Metformin Hcl combined with Zopiclone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Increased Other Serious 5/12/2006 36 Female 8/16/2006 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Increased Other Serious 5/12/2006 36 Female 10/24/2006 Pharmacist United Kingdom
Primary
Secondary
Cardiac Pacemaker Insertion Other Serious Male 12/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Death 8/22/2006 Male 12/15/2006 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Cardiac Pacemaker Insertion Other Serious 61 Male 12/16/2006 Physician United Kingdom
Primary
Concomitant
Vertigo Hospitalization 1/26/2006 67 Female 130 lb 12/5/2006 Physician Sweden
Primary
Concomitant
Weight Decreased Death 8/22/2006 Male 12/26/2006 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Cardiac Pacemaker Insertion Other Serious Male 12/19/2006 Physician United Kingdom
Primary
Concomitant
Cardiac Pacemaker Insertion Other Serious Male 2/7/2007 Physician United Kingdom
Primary
Concomitant
Cardiac Pacemaker Insertion Other Serious Male 2/23/2007 Physician United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 12/11/2006 Female 243 lb 3/5/2007 Consumer United Kingdom
Primary
Concomitant
Rash Other Serious 8/1/2006 50 Male 4/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Red Blood Cell Count Decreased Other Serious 1/25/2007 38 Male 106 lb 5/31/2007 Pharmacist United Kingdom
Primary
Concomitant
Vision Blurred Other Serious 77 Male 6/1/2007 Physician Sweden
Primary
Concomitant
Tearfulness Other Serious 3/26/2007 69 Female 116 lb 6/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pleuropericarditis Hospitalization 6/18/2006 Male 198 lb 6/29/2007 Physician Canada
Primary
Concomitant
Tachycardia Hospitalization 12/11/2006 Female 243 lb 7/6/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 1/25/2007 38 Male 106 lb 7/23/2007 Pharmacist United Kingdom
Primary
Concomitant
Suicide Attempt Other Serious 7/6/2007 58 Female 8/2/2007 Other Health Professional Germany
Primary
Secondary
Tremor Other Serious 3/10/2007 70 Female 251 lb 8/3/2007 Physician
Primary
Secondary
Concomitant
Tremor Other Serious 70 Female 8/10/2007 Other Health Professional United Kingdom
Primary
Concomitant
Tremor Other Serious 3/10/2007 70 Female 8/20/2007 Physician
Primary
Secondary
Concomitant
Tremor Other Serious 5/18/2007 70 Female 8/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Platelet Count Increased Other Serious 6/23/2007 50 Male 320 lb 9/13/2007 Physician United Kingdom
Primary
Concomitant
Pain In Extremity Other Serious 5/1/2007 68 Male 198 lb 10/5/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 5/1/2007 68 Male 198 lb 10/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Hyperkalaemia Life Threatening 12/5/2007 71 Male 1/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vascular Purpura Hospitalization 1/5/2008 Male 2/29/2008 Other Health Professional France
Primary
Secondary
Concomitant
Dysarthria Other Serious Female 183 lb 3/11/2008 Canada
Primary
Concomitant
Dysarthria Other Serious Female 183 lb 4/4/2008 Canada
Primary
Concomitant
Chest Pain Other Serious 3/1/2008 Female 194 lb 5/9/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vasculitis Other Serious 5/16/2008 Female 6/5/2008 Physician Sweden
Primary
Concomitant
Vasculitis Other Serious 5/16/2008 Female 6/9/2008 Physician Sweden
Primary
Concomitant
Suicide Attempt Hospitalization 6/21/2008 Female 6/26/2008 Physician Germany
Primary
Secondary
Suicide Attempt Hospitalization 6/21/2008 Female 7/3/2008 Other Health Professional Germany
Primary
Secondary
Circulatory Collapse Other Serious 2/21/2008 81 Male 7/9/2008 Consumer Germany
Primary
Concomitant
Circulatory Collapse 2/21/2008 81 Male 7/22/2008 Consumer Germany
Primary
Concomitant
Tremor Hospitalization 6/5/2008 Female 8/1/2008 Other Health Professional France
Primary
Concomitant
