Metformin Hcl combined with Rituximab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Myelodysplastic Syndrome Life Threatening 9/14/2006 63 Female 196 lb 12/6/2006 Other Health Professional Norway
Primary
Concomitant
Aplasia Pure Red Cell Other Serious 1/25/2007 Male 211 lb 2/13/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased 4/28/2007 69 Female 4/29/2007 United States
Primary
Concomitant
Pneumonia Hospitalization 7/1/2007 Male 216 lb 8/31/2007 Physician Australia
Primary
Concomitant
Sputum Culture Positive Life Threatening 7/20/2007 Male 154 lb 8/31/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 9/20/2007 Physician United States
Primary
Concomitant
Pleural Effusion Hospitalization 9/26/2007 Female 158 lb 10/8/2007 Physician United States
Primary
Secondary
Concomitant
Urticaria Other Serious 10/22/2007 64 Female 11/7/2007 Pharmacist United States
Primary
Concomitant
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 11/12/2007 Physician United States
Primary
Concomitant
Neoplasm Malignant Other Serious 11/21/2007 Physician United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 64 Female 11/27/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 11/28/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 8/2/2007 Female 123 lb 11/28/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 64 Female 12/7/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 12/21/2007 Physician United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 1/9/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vision Blurred Hospitalization 8/28/2005 Male 182 lb 1/11/2008 Consumer United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 1/18/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 2/12/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 2/15/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 2/23/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumonia Fungal Hospitalization 4/4/2008 Male 143 lb 4/25/2008 Physician United Kingdom
Primary
Concomitant
Pneumonia Fungal Hospitalization 4/4/2008 Male 143 lb 5/9/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/8/2008 Male 5/27/2008 Physician United Kingdom
Primary
Concomitant
Sepsis Hospitalization 5/8/2008 Male 7/18/2008 Physician United Kingdom
Primary
Concomitant
Pneumonia Fungal Hospitalization 4/4/2008 Male 143 lb 7/25/2008 Physician United Kingdom
Primary
Concomitant
Septic Embolus Other Serious 7/14/2008 Female 205 lb 8/19/2008 United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 9/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Life Threatening 10/28/2007 Female 143 lb 9/17/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Constipation Hospitalization 7/9/2008 Male 163 lb 10/7/2008 Consumer Ireland
Primary
Secondary
Concomitant
Febrile Neutropenia Life Threatening 10/10/2008 Female 11/5/2008 Physician United Kingdom
Primary
Concomitant
Renal Failure Other Serious 7/28/2008 66 Male 11/13/2008 Other Health Professional Mexico
Primary
Secondary
Cerebrovascular Accident Hospitalization 10/21/2008 Female 11/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Proteinuria Other Serious 11/4/2008 12/12/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Lethargy Hospitalization 10/21/2008 Female 1/14/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/7/2009 Male 1/23/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 7/14/2008 Female 205 lb 2/2/2009 United States
Primary
Concomitant
Renal Failure Hospitalization 1/28/2009 81 Male 165 lb 2/4/2009 Physician Australia
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/17/2009 Female 2/11/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/27/2009 Female 2/11/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/7/2009 Male 2/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 1/27/2009 Female 2/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 2/27/2009 Female 3/18/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypotension Hospitalization 3/14/2009 54 Male 159 lb 3/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 3/14/2009 54 Male 159 lb 4/3/2009 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/14/2009 54 Male 159 lb 4/6/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2008 Male 194 lb 4/6/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 11/30/2008 Male 4/10/2009 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 2/27/2009 Female 4/10/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Tachycardia Other Serious 3/14/2009 54 Male 159 lb 4/15/2009 Physician United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 3/14/2009 54 Male 159 lb 4/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 3/24/2009 Female 205 lb 4/28/2009 Physician United States
Primary
Concomitant
Tachycardia Other Serious 3/6/2009 54 Male 159 lb 5/6/2009 Physician United States
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Infection Other Serious 4/1/2008 Male 5/11/2009 Physician France
Primary
Secondary
Concomitant
