Metformin Hcl combined with Warfarin Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Refusal Of Treatment By Patient Hospitalization Female 1/4/2006 United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 72 Female 1/4/2006 United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 72 Female 1/5/2006 Physician United States
Primary
Secondary
Pruritus Death 7/22/2004 Male 187 lb 1/25/2006 United Kingdom
Primary
Concomitant
Nervous System Disorder Other Serious 58 Female 176 lb 7/14/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 74 Male 7/31/2006 Other Health Professional Denmark
Primary
Secondary
Concomitant
Right Ventricular Failure Hospitalization 7/8/2004 45 Female 231 lb 8/15/2006 Other Health Professional United States
Primary
Concomitant
Leukopenia Required Intervention 9/12/2005 60 Male 156 lb 1/9/2006 Consumer United States
Primary
Concomitant
Haemorrhage Other Serious 7/11/2006 61 Male 189 lb 7/14/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 7/14/2006 55 Male 9/1/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Vasculitic Rash Hospitalization 5/18/2006 Male 9/21/2006 Pharmacist United States
Primary
Concomitant
Nausea Hospitalization 9/25/2006 44 Male 283 lb 9/26/2006 Pharmacist United States
Primary
Concomitant
Swelling Face Other Serious 9/14/2006 65 Male 10/11/2006 Consumer United Kingdom
Primary
Concomitant
Cerebrovascular Accident Other Serious 11/4/2005 66 Male 10/12/2006 Consumer United States
Primary
Concomitant
Cardiac Failure Congestive Other Serious 52 Female 10/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pain In Extremity Other Serious Female 200 lb 10/11/2006 Consumer United States
Primary
Secondary
Concomitant
Haemorrhagic Stroke Hospitalization 7/4/2006 80 Female 10/11/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/18/2006 75 Female 10/11/2006 United Kingdom
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 9/11/2006 59 Male 10/24/2006 United States
Primary
Concomitant
Headache 6/8/2006 Male 10/30/2006 Consumer United States
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization Male 10/31/2006 Pharmacist Germany
Primary
Secondary
Drug Ineffective Other Serious 1/1/2001 51 Male 11/9/2006 Consumer United States
Primary
Secondary
Concomitant
Malnutrition Hospitalization 1/1/2006 77 Male 132 lb 11/28/2006 Physician Canada
Primary
Concomitant
Urinary Tract Infection Hospitalization 3/15/2006 66 Female 12/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Death 9/29/2006 81 Female 143 lb 12/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 42 Female 12/19/2006
Primary
Secondary
Concomitant
Malnutrition Hospitalization 1/1/2006 77 Male 132 lb 12/22/2006 Physician Canada
Primary
Concomitant
Somnolence Required Intervention 75 Female 12/14/2006 Physician Norway
Primary
Secondary
Concomitant
Post Procedural Complication Hospitalization 1/1/2006 62 Female 200 lb 1/9/2007 Consumer United States
Primary
Concomitant
Nausea 47 Male 226 lb 10/24/2006 Other Health Professional United States
Primary
Concomitant
Platelet Count Decreased Death 9/29/2006 81 Female 143 lb 1/12/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Dry Throat 1/1/2006 47 Female 130 lb 10/24/2006 United States
Primary
Concomitant
Heart Rate Increased 8/1/2006 74 Male 175 lb 10/24/2006 United States
Primary
Concomitant
Rash Hospitalization 7/14/2006 63 Male 181 lb 10/20/2006 Pharmacist United States
Primary
Secondary
Concomitant
Skin Discolouration Other Serious 7/17/2006 46 Male 258 lb 11/28/2006 Pharmacist United States
Primary
Concomitant
Weight Decreased 7/1/2006 68 Female 191 lb 10/16/2006 United States
Primary
Secondary
Concomitant
