Loxonin combined with Sunitinib Malate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Haemothorax Other Serious 10/3/2008 2/25/2009 Physician Japan
Primary
Concomitant
Shock Haemorrhagic Death 4/23/2006 3/2/2009 Physician Singapore
Primary
Concomitant
Haemothorax Other Serious 10/2/2008 3/20/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 9/24/2008 4/1/2009 Physician Japan
Primary
Concomitant
Hypercalcaemia Life Threatening 1/23/2009 5/4/2009 Physician Japan
Primary
Concomitant
Death Death 4/13/2009 60 5/21/2009 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Life Threatening 1/23/2009 26 5/22/2009 Physician Japan
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Other Serious 9/19/2008 67 6/3/2009 Physician Japan
Primary
Concomitant
Palpitations Other Serious 9/21/2008 78 6/5/2009 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 11/18/2008 75 6/11/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 9/24/2008 62 6/16/2009 Physician Japan
Primary
Concomitant
Hypoxia Other Serious 3/19/2009 54 6/22/2009 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Hospitalization 5/14/2009 77 6/23/2009 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Death 4/13/2009 60 6/24/2009 Physician Japan
Primary
Concomitant
Palpitations 9/21/2008 78 7/7/2009 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 11/18/2008 75 7/15/2009 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Other Serious 9/19/2008 67 7/17/2009 Physician Japan
Primary
Concomitant
Death Death 5/30/2009 64 7/29/2009 Physician Japan
Primary
Concomitant
Death Death 5/30/2009 64 7/30/2009 Physician Japan
Primary
Concomitant
Platelet Count Decreased Hospitalization 5/11/2009 77 7/30/2009 Physician Japan
Primary
Concomitant
Tumour Haemorrhage Death 8/2/2009 62 8/31/2009 Physician Japan
Primary
Concomitant
Renal Impairment Life Threatening 7/7/2009 56 9/15/2009 Physician Japan
Primary
Concomitant
Nausea Life Threatening 4/29/2009 58 9/23/2009 Physician Japan
Primary
Concomitant
Platelet Count Decreased Life Threatening 7/7/2009 56 9/28/2009 Physician Japan
Primary
Concomitant
Malaise Hospitalization 10/7/2009 59 10/19/2009 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 4/6/2009 72 10/27/2009 Physician Japan
Primary
Concomitant
Lung Infection Hospitalization 7/27/2009 68 10/28/2009 Physician Japan
Primary
Secondary
Concomitant
Myocardial Ischaemia Other Serious 8/18/2009 68 Female 11/4/2009 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/30/2009 61 Male 141 lb 11/11/2009 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 12/11/2008 72 Male 104 lb 11/16/2009 Physician Japan
Primary
Concomitant
Malaise Hospitalization 10/7/2009 67 Male 130 lb 11/17/2009 Physician Japan
Primary
Concomitant
Myocardial Infarction Death 10/8/2009 73 Male 124 lb 11/17/2009 Physician Japan
Primary
Concomitant
Blood Bilirubin Increased Hospitalization 7/31/2009 65 Male 129 lb 11/17/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/7/2009 67 Male 130 lb 11/19/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Death 10/8/2009 73 Male 124 lb 11/27/2009 Physician Japan
Primary
Concomitant
Suicide Attempt Other Serious 10/2/2008 59 Male 161 lb 11/27/2009 Physician Japan
Primary
Concomitant
Lacunar Infarction Hospitalization 9/18/2009 70 Male 11/27/2009 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Other Serious 7/31/2009 42 Male 136 lb 12/2/2009 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 12/11/2008 72 Male 104 lb 12/3/2009 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Death 5/30/2009 64 Male 112 lb 12/17/2009 Physician Japan
Primary
Concomitant
Myocardial Infarction Death 10/8/2009 73 Male 124 lb 12/18/2009 Physician Japan
Primary
Concomitant
Lacunar Infarction Hospitalization 9/18/2009 70 12/21/2009 Physician Japan
Primary
Concomitant
Pneumonia Aspiration Life Threatening 8/20/2009 Male 116 lb 12/29/2009 Physician Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 6/30/2009 61 Male 141 lb 12/30/2009 Physician Japan
Primary
Concomitant
Lacunar Infarction Hospitalization 9/18/2009 70 Male 1/20/2010 Physician Japan
Primary
Concomitant
Nausea Life Threatening 4/29/2009 58 Male 125 lb 1/22/2010 Physician Japan
Primary
Concomitant
Pneumonia Aspiration Life Threatening 8/15/2009 60 Male 116 lb 1/29/2010 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 12/11/2008 72 Male 104 lb 2/1/2010 Physician Japan
Primary
Concomitant
Lung Infection Hospitalization 7/27/2009 68 Male 132 lb 2/5/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Cell Carcinoma Life Threatening 4/29/2009 58 Male 125 lb 2/18/2010 Physician Japan
Primary
Concomitant
Malaise Hospitalization 10/7/2009 67 Male 130 lb 3/5/2010 Physician Japan
Primary
Concomitant
