Mesna combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Neurotoxicity Death 36 Female 1/4/2006 Consumer Japan
Primary
Secondary
Tongue Disorder Other Serious 12/5/2005 Male 216 lb 12/27/2005 United States
Primary
Secondary
Neurotoxicity Death 36 Female 1/5/2006 Physician Turkey
Primary
Secondary
Concomitant
Respiratory Failure Death 7/13/2005 57 Female 159 lb 1/13/2006 Physician Germany
Primary
Concomitant
Leukoencephalopathy Death 36 Female 1/26/2006 Consumer Japan
Primary
Secondary
Transplant Failure Hospitalization 11/21/2005 Male 176 lb 2/1/2006 Physician Germany
Primary
Concomitant
Swelling Death 36 Female 1/31/2006 Physician Turkey
Primary
Secondary
Swelling Death 36 Female 2/13/2006 Physician Turkey
Primary
Secondary
Therapy Non-responder Death 36 Female 2/14/2006 Physician Turkey
Primary
Secondary
Staphylococcal Infection Hospitalization 11/23/2005 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
T-cell Lymphoma Hospitalization 36 Female 3/17/2006 Physician Turkey
Primary
Secondary
Rash Generalised Hospitalization 1/13/2006 59 Female 3/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Stupor Death 36 Female 3/24/2006 Turkey
Primary
Secondary
Concomitant
Performance Status Decreased Other Serious 3/13/2006 Male 216 lb 3/29/2006 United States
Primary
Secondary
Stem Cell Transplant Hospitalization 1/13/2006 59 Female 4/18/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 4/18/2006 Physician United States
Primary
Secondary
Concomitant
Ventricular Hypertrophy Life Threatening 3/27/2006 Female 116 lb 5/3/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 3/20/2006 70 Female 117 lb 5/11/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/7/2006 70 Female 5/12/2006 United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 5/26/2006 Physician United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 3/27/2006 Female 116 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 36 Female 7/14/2006 Other Health Professional Turkey
Primary
Secondary
Weight Increased Hospitalization 6/11/2006 Male 198 lb 8/9/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 4/7/2006 Female 116 lb 8/10/2006 Physician United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 3/4/2006 Male 311 lb 8/11/2006 United States
Primary
Secondary
Weight Increased Hospitalization 6/11/2006 Male 198 lb 8/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 11/9/2005 Male 164 lb 10/5/2006 Physician Australia
Primary
Concomitant
Weight Increased Hospitalization 6/13/2006 74 Male 198 lb 11/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 10/11/2006 65 Male 196 lb 11/3/2006 Physician Australia
Primary
Secondary
Pancreatitis Acute Other Serious 10/11/2006 65 Male 196 lb 12/7/2006 Physician Australia
Primary
Secondary
Stomatitis Hospitalization 7/2/2006 Female 51 lb 11/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Oesophageal Candidiasis Hospitalization 12/23/2006 56 Female 1/8/2007 Physician France
Primary
Secondary
Concomitant
Sepsis Death 1/14/2007 Female 14 lb 1/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 1/10/2007 Physician Finland
Primary
Secondary
Concomitant
Purpura Hospitalization 12/23/2006 56 Female 104 lb 1/24/2007 Physician France
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 8/12/2006 50 Male 166 lb 2/9/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 8/12/2006 51 Male 166 lb 2/20/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Stomatitis Life Threatening 1/29/2007 68 Male 159 lb 3/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Stomatitis Life Threatening 1/29/2007 68 Male 3/22/2007 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2007 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 6/11/2006 Male 198 lb 4/18/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 4/19/2007 Male 198 lb 5/8/2007 United States
Primary
Secondary
Oesophageal Ulcer Hospitalization 12/21/2006 56 Female 104 lb 5/11/2007 Physician France
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 36 Female 5/25/2007 Physician Turkey
Primary
Secondary
Tachycardia Hospitalization 6/3/2007 Male 188 lb 6/8/2007 United States
Primary
Secondary
