Marcumar combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Other Serious 2/7/2006 58 Female 3/19/2006 Physician Germany
Primary
Concomitant
Heart Rate Increased Other Serious Female 132 lb 6/22/2006 Physician Germany
Primary
Concomitant
Liver Function Test Abnormal Other Serious 3/22/2005 57 Female 143 lb 6/23/2006 Belgium
Primary
Concomitant
Polyneuropathy Other Serious 1/1/2005 Male 187 lb 8/3/2006 Physician Germany
Primary
Secondary
Soft Tissue Necrosis Other Serious 1/1/2006 Female 157 lb 9/6/2006 Physician Germany
Primary
Secondary
Concomitant
Paraesthesia Death 1/1/2006 Female 157 lb 9/7/2006 Physician Germany
Primary
Secondary
Concomitant
Septic Shock Other Serious 3/28/2006 73 Male 165 lb 9/1/2006 Physician Germany
Primary
Concomitant
Soft Tissue Necrosis Other Serious 1/1/2006 Female 157 lb 9/29/2006 Physician Germany
Primary
Secondary
Concomitant
Sudden Death Death 6/16/2006 57 Male 179 lb 10/5/2006 Physician Germany
Primary
Concomitant
Soft Tissue Necrosis Other Serious 1/1/2006 Female 157 lb 10/11/2006 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/1/2006 Female 157 lb 10/18/2006 Physician Germany
Primary
Secondary
Concomitant
Vision Blurred Other Serious 9/1/2006 78 Female 11/14/2006 Other Health Professional Germany
Primary
Concomitant
Visual Disturbance Other Serious 9/1/2006 78 Female 11/30/2006 Germany
Primary
Concomitant
Traumatic Brain Injury Death 80 Male 187 lb 12/15/2006 Physician Germany
Primary
Concomitant
Transaminases Increased Hospitalization 9/8/2006 61 Male 1/11/2007 Physician Germany
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 11/9/2006 73 Male 183 lb 1/19/2007 Physician Germany
Primary
Concomitant
International Normalised Ratio Decreased Hospitalization 11/10/2006 45 Male 1/24/2007 Physician Austria
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/1998 77 Male 209 lb 1/25/2007 Consumer Germany
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 8/1/2006 Male 1/30/2007 Other Health Professional Germany
Primary
Concomitant
International Normalised Ratio Decreased Hospitalization 11/10/2006 45 Male 1/31/2007 Other Health Professional Austria
Primary
Secondary
Concomitant
International Normalised Ratio Decreased Hospitalization 11/10/2006 45 Male 2/5/2007 Other Health Professional Austria
Primary
Concomitant
Interacting
Pulmonary Fibrosis Hospitalization 8/1/2006 Male 2/8/2007 Other Health Professional Germany
Primary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 4/18/2007 Physician Germany
Primary
Secondary
Concomitant
Prothrombin Time Prolonged 2/1/2007 53 Male 154 lb 4/25/2007 Physician Germany
Primary
Concomitant
Nephrotic Syndrome Other Serious 2/20/2007 Male 5/15/2007 Physician Germany
Primary
Secondary
Concomitant
Prolactinoma Other Serious 10/1/2006 55 Male 176 lb 5/23/2007 Physician Germany
Primary
Secondary
Concomitant
Sunburn Other Serious 1/1/2005 Male 6/6/2007 Other Health Professional Germany
Primary
Concomitant
Scleroderma Hospitalization 3/5/2007 61 Female 200 lb 6/12/2007 Physician Germany
Primary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 6/15/2007 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2007 60 Female 6/24/2007 Consumer Germany
Primary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 7/12/2007 Physician Germany
Primary
Secondary
Concomitant
Prothrombin Time Shortened Hospitalization 11/10/2006 45 Male 8/10/2007 Physician Austria
Primary
Secondary
Concomitant
Peripheral Arterial Occlusive Disease Life Threatening 5/13/2007 71 Male 8/15/2007 Physician Germany
Primary
Concomitant
Vomiting Other Serious 1/1/2007 60 Female 8/15/2007 Consumer Germany
Primary
Concomitant
Peripheral Arterial Occlusive Disease Life Threatening 5/13/2007 71 Male 8/20/2007 Physician Germany
Primary
Concomitant
International Normalised Ratio Decreased Hospitalization 11/10/2006 45 Male 8/31/2007 Other Health Professional Austria
