Loxonin combined with Zolpidem

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Optic Neuritis Retrobulbar Other Serious 8/22/2006 65 Female 6/23/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Other Serious 9/21/2006 70 Male 132 lb 6/29/2007 Japan
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 8/30/2006 70 Male 132 lb 7/5/2007 Physician Japan
Primary
Secondary
Concomitant
Lymphocyte Count Decreased Other Serious 2/7/2007 72 Male 125 lb 8/7/2007 Physician Japan
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious 11/4/2006 43 Female 165 lb 8/24/2007 Physician Japan
Primary
Secondary
Vitreous Haemorrhage Disability 8/6/2007 64 Female 139 lb 10/12/2007 Physician Japan
Primary
Concomitant
Renal Failure Acute Life Threatening 9/24/2007 73 Male 150 lb 10/24/2007 Physician Japan
Primary
Secondary
Concomitant
Vitreous Haemorrhage Disability 8/6/2007 64 Female 139 lb 10/26/2007 Physician Japan
Primary
Concomitant
Vitreous Haemorrhage Disability 8/6/2007 64 Female 139 lb 11/5/2007 Physician Japan
Primary
Concomitant
Hepatic Encephalopathy Other Serious 9/16/2007 51 Male 170 lb 11/5/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 9/24/2007 73 Male 150 lb 11/6/2007 Physician Japan
Primary
Secondary
Concomitant
Hepatic Encephalopathy Other Serious 9/16/2007 51 Male 170 lb 11/14/2007 Physician Japan
Primary
Secondary
Concomitant
Dizziness Hospitalization 11/29/2010 68 Female 5/6/2011 Physician Japan
Primary
Secondary
Alopecia Hospitalization 6/12/2008 51 Male 203 lb 5/18/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 6/11/2010 65 Female 101 lb 5/20/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 4/13/2011 72 Male 112 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Hospitalization 12/1/2010 58 Female 88 lb 5/24/2011 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Other Serious 8/7/2010 64 Male 143 lb 5/24/2011 Physician Japan
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Death 4/3/2011 Female 5/25/2011 Physician Japan
Primary
Concomitant
Cholangitis Life Threatening 7/21/2010 55 Male 176 lb 6/2/2011 Physician Japan
Primary
Concomitant
Post Procedural Infection Other Serious 4/12/2011 66 Female 143 lb 6/2/2011 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 4/12/2011 66 Female 143 lb 6/6/2011 Physician Japan
Primary
Secondary
Concomitant
Post Procedural Infection Hospitalization 4/12/2011 66 Female 6/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hospitalisation Hospitalization 5/27/2011 50 Female 6/8/2011 Physician Japan
Primary
Concomitant
Rhabdomyolysis Hospitalization 4/8/2011 83 Female 6/8/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 4/12/2011 66 Female 143 lb 6/9/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatitis B Antibody Positive Other Serious 5/25/2011 23 Male 90 lb 6/9/2011 Physician Japan
Primary
Concomitant
Cholestasis Hospitalization 4/12/2011 66 Female 143 lb 6/10/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 4/12/2011 66 Female 143 lb 6/13/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Urea Increased Death 11/3/2007 66 Male 6/11/2011 Other Health Professional Japan
Primary
Concomitant
Pancytopenia Hospitalization 4/12/2011 66 Female 143 lb 6/15/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Hospitalization 5/31/2011 63 Female 6/17/2011 Consumer Japan
Primary
Concomitant
Pyrexia Life Threatening 3/30/2010 57 Female 139 lb 6/10/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Other Serious 5/25/2010 63 Female 6/24/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Colorectal Cancer Death 12/1/2010 58 Female 88 lb 6/24/2011 Other Health Professional Japan
Primary
Concomitant
Interstitial Lung Disease Death 4/18/2011 72 Female 117 lb 6/27/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 5/31/2011 63 Female 6/24/2011 Consumer Japan
