Loxoprofen Sodium Hydrate combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tonsillitis Life Threatening 8/8/2008 Female 109 lb 9/3/2008 Japan
Primary
Concomitant
Tonsillitis Life Threatening 8/8/2008 Female 109 lb 9/8/2008 Japan
Primary
Concomitant
Tonsillitis Life Threatening 8/8/2008 Female 109 lb 10/20/2008 Japan
Primary
Concomitant
Respiratory Failure Life Threatening 9/6/2008 Male 143 lb 2/3/2009 Japan
Primary
Secondary
Concomitant
Tonsillitis Life Threatening 8/8/2008 Female 109 lb 2/10/2009 Japan
Primary
Concomitant
Tendon Rupture Hospitalization 12/25/2008 Female 110 lb 2/19/2009 Japan
Primary
Concomitant
Tendon Rupture Hospitalization 12/25/2008 Female 110 lb 3/16/2009 Japan
Primary
Concomitant
Tonsillitis Life Threatening 8/8/2008 Female 109 lb 4/8/2009 Japan
Primary
Concomitant
Pneumonia Hospitalization 5/1/2009 Female 139 lb 7/9/2009 Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/1/2009 Female 139 lb 7/15/2009 Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 5/1/2009 Female 139 lb 7/20/2009 Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Other Serious 3/24/2009 Female 7/31/2009 Japan
Primary
Concomitant
Pyrexia Hospitalization 6/26/2009 Female 106 lb 8/6/2009 Japan
Primary
Concomitant
Pyrexia Hospitalization 6/26/2009 Female 106 lb 8/13/2009 Japan
Primary
Concomitant
Pyrexia Hospitalization 6/26/2009 Female 106 lb 8/20/2009 Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 1/30/2009 Female 110 lb 8/21/2009 Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 9/25/2009 Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 1/30/2009 Female 110 lb 10/8/2009 Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 10/19/2009 Japan
Primary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 12/3/2009 Japan
Primary
Concomitant
Eye Movement Disorder Hospitalization 11/18/2009 Female 12/11/2009 Physician Japan
Primary
Concomitant
Malnutrition Hospitalization 11/18/2009 Female 12/23/2009 Physician Japan
Primary
Concomitant
Vasculitis Hospitalization 2/1/2009 Female 98 lb 12/30/2009 Japan
Primary
Secondary
Concomitant
Pain Other Serious 1/6/2010 Female 115 lb 1/28/2010 Japan
Primary
Secondary
Concomitant
Vasculitis Other Serious 2/1/2009 Female 98 lb 1/29/2010 Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 12/14/2009 Male 132 lb 2/10/2010 Japan
Primary
Concomitant
Fall Hospitalization 10/14/2009 Female 88 lb 2/11/2010 Japan
Primary
Concomitant
Pain Other Serious 1/6/2010 Female 115 lb 2/26/2010 Japan
Primary
Secondary
Concomitant
Fall Hospitalization 10/14/2009 Female 88 lb 3/10/2010 Japan
Primary
Concomitant
Pancytopenia Hospitalization 7/28/2009 Female 99 lb 3/11/2010 Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 11/24/2009 Male 3/18/2010 Japan
Primary
Secondary
Concomitant
Shock Other Serious 1/6/2010 Female 115 lb 3/26/2010 Japan
Primary
Secondary
Concomitant
Right Ventricular Failure Hospitalization 1/7/2010 Female 3/26/2010 Physician Japan
Primary
Concomitant
Suffocation Feeling Hospitalization 10/29/2009 Female 3/26/2010 Japan
Primary
Concomitant
Radius Fracture Hospitalization 11/19/2009 63 Female 98 lb 4/2/2010 Japan
Primary
Concomitant
Ileus Hospitalization Female 117 lb 4/9/2010 Japan
Primary
Concomitant
Right Ventricular Failure Hospitalization 10/1/2009 74 Female 4/12/2010 Physician Japan
Primary
Concomitant
Pruritus Hospitalization 11/24/2009 46 Male 4/20/2010 Japan
Primary
Secondary
Concomitant
Rectal Ulcer Hospitalization 4/1/2010 82 Female 117 lb 4/29/2010 Physician Japan
Primary
Concomitant
