Mercaptopurine combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 12/26/2005 Female 169 lb 1/9/2006 United States
Primary
Secondary
Malaise Hospitalization 10/15/2005 4 Female 1/5/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pancreatitis Necrotising Hospitalization 9/30/2005 7 Female 53 lb 1/23/2006 United States
Primary
Concomitant
Refusal Of Treatment By Relative Other Serious 1/5/2006 Female 124 lb 1/19/2006 United States
Primary
Secondary
Speech Disorder Hospitalization 11/14/2005 20 Female 218 lb 1/26/2006 Pharmacist United Kingdom
Primary
Concomitant
Respiratory Disorder Other Serious 17 Male 2/2/2006 Other Health Professional Ireland
Primary
Secondary
Pseudobulbar Palsy Other Serious 17 Male 2/3/2006 Other Health Professional Ireland
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 2/4/2006 Male 163 lb 2/14/2006 United States
Primary
Secondary
Prothrombin Time Prolonged Hospitalization 8/1/2005 10 Male 67 lb 1/31/2006 Pharmacist United States
Primary
Concomitant
Visual Disturbance Hospitalization 10/15/2005 4 Female 2/14/2006 France
Primary
Secondary
Concomitant
Tongue Paralysis Life Threatening 17 Male 2/15/2006
Primary
Secondary
Pseudobulbar Palsy Other Serious 17 Male 3/1/2006 Physician Ireland
Primary
Concomitant
Pancreatitis Acute Hospitalization 4/4/1973 4 Male 1/20/2006 Physician United States
Primary
Concomitant
Urinary Incontinence Disability 18 Male 3/15/2006
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 48 Female 3/15/2006
Primary
Concomitant
Sepsis Other Serious 15 Male 3/17/2006 United States
Primary
Secondary
Concomitant
Polyuria Other Serious 13 Female 3/17/2006 United States
Primary
Concomitant
Prothrombin Time Shortened Other Serious 12/12/2005 35 Female 3/24/2006 Italy
Primary
Secondary
Sepsis Required Intervention 3/20/2006 Female 40 lb 3/23/2006 United States
Primary
Secondary
Rheumatoid Arthritis Other Serious 10/11/2004 135 lb 4/11/2006 Physician United States
Primary
Concomitant
Mastoiditis Hospitalization 12/12/2005 35 Female 4/7/2006 Italy
Primary
Secondary
Vomiting Other Serious 3/3/2006 Male 23 lb 4/12/2006 United States
Primary
Secondary
Prothrombin Time Shortened Other Serious 12/12/2005 35 Female 4/13/2006 Other Health Professional Italy
Primary
Secondary
Ventricular Extrasystoles Hospitalization 4/19/2006 5 Female 38 lb 5/1/2006 Physician United States
Primary
Secondary
Thrombocytopenic Purpura Other Serious 6 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Thrombocytopenic Purpura Other Serious 10 Female 5/5/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 3/1/1997 16 Male 5/1/2006 Physician Spain
Primary
Secondary
Ventricular Arrhythmia Hospitalization 4/17/2006 5 Female 38 lb 5/18/2006 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/8/2006 Female 122 lb 6/7/2006 United States
Primary
Secondary
Idiopathic Thrombocytopenic Purpura Other Serious 10 Female 6/3/2006 Physician Canada
Primary
Secondary
Sepsis Hospitalization 3/20/2006 Female 40 lb 6/12/2006 United States
Primary
Secondary
Staphylococcal Infection Hospitalization 5/9/2006 Female 171 lb 7/7/2006 United States
Primary
Secondary
Metastasis Other Serious 3 Male 7/25/2006 Physician Turkey
Primary
Secondary
Mucoepidermoid Carcinoma Other Serious 13 Female 7/25/2006 Physician Turkey
Primary
Secondary
Primitive Neuroectodermal Tumour Death 10 Male 7/25/2006 Physician Turkey
Primary
Secondary
Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Staphylococcal Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Enterobacter Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Bacterial Sepsis Death 7/26/2006 Physician United States
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 3 Male 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Death 10 Male 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 13 Female 8/3/2006 Consumer United States
Primary
Secondary
Treatment Related Secondary Malignancy Death 14 Male 8/3/2006 Consumer United States
Primary
Secondary
Blood Growth Hormone Decreased Other Serious 12 Female 8/4/2006 Other Health Professional United States
Primary
