Metformin Hcl combined with Theophylline

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rash Generalised 5/7/2005 67 Female 151 lb 7/24/2006 United States
Primary
Secondary
Concomitant
Pneumonia 2/20/2006 60 Female 8/22/2006 United States
Primary
Concomitant
Peritonitis Bacterial Hospitalization 68 Female 10/19/2006 Other Health Professional United Kingdom
Primary
Secondary
Weight Fluctuation Hospitalization 9/9/2006 67 Male 255 lb 11/15/2006 Physician United States
Primary
Concomitant
Respiratory Arrest Hospitalization 12/31/2006 Male 120 lb 1/8/2007 Physician United States
Primary
Secondary
Concomitant
Weight Fluctuation Hospitalization 67 Male 255 lb 1/18/2007 Physician United States
Primary
Concomitant
Urticaria Hospitalization 1/25/2006 Female 238 lb 3/20/2006 Pharmacist United States
Primary
Concomitant
Death Hospitalization 12/31/2006 Male 120 lb 2/7/2007 Physician United States
Primary
Secondary
Concomitant
Hyperglycaemia Hospitalization 10/4/2006 58 Male 2/13/2007 Pharmacist United States
Primary
Concomitant
Sedation Other Serious 1/1/2007 37 Female 140 lb 3/29/2007 Consumer United States
Primary
Concomitant
Therapeutic Agent Toxicity Hospitalization 1/1/2006 Male 220 lb 1/8/2007 Other Health Professional United States
Primary
Concomitant
Tremor Hospitalization 1/1/2007 Female 160 lb 4/18/2007 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 86 Male 4/24/2007 Consumer United States
Primary
Secondary
Concomitant
Rash Hospitalization 9/1/2006 Female 186 lb 5/1/2007 Physician United States
Primary
Concomitant
Drug Ineffective 12/8/2006 84 Male 2/22/2007 United States
Primary
Concomitant
Tremor Hospitalization 1/1/2007 Female 160 lb 6/1/2007 Physician United States
Primary
Secondary
Concomitant
Throat Tightness 5/17/2006 71 Male 234 lb 6/22/2007 Consumer United States
Primary
Concomitant
Pneumonia Hospitalization 5/29/2007 69 Male 217 lb 7/10/2007 Physician Argentina
Primary
Concomitant
Injection Site Irritation 4/17/2007 59 Female 211 lb 6/11/2007 Other Health Professional United States
Primary
Concomitant
Injection Site Irritation 4/17/2007 59 Female 211 lb 6/11/2007 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 5/29/2007 69 Male 217 lb 7/24/2007 Physician Argentina
Primary
Concomitant
Renal Failure Hospitalization 8/21/2006 83 Male 8/19/2007 Pharmacist United States
Primary
Concomitant
Weight Decreased 1/1/2006 58 Female 211 lb 7/11/2007 Consumer United States
Primary
Concomitant
Coronary Artery Stenosis Hospitalization 4/10/2006 56 Female 182 lb 8/28/2007 United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 11/8/2007 Female 263 lb 11/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Stent Occlusion Other Serious 1/1/2004 80 Male 11/30/2007 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 59 5/6/2008 Physician United States
Primary
Concomitant
Visual Disturbance Other Serious Female 5/19/2008 Consumer United States
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 2/25/2008 Male 220 lb 5/29/2008 Physician United States
Primary
Concomitant
Oedema Peripheral Hospitalization 59 6/11/2008 Physician United States
Primary
Concomitant
Red Blood Cell Count Decreased Other Serious 3/1/2008 78 Female 175 lb 6/13/2008 Physician United States
Primary
Concomitant
Glossitis 81 Female 124 lb 6/24/2008 United States
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 3/1/2008 78 Female 180 lb 7/7/2008 Physician United States
Primary
Concomitant
Off Label Use Other Serious 3/1/2008 78 Female 180 lb 7/24/2008 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 2/1/2007 50 Male 200 lb 9/5/2008 Pharmacist United States
Primary
Concomitant
Oral Mucosal Discolouration 7/26/2008 Female 9/26/2008 Consumer
Primary
Concomitant
Arthralgia Hospitalization 66 Female 10/10/2008 United Kingdom
Primary
Concomitant
Accidental Drug Intake By Child Other Serious 2 Male 11/6/2008 Other Health Professional Germany
Primary
Secondary
Accidental Drug Intake By Child Other Serious 2 Male 11/6/2008 Other Health Professional Germany
Primary
Secondary
Sputum Purulent Other Serious Male 11/17/2008 Physician Switzerland
Primary
Concomitant
Somnolence Other Serious 11/21/2008 66 Male 12/1/2008 Other Health Professional Turkey
Primary
Secondary
Concomitant
Accidental Drug Intake By Child Other Serious 2 Male 11/24/2008 Other Health Professional Germany
Primary
Secondary
Accidental Drug Intake By Child Other Serious 2 Male 11/24/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
No Adverse Event Other Serious 2 Male 11/24/2008 Other Health Professional Germany
Primary
Secondary
Staphylococcal Infection Other Serious 8/1/2008 Female 12/8/2008 Consumer United States
