Melphalan Hydrochloride combined with Vincristine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Malignant Neoplasm Progression Other Serious 8/1/2006 51 Male 7/6/2009 Other Health Professional United Kingdom
Primary
Secondary
Thrombosis Death 7/5/2009 Female 8/17/2009 Pharmacist United Kingdom
Primary
Concomitant
Wound Secretion Other Serious 1/1/1999 Female 192 lb 9/2/2009 Physician United States
Primary
Secondary
Concomitant
Capillary Leak Syndrome Death Unknown 12/14/2009 Italy
Primary
Secondary
Wound Secretion Other Serious 1/1/1999 Female 192 lb 1/15/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 7/30/2001 Female 115 lb 1/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Agranulocytosis Hospitalization 7/7/2009 Male 1/26/2010 Physician United Kingdom
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 5/1/2008 Male 172 lb 2/4/2010 Other Health Professional United States
Primary
Concomitant
Sepsis Other Serious Female 2/9/2010 Consumer Czech Republic
Primary
Concomitant
Wound Secretion Other Serious 1/1/1999 Female 192 lb 2/9/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/1/2000 Male 2/11/2010 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Male 245 lb 3/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/1/2000 Male 3/22/2010 Physician United States
Primary
Concomitant
Visual Impairment Other Serious 7/12/1999 Female 3/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 7/30/2001 Female 115 lb 3/24/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Male 245 lb 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/1999 Male 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 5/1/2000 Female 3/26/2010 Physician United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 Female 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Male 245 lb 3/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 10/22/2008 64 Male 4/5/2010 Other Health Professional United States
Primary
Concomitant
Weight Decreased Other Serious 3/14/1999 48 Male 4/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 4/9/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 61 Male 245 lb 4/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 4/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/1999 48 Male 4/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 5/1/2000 75 Female 4/16/2010 Physician United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 4/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 61 Male 245 lb 4/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 4/28/2010 United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 65 Male 5/5/2010
Primary
Secondary
Weight Decreased Other Serious 3/14/1999 48 Male 5/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 5/10/2010 United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 5/1/2000 75 Female 5/12/2010 Physician United States
Primary
Secondary
Concomitant
Pneumonia Death Unknown 5/10/2010 France
Primary
Secondary
Pneumonia Bacterial Death 5/10/2010 France
Primary
Secondary
Pancreatitis Death 5/10/2010 France
Primary
Secondary
Cerebral Haemorrhage Death 5/10/2010 Italy
Primary
Secondary
Vomiting Other Serious 1/1/2002 58 Female 115 lb 5/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 5/26/2010 United States
Primary
Secondary
Concomitant
Tongue Disorder Other Serious 53 Female 5/25/2010 Other Health Professional Brazil
Primary
Secondary
Visual Field Defect Other Serious 8/1/2001 63 Male 6/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2002 58 Female 115 lb 6/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2005 61 Male 245 lb 6/21/2010 United States
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 6/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/23/2010 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/25/2010 Physician United States
Primary
Secondary
Vomiting Other Serious 11/25/1998 43 Female 170 lb 6/25/2010 United States
Primary
Secondary
Concomitant
Tongue Disorder Other Serious 53 Female 6/25/2010 Consumer Brazil
Primary
Secondary
Myelodysplastic Syndrome Other Serious 57 Female 199 lb 6/29/2010 Consumer United States
Primary
Secondary
Vomiting Other Serious 11/25/1998 43 Female 170 lb 6/29/2010 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2005 61 Male 245 lb 6/29/2010 United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 4/28/2010 57 Female 199 lb 6/30/2010 Consumer United States
Primary
Secondary
