Melphalan combined with Velcade

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Myopathy Steroid Death 1/5/2006 71 Male 2/2/2006 Pharmacist United States
Primary
Concomitant
Pneumonitis Other Serious 8/27/2004 Male 2/17/2006 Pharmacist United States
Primary
Concomitant
Swelling Other Serious 4/1/2006 83 Female 5/5/2006 United States
Primary
Concomitant
Abdominal Tenderness Life Threatening 4/15/2006 78 Male 160 lb 5/11/2006 Physician China
Primary
Concomitant
Multi-organ Failure Life Threatening 4/15/2006 78 Male 160 lb 5/18/2006 Physician China
Primary
Concomitant
Multi-organ Failure Life Threatening 4/15/2006 78 Male 160 lb 5/25/2006 Physician China
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 54 Female 123 lb 5/31/2006 Physician United States
Primary
Concomitant
Refusal Of Treatment By Patient Life Threatening 4/15/2006 78 Male 160 lb 6/15/2006 Physician China
Primary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 6/21/2006 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 2/1/2003 61 Male 6/22/2006 United States
Primary
Concomitant
Tooth Extraction Other Serious 2/1/2003 61 Male 6/30/2006 United States
Primary
Concomitant
Diarrhoea 4/21/2006 60 Male 200 lb 5/24/2006 Other Health Professional United States
Primary
Concomitant
Tooth Extraction Other Serious 2/1/2003 61 Male 7/25/2006 United States
Primary
Concomitant
Tooth Extraction Other Serious 5/1/2005 62 Male 152 lb 10/4/2006 Physician United States
Primary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 10/25/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/23/2006 52 Male 137 lb 10/20/2006 Physician Germany
Primary
Concomitant
Swelling Other Serious 4/1/2006 83 Female 11/21/2006 United States
Primary
Concomitant
Urethral Haemorrhage Other Serious 10/30/2006 Male 181 lb 12/4/2006 Physician Czech Republic
Primary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 130 lb 1/15/2007 Physician United States
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 2/19/2007 Physician Japan
Primary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 3/5/2007 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Other Serious 8/18/2006 68 Male 176 lb 3/7/2007 Physician United States
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 3/16/2007 Physician Japan
Primary
Concomitant
Osteonecrosis Other Serious 8/31/2006 80 Female 79 lb 4/19/2007 Pharmacist Germany
Primary
Concomitant
Tooth Loss Other Serious 8/31/2006 80 Female 79 lb 5/9/2007 Pharmacist Germany
Primary
Concomitant
Osteonecrosis Other Serious 8/31/2006 80 Female 79 lb 5/10/2007 Pharmacist Germany
Primary
Concomitant
Osteonecrosis Other Serious 8/31/2006 80 Female 79 lb 5/10/2007 Pharmacist Germany
Primary
Concomitant
Osteonecrosis Other Serious 68 Male 5/15/2007 Other Health Professional Spain
Primary
Concomitant
General Physical Health Deterioration Hospitalization 3/18/2007 66 5/3/2007 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 3/21/2007 61 Female 185 lb 5/15/2007 Other Health Professional United States
Primary
Concomitant
Cardiac Failure Hospitalization 6/20/2007 73 Male 7/3/2007 Physician Spain
Primary
Concomitant
Spondylolisthesis Hospitalization 6/15/2007 78 Female 119 lb 7/20/2007 Physician Spain
Primary
Secondary
West Nile Viral Infection Other Serious 8/18/2006 68 Male 176 lb 9/26/2007 Physician United States
Primary
Secondary
Concomitant
Sensory Loss Hospitalization 10/10/2007 84 Female 11/7/2007 Physician Italy
Primary
Secondary
Concomitant
Wound Decomposition Other Serious 9/1/2003 49 Male 130 lb 12/26/2007 Physician United States
Primary
Secondary
Concomitant
Pseudomonal Sepsis Death 1/1/2007 71 Female 1/22/2008 Other Health Professional France
Primary
Secondary
Pseudomonal Sepsis Other Serious 1/1/2007 71 Female 1/23/2008 Consumer United States
