Metformin Hydrochloride combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pneumonia Death 12/25/2005 57 Male 235 lb 2/14/2006 Other Health Professional United States
Primary
Concomitant
Angioneurotic Oedema Hospitalization 11/8/2005 64 Female 4/7/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Scar Hospitalization 11/8/2005 64 Female 4/27/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Insomnia Disability 4/5/2006 72 Female 146 lb 5/31/2006 Consumer United States
Primary
Concomitant
Postoperative Wound Infection Hospitalization 11/4/2005 Male 8/15/2006 Physician United States
Primary
Secondary
Concomitant
Sleep Apnoea Syndrome Hospitalization 8/17/2006 Female 3/9/2007 Physician United States
Primary
Concomitant
Lower Respiratory Tract Infection Disability 1/22/2007 59 Female 187 lb 5/29/2007 Physician United Kingdom
Primary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 9/28/2007 Physician Germany
Primary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 2/8/2008 Physician Germany
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/18/2008 74 Female 112 lb 3/18/2008 Physician
Primary
Concomitant
Postoperative Wound Infection Hospitalization 11/4/2005 Male 7/18/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 5/8/2008 Female 8/1/2008 Other Health Professional France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 5/8/2008 Female 8/11/2008 Other Health Professional France
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 8/16/2008 Male 225 lb 10/21/2008 United Kingdom
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Life Threatening 10/6/2008 55 Male 10/24/2008 Physician Italy
Primary
Secondary
Concomitant
Death Other Serious Female 150 lb 10/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Thrombosis Other Serious 2/13/2008 63 Male 214 lb 10/31/2008 Other Health Professional United Kingdom
Primary
Concomitant
Plantar Fasciitis 6/1/2007 Female 220 lb 3/14/2009 United States
Primary
Concomitant
Thrombocytopenia Other Serious 6/20/2007 67 Female 4/9/2009 Other Health Professional Greece
Primary
Secondary
Concomitant
Vertigo Hospitalization 4/18/2009 52 Female 208 lb 5/23/2009 Consumer Israel
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2008 Male 194 lb 6/2/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Procedural Complication 6/1/2008 Female 230 lb 6/11/2009 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 1/12/2008 Male 6/11/2009 Consumer
Primary
Concomitant
Injection Site Pain 1/1/2008 Male 289 lb 6/11/2009 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 10/1/2005 Female 150 lb 6/11/2009 United States
Primary
Concomitant
Injection Site Irritation 3/1/2008 Female 140 lb 6/12/2009 Consumer United States
Primary
Concomitant
Swelling Face 1/1/2009 Female 285 lb 6/12/2009 Consumer United States
Primary
Secondary
Concomitant
Myalgia 1/1/2008 Male 210 lb 6/12/2009 Physician United States
Primary
Secondary
Concomitant
Viral Infection 5/6/2009 Female 6/12/2009 United States
Primary
Concomitant
Upper Respiratory Tract Infection 4/3/2009 Female 160 lb 6/12/2009 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 1/12/2008 Male 6/12/2009 Consumer
Primary
Concomitant
Rheumatoid Arthritis 1/1/2005 Female 155 lb 6/15/2009 Other Health Professional United States
Primary
Concomitant
Muscular Dystrophy Other Serious 1/1/2007 59 7/23/2009 Netherlands
Primary
Secondary
Concomitant
Injection Site Pain 6/14/2008 Female 223 lb 9/12/2009 United States
Primary
Concomitant
Renal Failure Hospitalization 1/1/2008 71 Female 179 lb 9/29/2009 Lawyer United States
Primary
Concomitant
Staphylococcal Infection Other Serious 7/6/2009 Female 123 lb 10/14/2009 Physician Malaysia
Primary
Secondary
Concomitant
Thyroid Cancer Other Serious 8/4/2009 Female 10/14/2009 Physician United States
Primary
Concomitant
Surgery Other Serious 1/1/2008 Female 226 lb 10/14/2009 Canada
Primary
Concomitant
