Metformin Hcl combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Skin Graft Rejection Other Serious 9/15/2005 Male 192 lb 1/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Ankle Fracture Other Serious 8/1/2005 Female 281 lb 1/24/2006 Physician United States
Primary
Concomitant
Adverse Event Other Serious 8/3/2005 68 Female 1/25/2006 Physician Sweden
Primary
Concomitant
Pruritus Death 7/22/2004 Male 187 lb 1/25/2006 United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 8/25/2005 61 Male 2/8/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Death 12/25/2005 57 Male 235 lb 2/24/2006 Other Health Professional United States
Primary
Concomitant
Pyrexia Other Serious 11/1/2003 Female 197 lb 6/22/2006 Physician United States
Primary
Secondary
Concomitant
Visual Disturbance 5/1/2006 70 Female 197 lb 7/19/2006 Consumer United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 9/13/2006 Physician United States
Primary
Concomitant
Vomiting 63 Female 210 lb 7/19/2006 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 63 Male 273 lb 10/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Heart Rate Decreased Hospitalization 9/1/2006 Female 217 lb 10/18/2006 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 9/12/2006 65 Female 114 lb 11/1/2006 Physician United States
Primary
Secondary
Concomitant
Pyelonephritis Acute Other Serious 10/23/2006 46 Female 11/1/2006 Other Health Professional Thailand
Primary
Concomitant
Weight Decreased Hospitalization 6/17/2006 55 Male 245 lb 11/17/2006 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 6/6/2006 Female 163 lb 12/28/2006 Physician United States
Primary
Concomitant
Sick Sinus Syndrome Other Serious 8/14/2006 Female 199 lb 1/10/2007 Physician United States
Primary
Concomitant
Death Other Serious 12/16/2006 Male 187 lb 1/11/2007 Physician United Kingdom
Primary
Concomitant
Oesophageal Haemorrhage Hospitalization 7/8/2006 Female 105 lb 1/22/2007 Consumer Canada
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 12/12/2005 63 Male 273 lb 2/1/2007 Other Health Professional France
Primary
Secondary
Concomitant
Nausea 9/9/2006 58 Female 230 lb 10/16/2006 Consumer United States
Primary
Concomitant
Transaminases Increased Hospitalization 11/28/2006 72 Female 2/9/2007 France
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/17/2007 62 Female 239 lb 2/20/2007 Physician United States
Primary
Secondary
Concomitant
Urticaria Life Threatening 6/14/2006 Male 182 lb 2/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Malignant Melanoma Other Serious 7/1/2006 Male 3/1/2007 Physician United States
Primary
Concomitant
Motor Neurone Disease Other Serious 3/15/2006 Male 187 lb 3/6/2007 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 1/17/2007 62 Female 239 lb 3/7/2007 Physician United States
Primary
Secondary
Concomitant
Arterial Occlusive Disease Hospitalization 5/3/2005 Male 181 lb 3/7/2007 Consumer United Kingdom
Primary
Concomitant
Coronary Artery Occlusion Life Threatening 1/12/2007 72 Female 226 lb 3/8/2007 Physician United States
Primary
Concomitant
Mental Disorder Hospitalization 9/1/2006 58 Male 3/16/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Palpitations 61 Female 229 lb 3/27/2007 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Life Threatening 1/12/2007 72 Female 226 lb 3/21/2007 Other Health Professional United States
Primary
Concomitant
Joint Swelling Other Serious 11/1/2006 61 Female 269 lb 3/23/2007 United Kingdom
Primary
Secondary
Concomitant
Joint Swelling Required Intervention 11/1/2006 61 Female 3/26/2007 United Kingdom
Primary
Secondary
Concomitant
Bronchitis Other Serious Female 250 lb 4/5/2007 Physician United States
