Loxonin combined with Prograf

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Muscle Atrophy Other Serious 1/1/2004 Male 3/23/2006 Other Health Professional United Kingdom
Primary
Concomitant
Osteoporosis Other Serious 11/1/2003 Male 5/10/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteoporosis Other Serious 11/1/2003 Male 5/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteoporosis Disability 11/1/2003 68 Male 5/25/2006 Physician Japan
Primary
Secondary
Concomitant
Osteoporosis Disability 11/1/2003 Male 6/2/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/24/2006 Male 101 lb 7/25/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Disability 7/1/2003 52 Male 8/18/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Disability 10/4/2002 Male 8/23/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Disability 5/26/2003 52 Male 12/15/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/4/2002 Male 12/21/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/24/2006 Male 117 lb 1/4/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 6/24/2006 Male 117 lb 6/22/2007 Physician Japan
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 3/10/2007 Male 132 lb 9/21/2007 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 9/21/2006 Male 123 lb 11/9/2007 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 9/21/2006 Male 123 lb 3/12/2008 Physician Japan
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 74 Female 108 lb 3/28/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/17/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Congestive Disability 4/16/2007 46 Female 108 lb 4/22/2008 Physician Japan
Primary
Concomitant
Vertebral Artery Occlusion Hospitalization 5/28/2008 Female 86 lb 6/18/2008 Physician Japan
Primary
Concomitant
Vertebral Artery Occlusion Hospitalization 5/28/2008 Female 86 lb 7/14/2008 Physician Japan
Primary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 7/15/2008 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 9/21/2006 Male 123 lb 7/29/2008 Physician Japan
Primary
Concomitant
Weight Decreased Life Threatening 5/10/2008 Female 75 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Cardiomegaly Disability 4/16/2007 46 Female 108 lb 9/19/2008 Physician Japan
Primary
Secondary
Concomitant
Nephrotic Syndrome Hospitalization 6/28/2006 Female 101 lb 10/6/2008 Physician Japan
Primary
Concomitant
Weight Decreased Life Threatening 5/10/2008 Female 75 lb 10/9/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 5/10/2008 Female 75 lb 10/15/2008 Physician Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 9/21/2006 Male 123 lb 11/24/2008 Physician Japan
Primary
Concomitant
Pneumonia Other Serious 1/1/2007 Female 128 lb 2/5/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/1/2007 Female 128 lb 3/5/2009 Physician Japan
Primary
Secondary
Concomitant
Shock Life Threatening 9/1/2007 Male 161 lb 3/9/2009 Other Health Professional Japan
Primary
Concomitant
Shock Life Threatening 9/1/2007 Male 161 lb 3/20/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 8/19/2009 67 Male 9/9/2009 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 5/10/2008 Female 75 lb 10/21/2009 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Life Threatening 7/3/2008 Female 75 lb 10/21/2009 Physician Japan
Primary
Secondary
Concomitant
Synovectomy Hospitalization 4/1/2007 Female 88 lb 11/9/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 10/20/2008 Male 108 lb 12/15/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 11/30/2009 Female 104 lb 12/29/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 11/30/2009 Female 104 lb 12/31/2009 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 5/6/2008 Male 110 lb 1/8/2010 Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 1/22/2010 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 5/6/2008 Male 110 lb 1/25/2010 Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 5/6/2008 Male 110 lb 2/1/2010 Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/2/2010 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/4/2010 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 8/7/2008 Male 117 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 1/4/2010 56 Male 117 lb 2/12/2010 Physician Japan
Primary
Concomitant
C-reactive Protein Increased Other Serious 8/20/2008 Male 141 lb 2/17/2010 Physician Japan
Primary
Concomitant
Subdural Haematoma Hospitalization 9/17/2008 Female 93 lb 2/26/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 10/20/2008 Male 108 lb 3/9/2010 Physician Japan
Primary
Secondary
Concomitant