Primary
Secondary
Concomitant
Weight Decreased Other Serious 68 Male 9/26/2007 Physician Germany
Primary
Concomitant
Tachycardia Other Serious 74 Male 10/16/2007 Consumer Germany
Primary
Concomitant
Weight Increased Hospitalization Female 11/18/2007 Physician Germany
Primary
Concomitant
Systemic Inflammatory Response Syndrome Hospitalization 1/1/2007 70 Male 176 lb 11/20/2007 Physician Switzerland
Primary
Concomitant
Interacting
Systemic Inflammatory Response Syndrome Hospitalization 1/1/2007 70 Male 176 lb 11/20/2007 Consumer Germany
Primary
Secondary
Concomitant
Nausea Other Serious 10/29/2007 76 Female 11/17/2007 Physician Switzerland
Primary
Secondary
Concomitant
Tachycardia Other Serious 74 Male 11/30/2007 Physician Germany
Primary
Concomitant
Systemic Lupus Erythematosus Rash Hospitalization 8/22/2007 63 Female 11/27/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Hepatitis Hospitalization 11/16/2007 74 Male 12/27/2007 Physician Germany
Primary
Secondary
Concomitant
Death Other Serious 9/1/2005 Male 1/7/2008 Physician Germany
Primary
Concomitant
Right Ventricular Failure Hospitalization 8/28/2007 63 Female 1/3/2008 Pharmacist Germany
Primary
Secondary
Concomitant
Agranulocytosis Hospitalization 8/31/2007 Male 2/25/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Weight Decreased Other Serious 68 Male 2/28/2008 Physician Germany
Primary
Concomitant
Tachycardia Hospitalization 1/1/2008 Male 2/29/2008 Other Health Professional Germany
Primary
Concomitant
Jaundice Other Serious 1/1/2008 70 Male 3/12/2008 Physician Germany
Primary
Concomitant
Vomiting Life Threatening 3/6/2008 Female 222 lb 3/18/2008 Physician Germany
Primary
Concomitant
Jaundice Hospitalization 2/1/2008 Male 3/21/2008 Physician Germany
Primary
Secondary
Concomitant
Malaise Other Serious Male 179 lb 4/11/2008 Physician Germany
Primary
Secondary
Concomitant
Spinal Disorder Other Serious Male 179 lb 4/22/2008 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 3/1/2008 Female 222 lb 5/12/2008 Physician Germany
Primary
Concomitant
Osteoarthritis Other Serious 1/16/2008 65 Male 6/9/2008 Other Health Professional Austria
Primary
Concomitant
Systemic Sclerosis Hospitalization 3/5/2007 Female 200 lb 7/4/2008 Physician Germany
Primary
Concomitant
Leukopenia Other Serious Male 8/12/2008 Physician
Primary
Concomitant
Leukopenia Other Serious 8/1/2008 Male 168 lb 8/13/2008 Physician
Primary
Concomitant
Vasculitis Other Serious 1/1/2008 84 Female 126 lb 8/20/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Leukopenia Other Serious 8/1/2008 Male 168 lb 9/16/2008 Physician
Primary
Concomitant
Prothrombin Time Shortened Other Serious 8/1/2008 Female 231 lb 10/30/2008 Physician Germany
Primary
Concomitant
Dysuria Other Serious 10/1/2008 11/7/2008 Other Health Professional Germany
Primary
Concomitant
Prothrombin Time Shortened Other Serious 8/1/2008 Female 231 lb 11/28/2008 Physician Germany
Primary
Concomitant
Thrombocytopenia Other Serious 8/19/2008 Female 11/30/2008 Consumer Germany
Primary
Concomitant
Shock Haemorrhagic Hospitalization 4/30/2008 72 Male 12/8/2008 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/19/2008 Female 12/10/2008 Consumer Germany
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 4/10/2008 45 Female 12/10/2008 Consumer Germany
Primary
Concomitant
Pancytopenia Life Threatening 62 Male 154 lb 12/16/2008 Germany
Primary
Concomitant
Thrombocytopenia Other Serious 8/19/2008 Female 1/20/2009 Consumer Germany
Primary
Concomitant
Sepsis Life Threatening 12/27/2008 67 Male 154 lb 2/5/2009 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/19/2008 Female 2/6/2009 Consumer Germany
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Other Serious 1/1/2008 45 Female 2/13/2009 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 8/19/2008 Female 2/25/2009 Consumer Germany