Vomiting Other Serious 11/25/1998 43 Female 170 lb 7/5/2010 United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 7/5/2010 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 11/25/1998 43 Female 170 lb 7/7/2010 United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 7/8/2010 United States
Primary
Secondary
Concomitant
No Therapeutic Response Disability 64 Male 8/24/2010 United Kingdom
Primary
Concomitant
Sebaceous Carcinoma Other Serious 10/1/2009 46 Male 203 lb 9/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 11/25/1998 43 Female 170 lb 9/16/2010 United States
Primary
Secondary
Concomitant
Stress Cardiomyopathy Hospitalization 6/7/2007 67 Female 9/20/2010 Other Health Professional Japan
Primary
Secondary
Wound Drainage Other Serious 5/1/2000 75 Female 9/24/2010 United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/1/2010 50 Male 9/27/2010 Other Health Professional Netherlands
Primary
Secondary
Cerebrovascular Accident Other Serious 1/1/2010 65 Female 9/27/2010 Other Health Professional Netherlands
Primary
Secondary
Transient Ischaemic Attack Other Serious 1/1/2010 59 Male 9/27/2010 Other Health Professional Netherlands
Primary
Secondary
Weight Increased Other Serious 11/25/1998 43 Female 170 lb 9/27/2010 United States
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 1/1/1998 52 Female 9/29/2010 United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 7/12/1999 63 Female 9/29/2010 United States
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious 65 Female 9/24/2010 Netherlands
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 50 Male 9/24/2010 Netherlands
Primary
Secondary
Arterial Thrombosis Other Serious 63 Male 9/24/2010 Netherlands
Primary
Secondary
Myocardial Infarction Other Serious 59 Male 9/24/2010 Netherlands
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/14/1999 48 Male 9/30/2010 United States
Primary
Secondary
Concomitant
Liver Injury Other Serious 59 Female 10/4/2010 Consumer Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2002 58 Female 115 lb 10/4/2010 United States
Primary
Secondary
Concomitant
Venous Thrombosis Limb Other Serious 6/4/1999 46 Female 207 lb 10/5/2010 Physician United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 10/12/2003 73 Male 10/12/2010 United States
Primary
Secondary
Concomitant
Venous Thrombosis Limb Other Serious 6/4/1999 46 Female 207 lb 10/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2002 58 Female 115 lb 10/15/2010 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 11/25/1998 43 Female 170 lb 10/14/2010 United States
Primary
Secondary
Concomitant
Venous Thrombosis Limb Other Serious 6/4/1999 46 Female 207 lb 10/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/14/1999 48 Male 10/29/2010 United States
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 1/1/1998 52 Female 11/9/2010 United States
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 1/25/1998 52 Female 11/29/2010 United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 31 Female 11/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
X-ray Abnormal Other Serious 1/25/1998 52 Female 12/30/2010 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11 Male 1/27/2011 Other Health Professional Japan
Primary
Secondary
Febrile Neutropenia Other Serious 22 Male 2/28/2011 Other Health Professional Greece
Primary
Secondary
Concomitant
Pulmonary Oedema Death 59 Female 2/28/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious Male 3/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Dental Caries Death 1/1/2003 50 Female 207 lb 4/19/2011 United States
Primary
Secondary
Concomitant
Lymphopenia Death 10 Female 4/11/2011 Physician United States
Primary
Secondary
Concomitant
Full Blood Count Decreased Other Serious 9/5/2008 67 Male 5/9/2011 Other Health Professional United States
Primary
Secondary
Cholestasis Death 7/23/2009 60 Female 208 lb 5/9/2011 Physician United States
Primary
Secondary
Concomitant
Diabetic Ketoacidosis Other Serious 70 Female 5/11/2011 Other Health Professional Japan
Primary
Secondary
Death Other Serious 56 Female 5/11/2011 Other Health Professional United States
Primary
Secondary
Deep Vein Thrombosis Hospitalization 9/29/2010 65 Male 165 lb 5/11/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 64 Female 5/13/2011 Physician United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 6/4/2008 51 Female 5/16/2011 Other Health Professional United States
Primary
Secondary
Multiple Myeloma Other Serious 8/25/2010 56 Male 5/16/2011 Other Health Professional United States
Primary
Secondary