Uterine Leiomyoma Other Serious 8/7/2009 Female 3/19/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Cell Carcinoma Hospitalization 8/26/2009 50 Male 106 lb 3/22/2010 Physician Japan
Primary
Concomitant
Altered State Of Consciousness Hospitalization 1/23/2010 Female 112 lb 3/24/2010 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 3/27/2010 57 Female 132 lb 4/26/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 1/19/2010 70 Female 84 lb 4/26/2010 Physician Japan
Primary
Secondary
Altered State Of Consciousness Hospitalization 1/23/2010 76 Female 112 lb 5/3/2010 Physician Japan
Primary
Concomitant
Death Death 3/1/2010 70 Female 5/12/2010 Physician Japan
Primary
Concomitant
C-reactive Protein Increased Hospitalization 1/24/2010 76 Female 112 lb 5/27/2010 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 3/27/2010 57 Female 132 lb 5/28/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Life Threatening 2/5/2010 70 Female 84 lb 6/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 3/27/2010 57 Female 132 lb 6/8/2010 Physician Japan
Primary
Secondary
Sepsis Hospitalization 3/27/2010 57 Female 132 lb 6/14/2010 Physician Japan
Primary
Secondary
Renal Failure Life Threatening 3/1/2010 70 Female 6/16/2010 Physician Japan
Primary
Concomitant
Renal Impairment Hospitalization 8/7/2008 70 Male 117 lb 6/18/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 12/9/2008 59 Female 73 lb 6/29/2010 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 3/27/2010 57 Female 132 lb 7/9/2010 Physician Japan
Primary
Secondary
Pruritus Hospitalization 1/16/2009 63 Female 130 lb 7/16/2010 Physician Japan
Primary
Secondary
Concomitant
Pruritus Other Serious 1/16/2009 63 Female 130 lb 7/22/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 12/9/2008 59 Female 73 lb 7/23/2010 Physician Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 1/24/2010 76 Female 112 lb 7/30/2010 Physician Japan
Primary
Concomitant
Cerebral Thrombosis Death 8/8/2010 81 Female 99 lb 8/31/2010 Physician Japan
Primary
Concomitant
Pruritus Other Serious 1/16/2009 63 Female 130 lb 9/21/2010 Physician Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Disability 6/7/2010 49 Female 10/7/2010 Physician Japan
Primary
Concomitant
Vasculitis Life Threatening 1/1/2010 69 Female 84 lb 10/11/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 9/15/2010 79 Female 11/19/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/2010 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Disability 6/7/2010 49 Female 115 lb 1/24/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 1/16/2009 63 Female 130 lb 2/1/2011 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Other Serious 10/12/2010 80 Female 75 lb 2/23/2011 Physician Japan
Primary
Concomitant
Headache Other Serious 12/1/2010 21 Male 233 lb 2/24/2011 Pharmacist Japan
Primary
Concomitant
Melaena Hospitalization 7/15/2009 49 Female 165 lb 3/7/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Abscess Life Threatening 2/16/2011 78 Female 340 lb 4/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Abscess Other Serious 1/1/2010 77 Female 340 lb 6/27/2011 Physician Japan
Primary
Secondary
Concomitant
Pericarditis Rheumatic Hospitalization 7/10/2008 60 Female 82 lb 7/29/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 4/20/2011 76 Female 118 lb 8/3/2011 Physician Japan
Primary
Concomitant
Pericarditis Rheumatic Hospitalization 7/10/2008 60 Female 82 lb 8/4/2011 Physician Japan
Primary
Secondary
Concomitant
Cell Marker Increased Other Serious 5/24/2011 60 Female 8/4/2011 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 1/1/2010 70 Female 84 lb 8/11/2011 Physician Japan
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 3/15/2011 49 Male 9/6/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 6/21/2011 60 Female 9/6/2011 Physician Japan
Primary
Concomitant
Graft Versus Host Disease Disability 6/6/2011 13 Female 88 lb 9/20/2011 Physician Japan
Primary
Concomitant
Cell Marker Increased Other Serious 6/21/2011 60 Female 9/27/2011 Physician Japan
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 5/25/2011 76 Female 118 lb 10/6/2011 Other Health Professional Japan
Primary
Concomitant
Vasculitis Cerebral Life Threatening 1/1/2010 70 Female 88 lb 10/6/2011 Physician Japan
Primary
Concomitant
Cerebral Infarction Life Threatening 1/1/2010 70 Female 88 lb 10/11/2011 Physician Japan
Primary
Secondary
Concomitant
Appendix Disorder Hospitalization 11/24/2010 63 Male 110 lb 10/27/2011 Physician Japan
Primary
Secondary
Concomitant
Vasculitis Cerebral Death 1/1/2010 70 Female 88 lb 10/28/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 5/31/2011 77 Female 110 lb 11/3/2011 Physician Japan
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 5/8/2011 76 Female 118 lb 11/2/2011 Other Health Professional Japan
