Melphalan combined with Mycophenolate Mofetil

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 3 Male 11/6/2006
Primary
Concomitant
Vomiting Other Serious 3 Male 1/9/2007 Consumer Australia
Primary
Secondary
Concomitant
Renal Impairment Other Serious 56 Female 2/22/2007 Consumer Finland
Primary
Secondary
Concomitant
Somnolence Other Serious 56 Female 2/23/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Somnolence Death 56 Female 2/16/2007 Germany
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 56 Female 2/20/2007 Germany
Primary
Secondary
Concomitant
Somnolence Other Serious 56 Female 3/2/2007
Primary
Secondary
Neurotoxicity Other Serious 56 Female 3/22/2007 United States
Primary
Concomitant
Interacting
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 39 Female 7/10/2007 Other Health Professional United States
Primary
Concomitant
Venoocclusive Disease Life Threatening 7/12/2007 39 Male 8/21/2007 Physician United States
Primary
Secondary
Concomitant
Viraemia Other Serious 12 Male 9/21/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Death 7/28/2007 65 Male 10/26/2007 Japan
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/12/2007 39 Male 12/6/2007 Physician United States
Primary
Secondary
Concomitant
Skin Papilloma Other Serious 53 Female 2/16/2008 Germany
Primary
Secondary
Concomitant
Renal Failure Other Serious 2/22/2008 Other Health Professional United States
Primary
Secondary
Renal Disorder Other Serious 2/29/2008 Other Health Professional United States
Primary
Secondary
Human Herpesvirus 6 Infection Other Serious 11 Female 4/16/2008 Physician Austria
Primary
Secondary
Malignant Melanoma Death 53 Male 4/30/2008 Germany
Primary
Secondary
Streptococcal Sepsis Other Serious 6/5/2008 Germany
Primary
Secondary
Concomitant
Streptococcal Sepsis Other Serious 6/9/2008 Germany
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 64 Female 6/13/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Infection Death 6/26/2008 Spain
Primary
Secondary
Concomitant
Retinal Haemorrhage Other Serious 26 Female 7/11/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 26 Female 7/22/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious Male 8/20/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious Male 8/22/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Human Herpesvirus 6 Infection Other Serious 7/9/2002 11 Female 9/2/2008 Other Health Professional Austria
Primary
Secondary
Concomitant
Sepsis Other Serious 45 Male 9/26/2008 Other Health Professional United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 6/1/2007 26 Female 11/18/2008 Other Health Professional Japan
Primary
Concomitant
Visual Acuity Reduced Other Serious 6/1/2007 26 Female 11/18/2008 Other Health Professional Japan
Primary
Concomitant
Splenectomy Hospitalization 7 Female 11/24/2008
Primary
Secondary
Concomitant
Respiratory Disorder Death 43 Female 12/2/2008 Japan
Primary
Concomitant
Renal Failure Other Serious 1/27/2009 59 Male 2/25/2009 Other Health Professional Spain
Primary
Concomitant
Immune System Disorder Other Serious 1/1/2008 43 Female 3/6/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening 9/1/2008 21 Male 146 lb 3/20/2009 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 2/1/2009 59 Male 3/26/2009 Other Health Professional Spain
Primary
Concomitant
Immune System Disorder Other Serious 1/1/2008 43 Female 101 lb 4/3/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Gastric Cancer Other Serious 8/6/2008 52 Male 119 lb 4/6/2009 Physician Japan
Primary
Concomitant
Immune System Disorder Other Serious 1/1/2008 43 Female 101 lb 4/8/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Immune System Disorder Death 1/15/2008 43 Female 101 lb 4/22/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 4/23/2009 Other Health Professional United States
Primary
Concomitant
Graft Versus Host Disease Other Serious 2 4/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 4/29/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 5/13/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Other Serious 4/5/2009 Male 183 lb 5/25/2009 Other Health Professional United States
Primary
Concomitant
Tuberculosis Other Serious 12/1/2007 19 Male 7/3/2009 Other Health Professional Brazil
Primary
Secondary
Concomitant
Tuberculosis Other Serious 12/1/2007 19 Male 7/7/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 8/7/2007 Male 181 lb 7/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 9/1/2006 52 Male 9/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 9/1/2006 52 Male 9/15/2009 United Kingdom
Primary
Secondary
Concomitant