Primary
Secondary
Pulmonary Embolism Death 12/1/2007 45 Male 1/24/2008 Other Health Professional Colombia
Primary
Concomitant
Tooth Abscess Other Serious 1/1/2007 55 Male 2/6/2008 United States
Primary
Concomitant
Pseudomonal Sepsis Other Serious 1/1/2007 71 Female 2/19/2008 Consumer United States
Primary
Secondary
Stem Cell Transplant Hospitalization 2/7/2008 Male 2/14/2008 Physician United States
Primary
Concomitant
Syncope Hospitalization 1/27/2008 77 Male 2/22/2008 Physician Italy
Primary
Secondary
Concomitant
Tenderness Other Serious 1/1/2003 60 Male 4/2/2008 United States
Primary
Concomitant
Intestinal Ischaemia Other Serious 3/1/2008 4/10/2008 Physician United States
Primary
Concomitant
Unevaluable Event Hospitalization 6/23/2006 52 Male 137 lb 4/18/2008 Physician Germany
Primary
Concomitant
Osteonecrosis Other Serious 78 Male 4/25/2008 Other Health Professional United States
Primary
Concomitant
Thrombocytopenia Life Threatening 1/1/2007 61 Female 128 lb 4/18/2008 Other Health Professional France
Primary
Secondary
Concomitant
Skin Cancer Other Serious 2/25/2008 79 Female 4/22/2008 Physician United States
Primary
Concomitant
Leukaemia Hospitalization 2/6/2008 64 Male 198 lb 4/24/2008 Physician Israel
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2007 55 Male 5/21/2008 Physician United States
Primary
Concomitant
Syncope Hospitalization 1/27/2008 77 Male 5/22/2008 Physician Italy
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 1/1/2007 71 Female 7/29/2008 Consumer United States
Primary
Secondary
Pseudomonal Sepsis Other Serious 1/1/2007 71 Female 7/29/2008 Consumer United States
Primary
Secondary
Squamous Cell Carcinoma Other Serious 2/25/2008 79 Female 8/1/2008 Physician United States
Primary
Concomitant
Wound Decomposition Other Serious 9/1/2003 Male 130 lb 8/14/2008 Physician United States
Primary
Secondary
Concomitant
Sinus Tachycardia Required Intervention 7/19/2006 65 Female 1/22/2007 Physician United States
Primary
Secondary
Thrombocytopenia Other Serious 10/27/2008 Physician Greece
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 2/25/2008 79 Female 11/13/2008 Physician United States
Primary
Concomitant
Febrile Neutropenia Hospitalization 11/6/2008 74 Female 234 lb 11/24/2008 Physician United States
Primary
Secondary
Concomitant
Rash Hospitalization 11/5/2008 75 Male 191 lb 11/26/2008 Physician United States
Primary
Secondary
Vomiting Hospitalization 10/31/2008 69 Female 143 lb 11/26/2008 Physician United States
Primary
Secondary
Renal Failure Acute Hospitalization 6/16/2007 Male 187 lb 11/26/2008 Consumer United States
Primary
Secondary
Neuropathy Peripheral Hospitalization 8/28/2007 64 Male 12/4/2008 Consumer United States
Primary
Secondary
Concomitant
Sepsis Syndrome Hospitalization 8/28/2008 Male 12/11/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 51 Female 12/9/2008 Physician Kazakhstan
Primary
Concomitant
Vomiting Hospitalization 10/31/2008 69 Female 143 lb 12/15/2008 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/12/2008 79 Male 155 lb 12/19/2008 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/28/2007 64 Male 195 lb 12/22/2008 Physician United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 12/2/2008 83 Female 168 lb 12/30/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/30/2008 51 Female 12/22/2008 Physician Kazakhstan
Primary
Concomitant
Sepsis Syndrome Hospitalization 8/28/2008 Male 195 lb 12/31/2008 Consumer United States
Primary
Secondary
Concomitant
Infection Hospitalization 11/6/2008 74 Female 234 lb 1/6/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/31/2008 69 Female 143 lb 1/6/2009 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 5/23/2007 Male 223 lb 1/6/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/27/2007 64 Male 1/7/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/30/2008 51 Female 1/5/2009 Physician Kazakhstan