Pharyngeal Haemorrhage Other Serious 10/2/2009 59 Male 118 lb 3/12/2010 Physician Japan
Primary
Concomitant
Myocardial Ischaemia Death 8/18/2009 68 Female 110 lb 3/17/2010 Physician Japan
Primary
Concomitant
Death Other Serious 9/25/2008 60 Male 99 lb 3/18/2010 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Life Threatening 4/29/2009 58 Male 125 lb 3/23/2010 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Hospitalization 10/3/2009 60 Female 97 lb 3/23/2010 Physician Japan
Primary
Concomitant
Hypothyroidism Death 1/15/2010 44 Female 4/2/2010 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Other Serious 7/31/2009 42 Male 136 lb 4/8/2010 Physician Japan
Primary
Concomitant
Death Death 12/7/2009 82 Male 115 lb 4/9/2010 Physician Japan
Primary
Concomitant
Hypothyroidism Other Serious 7/29/2009 53 Female 88 lb 4/9/2010 Physician Japan
Primary
Concomitant
Myocardial Ischaemia Death 8/18/2009 68 Female 110 lb 4/9/2010 Physician Japan
Primary
Concomitant
Lung Infection Hospitalization 7/27/2009 68 Male 132 lb 4/9/2010 Physician Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 10/3/2009 60 Female 97 lb 4/13/2010 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Other Serious 7/29/2009 53 Female 88 lb 4/23/2010 Physician Japan
Primary
Concomitant
Metastatic Renal Cell Carcinoma Death 1/15/2010 44 Female 5/3/2010 Physician Japan
Primary
Concomitant
Pharyngeal Haemorrhage Other Serious 10/2/2009 59 Male 118 lb 5/7/2010 Physician Japan
Primary
Concomitant
Hypothyroidism Other Serious 7/2/2009 Male 109 lb 5/12/2010 Physician Japan
Primary
Concomitant
Tumour Haemorrhage Life Threatening 8/25/2009 53 Male 166 lb 5/12/2010 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Other Serious 4/6/2009 72 Male 5/18/2010 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 4/7/2010 62 Male 5/19/2010 Pharmacist Japan
Primary
Concomitant
Renal Failure Life Threatening 4/5/2010 62 Male 179 lb 5/26/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Gastrointestinal Stromal Tumour Death 8/8/2009 61 Male 99 lb 6/1/2010 Physician Japan
Primary
Concomitant
Pleural Effusion Life Threatening 11/23/2009 47 Male 157 lb 5/31/2010 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Other Serious 7/2/2009 Male 109 lb 5/31/2010 Physician Japan
Primary
Concomitant
Pneumothorax Life Threatening 2/17/2010 72 Male 6/1/2010 Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/2/2010 42 Male 192 lb 6/3/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 9/24/2008 62 Female 6/4/2010 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Hospitalization 10/30/2008 59 Male 143 lb 6/8/2010 Physician Japan
Primary
Concomitant
Depressed Level Of Consciousness Hospitalization 11/3/2009 61 Female 149 lb 6/8/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 11/24/2008 66 Male 128 lb 6/10/2010 Japan
Primary
Concomitant
Depressed Level Of Consciousness Hospitalization 11/3/2009 61 Female 149 lb 6/25/2010 Japan
Primary
Secondary
Concomitant
Tumour Haemorrhage Life Threatening 8/25/2009 53 Male 166 lb 6/28/2010 Japan
Primary
Concomitant
Pyrexia Hospitalization 10/30/2008 59 Male 143 lb 6/28/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/28/2009 56 Male 141 lb 6/30/2010 Japan
Primary
Concomitant
Pleural Effusion Life Threatening 11/23/2009 47 Male 157 lb 6/30/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 9/24/2008 62 Female 6/30/2010 Japan
Primary
Concomitant
Thrombocytopenia Life Threatening 4/5/2010 68 Male 132 lb 7/1/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/24/2008 66 Male 128 lb 7/7/2010 Physician Japan
Primary
Concomitant
Hypoglycaemia Death 12/7/2009 82 Male 115 lb 7/8/2010 Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 4/8/2009 70 Male 143 lb 7/8/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 12/14/2009 60 Male 134 lb 7/14/2010 Physician Japan
Primary
Concomitant
Haemorrhage Urinary Tract Hospitalization 9/15/2009 41 Male 117 lb 7/20/2010 Physician Japan
Primary
Concomitant
Pleural Effusion Life Threatening 11/23/2009 47 Male 157 lb 7/21/2010 Physician Japan
Primary
Concomitant
Tumour Haemorrhage Life Threatening 8/25/2009 53 Male 166 lb 7/26/2010 Physician Japan
Primary
Concomitant
Suicide Attempt Other Serious 10/2/2008 59 Male 161 lb 7/30/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Life Threatening 4/5/2010 68 Male 132 lb 8/3/2010 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Life Threatening 11/30/2009 63 Male 110 lb 8/4/2010 Physician Japan
Primary
Concomitant
Tumour Haemorrhage Life Threatening 8/25/2009 53 Male 166 lb 8/4/2010 Physician Japan
Primary
Concomitant
Platelet Count Decreased Hospitalization 4/8/2009 70 Male 143 lb 8/6/2010 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 1/22/2010 72 Male 8/9/2010 Pharmacist Japan
Primary
Concomitant
