Melatonin combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Rhabdomyolysis Other Serious 9/14/2006 51 Male 272 lb 3/6/2007 Pharmacist United States
Primary
Secondary
Concomitant
Muscle Spasms 1/1/2008 74 Female 117 lb 3/6/2008 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 Female 161 lb 5/27/2008
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 62 Female 161 lb 6/5/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 Female 172 lb 6/10/2008
Primary
Secondary
Concomitant
Pain 1/1/2008 Female 118 lb 6/12/2008 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 5/9/2008 62 Female 172 lb 6/26/2008 Consumer United States
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 9/27/2008 Female 154 lb 10/1/2008 Physician Germany
Primary
Secondary
Wound Dehiscence Other Serious 1/1/2002 2/14/2009 Physician United States
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 1/1/2002 5/20/2009 Physician United States
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 5/1/2009 67 Male 7/1/2009 Physician United Kingdom
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 5/6/2009 67 Male 7/1/2009 Other Health Professional United Kingdom
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 5/1/2009 67 Male 7/10/2009
Primary
Secondary
Concomitant
Blood Glucose Increased 5/15/2009 Male 247 lb 8/22/2009 United States
Primary
Concomitant
Skin Burning Sensation 7/14/2009 Male 8/29/2009 United States
Primary
Secondary
Concomitant
Urinary Retention Other Serious 5/30/2009 Male 9/19/2009 Consumer
Primary
Concomitant
Death Death Male 171 lb 1/19/2010 Consumer United States
Primary
Concomitant
Restless Legs Syndrome Other Serious 1/1/2010 Male 174 lb 3/25/2010 Consumer United States
Primary
Concomitant
Memory Impairment Other Serious Female 4/2/2010 Consumer United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 11/1/2009 62 Female 6/28/2010 Consumer United States
Primary
Concomitant
Tremor Hospitalization 6/1/2010 62 Male 170 lb 8/4/2010 Consumer United States
Primary
Concomitant
Tremor Hospitalization 6/1/2010 62 Male 170 lb 8/20/2010 Consumer United States
Primary
Concomitant
Rash Pruritic 2/11/2010 68 Female 8/28/2010 United States
Primary
Concomitant
Blood Glucose Increased 3/3/2010 70 Male 8/28/2010 United States
Primary
Concomitant
Respiratory Failure Other Serious 9/13/2010 74 Male 10/7/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Ineffective 74 Female 10/13/2010 United States
Primary
Concomitant
Respiratory Failure Other Serious 9/13/2010 74 Male 10/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Pruritic 2/11/2010 68 Female 11/2/2010 United States
Primary
Concomitant
Prothrombin Time Shortened 1/1/2010 66 Female 172 lb 9/20/2010 United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 9/13/2010 74 Male 12/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Injection Site Haemorrhage 11/15/2010 54 Female 1/30/2011 Consumer United States
Primary
Concomitant
Metastases To Liver Hospitalization 10/12/2010 74 Male 240 lb 2/1/2011 Physician Germany
Primary
Secondary
Concomitant
Anosmia 72 Male 190 lb 1/25/2011 United States
Primary
Concomitant
Small Cell Lung Cancer Stage Unspecified Hospitalization 10/12/2010 74 Male 240 lb 3/24/2011 Physician Germany
Primary
Secondary
Concomitant
Drug Tolerance Other Serious 6/1/2010 52 Female 251 lb 4/18/2011 Consumer United States
Primary
Concomitant
Paraesthesia Hospitalization 6/1/2010 62 Male 170 lb 4/20/2011 Consumer United States
Primary
Concomitant
Back Disorder Hospitalization 4/1/2011 78 Female 5/3/2011 Consumer United States
Primary
Concomitant
Cough Hospitalization 4/1/2011 78 Female 104 lb 5/13/2011 Physician United States