Primary
Concomitant
Sepsis Syndrome Hospitalization 8/28/2007 Male 195 lb 1/7/2009 Consumer United States
Primary
Secondary
Concomitant
Escherichia Urinary Tract Infection Hospitalization 11/6/2008 74 Female 234 lb 1/12/2009 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/3/2008 79 Female 157 lb 1/12/2009 Consumer United States
Primary
Secondary
Pyrexia Other Serious 8/28/2007 64 Male 195 lb 1/13/2009 Physician United States
Primary
Secondary
Concomitant
Vertebroplasty Other Serious 1/1/2003 Male 1/15/2009 Physician United States
Primary
Concomitant
Dehydration Hospitalization 12/17/2008 85 Male 196 lb 1/23/2009 Consumer United States
Primary
Secondary
Somnolence Other Serious 3/22/2008 78 Female 1/19/2009 Consumer Canada
Primary
Secondary
Concomitant
Rash Hospitalization 1/8/2009 42 Male 196 lb 1/27/2009 Physician United States
Primary
Secondary
Septic Shock Hospitalization 10/4/2008 41 Male 1/29/2009 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 8/20/2008 73 Male 2/2/2009 Physician United States
Primary
Secondary
Concomitant
Retrograde Amnesia Other Serious 10/5/2008 Male 2/6/2009 Pharmacist Germany
Primary
Secondary
Concomitant
Acute Myocardial Infarction Other Serious 1/1/2009 79 Male 2/18/2009 Consumer United States
Primary
Secondary
Respiratory Syncytial Virus Infection Hospitalization 1/13/2009 49 Female 178 lb 2/19/2009 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/1/2008 Male 2/23/2009 Physician United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 12/2/2008 83 Female 168 lb 3/6/2009 Consumer United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 11/20/2007 52 Male 3/9/2009 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/7/2008 38 Female 139 lb 3/9/2009 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/30/2008 38 Female 139 lb 3/9/2009 Physician United States
Primary
Secondary
Concomitant
Pulse Absent Death 5/22/2007 57 Male 212 lb 3/10/2009 Consumer United States
Primary
Secondary
Joint Swelling Hospitalization 1/6/2008 57 Female 107 lb 3/10/2009 Consumer United States
Primary
Secondary
Weight Increased Other Serious 7/6/2005 Male 3/18/2009 Physician United States
Primary
Concomitant
Soft Tissue Necrosis Other Serious Female 3/16/2009 Pharmacist Germany
Primary
Concomitant
Dyspnoea Hospitalization 2/27/2009 71 Male 153 lb 3/24/2009 Physician United States
Primary
Secondary
Concomitant
Scrotal Swelling Other Serious 3/4/2009 72 Male 227 lb 3/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Right Ventricular Dysfunction Other Serious 7/1/2008 77 Male 3/26/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Acute Myocardial Infarction Other Serious 1/1/2009 79 Male 191 lb 3/31/2009 Consumer United States
Primary
Secondary
Scrotal Swelling Other Serious 3/4/2009 72 Male 227 lb 4/3/2009 Physician United States
Primary
Secondary
Concomitant
Scrotal Swelling Other Serious 3/4/2009 72 Male 227 lb 4/13/2009 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/5/2009 79 Female 123 lb 4/14/2009 Physician United States
Primary
Secondary
Concomitant
Rash Pruritic Other Serious 3/28/2009 76 Female 4/17/2009 Consumer United States
Primary
Secondary
Concomitant
Testicular Swelling Other Serious 3/24/2009 85 Male 135 lb 4/20/2009 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/12/2008 79 Male 155 lb 4/23/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Haemorrhage Other Serious 4/24/2009 Italy
Primary
Secondary
Concomitant
Weight Increased Other Serious 7/6/2005 Male 4/24/2009 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 4/29/2009 Physician Korea, Republic Of