Acute Myeloid Leukaemia Other Serious 11/24/2010 43 Male 5/16/2011 Other Health Professional United States
Primary
Secondary
Premature Baby Other Serious 5/17/2011 Physician Netherlands
Primary
Secondary
Drug Exposure During Pregnancy Other Serious Female 5/17/2011 Physician Netherlands
Primary
Secondary
Erosive Oesophagitis Hospitalization 1/1/2003 50 Female 207 lb 5/18/2011 United States
Primary
Secondary
Concomitant
Syncope Hospitalization 5/3/2011 70 Female 5/20/2011 Physician United States
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 4/8/2011 51 Female 132 lb 5/20/2011 Consumer United Kingdom
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Hospitalization 7/1/2010 75 Male 159 lb 5/20/2011 Other Health Professional United States
Primary
Concomitant
Back Pain Other Serious 10/1/2010 68 Female 5/20/2011 Other Health Professional United Kingdom
Primary
Concomitant
Lung Disorder Hospitalization 3/1/2011 80 Male 165 lb 5/20/2011 Consumer United Kingdom
Primary
Concomitant
Liver Disorder Other Serious 70 Female 5/23/2011 Other Health Professional Japan
Primary
Secondary
Hypotension Hospitalization 1/1/2002 58 Female 115 lb 5/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 1 5/18/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 2 5/18/2011 Other Health Professional United States
Primary
Concomitant
Neoplasm Progression Other Serious 3 5/18/2011 Other Health Professional United States
Primary
Concomitant
Lividity Hospitalization 70 Female 6/2/2011 Other Health Professional Japan
Primary
Secondary
Pyrexia Hospitalization 68 Female 6/6/2011 Other Health Professional Spain
Primary
Secondary
Respiratory Tract Infection Other Serious Male 6/6/2011 Other Health Professional Spain
Primary
Secondary
Vitreous Haemorrhage Other Serious 5 5/27/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Disability 2 5/27/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 3 5/27/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Disability 2 5/27/2011 Physician United States
Primary
Concomitant
Retinal Exudates Other Serious Female 5/31/2011 Physician United States
Primary
Concomitant
Erythema Multiforme Hospitalization 70 Female 6/14/2011 Other Health Professional Japan
Primary
Secondary
Anaemia Other Serious 4/1/2008 54 Male 6/15/2011 Other Health Professional Spain
Primary
Secondary
Pyrexia Hospitalization 68 Female 6/15/2011 Physician Spain
Primary
Secondary
Alanine Aminotransferase Increased Hospitalization 1/1/2003 50 Female 207 lb 6/17/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 60 Male 6/20/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Type 1 Diabetes Mellitus Hospitalization 1/1/2010 70 Female 6/21/2011 Other Health Professional Japan
Primary
Secondary
Skin Haemorrhage Other Serious 1/4/2001 64 Female 6/22/2011 Consumer United States
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 68 Male 6/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 68 Male 6/27/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Other Serious 70 Female 6/30/2011 Other Health Professional Japan
Primary
Secondary
Nasal Discomfort Other Serious 1/1/2005 60 Male 6/30/2011 Lawyer United States
Primary
Concomitant
Intervertebral Disc Degeneration Other Serious 3/14/1999 48 Male 7/7/2011 Lawyer United States
Primary
Secondary
Concomitant
Metabolic Acidosis Other Serious 70 Female 6/27/2011 Other Health Professional Japan
Primary
Secondary
Toxicity To Various Agents Death 7/18/2011 Physician Denmark
Primary
Secondary
Toxicity To Various Agents Death 7/18/2011 Physician Denmark
Primary
Secondary
Wound Infection Hospitalization 1/1/2003 50 Female 207 lb 7/26/2011 United States
Primary
Secondary
Concomitant
Hodgkin's Disease Recurrent Other Serious Male 7/20/2011 Other Health Professional Italy
Primary
Secondary
Blood Lactate Dehydrogenase Increased Hospitalization 5/9/1997 37 Female 193 lb 7/29/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Proteinuria Other Serious Male 132 lb 7/29/2011 Lawyer United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious Female 8/3/2011 Physician Japan
Primary
Secondary
Concomitant
Osteopenia Hospitalization Male 132 lb 8/8/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cardiomyopathy Hospitalization 1/1/2002 58 Female 115 lb 8/10/2011 Lawyer United States
Primary
Secondary
Concomitant
Disease Progression Hospitalization 2/10/2009 57 Female 4/16/2011 Other Health Professional Japan
Primary
Concomitant
Os Trigonum Syndrome Other Serious 5/9/1997 37 Female 193 lb 8/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant

Drug Data