Metformin Hydrochloride combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Skin Ulcer Hospitalization 2/13/2002 Female 1/4/2006 France
Primary
Concomitant
Renal Failure Life Threatening 9/2/2003 Male 1/4/2006 Finland
Primary
Concomitant
Aortic Aneurysm Rupture Death 11/21/2003 Male 1/4/2006 France
Primary
Concomitant
Bone Marrow Failure Other Serious 9/13/2004 Male 1/4/2006 Australia
Primary
Concomitant
Coronary Artery Disease Hospitalization 5/1/2005 56 Male 1/5/2006 Consumer United States
Primary
Concomitant
Quadruple Vessel Bypass Graft Hospitalization 5/1/2005 56 Male 1/20/2006 Consumer United States
Primary
Concomitant
Fat Tissue Increased Hospitalization 12/15/2003 53 Female 1/25/2006 Netherlands
Primary
Concomitant
Swelling 7/1/2004 60 Female 115 lb 1/25/2006 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Myocardial Infarction Life Threatening 8/30/2005 Male 139 lb 2/9/2006 United States
Primary
Concomitant
Skin Exfoliation Disability 8/24/2004 72 Female 188 lb 2/13/2006 Physician Brazil
Primary
Secondary
Concomitant
Lung Squamous Cell Carcinoma Stage Unspecified Other Serious 12/6/2005 59 Female 3/1/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Lung Squamous Cell Carcinoma Stage Unspecified Other Serious 12/6/2005 59 Female 3/13/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Cough Other Serious 1/31/2006 74 Male 256 lb 2/10/2006 Pharmacist United States
Primary
Concomitant
Rash Other Serious 2/3/2006 80 Male 158 lb 2/6/2006 Pharmacist United States
Primary
Concomitant
Rash Other Serious 2/3/2006 80 Male 158 lb 2/6/2006 Pharmacist United States
Primary
Concomitant
Orthostatic Hypotension Hospitalization 3/15/2006 72 Male 215 lb 3/22/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Other Serious 2/17/2006 75 Male 3/31/2006 Other Health Professional France
Primary
Concomitant
Rhabdomyolysis Hospitalization 2/4/2006 Female 126 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 3/22/2006 88 Male 193 lb 4/6/2006 Pharmacist United States
Primary
Concomitant
Myalgia Other Serious 7/22/2005 51 Male 227 lb 4/13/2006 Pharmacist United States
Primary
Concomitant
Vertigo Other Serious 2/27/2006 78 Male 188 lb 2/27/2006 Pharmacist United States
Primary
Concomitant
Vomiting Other Serious 3/1/2006 74 Male 263 lb 3/23/2006 Pharmacist United States
Primary
Concomitant
Urticaria Other Serious 3/1/2006 56 Male 196 lb 3/1/2006 Pharmacist United States
Primary
Concomitant
Lung Squamous Cell Carcinoma Stage Unspecified Other Serious 12/6/2005 59 Female 4/27/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Osteonecrosis Disability 69 Male 5/18/2006 Physician Australia
Primary
Concomitant
Rash Hospitalization 5/15/2006 64 Male 284 lb 5/15/2006 Pharmacist United States
Primary
Concomitant
Stomach Discomfort Other Serious 3/15/2006 Male 227 lb 6/8/2006 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 3/29/2006 67 Female 6/14/2006 Other Health Professional Denmark
Primary
Concomitant
Death Death 3/29/2006 67 Female 6/28/2006 Other Health Professional Denmark
Primary
Concomitant
Vision Blurred Disability 1/23/2006 Male 184 lb 6/26/2006 Pharmacist United States
Primary
Concomitant
Pyrexia Hospitalization 5/15/2006 38 Male 234 lb 7/7/2006 Pharmacist United States
Primary
Secondary
Concomitant
Lethargy Hospitalization 5/5/2006 70 Male 7/5/2006 Pharmacist United States
Primary
Secondary
Concomitant
Rash Hospitalization 5/29/2006 81 Male 243 lb 7/14/2006 Pharmacist United States
Primary
Concomitant
Heart Rate Irregular Hospitalization 5/21/2006 64 Male 224 lb 5/23/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 7/22/2005 74 Male 8/1/2006 Consumer United States
Primary
Concomitant