Primary
Secondary
Concomitant
Sinus Congestion 9/18/2008 80 Female 172 lb 12/18/2008 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 6/1/2006 62 Female 226 lb 12/22/2008 Consumer United States
Primary
Concomitant
Syncope Hospitalization 11/1/2008 75 Female 12/17/2008 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 7/10/2008 58 Male 234 lb 1/21/2009 Physician Germany
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 3/9/2009 60 Male 4/1/2009 Physician United Kingdom
Primary
Concomitant
Weight Decreased Other Serious 8/12/2003 60 Male 216 lb 4/3/2009 United States
Primary
Concomitant
Insomnia 4/8/2008 59 Male 226 lb 12/29/2008 Pharmacist United States
Primary
Concomitant
Gastrooesophageal Reflux Disease Hospitalization 1/28/2009 Female 217 lb 4/30/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 10/22/2004 43 Male 218 lb 5/19/2009 Other Health Professional United States
Primary
Concomitant
Xerosis Other Serious 1/1/2000 42 Female 320 lb 5/20/2009 United States
Primary
Concomitant
Weight Increased Other Serious 1/24/2000 40 Female 185 lb 5/21/2009 United States
Primary
Concomitant
Pruritus 2/3/2009 Female 195 lb 5/27/2009 Consumer United States
Primary
Concomitant
Asthma Hospitalization 5/14/2009 Male 291 lb 6/18/2009 Consumer United States
Primary
Concomitant
Unevaluable Event Hospitalization 47 Male 8/11/2009 United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 10/20/2004 38 Female 234 lb 8/28/2009 United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Hospitalization 1/1/2005 Male 195 lb 9/1/2009 Consumer United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 68 Male 183 lb 8/26/2009 United States
Primary
Concomitant
Unevaluable Event Hospitalization 47 Male 9/2/2009 United States
Primary
Concomitant
Surgery Hospitalization 47 Male 9/3/2009 United States
Primary
Concomitant
Weight Decreased Hospitalization 68 Male 183 lb 9/3/2009 Lawyer United States
Primary
Concomitant
Sepsis Other Serious 71 Female 9/21/2009 Physician United Kingdom
Primary
Secondary
Drug Ineffective 1/1/2008 60 Male 9/16/2009 Consumer United States
Primary
Concomitant
Road Traffic Accident Hospitalization 2/23/2001 59 Male 190 lb 9/23/2009 Other Health Professional United States
Primary
Concomitant
Circulatory Collapse Other Serious 9/16/2009 Male 9/29/2009 Consumer United Kingdom
Primary
Concomitant
Sepsis Other Serious 71 Female 10/5/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sepsis Other Serious 71 Female 10/5/2009 Other Health Professional United Kingdom
Primary
Secondary
Sepsis Other Serious 71 10/9/2009 Physician United Kingdom
Primary
Secondary
Sepsis Other Serious 71 Female 10/8/2009 Physician
Primary
Secondary
Unresponsive To Stimuli Hospitalization 79 Male 10/10/2009 United States
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 48 Male 456 lb 10/16/2009 Lawyer United States
Primary
Concomitant
Pain In Extremity Hospitalization 47 Male 10/27/2009 United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 10/5/2009 74 Female 11/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 79 Male 11/9/2009 United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 79 Male 11/18/2009 United States
Primary
Concomitant
Wheezing Hospitalization 68 Male 183 lb 11/24/2009 Consumer United States
Primary
Concomitant
Dystonia Hospitalization 3/19/2009 Female 126 lb 12/7/2009 Physician United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 10/5/2009 74 Female 12/15/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Ineffective Male 2/1/2010 Consumer
Primary
Concomitant
Renal Failure Acute Hospitalization 12/5/2009 50 Female 176 lb 2/5/2010 Physician Germany
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 1/29/2010 Israel
Primary
Concomitant
Respiratory Failure Other Serious 5/27/2009 63 Male 219 lb 2/9/2010 Physician United States
Primary
Concomitant
Wheezing Hospitalization 79 Male 2/5/2010 United States
Primary
Concomitant
Drug Ineffective Male 2/24/2010 Consumer
Primary
Concomitant
Sensation Of Foreign Body Hospitalization 1/1/2010 Female 3/15/2010 Consumer
Primary
Concomitant
Sepsis Other Serious 71 Female 4/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization Female 6/16/2010 Physician France
Primary
Secondary
Thrombocytopenia Hospitalization 70 Female 6/18/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/22/2010 Other Health Professional France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 6/29/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Product Quality Issue 6/17/2010 66 Female 151 lb 6/28/2010 Consumer United States
Primary
