Meropenem combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Increased Other Serious 6/26/2004 Male 121 lb 2/17/2006 Physician United Kingdom
Primary
Concomitant
Transplant Rejection Other Serious 6/27/2005 1 Male 19 lb 3/17/2006 Japan
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 7/3/2003 35 Female 8/24/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Infection Other Serious 6/26/2004 Male 121 lb 9/18/2006 Physician United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 7/6/2006 77 Male 11/10/2006 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Hospitalisation Other Serious 1/19/2006 Female 179 lb 11/20/2006 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Other Serious 11/1/2005 Female 179 lb 12/12/2006 Other Health Professional United States
Primary
Concomitant
Polyserositis Other Serious 10/15/2006 Female 104 lb 4/6/2007 Physician Switzerland
Primary
Secondary
Concomitant
Nephritis Interstitial Other Serious 56 5/1/2007 Consumer Australia
Primary
Concomitant
Pancreatitis Acute Other Serious 11/1/2004 9 Male 6/29/2007 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 7/10/2007 Other Health Professional Sweden
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9 Male 8/3/2007 Other Health Professional Sweden
Primary
Concomitant
Toxic Epidermal Necrolysis Required Intervention 10 Male 9/17/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Vomiting Other Serious 8 Male 10/2/2007
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10 Male 11/8/2007 Sweden
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10 Male 12/14/2007 Sweden
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/21/2008 Female 267 lb 3/25/2008 Australia
Primary
Secondary
Concomitant
Protein Total Decreased Other Serious Male 176 lb 4/21/2008 Pharmacist Australia
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/21/2008 Female 267 lb 6/24/2008 Australia
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 9 Female 7/3/2008
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 8/13/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 8/15/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 8/15/2008 Other Health Professional Brazil
Primary
Concomitant
Ventricular Fibrillation Other Serious 8/1/2008 54 Female 170 lb 8/21/2008 Physician Germany
Primary
Secondary
Concomitant
Septic Shock Life Threatening 1/1/2007 53 Male 8/29/2008 Physician Poland
Primary
Concomitant
Transverse Sinus Thrombosis Hospitalization 8/28/2008 Male 197 lb 9/3/2008 United States
Primary
Secondary
Concomitant
Septic Shock Life Threatening 1/1/2007 53 Male 9/5/2008 Physician Poland
Primary
Concomitant
Ventricular Fibrillation Other Serious 8/1/2000 54 Female 170 lb 9/5/2008 Physician Germany
Primary
Secondary
Concomitant
Fungal Rhinitis Other Serious 41 Male 7/8/2008 Other Health Professional Italy
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 10/10/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 10/16/2008 Other Health Professional Brazil
Primary
Secondary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 10/16/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Acuity Reduced Other Serious 4/18/2008 Male 57 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Impairment Other Serious 4/21/2008 Male 36 lb 11/4/2008 Pharmacist Brazil
Primary
Concomitant
Vomiting Hospitalization 7/22/2007 Male 97 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vomiting Other Serious 5/19/2008 Male 52 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Weight Increased Other Serious 5/16/2008 Female 166 lb 11/5/2008 Other Health Professional Brazil
Primary
Concomitant
Drug Toxicity Other Serious 4 Female 11/21/2008
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/16/2008 Physician Spain
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 54 Male 1/30/2009 Other Health Professional Spain
Primary
Concomitant
Interacting
Thrombocytopenia Hospitalization 12/29/2008 3/24/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 12/29/2008 5/5/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 54 Male 5/11/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 54 Male 5/18/2009 Other Health Professional Spain
Primary
Secondary
Concomitant
Neutropenia Other Serious 3/9/2009 52 Male 165 lb 6/8/2009 Physician Spain
Primary
Secondary
Concomitant
Pneumonia Other Serious 3/9/2009 51 Male 6/16/2009 Other Health Professional Spain
Primary
Concomitant
Stomatitis Death 3/12/2008 Male 126 lb 7/31/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 12 Male 9/7/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 12 Male 9/18/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 12 Male 9/18/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 5 Male 9/23/2009