Secondary
Epiphyseal Disorder Other Serious 15 Male 8/4/2006 Other Health Professional United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 26 Female 8/16/2006 Physician United States
Primary
Secondary
Vomiting Hospitalization 8/14/2006 Female 180 lb 8/15/2006 United States
Primary
Secondary
Concomitant
Urticaria Generalised Hospitalization 8/25/2006 Female 33 lb 8/29/2006 United States
Primary
Secondary
Concomitant
Urinary Incontinence Required Intervention 16 Male 9/1/2006 Other Health Professional Spain
Primary
Concomitant
Urticaria Generalised Hospitalization 8/25/2006 Female 33 lb 9/1/2006 United States
Primary
Secondary
Vertigo Hospitalization 7/16/2006 57 Male 198 lb 9/5/2006 United Kingdom
Primary
Concomitant
Vomiting Hospitalization 8/14/2006 Female 180 lb 9/5/2006 United States
Primary
Secondary
Concomitant
Ocular Icterus Hospitalization 8/30/2006 Female 172 lb 8/31/2006 United States
Primary
Secondary
Weight Decreased Life Threatening 9/28/1999 57 Female 8/8/2006 Germany
Primary
Secondary
Concomitant
Urinary Incontinence Required Intervention 1/1/1997 16 Male 9/20/2006 Other Health Professional Spain
Primary
Concomitant
Vomiting 8/30/2006 Female 172 lb 9/20/2006 United States
Primary
Secondary
Tremor Hospitalization 3 Male 10/12/2006
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 67 Female 10/18/2006 Other Health Professional France
Primary
Secondary
Blood Bilirubin Increased Hospitalization 10/14/2006 Male 33 lb 10/20/2006 United States
Primary
Secondary
Concomitant
Skin Ulcer Hospitalization 67 Female 10/20/2006 Other Health Professional France
Primary
Secondary
Concomitant
Thrombophlebitis Other Serious 17 Male 11/6/2006 Physician Poland
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 8/30/2006 Female 172 lb 10/24/2006 United States
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Other Serious 10/25/2004 7 Male 11/13/2006
Primary
Secondary
Sepsis Hospitalization Female 87 lb 11/9/2006 United States
Primary
Secondary
Concomitant
Thrombosis 9/29/2006 Pharmacist United States
Primary
Concomitant
Gait Disturbance Hospitalization 11/20/2006 Male 121 lb 11/21/2006 United States
Primary
Secondary
Wheezing Hospitalization 12/1/2006 Male 38 lb 12/6/2006 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 10/18/2006 Female 87 lb 12/13/2006 United States
Primary
Secondary
Concomitant
Wheezing Hospitalization 12/1/2006 Male 38 lb 12/14/2006 United States
Primary
Secondary
Pancreatitis Other Serious 10/20/2006 17 Female 112 lb 12/18/2006 United Kingdom
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 7/4/2003 17 Female 10/7/2006 United States
Primary
Concomitant
Neurotoxicity Other Serious 13 Male 10/7/2006 United States
Primary
Concomitant
Hemiparesis Hospitalization 11/20/2006 Male 121 lb 12/29/2006 United States
Primary
Secondary
Hypokalaemia Other Serious 10/29/2005 38 Female 1/4/2007 Italy
Primary
Secondary
Concomitant
Hypokalaemia Other Serious 10/29/2005 38 Female 1/10/2007 Italy
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 52 Male 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 52 Male 1/18/2007 Physician Israel
Primary
Secondary
Concomitant
Jaundice Cholestatic 52 Male 1/26/2007 Israel
Primary
Secondary
Concomitant
Liver Disorder Other Serious 52 Male 2/7/2007 Israel
Primary
Secondary
Polyserositis Other Serious 10/15/2006 15 Female 104 lb 2/22/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Jaundice Cholestatic Other Serious 52 Male 2/23/2007
Primary
Secondary
Polyserositis Other Serious 10/15/2006 15 Female 104 lb 2/27/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Somnolence Other Serious 56 Female 3/2/2007
Primary
Secondary
Metastasis Death 11 Female 3/5/2007
Primary
Secondary
Metastasis Death 11 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Female 3/5/2007
Primary
Secondary
Metastasis Death 12 Male 3/5/2007
Primary
Secondary
Metastasis Death 19 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Male 3/5/2007
Primary
Secondary
Papilloedema Hospitalization 10/1/2003 23 Male 2/28/2007 Japan
Primary
Secondary