Haemorrhage Urinary Tract Hospitalization 9/10/2009 41 Male 117 lb 8/12/2010 Physician Japan
Primary
Concomitant
Renal Failure Life Threatening 4/5/2010 62 Male 179 lb 8/12/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Respiratory Disorder Hospitalization 6/29/2010 68 Female 115 lb 8/13/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 5/14/2009 78 Male 119 lb 8/18/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/28/2009 56 Male 141 lb 8/23/2010 Physician Japan
Primary
Concomitant
Tumour Haemorrhage Life Threatening 11/30/2009 63 Male 110 lb 8/30/2010 Physician Japan
Primary
Concomitant
Vomiting Life Threatening 1/22/2010 72 Male 9/1/2010 Pharmacist Japan
Primary
Concomitant
Pneumonia Bacterial Other Serious 5/14/2009 78 Male 119 lb 9/6/2010 Physician Japan
Primary
Concomitant
Renal Cell Carcinoma Death 12/7/2009 82 Male 115 lb 9/7/2010 Physician Japan
Primary
Concomitant
Suicide Attempt Other Serious 10/2/2008 59 Male 161 lb 9/28/2010 Physician Japan
Primary
Concomitant
Suicide Attempt Other Serious 10/2/2008 59 Male 161 lb 9/28/2010 Physician Japan
Primary
Concomitant
Respiratory Disorder Hospitalization 6/29/2010 68 Female 115 lb 10/11/2010 Physician Japan
Primary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 10/25/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Haemorrhagic Death 4/23/2006 38 Female 11/5/2010 Physician Singapore
Primary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 11/5/2010 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 3/20/2010 60 Male 11/15/2010 Physician Japan
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 7/1/2010 45 Male 132 lb 11/17/2010 Physician Japan
Primary
Concomitant
Respiratory Disorder Hospitalization 6/29/2010 68 Female 115 lb 11/19/2010 Physician Japan
Primary
Concomitant
Cholecystitis Acute Hospitalization 11/2/2010 64 Female 117 lb 11/19/2010 Physician Japan
Primary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 11/29/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Other Serious 5/14/2009 78 Male 119 lb 12/3/2010 Physician Japan
Primary
Concomitant
Stomatitis Hospitalization 10/12/2010 73 Female 94 lb 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Lacunar Infarction Hospitalization 9/18/2009 70 12/21/2009 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 10/16/2010 67 Male 141 lb 12/23/2010 Physician Japan
Primary
Concomitant
Cholecystitis Acute Hospitalization 11/2/2010 64 Female 117 lb 1/17/2011 Physician Japan
Primary
Concomitant
Pulmonary Hypertension Hospitalization 10/12/2010 73 Female 94 lb 1/21/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious 10/25/2010 61 Male 143 lb 1/28/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 1/24/2011 66 Female 2/11/2011 Physician Japan
Primary
Concomitant
Haemoglobin Decreased Other Serious 10/18/2010 53 Male 141 lb 4/15/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/31/2011 71 Female 4/22/2011 Physician Japan
Primary
Concomitant
Meningitis Other Serious 7/13/2010 70 Male 117 lb 4/26/2011 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 1/22/2010 72 Male 4/29/2011 Pharmacist Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/31/2011 71 Female 5/2/2011 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 3/31/2011 71 Female 5/2/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/31/2011 71 Female 5/5/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/31/2011 71 Female 5/6/2011 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 10/16/2010 67 Male 141 lb 6/6/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/31/2011 71 Female 6/8/2011 Physician Japan
Primary
Concomitant
Haemoglobin Decreased Other Serious 3/25/2010 60 Male 6/14/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Other Serious 10/18/2010 53 Male 141 lb 6/23/2011 Physician Japan
Primary
Concomitant
Blood Alkaline Phosphatase Increased Other Serious Male 6/28/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 1/24/2011 66 Female 8/2/2011 Physician Japan
Primary
Concomitant
Convulsion Other Serious 12/19/2010 59 Male 128 lb 8/17/2011 Physician Japan
Primary
Concomitant
Anaemia Other Serious 1/24/2011 66 Female 9/7/2011 Physician Japan
Primary
Concomitant
Neoplasm Malignant Other Serious 8/2/2010 60 Male 143 lb 10/3/2011 Physician Japan
Primary
Concomitant
Death Death 11/9/2010 59 Male 10/7/2011 Physician Japan
Primary
Concomitant
Neoplasm Progression Hospitalization 9/2/2010 60 Female 10/11/2011 Physician Japan
Primary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 8/26/2010 57 Male 110 lb 11/2/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/31/2011 71 Female 11/7/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/31/2011 71 Female 12/7/2011 Physician Japan
Primary
Concomitant

Drug Data