Urinary Tract Infection Hospitalization 8/16/2007 59 Male 12/28/2007 France
Primary
Concomitant
Joint Effusion Other Serious Female 175 lb 11/10/2008 Canada
Primary
Concomitant
Confusional State Other Serious 10/24/2008 75 Female 11/17/2008 Other Health Professional United Kingdom
Primary
Concomitant
Suicide Attempt Hospitalization 6/1/2008 58 Female 11/20/2008 Other Health Professional Denmark
Primary
Concomitant
Injection Site Urticaria Other Serious 11/10/2008 42 Female 290 lb 12/8/2008 Pharmacist Canada
Primary
Concomitant
Injection Site Urticaria Other Serious 10/18/2008 42 Female 290 lb 12/23/2008 Pharmacist Canada
Primary
Secondary
Concomitant
Injection Site Urticaria Other Serious 10/18/2008 42 Female 290 lb 12/29/2008 Pharmacist Canada
Primary
Secondary
Concomitant
Thinking Abnormal Hospitalization 6/1/2008 58 Female 1/7/2009 Other Health Professional Germany
Primary
Concomitant
Mobility Decreased Other Serious 11/1/2008 73 Male 280 lb 1/29/2009 Physician United Kingdom
Primary
Concomitant
Agranulocytosis Other Serious 1/12/2009 69 Female 143 lb 3/16/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Syncope Other Serious 11/1/2008 73 Male 278 lb 3/12/2009 Physician United Kingdom
Primary
Concomitant
Agranulocytosis Other Serious 1/12/2009 3/16/2009 Physician Germany
Primary
Secondary
Concomitant
Purpura Hospitalization 3/17/2009 75 Male 3/27/2009 Physician France
Primary
Concomitant
Agranulocytosis Other Serious 1/12/2009 3/30/2009 Physician Germany
Primary
Secondary
Concomitant
Sudden Death Death 8/27/2008 49 Female 4/6/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Toxicity Death 49 Female 4/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 8/27/2008 49 Female 4/7/2009
Primary
Secondary
Concomitant
Hepatitis Acute Hospitalization 4/9/2009 47 Male 5/18/2009 Norway
Primary
Secondary
Concomitant
Hemiparesis Other Serious 11/1/2008 57 Female 5/28/2009 Physician New Zealand
Primary
Concomitant
Agranulocytosis Other Serious 1/12/2009 69 5/29/2009 Physician Germany
Primary
Secondary
Concomitant
Lethargy Hospitalization 3/3/2009 Male 7/15/2009 Consumer United States
Primary
Secondary
Concomitant
Drug Level Increased Death 8/27/2008 49 Female 8/18/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Hypoaesthesia Facial Hospitalization 3/2/2009 Male 8/18/2009 Consumer United States
Primary
Secondary
Concomitant
Drug Toxicity Death 49 Female 8/25/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Leukocytoclastic Vasculitis Hospitalization 3/16/2009 75 Male 287 lb 8/27/2009 Physician France
Primary
Concomitant
Renal Impairment Death 8/27/2008 49 Female 8/26/2009
Primary
Secondary
Concomitant
Sudden Death Death 8/27/2008 49 Female 9/9/2009 United States
Primary
Secondary
Concomitant
Supraventricular Tachycardia Hospitalization Female 10/22/2009 Consumer United Kingdom
Primary
Concomitant
Hypoaesthesia Facial Hospitalization 3/2/2009 Male 10/23/2009 Consumer United States
Primary
Secondary
Concomitant
Lethargy Hospitalization 3/2/2009 Male 10/23/2009 Consumer United States
Primary
Secondary
Concomitant
Hypoaesthesia Facial Hospitalization 3/2/2009 Male 10/28/2009 Consumer United States
Primary
Secondary
Concomitant
Lethargy Hospitalization 3/2/2009 Male 10/28/2009 Consumer United States
Primary
Secondary
Concomitant
Mental Disorder Other Serious 10/24/2008 75 Female 10/23/2009 United Kingdom
Primary
Concomitant
Supraventricular Tachycardia Hospitalization Female 11/12/2009 Consumer United Kingdom
Primary
Concomitant
Drug Toxicity Death 8/27/2008 49 Female 12/1/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Sudden Death Death 49 Female 11/30/2009 Other Health Professional United Kingdom
Primary
Concomitant
Poisoning Death 49 Female 12/1/2009 United Kingdom
Primary
Concomitant
Thirst Other Serious 3/13/2009 83 Male 205 lb 12/14/2009 Other Health Professional Canada
Primary
Concomitant