Graft Versus Host Disease In Lung Other Serious 2/1/2006 45 Female 9/14/2009 United Kingdom
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/1/2006 60 Male 10/12/2009 Other Health Professional Italy
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 44 Female 10/20/2009 Other Health Professional Japan
Primary
Concomitant
Weight Increased Other Serious 44 Female 10/20/2009 Other Health Professional Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 58 Male 10/27/2009 Physician Japan
Primary
Concomitant
Weight Increased Other Serious 55 Female 11/9/2009 Other Health Professional Japan
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 31 Male 11/9/2009 Other Health Professional Japan
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious 42 Male 11/25/2009 Other Health Professional France
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 57 Male 11/25/2009 Other Health Professional France
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 51 Female 11/25/2009 Other Health Professional France
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 47 Female 11/27/2009 Other Health Professional France
Primary
Secondary
Concomitant
Weight Increased Other Serious 12/1/2008 55 Female 12/1/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 12/1/2008 31 Male 12/1/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 12/1/2008 31 Male 12/1/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 12/1/2008 55 Female 12/1/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 1/1/2008 31 Male 12/2/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 1/1/2008 31 Male 12/2/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 55 Female 12/2/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 44 Female 12/7/2009 Other Health Professional Japan
Primary
Concomitant
Weight Increased Other Serious 1/1/2008 55 Female 12/23/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 1/1/2008 31 Male 12/23/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 1/1/2008 31 Male 12/23/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Sinusitis Hospitalization 2/15/2010 Female 3/1/2010 Physician United States
Primary
Secondary
Staphylococcal Skin Infection Hospitalization 8 Male 7/28/2010 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Renal Failure Life Threatening 8/1/2010 56 Male 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Skin Infection Other Serious 9 Male 8/20/2010 Other Health Professional Netherlands
Primary
Concomitant
Pulmonary Veno-occlusive Disease Other Serious 8/14/2009 2 Female 21 lb 8/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 25 Female 12/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 18 Female 12/27/2010 Other Health Professional Japan
Primary
Concomitant
Pneumonia Fungal Death 1/4/2011 Physician United States
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Other Serious 19 Male 1/25/2011 Physician Germany
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 68 Male 1/27/2011 Physician Germany
Primary
Secondary
Concomitant
Peritonitis Other Serious 47 Male 1/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Pneumonia Respiratory Syncytial Viral Other Serious 42 Male 1/27/2011 Consumer Germany
Primary
Secondary
Concomitant
Adenovirus Infection Other Serious 19 Male 1/27/2011 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Respiratory Syncytial Viral Other Serious 42 Male 1/27/2011 Physician Germany
Primary
Secondary
Concomitant
Hepatic Failure Death 38 Female 1/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cerebral Toxoplasmosis Other Serious 68 Male 1/28/2011 Physician Germany
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious 66 Male 1/28/2011 Physician Germany
Primary
Secondary
Concomitant
Cerebral Toxoplasmosis Other Serious 66 Male 1/28/2011 Physician Germany
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 47 Male 2/1/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Renal Impairment Death 10/11/2007 Male 14 lb 2/4/2011 Pharmacist United States
Primary
Secondary
Concomitant
Candidiasis Other Serious 27 Male 2/7/2011 Physician France
Primary
Secondary
Concomitant
Renal Impairment Death 10/11/2007 Male 14 lb 2/7/2011 Pharmacist United States
Primary
Secondary
Concomitant
Infection Other Serious 2/7/2011 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 7/19/2010 32 Female 108 lb 2/18/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/3/2011 49 Female 2/21/2011 Consumer United States
Primary
Secondary
Concomitant
Multi-organ Failure Death 4/25/2010 43 Male 168 lb 2/23/2011 Physician United States
Primary
Secondary
Concomitant
Ileus Other Serious 3/1/2011 Physician United States