Primary
Secondary
Concomitant
Sepsis Life Threatening 12/27/2008 67 Male 154 lb 3/2/2009 Physician Germany
Primary
Secondary
Concomitant
Mental Disorder Hospitalization 1/7/2009 79 Male 3/6/2009 Physician Germany
Primary
Secondary
Concomitant
Swelling Other Serious 1/15/2009 Male 3/10/2009 Pharmacist Germany
Primary
Concomitant
International Normalised Ratio Increased Other Serious Female 3/17/2009 Consumer Austria
Primary
Concomitant
Interacting
Sepsis Life Threatening 12/27/2008 67 Male 154 lb 3/19/2009 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious Male 3/27/2009 Consumer Switzerland
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 10/27/2008 72 Male 258 lb 3/31/2009 Other Health Professional Germany
Primary
Secondary
Interacting
Rhabdomyolysis Other Serious 1/1/2009 Female 4/9/2009 Physician Austria
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1/1/2009 Female 4/17/2009 Physician Austria
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 4/18/2009 Male 258 lb 4/24/2009 Other Health Professional Germany
Primary
Secondary
Rhabdomyolysis Other Serious 1/1/2009 Female 132 lb 4/30/2009 Physician Austria
Primary
Secondary
Concomitant
Suicide Attempt Hospitalization 4/18/2009 Male 258 lb 5/7/2009 Other Health Professional Germany
Primary
Secondary
Hepatotoxicity Hospitalization 70 5/11/2009 Physician Germany
Primary
Secondary
Concomitant
Skin Discolouration Other Serious 1/15/2009 Male 196 lb 5/22/2009 Pharmacist Germany
Primary
Concomitant
International Normalised Ratio Increased Other Serious Female 6/4/2009 Physician Austria
Primary
Concomitant
Interacting
Diarrhoea Other Serious 5/1/2007 Male 168 lb 6/8/2009 Physician Germany
Primary
Concomitant
Myocardial Infarction Other Serious 5/1/2007 Male 168 lb 6/17/2009 Physician Germany
Primary
Concomitant
Hepatotoxicity Hospitalization 70 6/26/2009 Physician Germany
Primary
Secondary
Concomitant
Hiatus Hernia Hospitalization 3/1/2009 57 Male 7/15/2009 Consumer Brazil
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 6/11/2009 Female 187 lb 7/16/2009 Physician Switzerland
Primary
Concomitant
Myocardial Infarction Other Serious 5/1/2007 Male 168 lb 7/17/2009 Physician Germany
Primary
Concomitant
Paraesthesia Hospitalization 6/11/2009 Female 187 lb 7/21/2009 Physician Switzerland
Primary
Concomitant
Myocardial Infarction Other Serious 5/1/2007 Male 168 lb 7/28/2009 Physician Germany
Primary
Concomitant
Thrombocytopenia Other Serious 8/19/2008 Female 148 lb 8/3/2009 Physician Germany
Primary
Concomitant
Thrombocytopenia Hospitalization 8/19/2008 Female 148 lb 8/12/2009 Physician Germany
Primary
Secondary
Concomitant
Cardioversion Hospitalization 1/1/2009 Female 201 lb 8/14/2009 Germany
Primary
Concomitant
Vertigo Other Serious 72 Female 8/19/2009 Physician Germany
Primary
Secondary
Periorbital Haematoma Hospitalization 6/19/2009 60 Female 9/1/2009 Other Health Professional Germany
Primary
Concomitant
Pemphigoid Other Serious 6/23/2009 75 9/10/2009 Germany
Primary
Concomitant
Thrombocytopenia Life Threatening 8/13/2009 Female 154 lb 9/24/2009 Physician
Primary
Concomitant
Bronchial Carcinoma Hospitalization 7/3/2009 70 Male 9/25/2009 Germany
Primary
Concomitant
Vertigo Other Serious 72 Female 9/25/2009 Physician Germany
Primary
Secondary
Vertigo Other Serious 72 Female 9/25/2009 Physician Germany
Primary
Secondary
Bronchial Carcinoma Hospitalization 7/3/2009 70 Male 9/28/2009 Germany
Primary
Concomitant
Bronchial Carcinoma Hospitalization 7/3/2009 70 Male 10/14/2009 Germany
Primary
Concomitant
Bronchial Carcinoma Hospitalization 7/3/2009 70 Male 10/20/2009 Germany
Primary
Concomitant
Heart Rate Increased Other Serious 10/22/2009 Male 11/3/2009 Consumer Germany
Primary
Concomitant
Gastric Ulcer Haemorrhage Other Serious 10/19/2009 Male 309 lb 11/9/2009 Physician Germany
Primary
Secondary
Concomitant
