Loxonin combined with Xeloda

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Leukoencephalopathy Other Serious 5/1/2006 46 Female 99 lb 9/11/2006 Physician Japan
Primary
Concomitant
Leukoencephalopathy Other Serious 5/1/2006 46 Female 99 lb 9/19/2006 Physician Japan
Primary
Concomitant
Gait Disturbance Other Serious 2/14/2006 46 Female 119 lb 10/30/2006 Physician Japan
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 2/14/2006 46 Female 119 lb 11/17/2006 Physician Japan
Primary
Secondary
Concomitant
Rectal Stenosis Hospitalization 1/11/2007 Male 1/29/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Rectal Stenosis Hospitalization 1/11/2007 Male 4/4/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Visual Acuity Reduced Disability 7/1/2007 68 Female 104 lb 9/28/2007 Physician Japan
Primary
Concomitant
Renal Failure Acute Death 7/10/2007 52 Female 10/29/2007 Physician Japan
Primary
Secondary
Concomitant
Visual Acuity Reduced Hospitalization 7/20/2007 68 Female 104 lb 11/2/2007 Physician Japan
Primary
Concomitant
Hyperammonaemia Other Serious 4/9/2004 58 Female 12/18/2007 Physician Japan
Primary
Concomitant
Hypercalcaemia Disability 4/5/2004 40 Female 99 lb 12/18/2007 Physician Japan
Primary
Concomitant
Shock Hospitalization 1/1/2008 55 Male 132 lb 3/14/2008 Physician Japan
Primary
Secondary
Concomitant
Nausea Death 10/7/2005 49 Female 95 lb 3/31/2008 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/1/2008 55 Male 132 lb 4/1/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 5/2/2008 9/9/2008 Physician Japan
Primary
Concomitant
Rectal Ulcer Other Serious 6/24/2008 Female 132 lb 9/29/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 5/2/2008 10/3/2008 Physician Japan
Primary
Concomitant
Rectal Ulcer Hospitalization 6/24/2008 Female 132 lb 10/13/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 5/2/2008 Female 106 lb 1/7/2009 Physician Japan
Primary
Concomitant
Thirst Other Serious 10/1/2008 2/5/2009 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Life Threatening 9/16/2008 68 Female 143 lb 4/1/2009 Physician Japan
Primary
Secondary
Concomitant
Malaise Death 6/1/2009 Female 90 lb 8/17/2009 Physician Japan
Primary
Concomitant
Malaise Other Serious 6/1/2009 Female 90 lb 9/14/2009 Physician Japan
Primary
Concomitant
Pyrexia Death 1/25/2008 Female 9/21/2009 Physician Japan
Primary
Concomitant
Malaise Other Serious 6/1/2009 Female 90 lb 9/23/2009 Physician Japan
Primary
Concomitant
Large Intestine Perforation Life Threatening 11/7/2009 Male 110 lb 12/16/2009 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Life Threatening 11/7/2009 Male 110 lb 12/21/2009 Physician Japan
Primary
Secondary
Concomitant
Toothache Other Serious 3/1/2009 Female 101 lb 12/21/2009 Pharmacist Japan
Primary
Concomitant
Large Intestine Perforation Life Threatening 11/11/2009 56 Male 110 lb 12/23/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Large Intestine Perforation Life Threatening 11/7/2009 56 Male 110 lb 1/12/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/3/2009 Female 134 lb 1/20/2010 Other Health Professional Japan
Primary
Concomitant
Nausea Hospitalization 10/12/2009 Female 101 lb 2/10/2010 Physician Japan
Primary
Concomitant
Nausea Hospitalization 10/12/2009 Female 101 lb 3/16/2010 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 9/16/2008 68 Female 143 lb 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Life Threatening 11/11/2009 56 Male 110 lb 4/20/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Nausea Death 7/17/2009 37 Female 106 lb 5/3/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 8/24/2009 60 Female 5/5/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Thrombosis Life Threatening 8/27/2009 54 Female 187 lb 5/18/2010 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Necrosis Life Threatening 4/27/2010 61 Female 117 lb 5/19/2010 Physician Japan
Primary
Secondary
Concomitant
Nausea Death 7/17/2009 37 Female 106 lb 5/25/2010 Physician Japan
Primary
Concomitant
Gastrointestinal Necrosis Death 4/27/2010 61 Female 117 lb 6/2/2010 Physician Japan
Primary
Secondary
Concomitant
Tachypnoea Death 4/2/2010 66 Female 93 lb 7/1/2010 Physician Japan
Primary
Concomitant
Pain In Jaw Other Serious 1/20/2010 51 Female 7/7/2010 Physician Japan
Primary
Concomitant
Pulmonary Thrombosis Life Threatening 8/27/2009 54 Female 192 lb 7/8/2010 Physician Japan
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 1/20/2010 51 Female 7/16/2010 Physician Japan
Primary
Concomitant
Tachypnoea Death 4/2/2010 66 Female 93 lb 7/27/2010 Physician Japan
Primary
Concomitant
Disease Progression Disability 2/1/2010 73 Female 104 lb 8/16/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/9/2009 44 Female 99 lb 8/16/2010 Physician Japan
Primary
Concomitant
Pneumonia Life Threatening 1/18/2010 61 Female 112 lb 9/1/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/9/2009 44 Female 99 lb 9/3/2010 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 10/10/2008 78 Female 9/3/2010 Physician Japan