Primary
Concomitant
Dysstasia 4/1/2011 76 Male 6/7/2011 Consumer United States
Primary
Concomitant
Suicidal Ideation Other Serious 1/1/2011 67 Female 148 lb 6/9/2011 Consumer United States
Primary
Secondary
Concomitant
Pain Other Serious 1/1/2011 67 Female 148 lb 6/13/2011 Consumer United States
Primary
Secondary
Concomitant
Tremor Hospitalization 6/1/2010 62 Male 170 lb 6/16/2011 Physician United States
Primary
Concomitant
Abdominal Pain Upper Other Serious 2/1/2003 6/24/2011 Physician United States
Primary
Secondary
Concomitant
Arthralgia 4/1/2011 76 Male 6/30/2011 Consumer United States
Primary
Concomitant
Blood Calcium Increased Hospitalization 4/1/2011 78 Female 104 lb 7/11/2011 Physician United States
Primary
Concomitant
Metastases To Spine Other Serious 2/1/2003 7/27/2011 Consumer United States
Primary
Secondary
Concomitant
Pain Other Serious 5/28/2010 66 Female 148 lb 8/2/2011 Consumer United States
Primary
Secondary
Concomitant
Erythema 12/20/2010 70 Male 155 lb 8/5/2011 Consumer United States
Primary
Concomitant
Scoliosis Other Serious 2/1/2003 64 Male 8/31/2011 Lawyer United States
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Other Serious 2/1/2003 64 Male 165 lb 9/21/2011 Physician United States
Primary
Secondary
Concomitant
Adrenal Insufficiency Other Serious 2/1/2003 64 Male 165 lb 10/6/2011 Consumer United States
Primary
Secondary
Concomitant
Peptic Ulcer Other Serious 2/1/2003 64 Male 165 lb 10/12/2011 Lawyer United States
Primary
Secondary
Concomitant
Lumbar Spinal Stenosis Other Serious 2/1/2003 64 Male 165 lb 10/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Renal Failure Chronic Hospitalization 7/25/2011 10/19/2011 Consumer United States
Primary
Concomitant
Muscle Twitching 8/17/2011 86 Male 161 lb 9/28/2011 Consumer United States
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 3/1/2011 82 Male 190 lb 10/26/2011 Physician United States
Primary
Concomitant
Erythema Other Serious 59 Male 165 lb 10/26/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective 6/25/2011 77 Female 10/24/2011 Consumer United States
Primary
Concomitant
Fatigue Other Serious 10/4/2011 83 Female 100 lb 11/8/2011 Consumer United States
Primary
Concomitant
No Adverse Event Other Serious Male 11/29/2011 Consumer United States
Primary
Concomitant
Fibromyalgia 37 Female 11/29/2011 Consumer United States
Primary
Secondary
Concomitant
Spinal Column Stenosis Other Serious 4/1/2011 55 Female 185 lb 11/18/2011 Other Health Professional United States
Primary
Concomitant
Scoliosis Other Serious 4/1/2011 55 Female 185 lb 12/5/2011 Other Health Professional United States
Primary
Concomitant
Intervertebral Disc Protrusion Other Serious 4/1/2011 55 Female 185 lb 12/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Seborrhoeic Keratosis Other Serious 2/1/2003 64 Male 165 lb 12/28/2011 Physician United States
Primary
Secondary
Concomitant
Prostatic Specific Antigen Increased Life Threatening 9/30/2011 61 Male 124 lb 12/29/2011 Physician United States
Primary
Secondary
Concomitant
Somnolence Other Serious 1/1/2011 55 Female 1/9/2012 Consumer United States
Primary
Secondary
Concomitant
Seborrhoeic Keratosis Other Serious 2/1/2003 64 Male 165 lb 1/12/2012 Physician United States
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 12/9/2011 71 Male 220 lb 12/15/2011 Pharmacist United States
Primary
Concomitant
Hydronephrosis Life Threatening 1/1/2006 55 Female 280 lb 1/20/2012 Consumer United States
Primary
Concomitant
Stomatitis 12/1/2010 64 Female 1/27/2012 Consumer United States
Primary
Concomitant
Dysuria 1/1/2012 87 Male 2/7/2012 Consumer United States
Primary
Concomitant
