Melphalan Hydrochloride combined with Velcade

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Distress Other Serious 7/4/2007 65 Female 101 lb 6/29/2009 Physician United States
Primary
Secondary
Thrombotic Thrombocytopenic Purpura Death 5/25/2009 57 Male 219 lb 7/12/2009 Physician United States
Primary
Secondary
Thrombocytopenia Hospitalization 7/10/2009 80 Female 148 lb 7/21/2009 Physician United States
Primary
Secondary
Depression Hospitalization 6/26/2009 74 Female 176 lb 7/28/2009 Physician Germany
Primary
Secondary
Pancreas Lipomatosis Hospitalization 7/17/2009 64 Female 137 lb 7/30/2009 Physician Taiwan, Province Of China
Primary
Secondary
Tumour Lysis Syndrome Other Serious 11/4/2007 56 Male 155 lb 7/31/2009 Physician United States
Primary
Secondary
Concomitant
Stem Cell Transplant Life Threatening 6/2/2009 61 Female 132 lb 8/3/2009 Physician France
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/28/2009 78 Female 172 lb 8/3/2009 Physician Italy
Primary
Secondary
Vomiting Hospitalization 7/17/2009 64 Female 137 lb 8/5/2009 Physician Taiwan, Province Of China
Primary
Secondary
Tumour Lysis Syndrome Other Serious 1/26/2009 64 Male 121 lb 8/6/2009 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 5/12/2009 75 Female 8/6/2009 Physician Spain
Primary
Concomitant
Pyrexia Other Serious 5/23/2009 73 Male 170 lb 8/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Thrombocytopenia Hospitalization 7/10/2009 80 Female 148 lb 8/4/2009 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/17/2009 Consumer United States
Primary
Secondary
Concomitant
Stem Cell Transplant Life Threatening 6/2/2009 61 Female 143 lb 8/12/2009 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/18/2009 Consumer United States
Primary
Secondary
Concomitant
Weight Bearing Difficulty Hospitalization 8/3/2009 79 Male 151 lb 8/11/2009 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/25/2009 Consumer United States
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 5/12/2007 Male 223 lb 8/28/2009 Consumer United States
Primary
Secondary
Concomitant
Acute Febrile Neutrophilic Dermatosis Other Serious 7/24/2009 65 Male 203 lb 8/28/2009 Physician Spain
Primary
Secondary
Concomitant
Optic Neuropathy Other Serious 4/30/2009 83 Male 153 lb 9/8/2009 Consumer United States
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Life Threatening 9/5/2009 52 Female 137 lb 9/22/2009 Physician Thailand
Primary
Secondary
Transient Ischaemic Attack Hospitalization 8/3/2009 79 Male 151 lb 9/23/2009 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/7/2008 69 Female 142 lb 9/30/2009 Physician United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 9/13/2009 72 Female 10/12/2009 Physician Japan
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Life Threatening 9/5/2009 52 Female 137 lb 10/27/2009 Physician Thailand
Primary
Secondary
Ultrasound Kidney Abnormal Other Serious 10/8/2009 50 Female 164 lb 10/29/2009 Physician United States
Primary
Secondary
Nausea Hospitalization 10/5/2009 81 Female 144 lb 11/2/2009 Physician United States
Primary
Secondary
Concomitant
Renal Atrophy Other Serious 10/8/2009 50 Female 164 lb 11/8/2009 Physician United States
Primary
Secondary
Stem Cell Transplant Life Threatening 10/29/2009 65 Female 146 lb 11/13/2009 Physician Finland
Primary
Secondary
Viral Infection Hospitalization 11/5/2009 50 Female 163 lb 11/17/2009 Physician United States
Primary
Secondary
Tooth Extraction Other Serious 1/14/2004 Male 1/12/2010 Physician United States
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 12/13/2009 1/13/2010 Physician Taiwan, Province Of China
Primary
Secondary
Wound Drainage Other Serious 4/2/2002 Female 125 lb 1/13/2010 United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/1/2002 Male 1/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Ureteric Obstruction Other Serious 10/4/2009 69 Male 154 lb 1/14/2010 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 7/6/2005 Male 1/21/2010 Physician United States
Primary
Concomitant
Tooth Loss Other Serious 11/1/2005 Female 1/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Pneumococcal Hospitalization 12/13/2009 1/25/2010 Physician Taiwan, Province Of China
Primary
Secondary
Vasculitis Other Serious 11/1/2009 1/26/2010 Physician France
Primary
Concomitant
Bronchopulmonary Aspergillosis Life Threatening 6/2/2009 Female 143 lb 1/26/2010 France
Primary
Secondary
Concomitant
Productive Cough Hospitalization 8/9/2009 61 Male 190 lb 1/26/2010 Physician United States
Primary
Secondary
Concomitant
Cellulitis Hospitalization 11/18/2009 Female 234 lb 1/27/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/25/2009 1/28/2010 Physician Italy
Primary
Concomitant
Pleurisy Other Serious 1/28/2010 Physician France
Primary
Concomitant
Pneumonia Pneumococcal Hospitalization 12/13/2009 1/29/2010 Physician Taiwan, Province Of China