Primary
Concomitant
Septic Shock Life Threatening 4/23/2010 52 Female 75 lb 9/8/2010 Physician Japan
Primary
Secondary
Concomitant
Tumour Necrosis Life Threatening 4/23/2010 52 Female 75 lb 9/23/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/29/2008 52 Female 9/27/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 6/26/2010 81 Female 9/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pain In Jaw Other Serious 1/20/2010 51 Female 10/6/2010 Physician Japan
Primary
Concomitant
Haemoglobin Decreased Other Serious 8/4/2010 61 Male 126 lb 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 6/17/2010 81 Female 10/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombosis Other Serious 4/27/2010 61 Female 117 lb 11/3/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 4/13/2010 59 Male 11/5/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Death 6/17/2010 81 Female 11/10/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 4/13/2010 59 Male 11/10/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Hypocalcaemia Death 8/1/2007 49 Female 11/25/2010 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 6/17/2010 81 Female 12/7/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Skin Chapped Disability 12/1/2009 58 Female 130 lb 12/8/2010 Physician Japan
Primary
Concomitant
Thrombosis Other Serious 1/1/2010 60 Female 117 lb 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Tachypnoea Death 4/2/2010 66 Female 93 lb 12/14/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Death 8/1/2007 49 Female 12/31/2010 Physician Japan
Primary
Concomitant
Decreased Appetite Other Serious 2/22/2010 72 Male 123 lb 1/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 10/3/2010 66 Female 143 lb 1/20/2011 Other Health Professional Japan
Primary
Concomitant
Shock Hospitalization 9/16/2008 68 Female 143 lb 1/24/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Chapped Disability 12/1/2009 58 Female 130 lb 2/8/2011 Physician Japan
Primary
Concomitant
Nausea Hospitalization 10/3/2010 66 Female 143 lb 2/16/2011 Pharmacist Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Disability 12/1/2009 58 Female 130 lb 2/17/2011 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 8/25/2010 47 Male 2/23/2011 Physician Japan
Primary
Concomitant
Anaemia Hospitalization 8/27/2009 54 Female 192 lb 3/2/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/7/2011 66 Female 3/8/2011 Other Health Professional Japan
Primary
Concomitant
Nasopharyngitis Death 1/18/2010 61 Female 112 lb 3/9/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Death 7/12/2009 56 Female 99 lb 3/9/2011 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Hospitalization 1/19/2011 62 Female 3/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Intestinal Perforation Other Serious 2/10/2011 62 Female 108 lb 3/16/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 8/25/2010 47 Male 183 lb 3/21/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Death 7/12/2009 56 Female 99 lb 3/28/2011 Physician Japan
Primary
Concomitant
Drug Eruption Hospitalization 7/25/2009 37 Female 106 lb 4/5/2011 Physician Japan
Primary
Concomitant
Blood Creatinine Increased Hospitalization 4/13/2010 68 Female 93 lb 4/7/2011 Physician Japan
Primary
Secondary
Concomitant
Hypercapnia Life Threatening 8/1/2009 48 Female 148 lb 4/8/2011 Physician Japan
Primary
Concomitant
Haemolytic Anaemia Disability 8/25/2010 47 Male 183 lb 4/11/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening 7/14/2009 47 Male 187 lb 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Intestinal Perforation Hospitalization 2/4/2011 62 Female 108 lb 4/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 8/16/2010 69 Female 90 lb 4/14/2011 Physician Japan
Primary
Secondary
Concomitant
Dizziness Hospitalization 9/16/2009 50 Female 152 lb 4/21/2011 Physician Japan
Primary
Concomitant
Thrombosis Other Serious 7/14/2009 47 Male 183 lb 4/22/2011 Physician Japan
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 5/26/2010 57 Female 132 lb 4/27/2011 Physician Japan
Primary
Concomitant
Drug Eruption Hospitalization 7/25/2009 37 Female 106 lb 5/5/2011 Physician Japan
Primary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 7/14/2009 47 Male 187 lb 6/30/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 3/11/2011 34 Female 88 lb 7/7/2011 Physician Japan
Primary
Secondary
Concomitant
Urticaria Hospitalization 7/14/2009 47 Male 183 lb 7/8/2011 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 6/1/2009 58 Female 90 lb 8/2/2011 Physician Japan
Primary
Concomitant
Jaundice Hospitalization 3/11/2011 34 Female 88 lb 8/5/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 11/19/2009 60 Female 8/26/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Disability 12/22/2009 67 Female 93 lb 9/2/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Progression Hospitalization 8/17/2010 36 Female 9/6/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Death 8/17/2010 36 Female 9/10/2011 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization Female 88 lb 10/14/2011 Physician Japan