Ageusia 21 Male 172 lb 2/1/2012 Consumer United States
Primary
Concomitant
Salmonellosis Hospitalization Male 2/15/2012 Pharmacist Australia
Primary
Concomitant
Lipoma Other Serious 2/1/2003 64 Male 165 lb 3/1/2012 Physician United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 4/1/2011 78 Female 104 lb 3/2/2012 Consumer United States
Primary
Concomitant
Drug Ineffective For Unapproved Indication 47 Female 246 lb 3/7/2012 United States
Primary
Secondary
Concomitant
Economic Problem Hospitalization 5/1/2010 66 Female 160 lb 3/6/2012 Lawyer United States
Primary
Concomitant
Nausea 12/16/2011 60 Female 3/22/2012 Consumer United States
Primary
Secondary
Concomitant
Hyperthermia Malignant Other Serious 7/20/2011 76 Female 235 lb 3/29/2012 Consumer United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 4/1/2011 78 Female 104 lb 4/2/2012 Physician United States
Primary
Concomitant
Anxiety Hospitalization 2/1/2009 45 Female 139 lb 4/9/2012 Physician United States
Primary
Secondary
Concomitant
Hyperthermia Malignant Death 1/1/2011 75 Female 235 lb 4/25/2012 Physician United States
Primary
Concomitant
Interacting
Serotonin Syndrome Death 1/1/2011 75 Female 235 lb 5/3/2012 Consumer United States
Primary
Concomitant
Interacting
Respiratory Failure Death 7/20/2011 76 Female 5/9/2012 Physician United States
Primary
Concomitant
Respiratory Failure Hospitalization 7/20/2011 76 Female 5/23/2012 Consumer United States
Primary
Concomitant
Vomiting Disability 60 Female 6/14/2012 Physician United States
Primary
Secondary
Concomitant
Haematochezia Hospitalization 5/16/2012 73 Male 220 lb 6/14/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Dysstasia Hospitalization 6/20/2012 46 Male 176 lb 7/9/2012 Other Health Professional Denmark
Primary
Concomitant
Death Death 5/31/2012 71 Female 7/9/2012 Consumer United States
Primary
Concomitant
Musculoskeletal Discomfort 48 Male 155 lb 7/16/2012 Consumer United States
Primary
Secondary
Concomitant
Drug Interaction Other Serious 1/1/2011 71 Female 119 lb 7/18/2012 Consumer United States
Primary
Concomitant
Interacting
Constipation Other Serious 2/1/2003 64 Male 165 lb 7/23/2012 Physician United States
Primary
Secondary
Concomitant
Impaired Self-care Other Serious 87 Male 7/25/2012 Consumer United States
Primary
Concomitant
Insomnia 85 Female 7/26/2012 Consumer United States
Primary
Secondary
Concomitant
Anaemia Other Serious 9/12/2011 60 Male 174 lb 7/27/2012 Consumer Germany
Primary
Secondary
Concomitant
Panic Disorder 1/1/2010 51 Female 160 lb 8/1/2012 United States
Primary
Concomitant
Somnolence 48 Male 155 lb 8/10/2012 Consumer United States
Primary
Secondary
Concomitant
Conversion Disorder 48 Male 155 lb 8/10/2012 United States
Primary
Secondary
Concomitant
Memory Impairment 48 Male 155 lb 8/10/2012 Consumer United States
Primary
Secondary
Concomitant
Conversion Disorder 48 Male 155 lb 8/14/2012 United States
Primary
Secondary
Concomitant
Stress Hospitalization 48 Male 155 lb 8/20/2012 Consumer United States
Primary
Secondary
Concomitant
Swollen Tongue 7/31/2012 8/24/2012 Consumer United States
Primary
Secondary
Concomitant
Stress Hospitalization 2/2009 45 Female 139 lb 8/15/2013 Lawyer Us
Primary
Secondary
Concomitant
Spinal Disorder Hospitalization 3/23/2011 65 Female 175 lb 2/14/2013 Us
Primary
Concomitant
Thyroid Disorder 47 Female 246 lb 4/29/2013 Us
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 2011 Female 127 lb 1/23/2013 Other Health Professional Us
Primary
Concomitant
Weight Decreased Hospitalization 12/7/2011 63 Female 9/4/2012 Physician Us
Primary
Concomitant
Vitamin D Deficiency Hospitalization 3/21/2004 51 Male 7/23/2013 Us
Primary
Secondary
Concomitant