Primary
Concomitant
Pleural Effusion Hospitalization 5/12/2011 55 Male 160 lb 7/4/2011 Physician Japan
Primary
Concomitant
Viral Infection Life Threatening 10/8/2007 57 Male 205 lb 7/6/2011 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 3/11/2011 34 Female 88 lb 7/7/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Alkaline Phosphatase Increased Other Serious Male 6/28/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Death 8/31/2010 61 Male 115 lb 7/11/2011 Physician Japan
Primary
Concomitant
Hypertension Hospitalization 2/16/2011 79 Male 123 lb 7/14/2011 Physician Japan
Primary
Concomitant
Hepatitis B Antibody Positive Other Serious 5/25/2011 23 Male 90 lb 7/14/2011 Physician Japan
Primary
Concomitant
Retinal Detachment Hospitalization 7/8/2011 68 Male 7/20/2011 Physician Japan
Primary
Secondary
Colorectal Cancer Death 12/1/2010 58 Female 88 lb 7/20/2011 Other Health Professional Japan
Primary
Concomitant
Oedema Death 7/7/2010 76 Male 170 lb 7/22/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 4/18/2011 72 Female 117 lb 7/26/2011 Physician Japan
Primary
Concomitant
Encephalitis Fungal Death Male 139 lb 8/1/2011 Physician Japan
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/28/2010 63 Male 7/27/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Nephrotic Syndrome Hospitalization 10/15/2009 33 Female 8/5/2011 Physician Japan
Primary
Concomitant
Jaundice Hospitalization 3/11/2011 34 Female 88 lb 8/5/2011 Physician Japan
Primary
Secondary
Concomitant
Nephrotic Syndrome Hospitalization 10/15/2009 33 Female 8/15/2011 Other Health Professional Japan
Primary
Concomitant
Cataract Hospitalization 7/8/2011 68 Male 137 lb 8/19/2011 Physician Japan
Primary
Secondary
Hepatic Function Abnormal Other Serious 6/17/2011 68 Female 110 lb 8/24/2011 Physician Japan
Primary
Secondary
Concomitant
Death Death Female 132 lb 8/25/2011 Physician Japan
Primary
Concomitant
Hepatitis B Antibody Positive Other Serious 5/25/2011 23 Male 90 lb 8/25/2011 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 8/13/2010 65 Female 8/30/2011 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Chronic Other Serious 7/9/2010 54 Male 117 lb 9/1/2011 Physician Japan
Primary
Concomitant
Pleural Effusion Hospitalization 5/12/2011 55 Male 160 lb 9/1/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/28/2009 56 Female 101 lb 9/2/2011 Physician Japan
Primary
Secondary
Concomitant
Angina Pectoris Hospitalization 9/2/2011 54 Male 170 lb 9/15/2011 Physician Japan
Primary
Concomitant
Drug Eruption Other Serious 6/17/2011 68 Female 110 lb 9/15/2011 Physician Japan
Primary
Secondary
Concomitant
Angina Pectoris Hospitalization 9/2/2011 54 Male 170 lb 9/16/2011 Physician Japan
Primary
Concomitant
Vomiting Other Serious 87 Female 9/19/2011 Pharmacist Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 7/7/2011 78 Male 132 lb 9/19/2011 Physician Japan
Primary
Secondary
Concomitant
Retinal Detachment Hospitalization 7/8/2011 68 Male 137 lb 9/27/2011 Physician Japan
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 2/16/2009 63 Male 119 lb 9/28/2011 Physician Japan
Primary
Concomitant
Hyperglycaemia Hospitalization 1/13/2011 73 Male 10/3/2011 Physician Japan
Primary
Secondary
Concomitant
Dysuria Other Serious 9/14/2011 63 Female 10/4/2011 Pharmacist Japan
Primary
Concomitant
Ovarian Cancer Recurrent Death Female 132 lb 10/5/2011 Physician Japan
Primary
Concomitant
Pleural Effusion Hospitalization 5/12/2011 55 Male 160 lb 10/7/2011 Physician Japan
Primary
Concomitant
Pyrexia Hospitalization 1/13/2011 73 Male 10/7/2011 Physician Japan
Primary
Secondary
Concomitant
Death Death 11/9/2010 59 Male 10/7/2011 Physician Japan
Primary
Concomitant
