hospitalization 7/9/2011 60 Male 10/12/2011 Physician Sweden
Primary
Concomitant
Cardiac Failure Hospitalization 3/25/2011 10/12/2011 Physician France
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 3/18/2011 59 Female 209 lb 10/12/2011 Physician United States
Primary
Concomitant
Blood Disorder Hospitalization 2/1/2011 82 Male 240 lb 10/13/2011 Physician Israel
Primary
Concomitant
Chest Pain Other Serious 44 Female 10/13/2011 Physician Brazil
Primary
Secondary
Blood Triglycerides Increased Hospitalization 44 Female 10/13/2011 Brazil
Primary
Secondary
Clonus Life Threatening 9/21/2010 48 Female 134 lb 10/14/2011 Other Health Professional France
Primary
Secondary
Atrial Fibrillation Hospitalization 6/19/2011 69 Male 244 lb 10/17/2011 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 80 Male 12/8/2011 Pharmacist China
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 80 Male 12/15/2011 Pharmacist China
Primary
Secondary
Concomitant
Pneumonia Death 73 Male 236 lb 12/21/2011 Germany
Primary
Concomitant
Cystitis Other Serious 11/22/2011 72 Female 176 lb 12/22/2011 Consumer Brazil
Primary
Concomitant
Hepatic Steatosis Other Serious 10/14/2011 73 Female 1/4/2012 Physician Japan
Primary
Concomitant
Ileus Paralytic Hospitalization 1/1/2010 64 Male 209 lb 1/4/2012 Pharmacist United States
Primary
Concomitant
Haemoglobin Decreased Hospitalization 9/29/2011 76 Male 1/18/2012 Consumer Germany
Primary
Secondary
Concomitant
Dysmenorrhoea Hospitalization 5/11/2009 31 Female 255 lb 1/24/2012 Consumer United States
Primary
Concomitant
Abdominal Pain Upper Other Serious 12/1/2011 76 Female 1/24/2012 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Life Threatening 5/12/2011 74 Male 189 lb 1/25/2012 Physician United States
Primary
Secondary
Concomitant
Hypertension Hospitalization 12/1/2011 Male 2/6/2012 Physician Czech Republic
Primary
Concomitant
Skin Ulcer Disability 11/4/2011 85 Female 2/8/2012 Other Health Professional Denmark
Primary
Concomitant
Haemodynamic Instability Life Threatening 2/9/2012 65 Female 3/2/2012 Physician Denmark
Primary
Secondary
Concomitant
Malaise Disability 2/13/2012 75 Female 154 lb 3/8/2012 Other Health Professional United Kingdom
Primary
Concomitant
Sudden Death Death 2/13/2012 58 Male 287 lb 3/8/2012 Physician Denmark
Primary
Concomitant
Malignant Neoplasm Of Ampulla Of Vater Other Serious 8/19/2010 74 Male 190 lb 3/8/2012 Physician France
Primary
Secondary
Concomitant
Pruritus 2/1/2012 81 Female 3/9/2012 Consumer United States
Primary
Secondary
Concomitant
Constipation Hospitalization 7/9/2011 60 Male 3/16/2012 Physician Sweden
Primary
Concomitant
Hypotension Hospitalization 10/7/2011 83 Male 4/13/2012 Other Health Professional Italy
Primary
Concomitant
Hyperkalaemia Hospitalization 2/1/2012 71 Male 4/16/2012 Physician Denmark
Primary
Secondary
Concomitant
Blood Creatinine Increased Hospitalization 1/22/2012 87 Male 4/25/2012 Denmark
Primary
Concomitant
Dehydration 7/20/2007 82 Male 4/17/2012 Physician Germany
Primary
Concomitant
Chest Pain Hospitalization 1/11/2012 21 Female 154 lb 6/8/2012 Other Health Professional United States
Primary
Concomitant
Pleural Mesothelioma Hospitalization 9/20/2011 74 Female 194 lb 6/19/2012 Physician France
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 11/22/2011 72 Female 176 lb 6/20/2012 Consumer Brazil
Primary
Concomitant
Abdominal Pain Other Serious 6/4/2012 71 Female 6/20/2012 Physician France
Primary
Concomitant

Drug Data