Primary
Secondary
Pleural Effusion Hospitalization 1/29/2010 Physician Japan
Primary
Concomitant
Acute Respiratory Failure Death 11/26/2009 1/29/2010 Physician Spain
Primary
Secondary
Concomitant
Erythema Hospitalization 11/18/2009 69 Female 234 lb 2/3/2010 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Death 2/4/2010 Physician Australia
Primary
Concomitant
Bronchopulmonary Aspergillosis Life Threatening 6/2/2009 61 Female 143 lb 1/27/2010 Physician France
Primary
Secondary
Concomitant
Arrhythmia Death 12/10/2009 Male 182 lb 2/5/2010 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Life Threatening 10/29/2009 2/8/2010 Physician Finland
Primary
Secondary
Tachycardia Hospitalization 10/5/2009 81 Female 144 lb 1/28/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 4/15/2005 Male 195 lb 2/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Pneumococcal Hospitalization 12/13/2009 2/11/2010 Physician Taiwan, Province Of China
Primary
Secondary
Thrombosis Hospitalization 12/22/2009 2/12/2010 Physician France
Primary
Secondary
Concomitant
Tooth Loss Other Serious 1/1/2000 Female 140 lb 2/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2003 Male 161 lb 2/12/2010 Physician United States
Primary
Secondary
Concomitant
Pulmonary Embolism Death 2/12/2010 Physician Italy
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Male 245 lb 2/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 6/22/2005 Female 181 lb 2/15/2010 United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2002 Female 195 lb 2/16/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 2/16/2010 Physician Spain
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 7/19/2009 74 Female 2/10/2010 Other Health Professional China
Primary
Concomitant
Weight Decreased Other Serious 4/15/2005 Male 209 lb 2/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization Female 2/24/2010 Consumer United States
Primary
Secondary
White Blood Cell Count Decreased 4/21/2009 77 Male 2/24/2010 Physician United States
Primary
Secondary
Swelling Other Serious 1/1/2007 3/12/2010 Physician United States
Primary
Secondary
Concomitant
Febrile Infection Hospitalization 1/21/2010 3/12/2010 Physician Germany
Primary
Concomitant
Dyspnoea Hospitalization 2/4/2010 63 Female 123 lb 3/12/2010 Consumer United States
Primary
Secondary
Concomitant
Upper Limb Fracture Other Serious 1/27/2004 Male 3/12/2010 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Male 245 lb 3/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 7/1/2007 Female 125 lb 3/17/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/23/2001 Male 161 lb 3/17/2010 Physician United States
Primary
Secondary
Concomitant
H1n1 Influenza Life Threatening 10/29/2009 3/17/2010 Physician Finland
Primary
Secondary
Transaminases Increased Other Serious 5/1/2009 3/18/2010 Physician Spain
Primary
Secondary
Concomitant
Ulcer Other Serious 1/1/2002 Male 3/18/2010 Other Health Professional United States
Primary
Concomitant
Septic Shock Life Threatening 6/17/2007 Male 3/18/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Death 12/22/2006 3/19/2010 Physician Italy
Primary
Secondary
Concomitant
Tachyarrhythmia Life Threatening 10/2/2009 Male 139 lb 3/23/2010 Physician France
Primary
Secondary
Concomitant
Swelling Other Serious 1/1/2007 3/24/2010 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 6/22/2005 Female 181 lb 3/24/2010 United States
Primary
Concomitant
Thrombocytopenia Other Serious 12/12/2009 3/25/2010 Other Health Professional France
Primary
Concomitant
Pulmonary Embolism Death 12/22/2006 Female 3/25/2010 Consumer Italy
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2002 Female 195 lb 3/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Male 245 lb 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/23/2001 Male 161 lb 3/26/2010 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 4/15/2005 Male 209 lb 3/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 1/1/2005 Male 245 lb 3/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 45 Female 3/29/2010 Physician United States
Primary
Secondary
Sepsis Other Serious 12/1/2007 Female 3/30/2010 Physician Italy
Primary
Secondary
Wound Treatment Other Serious 1/1/2000 Female 140 lb 3/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 7/1/2007 Female 125 lb 3/30/2010 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2002 Female 195 lb 3/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Swelling Other Serious 1/1/2007 3/31/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/1/2002 Male 4/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Upper Limb Fracture Other Serious 1/27/2004 72 Male 4/1/2010 Physician United States
Primary
Concomitant
Hepatitis B Hospitalization 3/10/2010 4/1/2010 Physician Spain
Primary
Secondary
