Melphalan combined with Thiotepa

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Treatment Related Secondary Malignancy Other Serious 2/1/2004 1 Male 6/7/2006 Other Health Professional Japan
Primary
Secondary
Treatment Related Secondary Malignancy Other Serious 2/1/2004 5 Male 7/6/2006 Other Health Professional Japan
Primary
Secondary
Vomiting Hospitalization 8 Male 12/12/2006 Physician Sweden
Primary
Concomitant
Vomiting Other Serious 4/5/2007 Other Health Professional United States
Primary
Secondary
Venoocclusive Disease Life Threatening 7/12/2007 39 Male 8/2/2007 Physician United States
Primary
Secondary
Venoocclusive Disease Life Threatening 7/12/2007 39 Male 8/21/2007 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/12/2007 39 Male 12/6/2007 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 4 Male 12/28/2007 Consumer Japan
Primary
Secondary
Venoocclusive Liver Disease Death 4 Male 1/7/2008 Consumer Japan
Primary
Secondary
Venoocclusive Liver Disease Death 8/7/2006 4 Male 28 lb 1/29/2008 Physician Japan
Primary
Secondary
Concomitant
Serositis Death 1 3/6/2008 Consumer Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/11/2008 Consumer Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/11/2008 Consumer Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/11/2008 Consumer Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/11/2008 Consumer Japan
Primary
Concomitant
Serositis Death 1 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 15 3/24/2008 Physician Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Other Serious 6 3/24/2008 Physician Japan
Primary
Concomitant
Cystitis Haemorrhagic Other Serious 11 3/24/2008 Physician Japan
Primary
Concomitant
Venoocclusive Disease Other Serious 13 3/24/2008 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 14 3/24/2008 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 3/28/2008 Germany
Primary
Secondary
Respiratory Failure Other Serious 4/1/2008 United States
Primary
Secondary
Thyroid Cancer Other Serious 6 Female 4/11/2008 Other Health Professional Japan
Primary
Secondary
Thyroid Cancer Other Serious 6 Female 4/14/2008 Other Health Professional Japan
Primary
Secondary
Death Other Serious 4/17/2008 Germany
Primary
Secondary
Thrombotic Microangiopathy Other Serious 5/22/2008 Japan
Primary
Secondary
Concomitant
Thyroid Cancer Other Serious 3 Female 7/3/2008 Physician Japan
Primary
Secondary
Pyrexia Hospitalization 6/30/2008 45 Male 163 lb 7/16/2008 Physician Spain
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/30/2008 45 Male 163 lb 7/22/2008 Physician Spain
Primary
Secondary
Concomitant
Graft Versus Host Disease Hospitalization 8/9/2008 43 Male 8/28/2008 Physician Spain
Primary
Secondary
Concomitant
Fungal Infection Other Serious 9/10/2008 Other Health Professional Italy
Primary
Secondary
Stomatitis Other Serious 9/11/2008 Germany
Primary
Secondary
Sepsis Other Serious 17 Male 9/11/2008 Other Health Professional Germany
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 9/12/2008 Germany
Primary
Secondary
Stomatitis Other Serious 9/12/2008 Germany
Primary
Secondary
Stomatitis Other Serious 9/12/2008 Germany
Primary
Secondary
Infection Other Serious 44 Male 181 lb 9/15/2008 United States
Primary
Concomitant
Stomatitis Other Serious 9/15/2008 Germany
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 9/15/2008 Germany
Primary
Secondary
Rash Hospitalization 6/30/2008 45 Male 163 lb 9/17/2008 Physician Spain
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/1/2008 43 Male 10/8/2008 Other Health Professional Spain
Primary
Concomitant
Thrombocytopenia Hospitalization 9/9/2008 43 Male 10/30/2008 Other Health Professional Spain
Primary
Concomitant
Bone Sarcoma Other Serious 8 Male 12/1/2008 Consumer Japan
Primary
Secondary
Bone Sarcoma Other Serious 8 Male 12/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Haemoglobin Decreased Hospitalization 11/5/2008 63 Male 11/20/2008 Other Health Professional Spain
Primary
Concomitant
Surgical Procedure Repeated Other Serious 15 Male 11/27/2008 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 14 Male 11/27/2008 Physician United States
Primary
Secondary
Concomitant
Nervous System Disorder Other Serious 12 Female 11/27/2008 Physician United States
Primary
Secondary
Bone Sarcoma Other Serious 8 Male 12/2/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 11/5/2008 63 Male 12/4/2008 Other Health Professional Spain