Primary
Secondary
Concomitant
Pancreatic Necrosis Hospitalization 12/1/2008 63 Female 11/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 11/12/2009 Female 15 lb 12/30/2009 United States
Primary
Secondary
Concomitant
Stem Cell Transplant Death 9/16/2009 24 Female 126 lb 12/31/2009 Physician Japan
Primary
Concomitant
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
Pneumonia Fungal Life Threatening 5/26/2009 20 Female 2/4/2010 Physician Italy
Primary
Secondary
Concomitant
Transfusion Death 8/3/2007 2/23/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/3/2007 Male 126 lb 2/24/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumonia Fungal Life Threatening 5/26/2009 20 Female 3/8/2010 Physician Italy
Primary
Secondary
Concomitant
Stomatitis Death 3/12/2008 Male 126 lb 3/9/2010 Physician Japan
Primary
Secondary
Concomitant
Visual Impairment Life Threatening 7/27/2009 54 Male 135 lb 3/5/2010 Physician Japan
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 3 Male 24 lb 5/31/2010 Physician Turkey
Primary
Concomitant
Lobar Pneumonia Death 4/6/2008 56 Male 6/3/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 3/13/2009 16 Male 108 lb 5/26/2010 Physician Japan
Primary
Secondary
Concomitant
Vaginal Lesion Hospitalization 4/14/2010 3 Female 43 lb 6/17/2010 United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/4/2010 3 Female 43 lb 6/21/2010 United States
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 4/14/2010 60 Male 110 lb 6/25/2010 Physician Japan
Primary
Concomitant
Pleural Effusion Disability 2/18/2009 10 Female 44 lb 6/28/2010 Physician Japan
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 6/28/2010 Physician Japan
Primary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 7/12/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 2/16/2009 23 Male 161 lb 7/20/2010 Other Health Professional Japan
Primary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 7/26/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 1/9/2009 58 Female 97 lb 7/28/2010 Physician Japan
Primary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 8/20/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 5/3/2010 2 Male 8/16/2010 Physician United States
Primary
Concomitant
Sicca Syndrome Other Serious 8/31/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 9/8/2010 Physician United States
Primary
Secondary
Concomitant
Sicca Syndrome Other Serious 7/1/2009 48 Male 9/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sicca Syndrome Other Serious 7/1/2009 48 Male 9/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 9/24/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Life Threatening 9/20/2010 32 Female 188 lb 10/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Lipase Increased Other Serious 8/3/2010 13 Female 99 lb 10/14/2010 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 7/22/2010 14 Female 97 lb 10/22/2010 Physician Japan
Primary
Concomitant
Pneumonia Life Threatening 9/20/2010 32 Female 188 lb 11/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Other Serious 9/20/2010 32 Female 188 lb 11/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 5/1/2010 48 Male 11/17/2010 Physician Sweden
Primary
Secondary
Concomitant
Thyroid Disorder Other Serious 7/17/2009 28 Male 110 lb 11/23/2010 Physician Japan
Primary
Concomitant
Venoocclusive Liver Disease Hospitalization 5/26/2010 Male 18 lb 11/24/2010 Physician Japan
Primary
Concomitant
Stem Cell Transplant Other Serious 3/13/2009 16 Male 108 lb 11/12/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Life Threatening 11/11/2007 12 Female 80 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 12/6/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Disorder Life Threatening 10/10/2009 12 Male 92 lb 12/6/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Other Serious 4/23/2009 7 Female 40 lb 12/13/2010 Physician Hungary
Primary
Secondary
Concomitant
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Life Threatening 10/16/2002 51 Male 154 lb 12/20/2010 Physician Japan
Primary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Multi-organ Failure Life Threatening 9/15/2001 32 Female 88 lb 12/28/2010 Physician Japan
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 4/23/2009 7 Female 40 lb 12/30/2010 Physician Hungary
Primary
Secondary
Concomitant
Stomatitis Other Serious 54 Male 12/15/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/8/2009 15 Male 157 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 9/13/2010 58 Male 121 lb 1/6/2011 Physician Japan
Primary
Secondary
Concomitant