Weight Increased Other Serious 1/1/2002 56 Female 195 lb 4/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/1/2001 50 Female 4/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sinus Tachycardia Hospitalization 3/18/2010 56 Male 4/7/2010 Physician United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 4/7/2010 Consumer United States
Primary
Secondary
Weight Decreased Other Serious 1/23/2001 44 Male 161 lb 4/8/2010 Physician United States
Primary
Secondary
Concomitant
Hypophosphataemia Other Serious 3/11/2010 61 Male 4/7/2010 Physician United States
Primary
Secondary
Visual Field Defect Other Serious 8/1/2001 63 Male 4/9/2010 Physician United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 6/22/2005 80 Female 181 lb 4/9/2010 United States
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2005 61 Male 245 lb 4/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Syncope Other Serious 3/17/2010 54 Female 165 lb 4/14/2010 Physician United States
Primary
Secondary
Concomitant
Multiple Myeloma Death 1/1/2010 60 Female 4/15/2010 Other Health Professional Israel
Primary
Concomitant
Respiratory Failure Hospitalization 4/1/2010 Female 4/15/2010 Consumer United States
Primary
Secondary
Weight Decreased Other Serious 11/1/2001 50 Female 4/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Abscess Other Serious 1/1/2007 4/20/2010 Physician United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 75 Male 4/15/2010 Other Health Professional United States
Primary
Secondary
Thrombosis Hospitalization 12/28/2009 48 Male 231 lb 4/21/2010 Physician France
Primary
Secondary
Concomitant
Syncope Other Serious 3/17/2010 54 Female 165 lb 4/19/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 2/1/2010 59 Female 150 lb 4/23/2010 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious 1/1/2005 61 Male 245 lb 4/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombosis In Device Hospitalization 12/22/2009 4/26/2010 Physician France
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 4/28/2010 United States
Primary
Secondary
Concomitant
Hepatic Cirrhosis Hospitalization 3/18/2010 4/29/2010 Physician Germany
Primary
Secondary
Gastric Cancer Other Serious 4/20/2010 4/29/2010 Physician Japan
Primary
Secondary
Concomitant
Wound Drainage Other Serious 7/1/2007 52 Female 125 lb 4/29/2010 United States
Primary
Secondary
Concomitant
Syncope Other Serious 3/17/2010 54 Female 165 lb 5/4/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/1/2002 Male 5/4/2010 United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 4/15/2005 50 Male 209 lb 5/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Eruption Hospitalization 2/20/2010 5/6/2010 Physician Japan
Primary
Secondary
Concomitant
Hypophosphataemia Other Serious 3/11/2010 61 Male 5/6/2010 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 4/1/2010 76 Female 5/6/2010 Consumer United States
Primary
Secondary
Respiratory Failure Hospitalization 12/2/2009 5/10/2010 Other Health Professional Italy
Primary
Concomitant
Renal Failure Acute Hospitalization 4/23/2010 5/10/2010 Physician Spain
Primary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 5/10/2010 United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 5/10/2010 Physician Poland
Primary
Secondary
Varices Oesophageal Other Serious 7/1/2002 59 Female 142 lb 5/12/2010 United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2002 56 Female 195 lb 5/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/22/2010 55 Female 185 lb 5/19/2010 Physician United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Hospitalization 5/10/2010 5/20/2010 Physician Spain
Primary
Secondary
Pancytopenia Hospitalization 4/14/2010 69 Male 324 lb 5/25/2010 Other Health Professional United States
Primary
Concomitant
Gastric Cancer Other Serious 4/20/2010 5/21/2010 Physician Japan
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 8/1/2001 63 Male 5/26/2010 United States
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 7/23/2009 5/27/2010 Physician Germany
Primary
Secondary
Wound Drainage Other Serious 7/1/2007 52 Female 125 lb 5/28/2010 United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 4/1/2010 70 Female 6/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Graft Versus Host Disease Hospitalization 5/10/2010 5/31/2010 Physician Spain
Primary
Secondary
Septic Shock Life Threatening 5/27/2010 6/1/2010 Physician Taiwan, Province Of China
Primary
Secondary
Visual Field Defect Other Serious 8/1/2001 63 Male 6/7/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 6/8/2010 Physician Belgium
Primary
Concomitant
Thrombocytopenia Life Threatening 10/4/2009 69 Male 150 lb 6/2/2010 Physician Germany
Primary
Concomitant
Thrombocytopenia Hospitalization 4/14/2010 68 Male 325 lb 6/11/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/22/2010 63 Female 123 lb 6/11/2010 Physician United States
Primary
Secondary
Concomitant

Drug Data