Glioma Other Serious 2 Female 3/8/2007 Consumer Finland
Primary
Secondary
Nervous System Disorder Death 11 Female 3/2/2007 Physician Germany
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/12/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/12/2007 Consumer Finland
Primary
Secondary
Treatment Related Secondary Malignancy Death 11 Male 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 19 Male 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 15 Male 3/1/2007 Germany
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 15 Female 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 11 Female 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 12 Male 3/1/2007 Germany
Primary
Secondary
Glioma Death 13 Female 3/1/2007 Germany
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 15 Male 3/16/2007 Germany
Primary
Secondary
Glioma Death 19 Male 3/16/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 15 Female 3/16/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 12 Male 3/16/2007 Germany
Primary
Secondary
Glioblastoma Multiforme Death 11 Female 3/16/2007 Germany
Primary
Secondary
Pancytopenia Death 3/10/2007 37 Female 165 lb 3/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Glioma Death 13 Female 3/20/2007 Germany
Primary
Secondary
Glioma Death 11 Male 3/20/2007 Germany
Primary
Secondary
Urticaria Other Serious 1/1/2005 56 Female 270 lb 3/31/2006 United States
Primary
Concomitant
Neoplasm Malignant Death 15 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 13 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 11 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 15 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 19 Male 3/30/2007 Germany
Primary
Secondary
Neoplasm Malignant Death 12 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Spinal Cord Disorder Other Serious 26 Female 4/4/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Polyserositis Other Serious 10/15/2006 Female 104 lb 4/6/2007 Physician Switzerland
Primary
Secondary
Concomitant
Influenza Hospitalization 3/26/2007 Female 86 lb 4/3/2007 United States
Primary
Secondary
Spinal Cord Disorder Other Serious 26 Female 4/10/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Sepsis Death 26 Female 4/11/2007
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 26 Female 4/11/2007 Australia
Primary
Secondary
Concomitant
Spinal Cord Disorder Hospitalization 26 Female 4/13/2007 Consumer United States
Primary
Secondary
Concomitant
Septic Shock Other Serious 10/15/2006 15 Female 104 lb 4/16/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Septic Shock Other Serious 10/15/2006 15 Female 104 lb 4/16/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 26 Female 4/6/2007 Other Health Professional Australia
Primary
Secondary
Reaction To Drug Excipients Other Serious 12/1/2006 7 Male 60 lb 4/11/2007 Pharmacist United States
Primary
Concomitant
Deep Vein Thrombosis Other Serious 1/12/2006 Female 160 lb 4/25/2007 United States
Primary
Secondary
Nephritis Interstitial Other Serious 56 5/1/2007 Consumer Australia
Primary
Concomitant
Vomiting Other Serious 8/25/2006 Female 139 lb 5/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Death 1/1/2000 Male 112 lb 5/7/2007 Other Health Professional Finland
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Other Serious 65 Female 5/25/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 19 Female 5/25/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Neurotoxicity Other Serious 22 Male 5/25/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious 22 Male 6/8/2007 Other Health Professional United States
Primary
Secondary
Peroneal Nerve Palsy Hospitalization 6/18/2005 15 Female 108 lb 6/8/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Malignant Melanoma In Situ Other Serious Male 6/7/2007 Physician United States
Primary
Secondary
Concomitant
Septic Shock Death Male 6/12/2007
Primary
Secondary
Malignant Melanoma In Situ Other Serious 22 Male 6/12/2007
Primary
Secondary
Malignant Melanoma In Situ Required Intervention 22 Male 6/8/2007 Physician United States
Primary
Secondary

Drug Data