Medical Observation Hospitalization 6/4/2009 Male 6/18/2009 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Increased Other Serious 4/24/2009 Female 6/29/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Other Serious 4/24/2009 Female 6/23/2009
Primary
Secondary
Concomitant
Pneumonia Other Serious 4/24/2009 Female 6/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Other Serious 11/1/2007 Female 6/30/2009 Consumer United Kingdom
Primary
Concomitant
Vomiting Hospitalization 6/8/2009 74 Female 6/25/2009 Other Health Professional Netherlands
Primary
Concomitant
White Blood Cell Count Increased Other Serious 4/24/2009 Female 7/13/2009 United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization Female 7/15/2009 Other Health Professional Netherlands
Primary
Concomitant
Febrile Neutropenia Hospitalization 7/8/2009 Female 7/21/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Medical Observation Hospitalization 6/4/2009 Male 7/22/2009 Physician United Kingdom
Primary
Concomitant
Febrile Neutropenia Hospitalization 7/8/2009 Female 8/26/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 6/30/2009 Female 9/2/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Gastric Perforation Life Threatening 3/6/2009 Female 165 lb 10/26/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Cardiomyopathy Other Serious 2/6/2008 Female 11/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death 10/5/2009 Female 179 lb 12/4/2009 Consumer United Kingdom
Primary
Concomitant
Nervous System Disorder Other Serious 11/20/2009 Male 206 lb 12/10/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/25/2009 Male 140 lb 12/11/2009 Physician United Kingdom
Primary
Concomitant
Death Death 10/31/2009 Female 12/11/2009 Consumer United Kingdom
Primary
Concomitant
Nervous System Disorder Other Serious 11/20/2009 Male 206 lb 12/14/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiomyopathy Other Serious 2/6/2008 Female 143 lb 12/22/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Dementia Other Serious 11/20/2009 Male 206 lb 1/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 12/23/2009 Female 163 lb 2/2/2010 Physician United Kingdom
Primary
Concomitant
Streptococcal Sepsis Hospitalization 11/23/2009 Male 209 lb 3/24/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 10/31/2009 80 Female 4/23/2010 Consumer United Kingdom
Primary
Concomitant
Lung Adenocarcinoma Hospitalization 3/17/2010 68 Female 5/12/2010 Physician Netherlands
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/5/2010 36 Female 285 lb 5/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Lung Adenocarcinoma Hospitalization 3/17/2010 68 Female 6/3/2010 Physician Netherlands
Primary
Secondary
Concomitant
Lung Adenocarcinoma Hospitalization 3/17/2010 68 Female 6/11/2010 Physician Netherlands
Primary
Secondary
Concomitant
Thrombosis Death 10/5/2009 62 Female 179 lb 6/21/2010 Consumer United Kingdom
Primary
Concomitant
Skin Ulcer Other Serious 11/1/2008 78 Female 163 lb 6/24/2010 Physician United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 3/25/2010 76 Female 132 lb 7/6/2010 Consumer Sweden
Primary
Concomitant
Coronary Artery Disease Hospitalization 1/28/2010 66 Male 249 lb 7/9/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Dehydration Hospitalization 6/12/2010 56 Male 141 lb 7/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Speech Disorder Other Serious 12/1/2009 73 Female 198 lb 7/16/2010 Physician Brazil
Primary
Concomitant
White Blood Cell Count Abnormal Other Serious 51 Male 7/16/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Traumatic Lung Injury Hospitalization 6/30/2010 61 Male 155 lb 7/27/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Subdural Haemorrhage Hospitalization 3/24/2010 55 Male 247 lb 7/28/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Ventricular Extrasystoles Hospitalization 5/1/2009 57 Female 216 lb 8/6/2010 Physician Germany
Primary
Concomitant
Thrombosis Other Serious 1/1/2009 64 Male 8/26/2010 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 2/19/2008 64 Male 185 lb 8/26/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Arteriosclerosis Hospitalization 12/11/2008 66 Female 161 lb 10/1/2010 Consumer United Kingdom
Primary
Concomitant
Pain Other Serious 1/1/2010 75 Female 119 lb 10/1/2010 Consumer United Kingdom
Primary
Concomitant
Syncope Other Serious 4/24/2010 69 Male 193 lb 11/5/2010 Physician United Kingdom
Primary
Concomitant
Pain Other Serious 1/1/2006 71 Female 119 lb 11/5/2010 Consumer United Kingdom
Primary
Concomitant
Splenectomy Other Serious 6/4/2010 61 Male 11/10/2010 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 11/12/2010 65 Male 198 lb 11/19/2010 Physician New Zealand
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/12/2010 65 Male 198 lb 11/23/2010 Physician New Zealand
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/12/2010 56 Male 141 lb 12/15/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 12/10/2010 65 Male 216 lb 12/16/2010 Physician New Zealand
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 11/25/2010 73 Male 234 lb 12/20/2010 Physician Netherlands