Primary
Concomitant
Headache 10/24/2006 85 Male 1/12/2007 Consumer United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 11/15/2003 Female 4/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Rash Hospitalization 6/6/2006 Female 163 lb 4/18/2007 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 2/15/2007 Male 205 lb 4/19/2007 Consumer Canada
Primary
Concomitant
Coronary Artery Thrombosis Hospitalization 11/15/2006 Female 148 lb 4/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Hypoglycaemia Hospitalization 12/25/2006 70 183 lb 4/27/2007
Primary
Concomitant
Oesophageal Carcinoma Other Serious 3/22/2006 Male 192 lb 4/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Mobility Decreased Other Serious 69 Female 234 lb 5/3/2007 Consumer United Kingdom
Primary
Concomitant
Loss Of Consciousness Hospitalization 12/25/2006 70 183 lb 5/4/2007
Primary
Concomitant
Myocardial Infarction Death Male 174 lb 5/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 4/8/2007 59 Female 5/7/2007 Other Health Professional Mexico
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Life Threatening 1/12/2007 Male 150 lb 5/11/2007 Physician France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/18/2007 66 Male 5/9/2007 Pharmacist United States
Primary
Concomitant
Rash Hospitalization 6/6/2006 Female 163 lb 5/17/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 4/30/2007 Female 263 lb 5/22/2007 Consumer Canada
Primary
Concomitant
Pancytopenia Hospitalization 2/25/2007 61 Male 5/25/2007 Consumer France
Primary
Secondary
Concomitant
Tremor 11/30/2006 54 Female 3/13/2007 Consumer United States
Primary
Concomitant
Vomiting Hospitalization 4/30/2007 Female 263 lb 6/9/2007 Physician Canada
Primary
Concomitant
Facial Palsy Other Serious 5/8/2007 Male 230 lb 6/12/2007 Physician United States
Primary
Concomitant
Influenza Like Illness Other Serious 4/8/2007 Female 195 lb 6/15/2007 Physician United States
Primary
Concomitant
Nausea 1/22/2007 63 Male 4/10/2007 Consumer United States
Primary
Concomitant
Weight Decreased 1/8/2007 57 Female 290 lb 4/10/2007 Consumer United States
Primary
Concomitant
Cardiac Flutter Other Serious 3/1/2003 68 Female 6/21/2007 Consumer United States
Primary
Secondary
Concomitant
Postoperative Wound Infection Hospitalization 205 lb 6/25/2007 Consumer Canada
Primary
Concomitant
Rheumatoid Nodule Hospitalization 5/28/2007 Female 145 lb 6/29/2007 Consumer Canada
Primary
Concomitant
Vomiting Hospitalization 2/21/2007 66 Male 206 lb 4/10/2007 Consumer United States
Primary
Secondary
Concomitant
Sepsis Other Serious 3/27/2006 Female 130 lb 7/20/2007 Consumer United Kingdom
Primary
Concomitant
Rheumatoid Nodule Hospitalization 5/28/2007 Female 145 lb 7/20/2007 Canada
Primary
Concomitant
Pneumonia Hospitalization 2/1/2007 60 Female 176 lb 8/3/2007 Brazil
Primary
Concomitant
Intestinal Obstruction Hospitalization 7/19/2007 Male 148 lb 8/3/2007 Canada
Primary
Concomitant
Drug Ineffective Other Serious 3/1/2003 68 Female 8/31/2007 Consumer United States
Primary
Secondary
Concomitant
Regurgitation Other Serious 7/20/2007 Male 175 lb 8/31/2007 Consumer United States
Primary
Concomitant
Weight Decreased 5/1/2007 64 Female 240 lb 7/11/2007 Consumer United States
Primary
Concomitant
Motor Neurone Disease Other Serious 3/15/2006 Male 187 lb 9/5/2007 Physician United Kingdom
Primary
Concomitant
Motor Neurone Disease Other Serious 3/15/2006 Male 187 lb 9/5/2007 Other Health Professional United Kingdom
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 7/19/2007 Male 148 lb 9/5/2007 Canada
Primary
Concomitant
Thalassaemia Other Serious Male 9/20/2007 Belgium
Primary
