Loxonin combined with Tocilizumab

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Life Threatening 9/8/2005 34 Male 136 lb 3/3/2006 Physician Japan
Primary
Secondary
Concomitant
Palpitations Hospitalization 6/1/2006 56 Female 115 lb 6/16/2006 Physician Japan
Primary
Concomitant
Pancreatitis Hospitalization 7/7/2009 Male 1/20/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 1/22/2010 Physician Japan
Primary
Secondary
Concomitant
Bronchopneumonia Other Serious 7/6/2009 Female 1/25/2010 Physician Japan
Primary
Secondary
Concomitant
Glomerulonephritis Acute Hospitalization 10/8/2009 60 Male 176 lb 1/27/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/27/2007 Male 146 lb 2/1/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 11/4/2009 Female 2/1/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/2/2010 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 1/20/2010 Male 2/2/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 11/4/2009 Female 2/3/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/4/2010 Physician Japan
Primary
Concomitant
Death Death 12/9/2008 Female 2/8/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Hospitalization 12/9/2008 Male 2/12/2010 Physician Japan
Primary
Secondary
Concomitant
Dermatitis Bullous Hospitalization 4/26/2009 Female 126 lb 2/12/2010 Physician Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Hospitalization 1/23/2010 Female 112 lb 2/12/2010 Physician Japan
Primary
Concomitant
Pneumonia Staphylococcal Other Serious 1/1/2009 Male 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/4/2009 Female 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
C-reactive Protein Increased Other Serious 8/20/2008 Male 141 lb 2/17/2010 Physician Japan
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 1/20/2010 Female 99 lb 2/17/2010 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 7/7/2009 Male 2/19/2010 Physician Japan
Primary
Concomitant
Nasopharyngitis Death 11/4/2008 Male 106 lb 2/23/2010 Physician Japan
Primary
Concomitant
Tonsillitis Hospitalization 9/5/2008 Female 2/23/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 8/14/2009 Female 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 1/1/2009 Female 3/3/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculous Pleurisy Hospitalization 5/11/2009 Female 3/3/2010 Physician Japan
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 3/4/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 2/22/2010 Female 3/5/2010 Physician Japan
Primary
Concomitant
Vasculitis Other Serious 7/1/2008 Male 132 lb 3/9/2010 Other Health Professional Japan
Primary
Concomitant
Gastric Perforation Life Threatening 5/14/2009 Female 95 lb 3/11/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/27/2007 Male 146 lb 3/15/2010 Physician Japan
Primary
Concomitant
Melaena Hospitalization 7/15/2009 Female 165 lb 3/17/2010 Physician Japan
Primary
Secondary
Concomitant
Uterine Leiomyoma Other Serious 8/7/2009 Female 3/19/2010 Physician Japan
Primary
Secondary
Concomitant
Septic Shock Hospitalization 12/9/2008 Male 132 lb 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Death Death 12/9/2008 Female 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Hospitalization 1/23/2010 Female 112 lb 3/24/2010 Physician Japan
Primary
Concomitant
Pneumonia Staphylococcal Death 10/19/2009 Male 3/24/2010 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 1/20/2010 Male 3/24/2010 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 8/14/2009 Female 3/24/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/28/2009 Female 3/30/2010 Physician Japan
Primary
Secondary
Concomitant
Transient Global Amnesia Other Serious 10/14/2009 Female 3/30/2010 Physician Japan
Primary
Concomitant
Nasopharyngitis Death 11/4/2008 Male 106 lb 3/31/2010 Physician Japan
Primary
Concomitant
Upper Respiratory Tract Inflammation Hospitalization 1/26/2006 42 Male 82 lb 4/1/2010 Physician Japan
Primary
Secondary
Concomitant
Tuberculous Pleurisy Hospitalization 5/11/2009 85 Female 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 10/2/2008 28 Female 112 lb 4/6/2010 Physician Japan
Primary
Secondary
Concomitant
Glomerulonephritis Acute Other Serious 3/16/2010 61 Female 126 lb 4/6/2010 Physician Japan
Primary
Concomitant
Colitis Ulcerative Hospitalization 2/2/2010 58 Female 143 lb 4/6/2010 Physician Japan
Primary
Concomitant
Femoral Neck Fracture Hospitalization 12/8/2008 71 Male 114 lb 4/16/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 6/9/2008 58 Male 154 lb 4/16/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/28/2009 75 Female 4/23/2010 Physician Japan
Primary
Secondary
Concomitant
Varicose Vein Other Serious 9/26/2008 61 Female 150 lb 4/23/2010 Physician Japan
Primary
Concomitant
Transient Global Amnesia Other Serious 10/14/2009 63 Female 123 lb 4/26/2010 Physician Japan