Rectal Ulcer Hospitalization 4/1/2010 82 Female 117 lb 5/6/2010 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 7/24/2009 69 Female 99 lb 5/19/2010 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 5/28/2010 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Hospitalization 12/14/2009 72 Male 132 lb 6/4/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 6/10/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Sepsis Hospitalization 12/14/2009 72 Male 132 lb 6/14/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 1/6/2010 67 Female 115 lb 6/17/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 6/17/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/26/2009 49 Female 106 lb 6/18/2010 Physician Japan
Primary
Concomitant
Muscular Weakness Other Serious 11/5/2009 67 Male 115 lb 6/24/2010 Physician Japan
Primary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 6/28/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 6/30/2010 Physician Japan
Primary
Secondary
Concomitant
Radius Fracture Hospitalization 11/19/2009 63 Female 98 lb 7/8/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 6/26/2009 49 Female 106 lb 7/19/2010 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Other Serious 11/5/2009 67 Male 115 lb 7/19/2010 Physician Japan
Primary
Concomitant
Liver Disorder Other Serious 3/4/2010 75 Female 126 lb 7/23/2010 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 7/24/2009 69 Female 99 lb 7/28/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 7/26/2010 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Other Serious 3/4/2010 75 Female 126 lb 7/28/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/21/2010 55 Female 168 lb 8/2/2010 Physician Japan
Primary
Concomitant
Staphylococcal Infection Other Serious 11/5/2009 67 Male 115 lb 8/12/2010 Physician Japan
Primary
Concomitant
Disseminated Tuberculosis Other Serious 3/4/2010 75 Female 126 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/26/2009 49 Female 106 lb 8/17/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 4/28/2010 85 Female 126 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 1/6/2010 67 Female 115 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 8/18/2010 Physician Japan
Primary
Secondary
Concomitant
Rash Pruritic Hospitalization 2/26/2010 22 Female 8/19/2010 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Life Threatening 6/26/2010 64 Female 8/20/2010 Physician Japan
Primary
Concomitant
Spondylitis Other Serious 6/2/2010 64 Female 8/27/2010 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 6/26/2009 49 Female 106 lb 8/30/2010 Physician Japan
Primary
Concomitant
Pelvic Fracture Hospitalization 8/28/2009 78 Female 93 lb 9/10/2010 Physician Japan
Primary
Concomitant
Pelvic Fracture Hospitalization 5/9/2010 78 Female 93 lb 9/13/2010 Physician Japan
Primary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 9/14/2010 Physician Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 11/24/2009 46 Male 9/16/2010 Physician Japan
Primary
Secondary
Concomitant
Rash Pruritic Hospitalization 2/26/2010 22 Female 10/7/2010 Physician Japan
Primary
Concomitant
Spondylitis Other Serious 6/2/2010 64 Female 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 2/17/2010 68 Male 119 lb 10/20/2010 Physician Japan
Primary
Secondary
Concomitant
Pruritus Hospitalization 11/10/2009 46 Male 10/22/2010 Physician Japan
Primary
Secondary
Concomitant
Pelvic Fracture Hospitalization 5/9/2010 78 Female 93 lb 10/27/2010 Physician Japan
Primary
Concomitant
Pneumonia Other Serious 1/19/2010 47 Female 11/8/2010 Physician Japan
Primary
Concomitant
Myositis Hospitalization 6/7/2010 57 Female 11/12/2010 Physician Japan
Primary