Glossitis Hospitalization 9/13/2010 58 Male 121 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Other Serious 7/14/2010 39 Female 101 lb 1/10/2011 Other Health Professional Colombia
Primary
Secondary
Circulatory Collapse Life Threatening 9/15/2001 32 Female 88 lb 1/12/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Life Threatening 10/16/2002 51 Male 154 lb 1/12/2011 Physician Japan
Primary
Concomitant
Staphylococcal Infection Death 4/14/2010 60 Male 110 lb 1/20/2011 Physician Japan
Primary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2009 18 Male 137 lb 1/24/2011 Physician Japan
Primary
Concomitant
Pneumonia Life Threatening 4/22/2007 41 Male 132 lb 2/4/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 2/14/2008 17 Female 134 lb 2/9/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Death 7/18/2010 29 Female 82 lb 2/9/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Death 9/18/2010 56 Male 159 lb 2/14/2011 Physician Japan
Primary
Concomitant
Cardiac Failure Death 7/25/2010 60 Female 93 lb 2/14/2011 Physician Japan
Primary
Secondary
Concomitant
Emotional Distress Other Serious Male 216 lb 3/29/2011 Consumer United States
Primary
Concomitant
Nervousness Other Serious Male 216 lb 3/29/2011 Other Health Professional United States
Primary
Concomitant
Herpes Zoster Other Serious 9/9/2009 36 Female 125 lb 3/31/2011 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Skin Hospitalization 9/9/2009 36 Female 125 lb 4/7/2011 Physician Japan
Primary
Concomitant
Leukoencephalopathy Other Serious 8/4/2010 13 Female 99 lb 4/12/2011 Physician United States
Primary
Secondary
Concomitant
Renal Disorder Hospitalization 7/25/2010 60 Female 93 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Death 7/17/2010 29 Female 82 lb 4/20/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Death 1/26/2011 81 Female 129 lb 4/21/2011 Physician Japan
Primary
Concomitant
Drug Ineffective Other Serious 63 Female 4/21/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Death 63 Female 4/21/2011 Physician Japan
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Hospitalization 8/6/2006 63 Female 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/13/2010 58 Male 121 lb 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 9/1/2010 56 Male 159 lb 4/25/2011 Physician Japan
Primary
Concomitant
Nervousness Hospitalization 11/14/2007 45 Male 217 lb 4/27/2011 Other Health Professional United States
Primary
Concomitant
Renal Failure Hospitalization 4/21/2011 15 Male 5/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 4/22/2007 41 Male 132 lb 5/6/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Other Serious 4/1/2011 58 Female 106 lb 5/10/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Renal Disorder Life Threatening 7/25/2010 60 Female 93 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Death 8/31/2010 56 Male 159 lb 5/27/2011 Physician Japan
Primary
Concomitant
Tuberculosis Other Serious 4/14/2011 58 Female 106 lb 6/1/2011 Physician Korea, Republic Of
Primary
Concomitant
Hepatic Function Abnormal Death 8/31/2010 56 Male 159 lb 6/7/2011 Physician Japan
Primary
Concomitant
Abdominal Pain Hospitalization 10/21/2007 16 Male 99 lb 6/14/2011 Physician Japan
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 9/2/2010 2 Female 18 lb 6/21/2011 Physician Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease Hospitalization 5/25/2010 23 Female 73 lb 6/23/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Haemorrhage Other Serious 1/1/2007 63 Female 6/30/2011 Other Health Professional Japan
Primary
Concomitant
Venoocclusive Liver Disease Death 8/6/2010 56 Male 6/22/2011 Other Health Professional Japan
Primary
Concomitant
Acute Respiratory Distress Syndrome Life Threatening 11/11/2007 12 Female 80 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Bacterial Infection Life Threatening 11/8/2009 15 Male 157 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Arrhythmia Life Threatening 2/14/2008 17 Female 134 lb 7/5/2011 Physician Japan
Primary
Secondary
Concomitant
Pericardial Effusion Life Threatening 10/10/2009 12 Male 92 lb 7/5/2011 Physician Japan
Primary
Concomitant
Hypertension Life Threatening 4/22/2010 13 Male 90 lb 7/5/2011 Physician Japan
Primary
Concomitant
Blood Creatinine Increased Hospitalization 4/21/2011 15 Male 153 lb 7/7/2011 Physician United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Hospitalization 7/26/2010 58 Male 6/27/2011 Other Health Professional Japan
Primary
Concomitant
Anxiety Hospitalization 45 Male 217 lb 7/11/2011 Lawyer United States
Primary
Concomitant
Staphylococcal Infection 10/21/2009 7/12/2011 Physician Japan
Primary
Concomitant
Engraft Failure Other Serious 6/9/2010 10 Female 88 lb 7/15/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data