Drug Ineffective 2/1/2009 Female 10/15/2009 Consumer
Primary
Concomitant
Malnutrition Hospitalization 11/18/2009 Female 12/23/2009 Physician Japan
Primary
Concomitant
Quadriparesis Hospitalization 1/1/2010 Female 1/15/2010 Physician Japan
Primary
Secondary
Concomitant
Muscular Weakness Other Serious 10/6/2009 Female 1/21/2010 Physician Germany
Primary
Concomitant
Ischaemic Stroke Hospitalization 10/1/2009 72 Female 2/1/2010 Other Health Professional France
Primary
Concomitant
Wound Infection Other Serious 10/1/2007 Male 210 lb 2/10/2010 United States
Primary
Concomitant
Pneumonia Other Serious 2/1/2010 77 Female 2/17/2010 Consumer Canada
Primary
Concomitant
Breast Cancer In Situ Other Serious 4/1/2009 65 Female 174 lb 3/1/2010 Other Health Professional United Kingdom
Primary
Concomitant
Cholecystitis Acute Hospitalization 11/16/2009 Female 130 lb 3/5/2010 Physician India
Primary
Concomitant
Small Cell Lung Cancer Metastatic Other Serious 3/27/2006 Female 137 lb 3/8/2010 Physician United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 11/1/2009 57 Female 150 lb 3/10/2010 Consumer United States
Primary
Concomitant
Acute Respiratory Failure Hospitalization 65 Male 223 lb 3/11/2010 Consumer United States
Primary
Concomitant
Pulmonary Oedema Hospitalization 4/1/2009 Female 132 lb 3/15/2010 Brazil
Primary
Concomitant
Mixed Hepatocellular Cholangiocarcinoma Life Threatening Male 5/10/2010 Other Health Professional Germany
Primary
Concomitant
Speech Disorder Other Serious 12/1/2009 73 Female 198 lb 5/11/2010 Physician Brazil
Primary
Concomitant
H1n1 Influenza Other Serious 7/2/2009 53 Female 148 lb 5/13/2010 Other Health Professional Chile
Primary
Secondary
Concomitant
Pancreatic Neoplasm Hospitalization 7/31/2008 70 Male 164 lb 5/13/2010 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 4/8/2010 59 Female 165 lb 5/15/2010 Physician Brazil
Primary
Concomitant
Flushing 5/2/2009 69 Female 214 lb 5/17/2010 United States
Primary
Concomitant
Psoriatic Arthropathy Other Serious 1/1/2009 65 Male 170 lb 5/18/2010 Canada
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2008 64 Male 194 lb 5/20/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 5/8/2010 47 Female 235 lb 5/11/2010 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2008 62 Male 243 lb 5/17/2010 Consumer United States
Primary
Concomitant
Psoriasis Life Threatening 3/3/2010 62 Male 5/27/2010 Physician Brazil
Primary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 5/28/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 6/10/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 6/17/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 7/26/2010 Physician Japan
Primary
Secondary
Concomitant
Extranodal Marginal Zone B-cell Lymphoma (Malt Type) Hospitalization 12/7/2009 61 Female 141 lb 7/29/2010 Physician China
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 1/15/2010 74 Male 225 lb 9/10/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pancytopenia Hospitalization 7/31/2010 51 Female 100 lb 9/21/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 9/27/2010 52 Female 110 lb 10/29/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Pancytopenia Hospitalization 7/31/2010 51 Female 100 lb 10/29/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Tuberculosis Gastrointestinal Hospitalization 1/25/2010 65 Female 93 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 9/1/2010 63 Female 161 lb 12/9/2010 Other Health Professional Canada
Primary
Concomitant
Chronic Lymphocytic Leukaemia Other Serious 10/1/2009 12/14/2010 Physician United States
Primary
Secondary
Concomitant
Peritonitis Life Threatening 12/8/2010 66 Male 117 lb 12/17/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/20/2010 Physician United States
Primary
Concomitant
Upper Respiratory Tract Infection 1/1/2010 12/22/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 7/31/2010 51 Female 100 lb 12/17/2010 Other Health Professional Korea, Republic Of