Lactic Acidosis Other Serious 75 Female 1/29/2007 Other Health Professional Norway
Primary
Secondary
Concomitant
Presyncope Other Serious Male 229 lb 11/14/2006 United States
Primary
Secondary
Concomitant
Platelet Count Decreased Death 9/29/2006 81 Female 143 lb 1/29/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased 1/1/2006 76 Female 200 lb 10/16/2006 Consumer United States
Primary
Concomitant
Haemorrhage Life Threatening 1/22/2007 76 Male 254 lb 1/26/2007 Pharmacist United States
Primary
Concomitant
Tachycardia Life Threatening 11/26/2006 Male 1/26/2007 Pharmacist United States
Primary
Concomitant
Somnolence Life Threatening 75 Female 1/25/2007 Other Health Professional Norway
Primary
Secondary
Concomitant
Somnolence Hospitalization 75 Female 1/22/2007 Norway
Primary
Secondary
Concomitant
Subdural Haematoma Life Threatening 75 Male 1/26/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint 1/25/2007 52 Male 1/29/2007 Pharmacist United States
Primary
Concomitant
Lactic Acidosis Other Serious 75 Female 2/6/2007 Other Health Professional Norway
Primary
Secondary
Concomitant
International Normalised Ratio Decreased Other Serious 2/28/2006 66 Male 406 lb 8/17/2006 United States
Primary
Concomitant
Subdural Haematoma Hospitalization 75 Male 2/6/2007 United States
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 75 Male 2/13/2007 Other Health Professional United States
Primary
Concomitant
Interacting
Hypnopompic Hallucination Other Serious 12/1/2006 70 Female 2/13/2007 Consumer United States
Primary
Secondary
Concomitant
Torsade De Pointes Other Serious 4/1/2006 87 Female 126 lb 2/13/2007 Other Health Professional United States
Primary
Concomitant
Cataract Subcapsular Disability 6/1/2004 Female 144 lb 2/15/2007 Singapore
Primary
Concomitant
Epistaxis Hospitalization 2/7/2007 74 Male 138 lb 2/12/2007 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 12/1/2006 68 Male 2/16/2007 Pharmacist United States
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 74 Male 2/26/2007 Consumer France
Primary
Concomitant
Weight Decreased Other Serious 11/3/2006 Male 215 lb 3/8/2007 Consumer United States
Primary
Concomitant
Asthma Other Serious 49 Female 3/13/2007 Consumer United States
Primary
Secondary
Concomitant
Asthma Other Serious 49 Female 3/16/2007 Consumer United States
Primary
Secondary
Concomitant
Pain Other Serious 1/20/2007 Female 297 lb 3/21/2007 Consumer Canada
Primary
Concomitant
Myositis Other Serious 2/1/2007 64 Female 220 lb 3/14/2007 United Kingdom
Primary
Secondary
Concomitant
Protein Urine Required Intervention 70 Male 2/23/2006 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 2/1/2006 67 Female 8/17/2006 Physician United States
Primary
Concomitant
Protein Urine Required Intervention 7/21/2005 70 Male 189 lb 6/2/2006 United States
Primary
Concomitant
Cardioversion Other Serious 3/1/2006 77 Male 3/29/2007 Consumer Australia
Primary
Concomitant
Pain In Extremity 8/1/2006 74 Male 175 lb 1/23/2007 Other Health Professional United States
Primary
Concomitant
Palpitations 37 Female 224 lb 1/23/2007 Consumer United States
Primary
Concomitant
Yawning 9/1/2006 62 Male 275 lb 1/12/2007 Consumer United States
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 3/1/2007 54 Female 3/26/2007 Physician Peru
Primary
Secondary
Concomitant
Condition Aggravated Other Serious 59 Male 4/6/2007 Pharmacist Ireland
Primary
Concomitant
Skin Ulcer Other Serious 2/13/2007 62 Male 2/27/2007 United States
Primary
Secondary
Concomitant
Vomiting 11/7/2006 63 Male 205 lb 1/12/2007 Consumer United States
Primary
Concomitant
Hypersomnia Hospitalization 11/4/2006 61 Male 278 lb 4/12/2007 Pharmacist United States
Primary