Wound Abscess Hospitalization 6/6/2007 Male 45 lb 6/21/2007 United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
Vith Nerve Paralysis Other Serious 10/22/2006 23 Male 172 lb 7/9/2007 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/18/2007 Female 141 lb 7/20/2007 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Vomiting Hospitalization 7/25/2007 Male 187 lb 7/30/2007 United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 3 Male 35 lb 8/28/2007
Primary
Secondary
Pancytopenia Hospitalization 12/21/2006 56 Female 104 lb 8/22/2007 Physician France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 12/23/2006 56 Female 104 lb 9/20/2007 Physician France
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 21 Female 8/16/2007 Physician United States
Primary
Secondary
Sepsis Neonatal Hospitalization Male 8/16/2007 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Death 54 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 61 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Death 79 9/27/2007 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Hospitalization 9/18/2007 Male 492 lb 10/2/2007 United States
Primary
Secondary
Wound Secretion Hospitalization 9/27/2007 Male 467 lb 10/8/2007 United States
Primary
Secondary
Hypersensitivity Other Serious 16 Female 11/20/2007 Other Health Professional Australia
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Vomiting Other Serious 11/11/2007 Male 289 lb 12/4/2007 United States
Primary
Secondary
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Peptic Ulcer Other Serious 12/23/2006 56 Female 104 lb 12/12/2007 Physician France
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 12/12/2007 Female 166 lb 1/2/2008 United States
Primary
Secondary
Tachycardia Hospitalization 12/21/2007 Male 289 lb 1/7/2008 United States
Primary
Secondary
Vomiting Other Serious 12/17/2007 69 Male 1/23/2008 Consumer United States
Primary
Secondary
Concomitant
Somnolence Death 12/19/2007 Male 176 lb 2/8/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Condition Aggravated Hospitalization 2/7/2008 Male 190 lb 2/12/2008 United States
Primary
Secondary
Treatment Noncompliance Hospitalization 2/19/2008 Male 187 lb 2/28/2008 United States
Primary
Secondary
Weight Increased Hospitalization 6/13/2006 74 Male 198 lb 3/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Petechiae Other Serious 7/23/2007 Female 179 lb 3/10/2008 Physician Germany
Primary
Concomitant
Generalised Erythema Other Serious 11/14/2007 Female 132 lb 3/10/2008 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 6/13/2006 74 Male 198 lb 3/6/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 10/16/2007 Female 3/21/2008 Other Health Professional France
Primary
Secondary
Concomitant
Thrombocytopenia 1/1/2006 31 Male 3/28/2008 Physician United States
Primary
Concomitant
Ventricular Fibrillation Death 1/1/2008 Male 4/10/2008 Other Health Professional France
Primary
Secondary
Concomitant
Weight Increased Other Serious 6/13/2006 74 Male 198 lb 4/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Hypocalcaemia Hospitalization 3/4/2008 Male 183 lb 5/8/2008 United States
Primary
Secondary
Neutropenic Sepsis Other Serious 4/16/2008 52 Male 157 lb 5/21/2008 Physician Malaysia
Primary
Concomitant
Ureteric Dilatation Other Serious 14 Male 5/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 14 Male 6/12/2008 Consumer United States
Primary
Secondary
Concomitant
Haematuria Other Serious 14 Male 6/12/2008 United Kingdom
Primary
Secondary
Concomitant
Haematuria Other Serious 1/1/2008 14 Male 6/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 5/1/2008 14 Male 143 lb 6/19/2008 Consumer United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/19/2008 Lawyer United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 6/23/2008 Lawyer United States
Primary
Secondary
Concomitant
Telangiectasia Other Serious 14 Male 6/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Muscle Disorder Disability 5/13/2006 Male 6/23/2008 Consumer Germany
Primary
Secondary
Concomitant
Nocturia Life Threatening 14 Male 6/16/2008 United Kingdom
Primary
Secondary