International Normalised Ratio Decreased 11/15/2005 74 Male 183 lb 8/1/2006 Pharmacist United States
Primary
Concomitant
Thrombosis Other Serious 66 Male 7/28/2006 Pharmacist Germany
Primary
Concomitant
Renal Failure Acute Other Serious 2/17/2006 75 Male 8/8/2006 Denmark
Primary
Concomitant
Granulocytopenia Required Intervention 9/13/2005 58 Male 1/9/2006 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 6/19/2006 77 Male 8/23/2006 Other Health Professional France
Primary
Concomitant
Stomach Discomfort Other Serious 3/15/2006 Male 8/18/2006 Other Health Professional Denmark
Primary
Concomitant
Cough Other Serious 74 Female 8/24/2006 Other Health Professional France
Primary
Concomitant
Hypoglycaemia Other Serious 6/3/2006 81 Female 8/21/2006 United Kingdom
Primary
Concomitant
Myalgia Other Serious 4/28/2006 59 Male 221 lb 6/23/2006 Pharmacist United States
Primary
Concomitant
Rash Other Serious 6/30/2006 66 Male 208 lb 6/30/2006 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 3/17/2006 66 Female 9/1/2006 United Kingdom
Primary
Concomitant
Hypoglycaemia Other Serious 6/26/2006 71 Male 9/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Hospitalization 7/18/2006 58 Male 419 lb 7/24/2006 Pharmacist United States
Primary
Concomitant
Renal Impairment Hospitalization 5/6/2005 60 Female 11/27/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 10/25/2006 71 Female 12/13/2006 Other Health Professional United Kingdom
Primary
Concomitant
Lactic Acidosis Hospitalization 64 Male 1/22/2007 Physician United States
Primary
Concomitant
Palpitations Other Serious 1/12/2007 52 Male 205 lb 2/16/2007 Other Health Professional United Kingdom
Primary
Concomitant
Upper Limb Fracture Required Intervention 70 Female 143 lb 4/6/2007 Physician Germany
Primary
Concomitant
Vomiting Other Serious 4/1/2007 45 Female 4/26/2007 United States
Primary
Concomitant
Transient Ischaemic Attack Other Serious 1/1/2006 83 Male 178 lb 12/13/2006 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 4/13/2007 70 Female 5/24/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 51 Female 5/30/2007 United States
Primary
Secondary
Concomitant
Rales Other Serious 5/8/2007 75 Male 159 lb 6/4/2007 Physician United Kingdom
Primary
Concomitant
Lichenoid Keratosis Other Serious 7/1/2006 76 Female 152 lb 6/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Hypoglycaemia Life Threatening 1/6/2007 51 Female 191 lb 4/26/2007 Physician United States
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 6/4/2007 61 Female 190 lb 7/3/2007 United Kingdom
Primary
Secondary
Concomitant
Wheezing Life Threatening 8/11/2004 Male 7/9/2007 Physician United States
Primary
Concomitant
Paraesthesia Other Serious 6/10/2007 69 Female 7/5/2007 United Kingdom
Primary
Concomitant
Hypotension Hospitalization 4/30/2007 75 Male 7/18/2007 Other Health Professional France
Primary
Concomitant
Interacting
Pancytopenia Life Threatening Female 7/16/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious 75 Female 7/18/2007 Belgium
Primary
Secondary
Concomitant
Shock Required Intervention 73 Male 7/26/2007 Spain
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 59 Female 216 lb 8/31/2007 Consumer United States
Primary
Concomitant
Glycosuria Other Serious 62 Male 9/18/2007 Other Health Professional European Union
Primary
Concomitant
Metabolic Acidosis Life Threatening 1/1/2007 73 Female 9/19/2007 United Kingdom
Primary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 9/28/2007 Physician Germany
Primary
Concomitant
Vitamin B12 Deficiency Disability 3/1/2006 Male 10/24/2007 United Kingdom
Primary
Concomitant
Pharmaceutical Product Complaint Other Serious 59 Female 216 lb 10/25/2007 United States
Primary
Concomitant