Concomitant
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 9/20/2007 Physician United States
Primary
Concomitant
Sepsis Life Threatening 8/3/2007 63 Female 132 lb 10/1/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2005 48 Female 179 lb 10/1/2007 Physician Sweden
Primary
Concomitant
Vision Blurred Other Serious 2/21/2007 Female 260 lb 10/5/2007 Canada
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/8/2007 Female 180 lb 11/1/2007 Canada
Primary
Concomitant
Pneumonia Other Serious 1/1/2005 67 Male 229 lb 11/9/2007 Consumer United States
Primary
Concomitant
Coronary Artery Occlusion Other Serious 10/18/2007 Male 148 lb 11/9/2007 Canada
Primary
Concomitant
Myocardial Infarction Hospitalization 9/1/2006 Male 11/12/2007 Physician United States
Primary
Concomitant
Anaemia Hospitalization 8/29/2007 47 Female 119 lb 11/12/2007 Physician United States
Primary
Concomitant
Hypotension 1/1/2006 62 Female 11/14/2007 Consumer United States
Primary
Concomitant
Rash Macular Hospitalization 11/5/2007 Female 190 lb 11/6/2007 United States
Primary
Secondary
Concomitant
Gastric Ulcer Other Serious 10/20/2006 Female 181 lb 11/27/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Vulval Cancer Other Serious 1/1/2003 Female 185 lb 12/6/2007 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 5/15/2006 Female 200 lb 12/6/2007 Physician United States
Primary
Concomitant
Rheumatoid Arthritis 4/6/2007 Female 208 lb 12/12/2007 Consumer United States
Primary
Secondary
Concomitant
Foreign Body Trauma Other Serious 1/1/2007 Female 12/12/2007 Pharmacist United States
Primary
Secondary
Concomitant
Contusion 6/1/2007 Male 235 lb 12/14/2007 Consumer United States
Primary
Concomitant
Nausea 6/1/2007 Female 148 lb 12/14/2007 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral 1/1/2007 Male 240 lb 12/14/2007 Consumer United States
Primary
Concomitant
Drug Ineffective 9/1/2007 Female 266 lb 12/14/2007 Consumer United States
Primary
Concomitant
Urinary Tract Infection 9/19/2007 Female 160 lb 12/14/2007 United States
Primary
Concomitant
Accidental Exposure 9/30/2007 Female 201 lb 12/14/2007 Consumer United States
Primary
Concomitant
Skin Irritation 8/1/2007 Male 12/14/2007 United States
Primary
Secondary
Concomitant
Injection Site Pain Female 220 lb 12/14/2007 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 10/23/2007 Female 180 lb 12/14/2007 Consumer United States
Primary
Concomitant
Oedema Peripheral 11/10/2007 Female 230 lb 12/15/2007 United States
Primary
Concomitant
Sepsis Life Threatening 8/3/2007 63 Female 132 lb 12/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased 8/1/2007 65 Male 10/9/2007 Consumer United States
Primary
Concomitant
Weight Decreased 5/1/2007 64 Female 240 lb 10/9/2007 Consumer United States
Primary
Concomitant
Nausea 12/12/2007 Female 1/15/2008 Consumer United States
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/16/2008 Physician Brazil
Primary
Concomitant
Pneumonia Hospitalization 12/5/2007 Female 1/16/2008 United Kingdom
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/22/2008 Physician Brazil
Primary
Concomitant
Rhinitis Other Serious 10/3/2007 50 Female 143 lb 1/25/2008 Brazil
Primary
Secondary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/28/2008 Physician Brazil
Primary
Concomitant
Tinnitus Hospitalization 1/7/2008 Female 110 lb 1/29/2008 Physician Brazil
Primary
Concomitant
Trichophytosis Other Serious 64 Female 1/31/2008
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 12/11/2007 46 Female 225 lb 1/31/2008 Consumer United Kingdom
Primary
Concomitant
Pulmonary Hypertension Hospitalization 10/1/2007 65 Female 2/6/2008 Physician Canada