Influenza Other Serious 12/5/2009 Male 12/22/2009 Pharmacist Canada
Primary
Concomitant
White Blood Cell Count Increased Other Serious Male 198 lb 12/30/2009 Pharmacist France
Primary
Concomitant
Sudden Death Death 8/27/2008 49 Female 1/13/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Sudden Death Death 8/27/2008 49 Female 1/13/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 9/1/2009 50 Female 1/16/2010 Physician France
Primary
Concomitant
Tremor Other Serious 5/18/2007 70 Female 1/20/2010 Physician United Kingdom
Primary
Concomitant
Sudden Death Death 8/27/2008 49 Female 1/27/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Sudden Death Death 8/27/2008 49 Female 1/27/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Death 49 Female 2/17/2010 United Kingdom
Primary
Secondary
Concomitant
Hypotension Other Serious 12/1/2007 Female 3/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Level Increased Death Female 3/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/17/2010 65 Female 200 lb 4/14/2010 Pharmacist Canada
Primary
Concomitant
Sudden Death Other Serious 3/29/2010 56 Male 181 lb 4/19/2010 Consumer United States
Primary
Secondary
Concomitant
Sudden Death Other Serious 3/29/2010 56 Male 181 lb 5/12/2010 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/11/2010 30 Male 172 lb 6/8/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Hyperthyroidism Other Serious 5/1/2010 82 Female 7/7/2010 Physician Canada
Primary
Concomitant
Renal Failure Acute Life Threatening 7/7/2010 61 Male 7/27/2010 Other Health Professional Canada
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 3/29/2010 56 Male 181 lb 8/13/2010 Physician Turkey
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 5/4/2010 70 Female 11/9/2010 Other Health Professional France
Primary
Secondary
Pyrexia Hospitalization 2/18/2008 68 Male 12/7/2010 Physician Canada
Primary
Concomitant
Vomiting Hospitalization 7/1/2010 73 Female 11/22/2010 Other Health Professional Sweden
Primary
Secondary
Concomitant
Venous Occlusion Other Serious 1/1/2009 73 Male 142 lb 12/21/2010 Physician Canada
Primary
Concomitant
Myelodysplastic Syndrome Death 12/6/2010 76 Male 136 lb 1/14/2011 Consumer United Kingdom
Primary
Concomitant
Fall Hospitalization 12/6/2010 76 Male 136 lb 1/27/2011 Consumer United Kingdom
Primary
Concomitant
Hypoglycaemia Other Serious 7/7/2010 61 Male 2/11/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Sleep-related Eating Disorder Other Serious 10/1/2010 66 Male 2/16/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Drug Interaction Hospitalization 9/8/2009 83 Female 3/15/2011 Consumer France
Primary
Concomitant
Interacting
Asthenia Hospitalization 9/8/2009 83 Female 3/21/2011 Other Health Professional France
Primary
Secondary
Concomitant
Interacting
Haemoglobin Decreased Other Serious 10/1/2010 65 Female 139 lb 5/9/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 44 Male 5/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 5/5/2011 80 Male 175 lb 5/17/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Pain Hospitalization 11/1/2010 71 Female 5/17/2011 Other Health Professional Sweden
Primary
Secondary
Concomitant
Drug Therapeutic Incompatibility Hospitalization 11/1/2010 71 Female 5/18/2011 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pneumonia Other Serious 12/1/2010 64 Male 553 lb 6/7/2011 Other Health Professional Canada
Primary
Concomitant
Neoplasm Malignant Death Male 6/8/2011 Physician United Kingdom
Primary
Concomitant
Disorientation Hospitalization 9/8/2009 83 Female 6/10/2011 Other Health Professional France
Primary
Secondary
Concomitant
Interacting
Blood Creatinine Increased Hospitalization 9/8/2009 83 Female 6/10/2011 Other Health Professional France
Primary
Secondary
Concomitant
Interacting
Depressed Level Of Consciousness Other Serious 46 Female 6/17/2011 Other Health Professional United Kingdom
Primary