Primary
Concomitant
Pancreatitis Hospitalization 7/7/2009 68 Male 80 lb 4/27/2010 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 4/4/2010 70 Female 132 lb 4/29/2010 Physician Japan
Primary
Concomitant
Altered State Of Consciousness Hospitalization 1/23/2010 76 Female 112 lb 5/3/2010 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 1/13/2010 46 Female 77 lb 5/12/2010 Physician Japan
Primary
Concomitant
Pancreatitis Acute Hospitalization 7/7/2009 68 Male 80 lb 5/12/2010 Physician Japan
Primary
Concomitant
Death Death 3/1/2010 70 Female 5/12/2010 Physician Japan
Primary
Concomitant
Pyelonephritis Hospitalization 4/27/2010 76 Female 119 lb 5/18/2010 Physician Japan
Primary
Concomitant
Small Cell Lung Cancer Stage Unspecified Death 4/23/2010 66 Male 5/19/2010 Other Health Professional Japan
Primary
Concomitant
Nasopharyngitis Death 11/4/2008 81 Male 106 lb 5/26/2010 Physician Japan
Primary
Concomitant
Colitis Ulcerative Hospitalization 2/2/2010 58 Female 143 lb 5/27/2010 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 8/14/2009 52 Female 5/27/2010 Physician Japan
Primary
Secondary
Concomitant
Adverse Reaction Death 3/31/2010 66 Female 5/27/2010 Physician Japan
Primary
Concomitant
C-reactive Protein Increased Hospitalization 1/24/2010 76 Female 112 lb 5/27/2010 Physician Japan
Primary
Concomitant
Hypertriglyceridaemia 9/26/2008 61 Female 150 lb 5/27/2010 Physician Japan
Primary
Concomitant
Platelet Count Increased 7/6/2009 77 Female 5/28/2010 Physician Japan
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Hospitalization 9/1/2009 66 Female 6/2/2010 Physician Japan
Primary
Concomitant
Cardiac Failure Congestive Hospitalization 1/20/2010 78 Male 132 lb 6/9/2010 Physician Japan
Primary
Concomitant
Transient Global Amnesia Other Serious 10/14/2009 63 Female 123 lb 6/9/2010 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 3/1/2010 70 Female 6/16/2010 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 8/7/2008 70 Male 117 lb 6/18/2010 Physician Japan
Primary
Secondary
Concomitant
Colitis Ulcerative Hospitalization 2/2/2010 58 Female 143 lb 6/21/2010 Physician Japan
Primary
Concomitant
Hyperhidrosis Hospitalization 10/28/2009 51 Male 117 lb 6/25/2010 Physician Japan
Primary
Concomitant
Pancreatitis Acute Hospitalization 7/7/2009 68 Male 80 lb 7/6/2010 Physician Japan
Primary
Concomitant
Rash Hospitalization 7/19/2008 72 Female 93 lb 7/6/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphopenia Other Serious 6/1/2009 71 Male 139 lb 7/9/2010 Physician Japan
Primary
Concomitant
Malaise Hospitalization 3/19/2009 51 Female 110 lb 7/9/2010 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 1/13/2010 46 Female 77 lb 7/14/2010 Physician Japan
Primary
Concomitant
Pruritus Hospitalization 1/16/2009 63 Female 130 lb 7/16/2010 Physician Japan
Primary
Secondary
Concomitant
Ileus Hospitalization 10/26/2009 59 Female 110 lb 7/16/2010 Physician Japan
Primary
Concomitant
Pancytopenia Other Serious Male 90 lb 7/19/2010 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Hospitalization 8/13/2009 61 Female 7/22/2010 Physician Japan
Primary
Secondary
Concomitant
Death Death 4/16/2010 66 Female 88 lb 7/22/2010 Physician Japan
Primary
Concomitant
Skin Ulcer Hospitalization 10/1/2009 49 Female 7/23/2010 Physician Japan
Primary
Concomitant
Ulcerative Keratitis Other Serious 1/1/2008 62 Male 7/23/2010 Physician Japan
Primary
Secondary
Concomitant
Blood Urea Increased Other Serious 8/19/2009 60 Female 119 lb 7/23/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 2/22/2010 66 Female 7/29/2010 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 4/2/2010 70 Female 134 lb 7/29/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 2/22/2010 66 Female 119 lb 7/30/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 1/24/2010 76 Female 112 lb 7/30/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/27/2010 70 Female 8/5/2010 Physician Japan
Primary
Secondary
Concomitant
Pyelonephritis Hospitalization 4/27/2010 76 Female 119 lb 8/16/2010 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Hospitalization 8/13/2009 61 Female 8/23/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 8/22/2008 73 Female 90 lb 8/25/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis 10/14/2009 49 Female 117 lb 8/27/2010 Physician Japan
Primary
Concomitant
Arthritis Bacterial Hospitalization 4/18/2010 76 Female 104 lb 8/27/2010 Physician Japan
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 9/18/2008 31 Female 8/27/2010 Physician Japan
Primary
Secondary
Concomitant
Ileus Hospitalization 2/22/2010 66 Female 119 lb 8/30/2010 Physician Japan
Primary
Concomitant
Death Death 4/16/2010 66 Female 88 lb 8/30/2010 Physician Japan
Primary
Concomitant
Angiosarcoma Death 8/16/2010 77 Female 104 lb 9/7/2010 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 11/30/2009 65 Female 128 lb 9/8/2010 Physician Japan