Primary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 2/8/2008 Physician Germany
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 1/25/2008 Belgium
Primary
Concomitant
Death Other Serious Female 143 lb 2/13/2008 Other Health Professional United Kingdom
Primary
Concomitant
Death Other Serious 4/24/2007 Female 143 lb 2/13/2008 Other Health Professional United Kingdom
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 2/6/2008 Belgium
Primary
Concomitant
Pneumonia Hospitalization 12/5/2007 Female 2/21/2008 United Kingdom
Primary
Concomitant
Renal Failure Acute Other Serious 2/3/2007 Female 143 lb 2/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Influenza Hospitalization 2/18/2008 Female 194 lb 2/28/2008 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 10/31/2007 Female 143 lb 2/29/2008 Other Health Professional United Kingdom
Primary
Concomitant
Tuberculosis Other Serious 7/19/2004 Female 163 lb 3/5/2008 United Kingdom
Primary
Concomitant
Sepsis Hospitalization 11/3/2007 Male 3/6/2008 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/18/2008 74 Female 3/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Lactic Acidosis Life Threatening 12/29/2007 Male 243 lb 4/3/2008 Pharmacist United States
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 4/8/2008 Physician Belgium
Primary
Concomitant
Rash Pustular Hospitalization 4/10/2007 Male 146 lb 4/18/2008 United Kingdom
Primary
Concomitant
Lung Neoplasm Malignant Death Female 148 lb 4/23/2008 United Kingdom
Primary
Concomitant
Dyspnoea Other Serious 72 Male 198 lb 5/5/2008 Physician Germany
Primary
Concomitant
Hyperhidrosis 12/1/2007 61 Female 154 lb 5/19/2008 Other Health Professional United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 10/10/2007 Male 5/21/2008 Other Health Professional Spain
Primary
Secondary
Concomitant
Nausea Other Serious 1/1/2008 Female 199 lb 5/21/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 159 lb 5/23/2008 Physician United States
Primary
Secondary
Concomitant
Hyperhidrosis 12/1/2007 61 Female 154 lb 5/29/2008 Other Health Professional United States
Primary
Concomitant
Nausea Other Serious 1/1/2008 Female 199 lb 6/2/2008 Physician United States
Primary
Concomitant
Pulmonary Hypertension Hospitalization 10/1/2007 65 Female 6/2/2008 Physician Canada
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 5/29/2008 Belgium
Primary
Concomitant
Mental Impairment 2/16/2008 6/12/2008 United States
Primary
Concomitant
Rotator Cuff Syndrome 2/1/2007 Female 232 lb 6/12/2008 Physician United States
Primary
Concomitant
Visual Disturbance 1/1/2008 Male 190 lb 6/12/2008 Physician United States
Primary
Concomitant
Oedema Peripheral 3/9/2008 Female 139 lb 6/12/2008 Consumer United States
Primary
Concomitant
Fatigue 1/1/2008 Female 170 lb 6/12/2008 United States
Primary
Concomitant
Accidental Exposure 4/22/2008 Male 235 lb 6/13/2008 Consumer United States
Primary
Concomitant
Oedema Peripheral 4/28/2008 Female 6/13/2008 United States
Primary
Concomitant
Injection Site Urticaria 5/25/2008 Female 192 lb 6/13/2008 United States
Primary
Concomitant
Weight Decreased 6/1/2005 61 Female 222 lb 4/10/2008 Consumer United States
Primary
Concomitant
Somnolence 1/1/2008 71 Female 4/10/2008 Consumer United States
Primary
Concomitant
Thoracic Vertebral Fracture Hospitalization 1/3/2008 83 Female 6/24/2008 Belgium
Primary
Concomitant
Sinus Disorder 5/1/2008 56 Female 212 lb 6/30/2008 Consumer United States
Primary
Concomitant
Pneumonia Other Serious 12/1/2007 72 Female 7/9/2008 Physician Australia
Primary
Concomitant
Rhabdomyolysis Hospitalization 12/25/2006 70 183 lb 8/5/2008
Primary
Concomitant

Drug Data