Retinal Detachment Hospitalization 10/1/2007 63 Female 10/24/2007 Pharmacist Netherlands
Primary
Secondary
Concomitant
Renal Impairment Other Serious 59 Male 11/1/2007 United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 6/13/2006 Female 11/6/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 10/7/2005 60 Male 11/9/2007
Primary
Concomitant
Myocardial Infarction Hospitalization 6/13/2006 Female 11/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Impaired Driving Ability Other Serious 10/1/2007 Male 250 lb 11/19/2007 Consumer United States
Primary
Concomitant
Chest Pain Other Serious 7/1/2007 44 Male 182 lb 11/19/2007 Consumer United Kingdom
Primary
Concomitant
Abortion Spontaneous Other Serious 40 Female 252 lb 11/19/2007 Consumer United Kingdom
Primary
Concomitant
Red Blood Cell Count Decreased Hospitalization 8/1/2007 Male 220 lb 11/13/2007 Consumer United States
Primary
Concomitant
Stomatitis Life Threatening 5/9/2007 Male 203 lb 11/20/2007 Physician Germany
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 5/19/2006 73 Male 280 lb 11/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Other Serious 10/14/2007 68 Female 11/27/2007 Sweden
Primary
Concomitant
Renal Failure Other Serious 1/24/2006 68 Male 227 lb 1/7/2008 Physician United States
Primary
Secondary
Concomitant
Peripheral Arterial Occlusive Disease Hospitalization 87 Male 1/15/2008 Physician Germany
Primary
Concomitant
Dyspnoea Hospitalization 10/7/2005 60 Male 1/22/2008
Primary
Concomitant
Retinal Detachment Hospitalization 10/1/2007 Female 2/5/2008 Pharmacist Netherlands
Primary
Secondary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 2/8/2008 Physician Germany
Primary
Concomitant
Urine Output Decreased Other Serious 70 Female 154 lb 3/1/2008 United Kingdom
Primary
Concomitant
Visual Disturbance Disability 10/1/2007 57 Female 315 lb 3/3/2008 Consumer United Kingdom
Primary
Concomitant
Nausea Hospitalization 11/1/2007 63 Female 3/10/2008 Other Health Professional United States
Primary
Concomitant
Urine Output Decreased Other Serious 70 Female 154 lb 3/9/2008 United Kingdom
Primary
Concomitant
Epistaxis Other Serious 2/13/2008 74 Male 3/18/2008 United Kingdom
Primary
Concomitant
Peripheral Ischaemia Other Serious 2/12/2008 79 Female 4/7/2008 Other Health Professional United Kingdom
Primary
Concomitant
Gout Other Serious 8/28/2007 66 Male 4/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 3/1/2008 69 Male 243 lb 4/17/2008 Consumer United States
Primary
Concomitant
Myocardial Infarction Other Serious 2/25/2008 69 Male 150 lb 4/23/2008 Physician Luxembourg
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 77 Female 4/22/2008 Other Health Professional Portugal
Primary
Concomitant
Skin Laceration Other Serious 8/1/2007 60 Male 4/23/2008 United States
Primary
Concomitant
Ventricular Fibrillation Death 8/24/2005 Male 5/13/2008 Czech Republic
Primary
Concomitant
Skin Laceration Other Serious 8/1/2007 60 Male 5/12/2008 United States
Primary
Concomitant
Protein Urine Present Hospitalization 38 Female 6/2/2008 Physician Japan
Primary
Concomitant
Protein Urine Present Hospitalization 38 Female 6/9/2008 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 4/10/2008 73 Female 6/6/2008 Other Health Professional Denmark
Primary
Concomitant
Vomiting Hospitalization 50 Female 6/27/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 75 Female 6/30/2008 Other Health Professional Sweden
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 50 Female 7/28/2008 Physician United States
Primary
Concomitant
Dyspnoea 1/1/2008 65 Female 250 lb 7/7/2008 Consumer United States
Primary
Concomitant
Vision Blurred Other Serious 7/5/2008 Male 249 lb 8/15/2008 Physician United Kingdom