Pruritus Other Serious 9/21/2010 65 Female 84 lb 10/7/2011 Physician Japan
Primary
Concomitant
Malaise Hospitalization 9/28/2011 45 Female 10/11/2011 Physician Japan
Primary
Concomitant
Hyperglycaemia Life Threatening 10/3/2011 Male 10/13/2011 Physician Japan
Primary
Concomitant
Eczema Death 7/31/2009 60 Female 10/16/2011 Japan
Primary
Secondary
Concomitant
Death Death 10/3/2011 Male 10/18/2011 Physician Japan
Primary
Concomitant
Ileus Other Serious 4/22/2010 79 Male 158 lb 10/26/2011 Pharmacist Japan
Primary
Concomitant
Dry Skin Death 10/1/2010 62 Female 79 lb 10/27/2011 Physician Japan
Primary
Concomitant
Acute Sinusitis Other Serious 6/18/2011 74 Female 93 lb 10/28/2011 Physician Japan
Primary
Concomitant
Ileus Other Serious 4/20/2010 79 Male 158 lb 10/31/2011 Physician Japan
Primary
Concomitant
Metabolic Acidosis Other Serious 10/4/2011 43 Male 11/3/2011 Physician Japan
Primary
Concomitant
Myelodysplastic Syndrome Other Serious 8/7/2010 64 Male 143 lb 11/4/2011 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 8/7/2010 64 Male 143 lb 11/4/2011 Physician Japan
Primary
Secondary
Concomitant
Delirium Other Serious 6/20/2011 71 Male 11/14/2011 Physician Japan
Primary
Secondary
Concomitant
Delirium Other Serious 6/20/2011 71 Male 11/18/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/7/2011 78 Female 11/18/2011 Physician Japan
Primary
Secondary
Concomitant
Bone Pain Hospitalization 1/13/2011 73 Male 11/18/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 7/7/2011 78 Male 132 lb 11/18/2011 Physician Japan
Primary
Secondary
Concomitant
Anxiety Disorder Hospitalization 9/28/2011 46 Female 11/22/2011 Physician Japan
Primary
Secondary
Concomitant
Anxiety Disorder Hospitalization 9/28/2011 46 Female 11/28/2011 Physician Japan
Primary
Secondary
Concomitant
Toxicity To Various Agents Life Threatening 7/15/2011 48 Male 163 lb 11/29/2011 Physician Japan
Primary
Secondary
Concomitant
Chronic Obstructive Pulmonary Disease Hospitalization 10/1/2010 62 Female 79 lb 11/30/2011 Physician Japan
Primary
Concomitant
Acute Sinusitis Death 5/23/2011 74 Female 93 lb 12/8/2011 Physician Japan
Primary
Concomitant
Renal Failure Acute Other Serious 60 Female 89 lb 12/9/2011 Physician Japan
Primary
Secondary
Concomitant
Chest Discomfort Hospitalization 9/28/2011 46 Female 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Ileus Other Serious 9/14/2009 41 Female 90 lb 12/14/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/7/2011 78 Female 97 lb 12/15/2011 Physician Japan
Primary
Secondary
Concomitant
Headache Death 11/12/2007 76 Male 165 lb 12/16/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 11/7/2011 78 Female 97 lb 12/20/2011 Physician Japan
Primary
Secondary
Concomitant
Delirium Other Serious 6/20/2011 71 Male 12/20/2011 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/13/2011 78 Female 101 lb 12/21/2011 Physician Japan
Primary
Secondary
Concomitant
Hypertension 2/16/2011 79 Male 123 lb 12/22/2011 Physician Japan
Primary
Concomitant
Restlessness Hospitalization 10/15/2009 56 Male 12/27/2011 Physician Japan
Primary
Secondary
Concomitant
Cholangitis Acute Hospitalization 12/11/2011 62 Male 146 lb 12/28/2011 Physician Japan
Primary
Concomitant
Bacterial Test Positive Other Serious 5/4/2011 63 Female 87 lb 12/28/2011 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Increased Death 8/7/2010 64 Male 143 lb 12/31/2011 Physician Japan
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 10/15/2009 56 Male 1/3/2012 Japan
Primary
Secondary
Concomitant
Anxiety Disorder Hospitalization 9/28/2011 46 Female 1/6/2012 Physician Japan
Primary
Secondary
Concomitant
Cholangitis Acute Hospitalization 12/11/2011 62 Male 146 lb 1/11/2012 Physician Japan
Primary
Concomitant