Concomitant
Angioedema Hospitalization 5/1/2009 34 Female 195 lb 7/1/2010 Consumer United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization Female 7/7/2010 Other Health Professional Israel
Primary
Secondary
Concomitant
Vomiting 9/1/2006 62 Male 170 lb 7/8/2010 Other Health Professional United States
Primary
Concomitant
Polyuria Other Serious 1/1/2006 69 Female 152 lb 7/8/2010 Consumer United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/9/2010 Physician United Kingdom
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/12/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 70 Female 7/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization Female 7/13/2010 Other Health Professional Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/6/2010 United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/8/2010 United Kingdom
Primary
Secondary
Concomitant
Fatigue 7/1/2007 58 Female 140 lb 7/15/2010 Consumer United States
Primary
Concomitant
Nausea 8/1/2007 60 Female 266 lb 7/16/2010 Consumer United States
Primary
Concomitant
Product Quality Issue 6/17/2010 66 Female 151 lb 7/19/2010 Consumer United States
Primary
Concomitant
Pain In Extremity Other Serious 2/25/2008 60 Male 220 lb 7/19/2010 Other Health Professional United States
Primary
Concomitant
Toxic Epidermal Necrolysis Death 70 Female 7/13/2010 Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 42 Female 296 lb 7/27/2010 United States
Primary
Concomitant
Pruritus Other Serious 2/12/2008 31 Female 203 lb 8/2/2010 Physician United States
Primary
Concomitant
Xerosis Other Serious 1/1/2000 42 Female 296 lb 8/6/2010 United States
Primary
Concomitant
Xerosis Other Serious 1/1/2000 42 Female 296 lb 8/24/2010 United States
Primary
Concomitant
Xerosis Other Serious 1/1/2000 42 Female 296 lb 10/20/2010 United States
Primary
Concomitant
Sinus Bradycardia Hospitalization 85 Male 10/15/2010 United States
Primary
Secondary
Concomitant
Rash Other Serious 9/20/2010 83 Male 11/4/2010 United Kingdom
Primary
Concomitant
Angioedema Hospitalization 5/1/2009 34 Female 267 lb 12/7/2010 Consumer United States
Primary
Concomitant
Fatigue Other Serious 10/1/2007 Female 263 lb 1/5/2011 Consumer Switzerland
Primary
Concomitant
Right Ventricular Failure Other Serious 1/1/2009 71 Female 207 lb 2/8/2011 Consumer Germany
Primary
Secondary
Concomitant
Pancreatitis Chronic Hospitalization 11/21/2010 30 Female 146 lb 2/16/2011 Physician United States
Primary
Concomitant
Cerebrovascular Accident Hospitalization 61 Female 4/1/2011 Consumer United States
Primary
Concomitant
Anaemia Hospitalization 12/16/2010 66 Male 5/9/2011 Pharmacist United States
Primary
Concomitant
Dehydration Hospitalization 1/1/2011 74 Male 270 lb 5/24/2011 Physician United States
Primary
Concomitant
Myocardial Ischaemia Hospitalization 5/25/2005 63 Male 211 lb 6/1/2011 Lawyer United States
Primary
Concomitant
Renal Cancer Other Serious 6/1/2008 63 Female 169 lb 6/13/2011 Consumer United States
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Muscle Twitching Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Physician Germany
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Physician Germany
Primary
Secondary
Concomitant
Neutralising Antibodies Positive Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pain Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Physician Germany
Primary
Secondary
Concomitant
Gastritis Erosive Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Physician Germany
Primary
Secondary
Concomitant
Gastritis Erosive Hospitalization 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Aplasia Pure Red Cell Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Fatigue Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Physician Germany
Primary
Secondary
Concomitant
Aplasia Pure Red Cell Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Cystitis Hospitalization 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Fatigue Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Neutralising Antibodies Positive Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Gastritis Erosive Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Physician Germany
Primary
Secondary
Concomitant
Haemorrhoids Hospitalization 1/1/2009 71 Female 207 lb 6/21/2011 Physician Germany
Primary
Secondary
Concomitant
Fatigue Hospitalization 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Gastritis Erosive Other Serious 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Anal Fissure Hospitalization 1/1/2009 71 Female 207 lb 6/21/2011 Other Health Professional Germany
Primary
Secondary
Concomitant

Drug Data