Concomitant
Haematuria Other Serious 14 Male 6/26/2008 United Kingdom
Primary
Concomitant
Sepsis Other Serious 63 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 39 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 28 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 57 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 33 Male 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Neurotoxicity Life Threatening 1/1/2007 37 Male 7/28/2008 Consumer United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 1/1/2007 37 Male 7/29/2008 India
Primary
Secondary
Concomitant
Malabsorption 7/28/2008 Male 125 lb 7/28/2008 United States
Primary
Secondary
Vasculitis Hospitalization 1/13/2006 59 Female 8/5/2008 France
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 7/22/2008 9 Male 76 lb 8/8/2008 Physician United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 8/15/2008 Other Health Professional Brazil
Primary
Concomitant
Haemoglobin Decreased Hospitalization 8/5/2008 Female 136 lb 8/18/2008 United States
Primary
Secondary
Wound Infection Bacterial Hospitalization 5/27/2007 Female 141 lb 6/20/2007 United States
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 1/1/2008 14 Male 143 lb 9/26/2008 Consumer United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 5 Male 10/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 12/19/2001 5 Male 10/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Death 10/13/2008 Physician United Kingdom
Primary
Secondary
Death Other Serious 10/13/2008 Physician United Kingdom
Primary
Secondary
Renal Failure Other Serious 10/13/2008 Physician United Kingdom
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 10/13/2008 Physician United Kingdom
Primary
Secondary
Neutropenic Sepsis Death 10/13/2008 Physician United Kingdom
Primary
Secondary
Pancreatitis Other Serious 10/13/2008 Physician United Kingdom
Primary
Secondary
Neurotoxicity Other Serious 10/13/2008 Physician United Kingdom
Primary
Secondary
Urine Leukocyte Esterase Positive Hospitalization 10/5/2008 Male 209 lb 10/9/2008 United States
Primary
Secondary
Liver Abscess Death 5/25/2008 1 Male 22 lb 10/10/2008 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 10/16/2008 Other Health Professional Brazil
Primary
Concomitant
Renal Failure Acute Hospitalization 10/2/2008 64 Female 10/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 43 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 11/1/2007 56 Male 10/7/2008 Physician United States
Primary
Concomitant
Renal Failure Acute Other Serious 12/1/2007 53 Male 10/7/2008 Physician United States
Primary
Concomitant
Staphylococcal Sepsis Other Serious 5 Male 10/28/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 10/28/2008 Physician United Kingdom
Primary
Secondary
Neutropenic Sepsis Death 10/28/2008 Physician United Kingdom
Primary
Secondary
Death Other Serious 10/29/2008 Physician United Kingdom
Primary
Secondary
Shock Haemorrhagic Life Threatening 5/25/2008 1 NotSpecified 22 lb 10/30/2008 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 166 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 5/25/2008 1 Male 22 lb 11/12/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 5/25/2008 1 Male 22 lb 11/17/2008 Physician Japan
Primary
Concomitant
Death Death 67 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 66 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Death Death 12/2/2008 Other Health Professional United Kingdom
Primary
Secondary
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Urine Leukocyte Esterase Positive Hospitalization 11/23/2008 Male 209 lb 1/8/2009 United States
Primary
Secondary
Pharyngeal Oedema Hospitalization 12/27/2008 Male 183 lb 12/30/2008 United States
Primary
Secondary
Sepsis Hospitalization 11/15/2008 Male 192 lb 2/9/2009 United States
Primary
Secondary
Clostridium Difficile Colitis 22 Female 2/19/2009 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 10/6/2008 Male 192 lb 2/11/2009 United States
Primary
Secondary
Pneumatosis Intestinalis Hospitalization 1/5/2009 1 Female 15 lb 3/30/2009 Consumer United States
Primary
Secondary
Concomitant

Drug Data