Primary
Concomitant
Rash Papular Other Serious 17 Female 12/15/2008 Other Health Professional United States
Primary
Secondary
Neuropathy Peripheral Other Serious 15 Male 12/29/2008 Other Health Professional United States
Primary
Secondary
Neuropathy Peripheral Other Serious 12 Female 12/29/2008 Other Health Professional United States
Primary
Secondary
Bone Sarcoma Life Threatening 5/1/2007 7 Male 1/5/2009 Other Health Professional Japan
Primary
Secondary
Spinal Disorder Other Serious 12 Female 1/6/2009 Other Health Professional United States
Primary
Secondary
Basal Cell Carcinoma Other Serious 1/1/2004 4 Female 1/7/2009 Italy
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious 15 Male 1/5/2009 Other Health Professional United States
Primary
Secondary
Sudden Death Hospitalization 14 Male 1/5/2009 Other Health Professional United States
Primary
Secondary
Stem Cell Transplant Other Serious 12 Female 1/6/2009 Physician United States
Primary
Secondary
Myelitis Transverse Other Serious 14 Male 1/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Myelitis Transverse Other Serious 15 Male 1/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Spinal Disorder Other Serious 12 Female 1/9/2009 United States
Primary
Secondary
Spinal Cord Disorder Other Serious 12 Female 1/14/2009 Other Health Professional United States
Primary
Secondary
Neuropathy Peripheral Other Serious 12 Female 1/22/2009 United States
Primary
Secondary
Neuropathy Peripheral Other Serious 12 Female 1/28/2009 United States
Primary
Secondary
Staphylococcal Infection Other Serious 11/5/2008 63 Male 1/26/2009 Other Health Professional Spain
Primary
Concomitant
Death 6/18/2008 Germany
Primary
Secondary
Pneumonia Cytomegaloviral Death 3/5/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Other Serious 1/27/2009 59 Male 2/25/2009 Other Health Professional Spain
Primary
Concomitant
Somnolence Other Serious 15 Female 3/6/2009
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 1/1/2008 12 Female 3/6/2009 Other Health Professional United States
Primary
Secondary
Thrombocytopenia Other Serious 1/27/2009 60 Male 163 lb 3/18/2009 Physician Spain
Primary
Secondary
Concomitant
Neutropenia Other Serious 3/9/2009 3/24/2009 Physician Spain
Primary
Secondary
Staphylococcal Infection Other Serious 2/1/2009 59 Male 3/26/2009 Other Health Professional Spain
Primary
Concomitant
Gastric Cancer Other Serious 8/6/2008 52 Male 119 lb 4/6/2009 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/1/2009 United States
Primary
Secondary
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/15/2009 United States
Primary
Secondary
Tuberculosis Other Serious 12/1/2007 19 Male 7/3/2009 Other Health Professional Brazil
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/1/2007 19 Male 7/7/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Bone Sarcoma Other Serious 11 Male 7/27/2009 Other Health Professional Japan
Primary
Secondary
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 9/29/2009 United States
Primary
Secondary
Rash Other Serious 41 Female 10/23/2009 Other Health Professional Italy
Primary
Concomitant
Parotitis Other Serious 8 Female 12/15/2009 Physician Japan
Primary
Secondary
Neuropathy Peripheral Other Serious 14 Male 12/29/2009 Other Health Professional United States
Primary
Secondary
Stomatitis 8/13/2009 Germany
Primary
Secondary
Pleural Effusion Other Serious 8/18/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Life Threatening 8/1/2010 56 Male 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 8/23/2010 Other Health Professional United States
Primary
Secondary
Pulmonary Veno-occlusive Disease Other Serious 8/14/2009 2 Female 21 lb 8/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 8/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Disease Progression Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Disease Progression Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Disease Progression Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Acute Leukaemia Death 9/6/2010 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 10/21/2010 6 Female 12/8/2010 Physician United States
Primary
Concomitant
Bone Sarcoma Other Serious 9 Male 12/22/2010 Consumer Japan
Primary
Secondary
Bone Sarcoma Other Serious 11 Male 12/22/2010 Other Health Professional Japan