Gastritis Other Serious 10/19/2009 Male 309 lb 11/12/2009 Physician Germany
Primary
Secondary
Concomitant
Gastritis Other Serious 10/19/2009 Male 309 lb 11/12/2009 Physician Germany
Primary
Secondary
Concomitant
Tachycardia Other Serious 10/1/2009 Male 11/12/2009 Physician Germany
Primary
Concomitant
Urinary Retention Death 9/8/2009 74 Female 11/16/2009 Physician Germany
Primary
Secondary
Concomitant
Interacting
Bronchial Carcinoma Hospitalization 7/3/2009 Male 11/16/2009 Germany
Primary
Concomitant
Hyponatraemia Life Threatening 9/8/2009 74 Female 11/20/2009 Physician Germany
Primary
Concomitant
Pallor Hospitalization 10/27/2008 72 Male 11/25/2009 Physician Germany
Primary
Secondary
Vomiting Other Serious 3/6/2008 Female 222 lb 12/1/2009 Physician Germany
Primary
Concomitant
Percutaneous Coronary Intervention Other Serious 2/1/2009 Male 229 lb 12/16/2009 Physician Germany
Primary
Concomitant
Pancytopenia Life Threatening 7/1/2009 60 Male 12/17/2009 Physician Germany
Primary
Secondary
Concomitant
Nervous System Disorder Life Threatening 9/8/2009 74 Female 12/20/2009 Physician Germany
Primary
Secondary
Concomitant
Nervous System Disorder Life Threatening 9/8/2009 74 Female 12/30/2009 Physician Germany
Primary
Secondary
Concomitant
Percutaneous Coronary Intervention Other Serious 1/19/2009 Male 229 lb 1/4/2010 Physician Germany
Primary
Concomitant
Weight Increased Other Serious 79 Male 2/5/2010 Physician Germany
Primary
Concomitant
Nervous System Disorder Life Threatening 9/8/2009 74 Female 2/15/2010 Physician Germany
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 12/17/2008 78 Male 2/4/2010 Other Health Professional Germany
Primary
Concomitant
Urinary Retention Death 9/8/2009 74 Female 2/19/2010 Physician Germany
Primary
Secondary
Concomitant
Interacting
Thrombocytopenia Life Threatening 1/1/2010 Male 2/22/2010 Physician Germany
Primary
Concomitant
Sudden Cardiac Death Death 1/18/2010 75 Male 176 lb 3/1/2010 Physician Germany
Primary
Concomitant
Sudden Cardiac Death Death 1/18/2010 75 Male 176 lb 3/5/2010 Physician Germany
Primary
Concomitant
Sudden Cardiac Death Death 1/18/2010 75 Male 176 lb 3/5/2010 Physician Germany
Primary
Concomitant
Thrombocytopenia Life Threatening 1/1/2010 Male 196 lb 3/9/2010 Physician Germany
Primary
Concomitant
Nasal Discomfort Other Serious 10/1/2009 73 Female 3/16/2010 Physician Germany
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 3/7/2010 53 Male 3/31/2010 Physician Germany
Primary
Concomitant
Transaminases Increased Other Serious 2/1/2010 67 Male 4/7/2010 Physician Germany
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Other Serious 2/5/2010 77 Male 185 lb 4/15/2010 Physician Germany
Primary
Concomitant
Bronchial Hyperreactivity Other Serious 11/1/2009 76 Male 4/12/2010 Germany
Primary
Concomitant
Ventricular Fibrillation Life Threatening 3/29/2010 68 Male 287 lb 4/20/2010 Physician Germany
Primary
Concomitant
Oedema Peripheral Other Serious 2/8/2010 77 Female 205 lb 4/21/2010 Physician Germany
Primary
Concomitant
Vascular Graft Other Serious 1/1/2005 73 Male 238 lb 4/26/2010 Physician Germany
Primary
Secondary
Concomitant
Serositis Other Serious 2/4/2010 71 Male 172 lb 5/18/2010 Physician Germany
Primary
Concomitant
Ejection Fraction Decreased Other Serious 1/22/2010 67 Male 5/18/2010 Physician Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/27/2010 79 Male 198 lb 6/1/2010 Physician Germany
Primary
Concomitant
Respiratory Tract Haemorrhage Hospitalization 9/7/2007 65 Female 5/31/2010 Physician Germany
Primary
Concomitant
Interacting
Pulmonary Haemorrhage Other Serious 7/11/2007 79 Male 124 lb 6/1/2010 Physician Germany
Primary
Concomitant
Interacting
Serum Ferritin Increased Other Serious 1/1/2010 68 Male 6/16/2010 Physician Germany
Primary
Concomitant
Somnolence Hospitalization 9/18/2008 83 Male 6/18/2010 Physician Germany
Primary
Secondary

Drug Data