Concomitant
Lymphadenopathy Other Serious 7/16/2010 66 Male 11/19/2010 Physician Japan
Primary
Concomitant
Lymphadenopathy Other Serious 7/16/2010 66 Male 11/30/2010 Physician Japan
Primary
Concomitant
Pelvic Fracture Hospitalization 5/9/2010 78 Female 93 lb 12/8/2010 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 8/1/2010 79 Female 83 lb 12/13/2010 Physician Japan
Primary
Concomitant
Tuberculosis Other Serious 2/17/2010 68 Male 119 lb 12/20/2010 Physician Japan
Primary
Secondary
Concomitant
Acute Pulmonary Oedema Hospitalization 9/26/2010 54 Female 12/20/2010 Physician Japan
Primary
Concomitant
Tuberculosis Other Serious 2/17/2010 68 Male 119 lb 12/21/2010 Physician Japan
Primary
Secondary
Concomitant
Scleroderma Hospitalization 6/7/2010 57 Female 90 lb 12/28/2010 Physician Japan
Primary
Secondary
Concomitant
Myositis Hospitalization 6/7/2010 57 Female 90 lb 1/3/2011 Physician Japan
Primary
Secondary
Concomitant
Computerised Tomogram Abnormal Hospitalization 2/17/2010 68 Male 119 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 12/9/2010 41 Male 170 lb 1/14/2011 Physician Japan
Primary
Secondary
Concomitant
Joint Stiffness Hospitalization 2/17/2010 68 Male 119 lb 1/14/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 12/9/2010 41 Male 170 lb 1/24/2011 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 8/1/2010 79 Female 83 lb 2/17/2011 Physician Japan
Primary
Concomitant
Arthralgia Hospitalization 2/17/2010 68 Male 119 lb 2/18/2011 Physician Japan
Primary
Secondary
Concomitant
Chest X-ray Abnormal Hospitalization 2/17/2010 68 Male 119 lb 2/23/2011 Physician Japan
Primary
Secondary
Concomitant
Rash Hospitalization 10/1/2010 75 Female 3/1/2011 Physician Japan
Primary
Concomitant
Interacting
Rash Hospitalization 10/1/2010 75 Female 3/2/2011 Physician Japan
Primary
Concomitant
Interacting
Hepatic Function Abnormal Hospitalization 7/24/2009 69 Female 99 lb 3/22/2011 Physician Japan
Primary
Secondary
Concomitant
Joint Stiffness Hospitalization 2/17/2010 68 Male 119 lb 3/25/2011 Physician Japan
Primary
Secondary
Concomitant
Myositis Hospitalization 6/7/2010 57 Female 90 lb 4/11/2011 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Abnormal Hospitalization 3/11/2011 69 Female 92 lb 4/11/2011 Physician Japan
Primary
Secondary
Concomitant
Organising Pneumonia Hospitalization 3/11/2011 69 Female 92 lb 4/13/2011 Physician Japan
Primary
Secondary
Concomitant
Streptococcus Test Positive Other Serious 12/1/2010 78 Female 88 lb 4/15/2011 Physician Japan
Primary
Secondary
Concomitant
Lymphadenopathy Hospitalization 10/5/2010 51 Female 119 lb 4/21/2011 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 3/11/2011 69 Female 92 lb 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Arthritis Hospitalization 3/11/2011 69 Female 92 lb 4/26/2011 Physician Japan
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 3/22/2010 59 Male 5/20/2011 Physician Japan
Primary
Secondary
Concomitant
Hypophagia Hospitalization 12/1/2010 78 Female 88 lb 5/23/2011 Physician Japan
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 3/22/2010 59 Male 6/7/2011 Physician Japan
Primary
Secondary
Concomitant
Myositis Hospitalization 6/7/2010 57 Female 90 lb 6/15/2011 Physician Japan
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 3/22/2010 59 Male 6/20/2011 Physician Japan
Primary
Secondary
Concomitant
Bone Tuberculosis Other Serious 7/30/2010 66 Male 7/18/2011 Physician Japan
Primary
Concomitant
Rash Hospitalization 1/1/2010 74 Female 8/3/2011 Physician Japan
Primary
Concomitant
Interacting