Primary
Concomitant
Peritonitis Other Serious 12/8/2010 66 Male 117 lb 12/30/2010 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Other Serious 12/8/2010 66 Male 117 lb 1/4/2011 Physician Japan
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 1/25/2010 65 Female 93 lb 1/11/2011 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 1/25/2010 65 Female 93 lb 1/24/2011 Physician Japan
Primary
Secondary
Concomitant
Nasopharyngitis 12/1/2009 62 Female 235 lb 1/28/2011 Consumer United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization Female 154 lb 2/28/2011 Consumer Brazil
Primary
Concomitant
Renal Failure Acute Hospitalization 7/9/2010 51 Female 108 lb 3/16/2011 United States
Primary
Secondary
Concomitant
Oral Herpes Other Serious 62 Female 3/24/2011 Physician United States
Primary
Concomitant
Epistaxis Other Serious 1/15/2011 66 Female 207 lb 5/3/2011 Other Health Professional Canada
Primary
Concomitant
Confusional State Hospitalization 6/10/2010 63 Female 132 lb 5/4/2011 Physician United Kingdom
Primary
Concomitant
Anxiety Other Serious 4/1/2011 70 Male 6/10/2011 Consumer United States
Primary
Secondary
Concomitant
Pain Hospitalization 1/1/2010 63 Female 176 lb 6/15/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Lung Infection Other Serious 1/1/2010 56 Male 247 lb 8/11/2011 Other Health Professional Brazil
Primary
Concomitant
Odynophagia Other Serious 9/15/2011 Switzerland
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 5/19/2011 Female 9/27/2011 Physician United States
Primary
Concomitant
Inappropriate Schedule Of Drug Administration Other Serious 2/15/2011 53 Male 258 lb 10/7/2011 Physician Greece
Primary
Concomitant
Bile Duct Cancer Hospitalization 5/5/2011 71 Female 10/7/2011 Physician Germany
Primary
Concomitant
Mucosal Inflammation Other Serious 2/1/2007 61 Female 170 lb 10/10/2011 Physician United States
Primary
Secondary
Concomitant
Arthralgia Other Serious 3/1/2010 59 Female 132 lb 10/12/2011 Brazil
Primary
Secondary
Concomitant
Osteomyelitis Acute Hospitalization 10/13/2011 Physician Switzerland
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 8/22/2011 68 Female 155 lb 10/14/2011 Consumer United States
Primary
Concomitant
Accident At Home Other Serious 8/31/2011 66 Female 198 lb 10/18/2011 Other Health Professional Canada
Primary
Concomitant
Rheumatoid Arthritis Hospitalization Female 152 lb 11/1/2011 Consumer Brazil
Primary
Concomitant
Haemorrhagic Stroke Life Threatening 11/11/2011 75 Female 1/2/2012 Physician Spain
Primary
Secondary
Concomitant
Hepatic Steatosis Other Serious 10/14/2011 73 Female 1/4/2012 Physician Japan
Primary
Concomitant
Hydrocele Life Threatening 11/11/2011 75 Female 1/13/2012 Physician Spain
Primary
Secondary
Concomitant
Hypertension Other Serious 10/1/2011 55 Female 260 lb 1/24/2012 Consumer United States
Primary
Concomitant
Hydrocele Other Serious 11/11/2011 75 Female 1/27/2012 Physician Spain
Primary
Secondary
Concomitant
Nasopharyngitis 12/1/2009 62 Female 235 lb 1/27/2012 Consumer United States
Primary
Secondary
Concomitant
Abdominal Discomfort Hospitalization 12/5/2009 62 Female 148 lb 2/29/2012 Brazil
Primary
Secondary
Concomitant
Mass Hospitalization 12/14/2011 85 Male 175 lb 3/8/2012 Consumer Canada
Primary
Concomitant
Osteomyelitis Acute Other Serious 68 Female 3/8/2012 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Pain In Extremity Hospitalization 8/16/2009 74 Female 3/8/2012 Physician Australia
Primary
Concomitant
Myocardial Infarction Hospitalization 2/21/2012 73 Female 132 lb 3/13/2012 Other Health Professional South Africa
Primary
Concomitant
Vision Blurred Other Serious 2/1/2012 56 Female 220 lb 3/16/2012 Other Health Professional United States
Primary
Concomitant
Diabetic Foot Other Serious Male 223 lb 3/19/2012 Other Health Professional Canada
Primary