Concomitant
Diarrhoea Other Serious 46 Female 6/23/2011 Other Health Professional Germany
Primary
Concomitant
Somnambulism Other Serious 10/1/2010 66 Male 159 lb 6/27/2011 Other Health Professional United Kingdom
Primary
Concomitant
Venous Occlusion Other Serious 1/1/2009 73 Male 142 lb 6/29/2011 Physician Canada
Primary
Concomitant
Somnambulism Other Serious 10/1/2010 66 Male 159 lb 7/1/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pancytopenia Hospitalization 5/4/2011 80 Male 175 lb 7/5/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Sleep-related Eating Disorder Other Serious 10/1/2010 66 Male 6/30/2011 Other Health Professional United Kingdom
Primary
Concomitant
Mean Cell Haemoglobin Increased Other Serious 4/26/2011 42 Male 176 lb 7/6/2011 Physician United Kingdom
Primary
Concomitant
Somnambulism Other Serious 10/1/2010 66 Male 159 lb 7/6/2011 Other Health Professional Denmark
Primary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 10/29/2009 40 Male 176 lb 7/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Hospitalization Female 8/3/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Neutropenic Sepsis Hospitalization 7/13/2009 77 Male 8/5/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Duodenal Ulcer Hospitalization 88 Female 8/9/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Nausea Hospitalization Female 8/10/2011 Physician Norway
Primary
Secondary
Concomitant
Weight Decreased Disability 11/9/2009 82 Female 136 lb 9/13/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Disability 11/9/2009 82 Female 136 lb 9/14/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Hospitalization 4/21/2011 71 Female 9/23/2011 Other Health Professional United Kingdom
Primary
Concomitant
Brief Psychotic Disorder With Marked Stressors Other Serious 4/7/2011 45 Female 225 lb 9/26/2011 Consumer France
Primary
Concomitant
Mean Cell Haemoglobin Increased Other Serious 10/29/2009 40 Male 176 lb 10/3/2011 Physician United Kingdom
Primary
Concomitant
Obesity Other Serious 8/9/2011 33 Male 10/5/2011 Other Health Professional United Kingdom
Primary
Concomitant
Colitis Other Serious 12/12/2010 66 Female 216 lb 10/6/2011 Physician Germany
Primary
Concomitant
Dyspnoea Hospitalization 9/19/2011 56 Female 10/19/2011 Consumer Canada
Primary
Concomitant
Allergic Oedema Other Serious 3/27/2010 71 Female 192 lb 10/19/2011 Consumer Germany
Primary
Secondary
Concomitant
Overweight Death 12/3/2010 78 Male 192 lb 10/19/2011 Physician United Kingdom
Primary
Concomitant
Heart Rate Irregular Hospitalization 5/18/2011 10/25/2011 Consumer Canada
Primary
Concomitant
Metastases To Lung Other Serious 7/7/2010 61 Male 11/7/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/1/2007 57 Male 291 lb 11/17/2011 Other Health Professional United Kingdom
Primary
Concomitant
Malaise Other Serious 8/9/2011 33 Male 251 lb 11/28/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Hyperhidrosis Other Serious 8/9/2011 33 Male 251 lb 11/29/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Life Threatening 10/17/2011 76 Female 11/29/2011 Other Health Professional Denmark
Primary
Concomitant
Myelodysplastic Syndrome Life Threatening 12/6/2010 76 Male 136 lb 12/14/2011 Consumer United Kingdom
Primary
Concomitant
Hiv Infection Other Serious Male 176 lb 1/3/2012 Other Health Professional Canada
Primary
Concomitant
Neutrophil Count Decreased Other Serious 8/9/2011 33 Male 251 lb 1/11/2012 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 1/1/2010 68 Female 160 lb 1/25/2012 Consumer Canada
Primary
Concomitant
Muscular Weakness Hospitalization 1/1/2010 68 Female 160 lb 1/25/2012 Physician Canada
Primary
Concomitant
Muscular Weakness Hospitalization 1/1/2010 68 Female 160 lb 2/1/2012 Physician Canada
Primary
Concomitant
Death Death 57 Female 183 lb 2/10/2012 Other Health Professional Canada
Primary
Secondary
Concomitant

Drug Data