Withdrawal Syndrome Hospitalization 12/24/2011 76 Female 104 lb 1/11/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 12/3/2011 81 Male 122 lb 1/19/2012 Physician Japan
Primary
Secondary
Concomitant
Adjustment Disorder Hospitalization 12/28/2011 76 Female 104 lb 1/19/2012 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 10/15/2009 56 Male 1/20/2012 Japan
Primary
Secondary
Concomitant
Restlessness Hospitalization 10/15/2009 56 Male 1/23/2012 Japan
Primary
Secondary
Concomitant
Drug Eruption Hospitalization 12/9/2010 61 Female 1/27/2012 Physician Japan
Primary
Secondary
Nasopharyngitis Death 11/12/2007 76 Male 165 lb 1/30/2012 Physician Japan
Primary
Concomitant
Adjustment Disorder Hospitalization 12/28/2011 76 Female 104 lb 2/3/2012 Physician Japan
Primary
Secondary
Concomitant
Contrast Media Reaction Hospitalization 12/9/2010 61 Female 2/8/2012 Physician Japan
Primary
Secondary
Rash Hospitalization 10/27/2011 65 Male 182 lb 2/10/2012 Physician Japan
Primary
Concomitant
Recall Phenomenon Other Serious 12/28/2011 72 Male 154 lb 2/14/2012 Consumer Japan
Primary
Secondary
Concomitant
Adjustment Disorder Hospitalization 12/28/2011 76 Female 104 lb 2/14/2012 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 10/13/2011 78 Female 101 lb 2/14/2012 Physician Japan
Primary
Secondary
Concomitant
Rectal Ulcer Haemorrhage Hospitalization 10/1/2011 51 Female 2/17/2012 Physician Japan
Primary
Concomitant
Blood Lactate Dehydrogenase Increased Hospitalization 10/27/2011 65 Male 182 lb 2/21/2012 Consumer Japan
Primary
Concomitant
Disease Progression Other Serious 8/9/2010 70 Male 99 lb 2/22/2012 Physician Japan
Primary
Secondary
Concomitant
White Blood Cells Urine Positive Other Serious 9/14/2011 63 Female 2/24/2012 Pharmacist Japan
Primary
Concomitant
Anaemia Hospitalization 10/27/2011 65 Male 182 lb 3/2/2012 Physician Japan
Primary
Concomitant
Diarrhoea Hospitalization 5/23/2010 46 Female 108 lb 3/2/2012 Physician Japan
Primary
Secondary
Concomitant
Optic Ischaemic Neuropathy Other Serious 12/28/2011 72 Male 154 lb 3/5/2012 Consumer Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 2/11/2012 66 Male 148 lb 3/5/2012 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Other Serious 2/11/2012 66 Male 148 lb 3/8/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/3/2012 56 Female 3/8/2012 Physician Japan
Primary
Concomitant
Oliguria Other Serious 10/12/2011 53 Male 95 lb 3/14/2012 Consumer Japan
Primary
Concomitant
Stomatitis Hospitalization 5/23/2010 46 Female 108 lb 3/15/2012 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 9/4/2009 78 Female 90 lb 3/21/2012 Physician Japan
Primary
Concomitant
Neutropenia Hospitalization 2/3/2012 56 Female 3/23/2012 Physician Japan
Primary
Concomitant
Cachexia Other Serious 12/13/2011 73 Male 106 lb 4/2/2012 Physician Japan
Primary
Concomitant
Pancytopenia Other Serious 2/11/2012 66 Male 148 lb 4/4/2012 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 11/16/2011 73 Male 106 lb 4/5/2012 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 2/11/2012 66 Male 148 lb 4/5/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutropenia Hospitalization 2/3/2012 56 Female 4/5/2012 Physician Japan
Primary
Concomitant
Hypertension Hospitalization 12/22/2010 61 Male 141 lb 4/9/2012 Physician Japan
Primary
Concomitant
Hepatic Function Abnormal Other Serious 7/23/2010 47 Female 4/10/2012 Physician Japan
Primary
Concomitant
Pneumopericardium Other Serious 11/1/2011 68 Male 110 lb 4/10/2012 Physician Japan
Primary
Secondary
Concomitant
Hepatic Cirrhosis Death Female 74 lb 4/4/2012 Physician Japan
Primary
Concomitant
Hypocalcaemia Hospitalization 12/1/2010 58 Female 88 lb 4/11/2012 Physician Japan
Primary
Concomitant
Neoplasm Malignant Hospitalization 8/7/2010 64 Male 143 lb 4/17/2012 Physician Japan
Primary
Secondary
Concomitant

Drug Data