Primary
Secondary
Thrombosis Other Serious 11/16/2010 58 Female 12/29/2010 Physician United States
Primary
Secondary
Dyspnoea Other Serious 11/16/2010 58 Female 1/4/2011 Physician United States
Primary
Secondary
Disease Progression Death Male 2/4/2011 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Death 9/27/2010 9 Male 2/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Death 9/27/2010 9 Male 2/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death Male 2/8/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 2/8/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Disease Progression Death 2/10/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 2/10/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Multi-organ Failure Death 4/25/2010 43 Male 168 lb 2/23/2011 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Life Threatening 11/16/2010 58 Female 2/25/2011 Consumer United States
Primary
Secondary
Respiratory Failure Hospitalization 9/27/2010 9 Male 2/28/2011 Physician United States
Primary
Secondary
Concomitant
Pneumonitis Hospitalization 2/21/2011 3/14/2011 Physician United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 2/21/2011 7 Male 45 lb 3/25/2011 Consumer United States
Primary
Secondary
Neoplasm Malignant Death 3/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death Male 3/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 4/25/2010 Male 168 lb 4/1/2011 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 4/25/2010 43 Male 168 lb 4/1/2011 Physician United States
Primary
Secondary
Concomitant
Hypogammaglobulinaemia Other Serious 10 Female 4/10/2011 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 4/25/2010 56 Male 168 lb 4/12/2011 Consumer United States
Primary
Secondary
Multi-organ Failure Death 7/30/2010 56 Male 223 lb 4/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Neoplasm Progression Death 2/21/2011 7 Male 45 lb 5/5/2011 Consumer United States
Primary
Secondary
Transplant Failure Death 29 Female 2/24/2012 Physician Germany
Primary
Secondary
Concomitant
Sepsis Death 1/13/2012 7 Female 55 lb 6/14/2013 Physician Us
Primary
Secondary
Concomitant
Somnolence Other Serious 14 Male 6/20/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Death NotSpecified 10/10/2012 Other Health Professional Fr
Primary
Secondary
Pyrexia Hospitalization 12/15/2012 14 Female 82 lb 2/21/2013 Consumer Us
Primary
Secondary
Concomitant
Transplant Failure Life Threatening 1/22/2013 9 Male 123 lb 4/23/2013 Consumer Us
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 8 Male 4/5/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 7 Male 4/5/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious NotSpecified 4/22/2013 Physician It
Primary
Secondary
Concomitant
Renal Failure Hospitalization 4 Male 4/16/2013 Physician Us
Primary
Secondary
Concomitant
Renal Tubular Disorder Other Serious 8 Male 6/6/2013 Physician Jp
Primary
Secondary
Thrombotic Microangiopathy Death 10 Female 6/7/2013 Physician Us
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 2007 4 Male 6/6/2013 Physician Us
Primary
Secondary
Concomitant
Leukoencephalopathy Disability 14 Male 6/26/2013 Other Health Professional Us
Primary
Concomitant
Leukoencephalopathy Disability 16 Female 6/26/2013 Other Health Professional Us
Primary
Concomitant
Leukoencephalopathy Disability 16 Female 6/28/2013 Us
Primary
Concomitant
Myocarditis Hospitalization 8/4/2012 50 Male 9/23/2013 Other Health Professional Fr
Primary
Secondary
Hodgkin's Disease Hospitalization 2/12/2013 39 Male 119 lb 10/1/2013 Physician It
Primary
Concomitant
Rhabdomyolysis Other Serious 47 Female 10/9/2013 Physician It
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Male 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Male 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious Female 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Male 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Male 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Female 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Thrombocytopenia Death Female 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious Male 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant
Thrombocytopenia Death Female 10/10/2013 Other Health Professional Kr
Primary
Secondary
Concomitant

Drug Data