Primary
Secondary
Concomitant
Vitreous Floaters Other Serious 12/1/2010 65 Male 216 lb 1/13/2011 Physician New Zealand
Primary
Secondary
Concomitant
Back Pain Other Serious 4/25/2010 64 Female 198 lb 1/14/2011 Consumer United Kingdom
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Other Serious 12/10/2010 65 Male 216 lb 2/16/2011 Physician New Zealand
Primary
Secondary
Concomitant
Musculoskeletal Pain Hospitalization 1/1/2010 63 Female 176 lb 3/4/2011 Consumer United Kingdom
Primary
Concomitant
General Physical Health Deterioration Hospitalization 11/16/2010 79 Male 168 lb 3/17/2011 Other Health Professional France
Primary
Secondary
Concomitant
Anaemia Hospitalization 2/23/2011 71 Female 123 lb 3/23/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 9/1/2010 75 Male 191 lb 3/29/2011 Other Health Professional United States
Primary
Concomitant
Anaemia Death 9/1/2010 75 Male 191 lb 4/1/2011 Other Health Professional United States
Primary
Concomitant
Renal Cell Carcinoma Hospitalization 8/23/2010 63 Female 317 lb 4/11/2011 Consumer United Kingdom
Primary
Concomitant
Pain Hospitalization 1/1/2010 63 Female 176 lb 5/17/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Confusional State Hospitalization 4/25/2011 80 Male 160 lb 5/31/2011 Consumer Canada
Primary
Concomitant
Traumatic Lung Injury Hospitalization 6/30/2010 61 Male 155 lb 5/31/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 4/25/2010 64 Female 198 lb 6/3/2011 Consumer United Kingdom
Primary
Concomitant
Dysplasia Other Serious 4/29/2011 60 Male 6/15/2011 Physician Spain
Primary
Concomitant
Pain Hospitalization 1/1/2010 63 Female 176 lb 6/15/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Orthostatic Hypotension Other Serious 10/9/2008 60 Male 6/22/2011 Physician United States
Primary
Secondary
Concomitant
Post Herpetic Neuralgia Hospitalization 4/21/2011 73 Female 212 lb 7/5/2011 Physician United Kingdom
Primary
Concomitant
Sinusitis Other Serious 3/1/2010 59 Female 132 lb 7/8/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Post Herpetic Neuralgia Hospitalization 4/21/2011 73 Female 212 lb 7/19/2011 Physician United Kingdom
Primary
Concomitant
Fall Death 4/25/2011 80 Male 168 lb 7/20/2011 Consumer Canada
Primary
Concomitant
Back Pain Other Serious 4/25/2010 64 Female 198 lb 8/2/2011 Consumer United Kingdom
Primary
Concomitant
Joint Swelling Other Serious 3/1/2010 59 Female 132 lb 8/11/2011 Physician Brazil
Primary
Secondary
Concomitant
Ulcer Haemorrhage Hospitalization 12/1/2010 50 Male 8/11/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Proteinuria Other Serious 9/4/2008 67 Female 146 lb 8/16/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Ulcer Haemorrhage Hospitalization 12/1/2010 50 Male 9/2/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Other Serious 12/10/2010 65 Male 216 lb 9/6/2011 Physician New Zealand
Primary
Secondary
Concomitant
Hypocoagulable State Death 4/12/2010 60 Male 9/12/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 4/12/2010 60 Male 9/13/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Constipation Hospitalization 7/16/2010 72 Female 146 lb 9/13/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Death 4/12/2010 60 Male 9/13/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Other Serious Female 174 lb 9/16/2011 Consumer United Kingdom
Primary
Concomitant
Hypocoagulable State Hospitalization 4/12/2010 60 Male 9/21/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Therapeutic Response Decreased Death Female 152 lb 9/21/2011 Consumer United Kingdom
Primary
Concomitant
Disease Recurrence Hospitalization 3/1/2011 57 Female 117 lb 9/22/2011 Consumer United States
Primary
Secondary
Concomitant
Constipation Other Serious 4/12/2010 60 Male 9/22/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Hospitalization 4/12/2010 60 Male 9/23/2011 Physician Japan
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Hospitalization 4/12/2010 60 Male 9/23/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypophosphataemia Hospitalization 9/15/2011 80 Female 106 lb 10/26/2011 Physician Netherlands
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 10/25/2011 80 Female 93 lb 11/16/2011 Physician Netherlands
Primary
Secondary
Concomitant
Rectal Haemorrhage Hospitalization 10/25/2011 80 Female 93 lb 11/18/2011 Physician Netherlands
Primary
Secondary
Concomitant
Decreased Appetite Hospitalization 1/31/2011 76 Male 154 lb 11/18/2011 Physician Japan
Primary
Concomitant
Pancytopenia Other Serious 6/2/2011 63 Male 11/18/2011 Physician France
Primary
Secondary
Concomitant
Neutropenia Death 4/13/2010 60 Male 11/28/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 11/13/2011 65 Male 218 lb 12/5/2011 Physician United States
Primary
Secondary
Concomitant
Anaemia Hospitalization 10/25/2011 80 Female 93 lb 12/15/2011 Physician Netherlands
Primary
Secondary
Concomitant
Hypophosphataemia Hospitalization 9/15/2011 79 Female 106 lb 12/16/2011 Physician Denmark
Primary
Secondary
Concomitant

Drug Data