Concomitant
Cholelithiasis Other Serious 1/25/2012 55 Female 247 lb 3/19/2012 Consumer Puerto Rico
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 12/23/2011 79 Female 3/19/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Back Pain Death 1/1/2011 75 Male 176 lb 6/8/2012 Physician United States
Primary
Concomitant
Asthenia Other Serious 1/1/2011 60 Female 137 lb 7/5/2012 Consumer Brazil
Primary
Secondary
Concomitant
Alcoholism Other Serious 52 Male 6/28/2012 Other Health Professional Denmark
Primary
Concomitant
Dyspnoea Hospitalization 6/6/2012 70 Male 7/13/2012 Other Health Professional United States
Primary
Secondary
Hepatic Failure Hospitalization 3/6/2012 58 Female 179 lb 7/13/2012 Physician Hungary
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 10/29/2010 34 Male 349 lb 7/13/2012 Consumer United States
Primary
Concomitant
Thrombosis Hospitalization 6/13/2012 78 Female 172 lb 7/16/2012 Consumer Canada
Primary
Concomitant
Infection Hospitalization 5/23/2011 50 Female 7/16/2012 Other Health Professional New Zealand
Primary
Secondary
Concomitant
Breast Mass Hospitalization 1/1/2008 66 Female 212 lb 7/17/2012 Consumer United States
Primary
Concomitant
Foot Deformity Other Serious 58 Female 115 lb 7/18/2012 Other Health Professional Australia
Primary
Concomitant
Rib Fracture Other Serious 5/29/2012 58 Female 176 lb 7/20/2012 Other Health Professional Canada
Primary
Concomitant
Hodgkin's Disease Other Serious 4/1/2012 69 Male 7/20/2012 Pharmacist United States
Primary
Concomitant
Malignant Melanoma Other Serious 67 Male 247 lb 7/25/2012 Physician New Zealand
Primary
Secondary
Concomitant
Gastrooesophageal Reflux Disease Other Serious 5/16/2012 74 Female 130 lb 7/26/2012 Physician United Kingdom
Primary
Concomitant
Aplasia Other Serious 6/4/2012 64 Female 7/27/2012 Other Health Professional France
Primary
Secondary
Concomitant
Glycosylated Haemoglobin Increased Other Serious 6/8/2012 42 Male 264 lb 7/30/2012 Consumer United States
Primary
Concomitant
Nephrolithiasis Hospitalization 5/26/2012 54 Female 292 lb 7/30/2012 Physician United States
Primary
Concomitant
Abdominal Pain Disability 3/1/2012 62 Male 107 lb 7/18/2012 Other Health Professional United Kingdom
Primary
Concomitant
Fatigue Hospitalization 4/6/2012 62 Female 150 lb 8/1/2012 Other Health Professional Canada
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2012 46 Female 151 lb 8/1/2012 Physician Netherlands
Primary
Concomitant
Nasopharyngitis Hospitalization 11/1/2011 Male 8/1/2012 Physician Germany
Primary
Concomitant
Decreased Appetite Hospitalization 1/1/2010 61 Female 8/2/2012 Physician United States
Primary
Concomitant
Muscular Weakness Hospitalization 10/29/2010 34 Male 349 lb 8/3/2012 Other Health Professional United States
Primary
Concomitant
Flushing 11/28/2011 71 Female 160 lb 8/3/2012 Consumer United States
Primary
Concomitant
Blood Glucose Increased 4/17/2012 64 Female 150 lb 8/3/2012 Consumer United States
Primary
Concomitant
Flushing 1/1/2008 60 Female 195 lb 8/3/2012 Consumer United States
Primary
Concomitant
Cystitis 7/1/2011 75 Female 135 lb 8/3/2012 Consumer United States
Primary
Concomitant
Nephrolithiasis Other Serious 12/1/2011 50 Female 8/7/2012 Consumer Argentina
Primary
Concomitant
Thyroid Cancer Recurrent Hospitalization 3/15/2012 Female 8/9/2012 Physician Germany
Primary
Secondary
Concomitant
Thyroid Cancer Hospitalization 3/15/2012 61 Female 8/10/2012 Physician Germany
Primary
Concomitant
Sepsis Hospitalization 8/1/2012 50 Female 223 lb 8/10/2012 Physician United States
Primary
Concomitant
Septic Shock Hospitalization 6/25/2012 50 Female 223 lb 8/10/2012 Physician United States
Primary
Concomitant
Localised Infection Other Serious 65 Female 150 lb 8/13/2012 Other Health Professional Canada
Primary
Secondary
Concomitant
Cardiac Disorder Hospitalization Female 201 lb 8/13/2012 Consumer Brazil
Primary
Concomitant

Drug Data