Computerised Tomogram Thorax Abnormal Other Serious 7/16/2010 66 Male 108 lb 8/29/2011 Physician Japan
Primary
Concomitant
Bone Tuberculosis Other Serious 7/16/2010 66 Male 108 lb 9/7/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 12/1/2010 74 Female 142 lb 9/9/2011 Physician Japan
Primary
Secondary
Concomitant
Back Pain Hospitalization 2/17/2010 68 Male 119 lb 9/15/2011 Physician Japan
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 1/1/2011 70 Female 9/28/2011 Physician Japan
Primary
Concomitant
Atrial Fibrillation Other Serious 8/27/2011 71 Female 9/30/2011 Physician Japan
Primary
Concomitant
Osteoporosis Death 11/12/2010 72 Female 12/2/2011 Physician Japan
Primary
Secondary
Concomitant
Back Pain Hospitalization 11/12/2010 72 Female 12/7/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Death 11/12/2010 72 Female 12/13/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Steatosis Other Serious 11/28/2011 71 Female 143 lb 12/30/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 12/22/2011 70 Female 1/5/2012 Physician Japan
Primary
Concomitant
Blood Pressure Decreased Other Serious 11/28/2011 71 Female 143 lb 1/18/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 8/1/2010 79 Female 83 lb 2/9/2012 Physician Japan
Primary
Concomitant
Bacteraemia Other Serious 11/28/2011 71 Female 143 lb 2/10/2012 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Hospitalization 8/1/2010 79 Female 83 lb 2/13/2012 Physician Japan
Primary
Concomitant
Disseminated Tuberculosis Other Serious 3/4/2010 75 Female 126 lb 2/24/2012 Physician Japan
Primary
Secondary
Concomitant
Aphasia Hospitalization 2/14/2012 51 Female 95 lb 2/29/2012 Physician Japan
Primary
Concomitant
Haemoptysis Hospitalization 1/1/2012 75 Female 3/5/2012 Physician Japan
Primary
Concomitant
Headache Hospitalization 2/14/2012 51 Female 95 lb 3/6/2012 Physician Japan
Primary
Secondary
Concomitant
Urobilinogen Urine Increased Hospitalization 3/4/2010 75 Female 126 lb 3/8/2012 Physician Japan
Primary
Secondary
Concomitant
Respiratory Disorder Death 11/28/2011 71 Female 143 lb 3/8/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Haemoptysis Hospitalization 1/1/2012 75 Female 3/20/2012 Physician Japan
Primary
Concomitant
Memory Impairment Hospitalization 2/14/2012 51 Female 95 lb 3/23/2012 Physician Japan
Primary
Secondary
Concomitant
Haemoptysis Hospitalization 1/1/2012 75 Female 4/2/2012 Physician Japan
Primary
Concomitant
Nasal Sinus Cancer Other Serious 1/1/2012 75 Female 4/13/2012 Physician Japan
Primary
Concomitant
Mobility Decreased Hospitalization 11/12/2010 72 Female 4/19/2012 Physician Japan
Primary
Secondary
Concomitant
Nasal Sinus Cancer Other Serious 1/1/2012 75 Female 4/23/2012 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Life Threatening 11/12/2010 72 Female 4/27/2012 Physician Japan
Primary
Secondary
Concomitant
Osteoporosis Hospitalization 11/12/2010 72 Female 4/30/2012 Physician Japan
Primary
Secondary
Concomitant
Back Pain Life Threatening 11/12/2010 72 Female 5/8/2012 Physician Japan
Primary
Secondary
Concomitant
Nasal Sinus Cancer Hospitalization 1/1/2012 75 Female 6/5/2012 Physician Japan
Primary
Concomitant
Skin Ulcer Hospitalization 4/7/2010 63 Female 6/8/2012 Physician Japan
Primary
Concomitant
Nasal Sinus Cancer Hospitalization 1/1/2012 75 Female 6/12/2012 Physician Japan
Primary
Concomitant
Nasal Sinus Cancer Other Serious 1/1/2012 75 Female 6/18/2012 Physician Japan
Primary
Concomitant
Skin Ulcer Hospitalization 4/7/2010 63 Female 6/21/2012 Physician Japan
Primary
Concomitant
Nasal Sinus Cancer Other Serious 1/1/2012 75 Female 7/3/2012 Physician Japan
Primary
Concomitant

Drug Data