Concomitant
Pneumonia Aspiration Hospitalization 1/2/2007 72 Male 216 lb 3/11/2007 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/4/2006 59 Male 230 lb 11/8/2006 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 11/3/2006 Male 215 lb 4/30/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 79 Male 2/16/2007 United States
Primary
Concomitant
Vomiting Life Threatening 4/21/2006 75 Male 5/16/2007 Consumer Germany
Primary
Secondary
Concomitant
Upper Limb Fracture Hospitalization 2/9/2007 67 Female 231 lb 5/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Diverticulum Intestinal Haemorrhagic Hospitalization 2/28/2006 80 Male 12/13/2006 Physician United States
Primary
Concomitant
Hypoglycaemia Other Serious 5/3/2007 Male 5/24/2007 Consumer United Kingdom
Primary
Concomitant
Cardiac Failure Other Serious 59 Male 5/25/2007 Ireland
Primary
Concomitant
Vomiting Life Threatening 4/21/2006 75 Male 5/14/2007 Australia
Primary
Secondary
Concomitant
Hypnopompic Hallucination Other Serious 12/1/2006 70 Female 6/1/2007 Consumer United States
Primary
Secondary
Concomitant
Increased Upper Airway Secretion Other Serious 1/1/2007 Male 195 lb 6/1/2007 Physician United States
Primary
Concomitant
Pyrexia Hospitalization Male 6/4/2007 Physician Canada
Primary
Concomitant
Pyrexia Hospitalization Male 6/5/2007 Physician Canada
Primary
Concomitant
Ischaemic Stroke Hospitalization 5/23/2007 64 Male 6/7/2007 Pharmacist United States
Primary
Concomitant
Hypotension 1/24/2007 84 Female 5/17/2007 United States
Primary
Concomitant
Pulmonary Hypertension Other Serious 6/1/2002 63 Male 269 lb 6/12/2007 Consumer United States
Primary
Concomitant
Vertigo Hospitalization 5/1/2007 66 Female 6/14/2007 Consumer United States
Primary
Concomitant
Muscle Spasms Other Serious 5/1/2007 60 Female 6/15/2007 Physician Canada
Primary
Concomitant
Drug Interaction Other Serious 59 Male 6/19/2007 Ireland
Primary
Concomitant
Interacting
Nausea Life Threatening 6/3/2007 Female 154 lb 6/21/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 6/20/2007 Male 6/20/2007 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Hospitalization 9/24/2006 Male 439 lb 5/15/2007 Pharmacist United States
Primary
Concomitant
Hyperglycaemia Other Serious 10/23/2005 68 Male 4/26/2007 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 59 Male 6/29/2007 Physician Canada
Primary
Concomitant
Oedema Peripheral 7/23/2007 Consumer United States
Primary
Concomitant
Death Death 7/4/2007 Male 137 lb 7/23/2007 Physician United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Other Serious 2/5/2007 61 Male 389 lb 7/23/2007 Consumer United States
Primary
Concomitant
Sleep Apnoea Syndrome Hospitalization 11/9/2003 59 Male 7/26/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 4/18/2007 59 Female 209 lb 7/31/2007 Other Health Professional France
Primary
Secondary
Concomitant
Tendonitis Hospitalization 11/1/2006 61 Female 7/27/2007 Consumer United States
Primary
Concomitant
Multiple Fractures Hospitalization 1/1/2005 Female 7/25/2007 Australia
Primary
Concomitant
Unresponsive To Stimuli Disability 4/14/2007 68 Male 262 lb 7/30/2007 Pharmacist United States
Primary
Concomitant
Hypothyroidism Hospitalization 3/3/2005 58 Female 8/3/2007 United States
Primary
Concomitant
Initial Insomnia 5/1/2007 56 Female 168 lb 7/10/2007 Consumer United States
Primary
Concomitant
Renal Impairment Hospitalization 1/1/2007 Male 240 lb 8/10/2007 Physician United States
Primary
Concomitant
Thrombophlebitis Superficial Hospitalization 9/8/2006 66 Female 167 lb 8/10/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 7/4/2007 Male 137 lb 8/13/2007 Physician United Kingdom
Primary
Concomitant