Primary
Concomitant
Eczema Death 7/31/2009 60 Female 10/16/2011 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/16/2010 69 Female 90 lb 11/1/2011 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Hospitalization Female 88 lb 11/4/2011 Physician Japan
Primary
Concomitant
Hepatic Cirrhosis Hospitalization 1/28/2011 48 Female 165 lb 11/15/2011 Physician Japan
Primary
Secondary
Concomitant
Brain Oedema Hospitalization 8/7/2011 47 Female 95 lb 12/7/2011 Physician Japan
Primary
Secondary
Concomitant
Bone Marrow Failure Hospitalization 8/26/2011 69 Male 154 lb 12/21/2011 Physician Japan
Primary
Secondary
Concomitant
Dyschezia Other Serious 11/14/2011 52 Male 132 lb 12/27/2011 Physician Japan
Primary
Secondary
Concomitant
Vomiting Death 1/28/2011 48 Female 165 lb 12/29/2011 Physician Japan
Primary
Secondary
Concomitant
Eczema Other Serious 2/1/2011 66 Female 154 lb 1/12/2012 Physician Japan
Primary
Secondary
Concomitant
Brain Oedema Hospitalization 8/7/2011 47 Female 95 lb 1/24/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 12/22/2009 67 Female 93 lb 1/26/2012 Physician Japan
Primary
Secondary
Concomitant
Pruritus Generalised Hospitalization 9/17/2011 61 Male 2/9/2012 Physician Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome 5/31/2011 67 Female 154 lb 2/17/2012 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Life Threatening 10/9/2011 56 Female 95 lb 2/22/2012 Physician Japan
Primary
Secondary
Hypertension Hospitalization 1/23/2011 56 Male 126 lb 2/27/2012 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 5/23/2010 46 Female 108 lb 3/2/2012 Physician Japan
Primary
Secondary
Concomitant
Dyschezia Other Serious 8/10/2010 50 Male 132 lb 3/2/2012 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 5/23/2010 46 Female 108 lb 3/15/2012 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 12/24/2010 61 Female 123 lb 4/27/2012 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 12/24/2010 61 Female 123 lb 5/1/2012 Physician Japan
Primary
Concomitant
Pruritus Generalised Life Threatening 9/17/2011 61 Male 5/8/2012 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 12/24/2010 61 Female 123 lb 5/22/2012 Physician Japan
Primary
Concomitant
C-reactive Protein Increased Other Serious 1/31/2012 61 Male 90 lb 6/11/2012 Physician Japan
Primary
Concomitant
Portal Vein Pressure Increased Life Threatening 8/10/2010 50 Male 132 lb 7/5/2012 Physician Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 2/25/2010 48 Female 73 lb 8/1/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Death 6/4/2012 50 Female 106 lb 8/13/2012 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Death 4/23/2010 53 Female 73 lb 9/20/2013 Physician Jp
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/16/2010 69 Female 90 lb 4/9/2013 Physician Jp
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/25/2010 48 Female 73 lb 3/12/2013 Physician Jp
Primary
Secondary
Concomitant
Vomiting Death 6/4/2012 51 Female 106 lb 12/12/2012 Physician Jp
Primary
Secondary
Concomitant
Grip Strength Decreased Other Serious 8/1/2012 69 Female 95 lb 10/12/2012 Physician Jp
Primary
Concomitant
Hypovolaemic Shock Death Male 139 lb 10/26/2012 Physician Jp
Primary
Secondary
Concomitant
Renal Impairment Death 11/3/2012 77 Male 123 lb 6/13/2013 Physician Jp
Primary
Secondary
Concomitant
Sepsis Life Threatening 8/23/2012 70 Female 117 lb 3/28/2013 Physician Jp
Primary
Secondary
Concomitant
Rectal Perforation Life Threatening 11/24/2012 78 Female 106 lb 1/7/2013 Physician Jp
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death Female 3/12/2013 Physician Jp
Primary
Secondary
Concomitant
Rash Other Serious 11/20/2009 Female 90 lb 2/1/2013 Physician Jp
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 8/5/2011 Female 101 lb 2/1/2013 Physician Jp
Primary
Secondary
Concomitant
Pancytopenia Other Serious 8/17/2009 Female 97 lb 1/31/2013 Physician Jp
Primary
Secondary
Concomitant
Skin Infection Hospitalization 12/12/2009 80 Female 3/26/2013 Physician Jp
Primary
Concomitant
Thrombocytopenic Purpura Other Serious Female 101 lb 4/11/2013 Pharmacist Jp
Primary
Secondary
Concomitant
Rash Other Serious 3/8/2011 41 Female 93 lb 3/28/2013 Physician Jp
Primary
Secondary
Concomitant
Metastases To Central Nervous System Death 11/20/2012 57 Female 90 lb 7/22/2013 Physician Jp
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 5/17/2013 66 Female 99 lb 6/21/2013 Pharmacist Jp
Primary
Secondary
Concomitant
Stomatitis Disability 10/18/2011 74 Female 123 lb 7/1/2013 Physician Jp
Primary
Secondary
Concomitant
Pulmonary Oedema Death 6/14/2013 70 Male 115 lb 9/11/2013 Consumer Jp
Primary
Secondary
Concomitant

Drug Data