Primary
Secondary
Haemorrhage Other Serious 4/29/2009 Italy
Primary
Secondary
Weight Increased Other Serious 7/6/2005 Male 5/1/2009 Physician United States
Primary
Concomitant
Testicular Swelling Other Serious 3/24/2009 85 Male 135 lb 5/6/2009 Consumer United States
Primary
Secondary
Concomitant
Death Death 3/1/2009 5/6/2009 Other Health Professional Colombia
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2003 Male 5/11/2009 United States
Primary
Secondary
Concomitant
Tremor Hospitalization 2/7/2008 5/12/2009 Consumer United States
Primary
Secondary
Vomiting Other Serious 1/1/2003 Male 5/21/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 4/21/2009 85 Male 158 lb 5/22/2009 Physician United States
Primary
Secondary
Dermatomyositis Other Serious Female 6/1/2009 Consumer United Kingdom
Primary
Secondary
Urinary Retention Other Serious 1/26/2009 64 Male 121 lb 5/29/2009 Physician Japan
Primary
Secondary
Concomitant
Urinary Retention Other Serious 1/26/2009 64 Male 121 lb 6/2/2009 Physician Japan
Primary
Secondary
Concomitant
Neutropenia Hospitalization Male 6/23/2009 Consumer United States
Primary
Secondary
Urinary Retention Hospitalization 3/29/2009 79 Female 115 lb 7/13/2009 Physician Belgium
Primary
Concomitant
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/6/2009 Consumer United States
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Life Threatening 6/2/2009 Female 143 lb 8/10/2009 France
Primary
Secondary
Concomitant
Septic Shock Other Serious 6/12/2009 75 Male 9/7/2009 Physician Spain
Primary
Concomitant
No Therapeutic Response Hospitalization 9/2/2009 62 Male 196 lb 9/16/2009 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/23/2009 Male 172 lb 9/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Tumour Lysis Syndrome Other Serious 60 Male 9/18/2009 Japan
Primary
Concomitant
Chronic Graft Versus Host Disease Other Serious 55 Female 9/18/2009 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 9/18/2009 Physician Japan
Primary
Concomitant
Abdominal Pain Hospitalization 9/14/2009 65 Male 220 lb 10/5/2009 Physician United States
Primary
Secondary
Neuropathy Peripheral Life Threatening 80 Male 10/16/2009 Other Health Professional Israel
Primary
Concomitant
Thrombocytopenia Life Threatening 10/5/2009 69 Male 154 lb 10/15/2009 Physician Germany
Primary
Concomitant
Weight Decreased Other Serious 68 Male 128 lb 10/17/2009 Physician Spain
Primary
Concomitant
Death Death 80 Unknown 10/13/2009 Physician Brazil
Primary
Concomitant
Death Death 10/13/2009 Physician Brazil
Primary
Concomitant
Death Death 65 10/13/2009 Physician Brazil
Primary
Concomitant
Pyrexia Other Serious 61 Female 132 lb 10/19/2009 Physician France
Primary
Concomitant
Death Death 80 10/13/2009 Physician Brazil
Primary
Concomitant
Vomiting Hospitalization 9/22/2009 62 Male 192 lb 10/27/2009 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 10/5/2009 69 Male 154 lb 10/22/2009 Physician Germany
Primary
Concomitant
Pancytopenia Hospitalization 9/15/2009 80 Female 190 lb 11/2/2009 Physician Germany
Primary
Secondary
Weight Decreased Other Serious 68 Male 128 lb 10/29/2009 Physician Spain
Primary
Concomitant
Hypoxia Hospitalization 6/2/2008 43 Male 11/5/2009 Consumer United States
Primary
Secondary
Concomitant
Ureteric Obstruction Life Threatening 10/5/2009 69 Male 154 lb 10/31/2009 Physician Germany
Primary
Concomitant
Therapeutic Response Decreased Other Serious 7/19/2009 74 Female 11/11/2009 Other Health Professional China
Primary
Concomitant
Wound Drainage Other Serious 4/2/2002 Female 125 lb 11/25/2009 United States
Primary
Secondary
Concomitant
Hospitalisation Hospitalization 11/4/2009 Female 130 lb 11/25/2009 Physician Germany
Primary
Concomitant

Drug Data