Primary
Secondary
Concomitant
Angiosarcoma Death 8/16/2010 77 Female 104 lb 9/13/2010 Physician Japan
Primary
Concomitant
Brain Abscess Death 2/26/2010 76 Female 104 lb 9/15/2010 Physician Japan
Primary
Concomitant
Glomerulonephritis Acute Other Serious 3/16/2010 61 Female 126 lb 9/23/2010 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 1/1/2009 58 Female 123 lb 9/24/2010 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia 11/29/2009 69 Male 90 lb 9/27/2010 Physician Japan
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 9/18/2008 31 Female 9/27/2010 Physician Japan
Primary
Secondary
Concomitant
Periodontitis Hospitalization 7/9/2008 28 Female 82 lb 9/27/2010 Physician Japan
Primary
Secondary
Concomitant
Rash Hospitalization 7/19/2008 72 Female 93 lb 10/5/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 4/26/2009 76 Female 104 lb 10/6/2010 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 9/18/2008 31 Female 10/6/2010 Physician Japan
Primary
Secondary
Concomitant
Ileus Hospitalization 10/26/2009 59 Female 110 lb 10/7/2010 Physician Japan
Primary
Concomitant
Malaise Hospitalization 3/19/2009 51 Female 110 lb 10/8/2010 Physician Japan
Primary
Concomitant
Brain Abscess Death 2/26/2010 76 Female 104 lb 10/8/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 10/2/2010 69 Female 125 lb 10/11/2010 Physician Japan
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Hospitalization 9/1/2009 66 Female 10/13/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 10/2/2010 69 Female 125 lb 10/12/2010 Physician Japan
Primary
Secondary
Concomitant
Supraventricular Tachycardia Hospitalization 5/27/2008 58 Female 121 lb 10/14/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 10/2/2010 69 Female 125 lb 10/20/2010 Physician Japan
Primary
Secondary
Concomitant
Brain Abscess Death 2/26/2010 76 Female 104 lb 10/20/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 10/2/2010 69 Female 125 lb 10/20/2010 Physician Japan
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization 10/2/2010 69 Female 125 lb 10/21/2010 Physician Japan
Primary
Secondary
Concomitant
Lip And/or Oral Cavity Cancer Hospitalization 8/27/2009 66 Female 10/27/2010 Physician Japan
Primary
Concomitant
Death Death 4/16/2010 66 Female 88 lb 10/28/2010 Physician Japan
Primary
Concomitant
Rheumatoid Arthritis Other Serious 9/18/2008 31 Female 11/9/2010 Physician Japan
Primary
Secondary
Concomitant
Brain Abscess Hospitalization 2/26/2010 76 Female 104 lb 11/12/2010 Physician Japan
Primary
Concomitant
Renal Disorder Hospitalization 3/1/2010 61 Female 134 lb 11/15/2010 Physician Japan
Primary
Concomitant
Pustular Psoriasis Hospitalization 3/1/2009 71 Female 99 lb 11/24/2010 Physician Japan
Primary
Concomitant
Blood Urea Increased Other Serious 8/19/2009 60 Female 119 lb 12/2/2010 Physician Japan
Primary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 70 Female 93 lb 12/3/2010 Physician Japan
Primary
Secondary
Concomitant
Pustular Psoriasis Hospitalization 3/1/2009 71 Female 110 lb 12/13/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphopenia Hospitalization 2/4/2009 71 Male 137 lb 12/28/2010 Physician Japan
Primary
Concomitant
Rash Other Serious 1/22/2010 27 Male 181 lb 12/30/2010 Physician Japan
Primary
Secondary
Concomitant
Blood Urea Increased Other Serious 2/5/2010 27 Male 181 lb 1/3/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 2/5/2010 27 Male 181 lb 1/10/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Melaena Hospitalization 7/15/2009 49 Female 165 lb 1/19/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 5/11/2009 85 Female 106 lb 1/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cytomegalovirus Infection Hospitalization 3/3/2010 61 Female 134 lb 1/31/2011 Other Health Professional Japan
Primary
Concomitant
Melaena Hospitalization 7/15/2009 49 Female 165 lb 2/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Decubitus Ulcer Hospitalization 5/11/2009 85 Female 106 lb 2/28/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Other Serious 8/2/2010 59 Male 110 lb 3/1/2011 Physician Japan
Primary
Concomitant
Melaena Hospitalization 7/15/2009 49 Female 165 lb 3/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Hospitalization 1/8/2006 18 Female 69 lb 3/7/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Creatinine Decreased Life Threatening 4/26/2009 76 Female 104 lb 3/16/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Arthralgia Life Threatening 1/8/2006 18 Female 69 lb 3/23/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 9/29/2008 47 Female 3/24/2011 Other Health Professional Japan
Primary
Concomitant
Joint Destruction Hospitalization 9/17/2008 70 Female 93 lb 3/29/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data