Primary
Concomitant
Pruritus Generalised 7/1/2008 Female 8/29/2008 United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 97 Female 8/27/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vitamin B12 Decreased Other Serious 70 9/12/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 50 Female 10/7/2008 Physician United States
Primary
Secondary
Concomitant
Lethargy Disability 8/22/2008 66 Female 183 lb 10/14/2008 Pharmacist Australia
Primary
Concomitant
Melaena Hospitalization 10/6/2008 52 Male 10/16/2008 Physician Russian Federation
Primary
Concomitant
Diarrhoea Hospitalization 78 Male 10/10/2008 United Kingdom
Primary
Concomitant
Pain In Jaw Hospitalization 8/1/2008 Female 220 lb 10/10/2008 Consumer United States
Primary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/17/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Myalgia Other Serious 5/1/2008 Male 247 lb 10/17/2008 Physician United States
Primary
Concomitant
Memory Impairment Other Serious 5/7/2008 Female 10/17/2008 Consumer
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 217 lb 10/18/2008 Consumer United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 3/1/2008 79 Female 183 lb 10/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2007 Male 235 lb 10/15/2008 Consumer United States
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 217 lb 10/20/2008 Consumer United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 7/1/2007 Female 229 lb 10/14/2008 Consumer United States
Primary
Concomitant
Pancreatitis Acute Hospitalization 1/1/2008 Male 10/18/2008 Physician Italy
Primary
Concomitant
Weight Decreased Life Threatening 9/1/2008 72 Male 159 lb 10/20/2008 Consumer Brazil
Primary
Concomitant
Underdose Hospitalization 10/13/2008 81 Male 10/17/2008 Other Health Professional United States
Primary
Concomitant
Drug Exposure During Pregnancy Other Serious 9/11/2008 40 Female 10/21/2008 Consumer South Africa
Primary
Concomitant
Gastrostomy Tube Insertion Hospitalization 1/1/2006 Male 10/21/2008 Physician Finland
Primary
Concomitant
Tooth Abscess Life Threatening 9/30/2008 72 Male 10/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Chronic Hospitalization 7/1/2007 59 Female 10/17/2008 Norway
Primary
Concomitant
Drug Ineffective 10/14/2008 71 Male 10/23/2008 Consumer
Primary
Concomitant
Swollen Tongue Life Threatening 9/30/2008 72 Male 10/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Withdrawal Syndrome Other Serious 1/1/2008 Female 217 lb 10/24/2008 Consumer United States
Primary
Secondary
Concomitant
Pallor Hospitalization Female 220 lb 10/24/2008 Physician Germany
Primary
Concomitant
Cough Other Serious 74 Female 10/22/2008 United Kingdom
Primary
Concomitant
Hypoglycaemia Other Serious 6/3/2006 81 Female 10/22/2008 United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 2/17/2006 75 Male 10/22/2008 Denmark
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/17/2006 72 Female 165 lb 10/27/2008 Physician Netherlands
Primary
Secondary
Concomitant
Muscle Spasms Other Serious 3/15/2006 Male 10/22/2008 Denmark
Primary
Concomitant
Night Sweats 9/22/2008 70 Male 174 lb 10/30/2008 Consumer United States
Primary
Concomitant
Thrombosis Other Serious 2/13/2008 63 Male 214 lb 10/31/2008 Other Health Professional United Kingdom
Primary
Concomitant
Surgery Other Serious 11/13/2008 12/10/2008 Consumer Brazil
Primary
Concomitant
Nephrolithiasis 5/16/2008 Male 12/12/2008 Other Health Professional United States
Primary
Concomitant
Hypertension Hospitalization 1/1/2008 64 Male 12/30/2008 Physician France
Primary
Concomitant
Ventricular Extrasystoles Other Serious 50 Female 12/30/2008 Physician United States
Primary
Secondary
Concomitant

Drug Data