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 68 Female 3/22/2011 Physician Japan
Primary
Concomitant
Drug Ineffective Other Serious 56 Male 3/22/2011 Physician Japan
Primary
Concomitant
Infection Death 59 3/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Infection Death 19 3/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Infection Death 35 3/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Infection Death 35 3/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 3/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 3/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 3/29/2011 Physician United States
Primary
Secondary
Concomitant
Drug Resistance Other Serious 53 Male 3/30/2011 Consumer Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 4/25/2010 43 Male 168 lb 4/1/2011 Physician United States
Primary
Secondary
Concomitant
Aneurysm Death 60 4/4/2011 Physician United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 52 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Transplant Failure Other Serious 70 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Multi-organ Failure Death 7/30/2010 56 Male 223 lb 4/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 59 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 49 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Herpes Viral Other Serious 46 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Hospitalization 4/9/2011 42 Female 197 lb 4/28/2011 Consumer United States
Primary
Secondary
Concomitant
Abdominal Infection Other Serious 10/11/2011 57 Female 79 lb 1/23/2012 Physician Japan
Primary
Concomitant
Cerebral Toxoplasmosis Life Threatening 10/1/2010 59 Female 82 lb 2/21/2012 Physician Japan
Primary
Secondary
Concomitant
Transplant Failure Death 29 Female 2/24/2012 Physician Germany
Primary
Secondary
Concomitant
Pseudomonal Sepsis Other Serious 10/21/2009 23 Female 104 lb 4/15/2013 Physician Jp
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 34 Female 12/5/2013 Physician Jp
Primary
Concomitant
Staphylococcal Sepsis Other Serious 5/21/2011 6 Male 40 lb 6/3/2013 Physician Jp
Primary
Secondary
Concomitant
Viral Infection Other Serious 1 Female 8/31/2012 Other Health Professional Hk
Primary
Secondary
Concomitant
Renal Failure Other Serious 4/2/2011 10/9/2012 Physician De
Primary
Concomitant
Cytomegalovirus Infection Hospitalization 9/23/2012 47 Male 167 lb 11/26/2012 Other Health Professional Us
Primary
Secondary
Mucosal Inflammation Death 10/22/2012 Other Health Professional Ch
Primary
Secondary
Concomitant
Interacting
Mucosal Inflammation Other Serious 10/22/2012 Other Health Professional Ch
Primary
Secondary
Concomitant
Interacting
Mucosal Inflammation Death 10/22/2012 Other Health Professional Ch
Primary
Secondary
Concomitant
Interacting
Pseudomonas Infection Other Serious 10/24/2012 Other Health Professional Ch
Primary
Secondary
Concomitant
Interacting
Toxicity To Various Agents Other Serious 10/24/2012 Other Health Professional Ch
Primary
Secondary
Concomitant
Interacting
Renal Failure Death 65 Male 11/12/2012 Other Health Professional De
Primary
Concomitant
Liver Injury Other Serious 11/20/2012 Physician Country Not Specified
Primary
Secondary
Renal Failure Acute Other Serious 54 Female 1/25/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 5 Female 1/15/2013 Physician Jp
Primary
Concomitant
Drug Ineffective Other Serious 26 Female 3/15/2013 Physician Jp
Primary
Concomitant
Graft Versus Host Disease Other Serious 2012 66 Male 8/21/2013 Physician Jp
Primary
Concomitant
Drug Ineffective Other Serious 13 Female 3/18/2013 Physician Jp
Primary
Concomitant
Drug Ineffective Other Serious 64 Male 3/19/2013 Physician Jp
Primary
Concomitant
Idiopathic Pneumonia Syndrome Other Serious 1 Female 10/31/2012 Other Health Professional Cn
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Death 6 Male 3/29/2013 Other Health Professional Br
Primary
Secondary
Concomitant
Tinnitus Other Serious NotSpecified 7/8/2013 Consumer Us
Primary
Secondary
Transplant Failure Other Serious 2 Male 6/26/2013 Other Health Professional Br
Primary
Secondary
Concomitant
Vomiting Hospitalization 67 Male 6/28/2013 Us
Primary
Secondary
Respiratory Failure Hospitalization 3/29/2013 60 Female 199 lb 7/30/2013 Physician Us
Primary
Secondary
Concomitant
Haemoptysis Death 7/11/2013 68 Female 154 lb 11/5/2013 Physician Fr
Primary
Concomitant
Renal Failure Acute Other Serious 34 Male 9/10/2013 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 3 Female 3/28/2013 Other Health Professional Cn
Primary
Secondary
Concomitant
Nausea Death 57 Male 143 lb 11/15/2013 Other Health Professional Jp
Primary
Concomitant

Drug Data