Therapeutic Response Unexpected Hospitalization 48 Male 155 lb 8/29/2012 Us
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious 9/12/2011 60 Male 174 lb 1/24/2013 Consumer Us
Primary
Secondary
Concomitant
Forearm Fracture Other Serious 6/22/2012 46 Male 330 lb 8/8/2012 Consumer Us
Primary
Concomitant
Dyspepsia 5/2012 Male 176 lb 9/27/2012 Physician Us
Primary
Concomitant
Weight Decreased Life Threatening 5/28/2012 57 Male 250 lb 11/6/2012 Consumer Us
Primary
Secondary
Concomitant
Injection Site Pain 56 Female 214 lb 10/24/2012 Other Health Professional Us
Primary
Concomitant
Pain Other Serious Female 10/31/2012 Consumer Us
Primary
Concomitant
Vascular Dementia Other Serious Female 12/3/2012 Physician Us
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 2012 51 Female 300 lb 4/4/2013 Physician Us
Primary
Concomitant
Product Quality Issue 1/9/2012 60 Female 170 lb 1/8/2013 Physician Us
Primary
Concomitant
Laryngitis 1/17/2013 Male 150 lb 2/12/2013 Consumer Us
Primary
Concomitant
Injection Site Pain 7/31/2012 37 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Urticaria 12/2012 72 Female 179 lb 2/14/2013 Us
Primary
Concomitant
Sensory Disturbance Hospitalization 1/3/2013 60 Female 4/2/2013 Physician Us
Primary
Concomitant
Shock Haemorrhagic Life Threatening 3/8/2013 86 Male 3/29/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Psoriatic Arthropathy Other Serious 1/2008 55 Female 4/24/2013 Physician Country Not Specified
Primary
Secondary
Concomitant
Overdose 1/1/2013 61 Male 271 lb 4/4/2013 Consumer Us
Primary
Concomitant
Dysphonia 65 Male 213 lb 7/29/2013 Pharmacist Us
Primary
Concomitant
Nausea 12/16/2011 60 Female 5/15/2013 Us
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 2010 50 Male 10/29/2012 Physician Us
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 2010 50 Male 12/25/2012 Physician Us
Primary
Secondary
Concomitant
Respiratory Tract Infection Other Serious 12/25/2012 54 Male 159 lb 8/12/2013 Other Health Professional Us
Primary
Concomitant
Off Label Use Female 6/25/2013 Consumer Us
Primary
Concomitant
Mesenteric Artery Thrombosis Death 6/2013 55 Male 7/9/2013 Physician Us
Primary
Concomitant
Tardive Dyskinesia Disability 2005 Female Us
Primary
Concomitant
Febrile Neutropenia Hospitalization 6/4/2013 71 Male 179 lb 7/16/2013 Physician Us
Primary
Concomitant
Pleurothotonus Other Serious 67 Male 7/23/2013 Other Health Professional Us
Primary
Concomitant
Pleurothotonus Hospitalization 67 Male 7/25/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Pleurothotonus Hospitalization 67 Male 7/30/2013 Pharmacist Us
Primary
Concomitant
Pleurothotonus Hospitalization 67 Male 8/6/2013 Other Health Professional Country Not Specified
Primary
Secondary
Pleurothotonus Other Serious 67 Male 8/1/2013 Pharmacist Us
Primary
Secondary
Concomitant
Cataract Other Serious 7/10/2013 58 Female 127 lb 8/2/2013 Pharmacist Us
Concomitant
Urinary Retention Other Serious 2013 74 Male 194 lb 8/8/2013 Consumer Us
Primary
Concomitant
Drug Ineffective 2012 Female 9/4/2013 Pharmacist Us
Primary
Concomitant
Wrong Technique In Drug Usage Process 5/2013 58 Male 287 lb 8/15/2013 Consumer Us
Primary
Concomitant
Pleurothotonus Other Serious NotSpecified 8/16/2013 Us
Primary
Secondary
Concomitant
Nausea 49 Female 8/20/2013 Consumer Country Not Specified
Primary
Concomitant
Thrombosis Hospitalization 2010 Male 229 lb 9/3/2013 Consumer Us
Primary
Concomitant
Product Substitution Issue 66 Male 190 lb 8/12/2013 Consumer Us
Primary
Secondary
Concomitant
Urticaria 42 Male 9/11/2013 Other Health Professional Us
Primary
Concomitant
Pain In Extremity Disability 2/1/2012 79 Female 150 lb 9/12/2013 Us
Primary
Concomitant

Drug Data