Cardiac Failure Congestive Hospitalization 2/8/2007 64 Female 8/14/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 7/18/2007 66 Male 329 lb 8/24/2007 Physician United Kingdom
Primary
Concomitant
International Normalised Ratio Decreased 3/1/2007 56 Male 240 lb 7/11/2007 Consumer United States
Primary
Concomitant
Injection Site Bruising 3/1/2007 72 Male 270 lb 7/11/2007 Consumer United States
Primary
Concomitant
Regurgitation Other Serious 7/20/2007 Male 175 lb 8/31/2007 Consumer United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious 5/2/2007 Male 8/31/2007 Physician Germany
Primary
Secondary
Concomitant
International Normalised Ratio Decreased Other Serious 79 Male 8/31/2007 United States
Primary
Concomitant
Interacting
Injection Site Haemorrhage 4/30/2007 73 Male 7/11/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 4/18/2007 59 Female 209 lb 9/5/2007 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 2/8/2007 64 Female 8/8/2007 United States
Primary
Secondary
Concomitant
Diarrhoea 3/13/2007 81 Male 9/6/2007 Consumer United States
Primary
Concomitant
Restless Legs Syndrome 11/1/2006 68 Male 9/6/2007 Consumer United States
Primary
Concomitant
Condition Aggravated Hospitalization 6/15/2007 Male 203 lb 9/14/2007 United Kingdom
Primary
Concomitant
Herpes Zoster Other Serious Male 181 lb 9/6/2007 United States
Primary
Concomitant
Haematochezia Other Serious 9/6/2007 78 Male 170 lb 9/11/2007 Consumer United States
Primary
Concomitant
Liver Function Test Abnormal Other Serious 5/2/2007 Male 9/20/2007 Physician Germany
Primary
Secondary
Concomitant
Somnambulism 35 Female 9/20/2007 Other Health Professional Canada
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 6/1/2007 86 Female 165 lb 10/2/2007 Consumer United States
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 8/23/2007 83 Male 9/27/2007 Pharmacist United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/1/2007 Female 10/5/2007 Consumer United States
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 9/11/2007 53 Male 10/12/2007 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 5/3/2007 Male 10/19/2007 Physician Germany
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 73 Male 10/22/2007 Consumer United Kingdom
Primary
Concomitant
Initial Insomnia 7/1/2007 72 Female 150 lb 10/5/2007 Consumer United States
Primary
Concomitant
Pain In Extremity Other Serious 73 Male 10/19/2007 United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 75 Male 10/23/2007 Pharmacist United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Other Serious 10/14/2007 54 Male 294 lb 10/30/2007 Consumer United Kingdom
Primary
Concomitant
Oedema Peripheral Other Serious 10/1/2007 64 Female 11/7/2007 Consumer Canada
Primary
Concomitant
Interacting
Liver Function Test Abnormal Other Serious 5/3/2007 Male 11/8/2007 Physician Germany
Primary
Secondary
Concomitant
Muscular Weakness 5/20/2007 82 Male 11/13/2007 Consumer United States
Primary
Concomitant
Stomach Discomfort 62 Male 11/13/2007 Consumer United States
Primary
Secondary
Concomitant
Muscular Weakness 1/1/2006 65 Female 11/14/2007 Consumer United States
Primary
Concomitant
Fatigue 81 Male 11/14/2007 Consumer United States
Primary
Concomitant
Hypotension 7/1/2007 72 Male 297 lb 11/14/2007 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 4/18/2007 59 Female 209 lb 11/15/2007 Other Health Professional France
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 5/1/2004 41 Female 147 lb 11/19/2007 Physician United States
Primary
Concomitant
International Normalised Ratio Decreased Hospitalization 79 Male 11/15/2007 Pharmacist United States
Primary
Concomitant

Drug Data