Primary
Concomitant
Visual Impairment Death 6/6/2011 13 Female 88 lb 11/8/2011 Physician Japan
Primary
Concomitant
Pulmonary Tuberculosis Other Serious 10/1/2011 65 Male 157 lb 11/9/2011 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Hospitalization 4/17/2009 76 Female 11/17/2011 Physician Japan
Primary
Secondary
Concomitant
Abdominal Pain Hospitalization 11/24/2010 63 Male 110 lb 11/22/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Other Serious 10/1/2011 65 Male 157 lb 11/28/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Hospitalization 5/31/2011 77 Female 110 lb 11/28/2011 Physician Japan
Primary
Secondary
Concomitant
Pleurisy Other Serious 7/14/2011 67 Male 11/28/2011 Physician Japan
Primary
Secondary
Concomitant
Arthritis Bacterial Life Threatening 4/17/2009 76 Female 12/20/2011 Japan
Primary
Secondary
Concomitant
Bacterial Test Positive Other Serious 5/4/2011 63 Female 87 lb 12/28/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 3/1/2010 50 Male 2/7/2012 Physician Japan
Primary
Secondary
Concomitant
Rectal Ulcer Haemorrhage Hospitalization 10/1/2011 51 Female 2/17/2012 Physician Japan
Primary
Concomitant
Menorrhagia Hospitalization 1/27/2012 19 Female 116 lb 3/19/2012 Physician Japan
Primary
Secondary
Concomitant
Anaphylactoid Reaction Other Serious 3/6/2012 78 Male 3/22/2012 Other Health Professional Japan
Primary
Concomitant
Malaise Other Serious 8/20/2010 61 Female 3/26/2012 Japan
Primary
Secondary
Concomitant
Blood Potassium Decreased Death 1/19/2010 70 Female 88 lb 4/16/2012 Physician Japan
Primary
Secondary
Concomitant
Blood Potassium Decreased Hospitalization 1/19/2010 70 Female 88 lb 4/25/2012 Physician Japan
Primary
Secondary
Concomitant
Femur Fracture Other Serious 10/18/2010 61 Female 84 lb 5/23/2012 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Hospitalization 1/1/2011 31 Female 148 lb 6/7/2012 Physician Japan
Primary
Concomitant
Skin Ulcer Hospitalization 12/1/2011 32 Female 148 lb 6/13/2012 Physician Japan
Primary
Concomitant
Computerised Tomogram Abnormal Other Serious 6/13/2011 70 Male 6/22/2012 Physician Japan
Primary
Concomitant
Computerised Tomogram Abnormal Death 6/13/2011 70 Male 6/22/2012 Consumer Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 12/10/2011 61 Female 99 lb 7/11/2012 Physician Japan
Primary
Concomitant
Fall Other Serious 7/13/2009 60 Female 86 lb 7/12/2012 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 1/16/2009 63 Female 130 lb 7/12/2012 Japan
Primary
Secondary
Concomitant
Diarrhoea Life Threatening 5/1/2012 84 Female 79 lb 7/27/2012 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Life Threatening 5/1/2012 84 Female 79 lb 7/31/2012 Consumer Japan
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 10/30/2008 65 Male 110 lb 7/31/2012 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 12/10/2011 61 Female 99 lb 8/17/2012 Physician Japan
Primary
Concomitant
Pruritus Hospitalization 1/16/2009 64 Female 130 lb 8/31/2012 Physician Jp
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 10/1/2011 65 Male 157 lb 9/28/2012 Physician Jp
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Death 2009 Female 97 lb 12/28/2012 Physician Country Not Specified
Primary
Secondary
Concomitant
Sepsis Hospitalization 3/2010 Male 10/8/2012 Physician Jp
Primary
Secondary
Concomitant
Vasculitis Hospitalization 12/2011 Female 148 lb 10/3/2012 Physician Jp
Primary
Concomitant
Zygomycosis Other Serious 9/22/2010 61 Female 84 lb 11/23/2012 Physician Country Not Specified
Primary
Concomitant
Joint Injury Hospitalization 7/13/2009 61 Female 86 lb 3/8/2013 Physician Jp
Primary
Secondary
Concomitant
Melaena Death 6/13/2011 70 Male 10/16/2012 Physician Jp
Primary
Concomitant
Hyponatraemia Hospitalization 5/2012 84 Female 79 lb 9/19/2012 Consumer Jp
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Other Serious 12/10/2011 61 Female 99 lb 9/17/2012 Physician Jp
Primary
Concomitant
Tumour Invasion Other Serious 10/30/2008 66 Male 110 lb 1/3/2013 Physician Jp
Primary
Secondary
Concomitant
Skin Mass 7/24/2012 82 Female 95 lb 9/21/2012 Physician Jp
Primary
Concomitant
Henoch-schonlein Purpura Nephritis Other Serious 8/2011 54 Female 101 lb 1/7/2013 Physician Jp
Primary
Concomitant
Large Intestine Polyp Hospitalization 2/7/2012 77 Female 104 lb 11/1/2012 Physician Jp
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 2012 70 Male 11/13/2012 Physician Jp
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Hospitalization 4/2/2012 77 Female 84 lb 3/19/2013 Other Health Professional Jp
Primary
Concomitant
Rheumatoid Arthritis Other Serious 9/10/2012 70 Male 12/3/2012 Physician Jp
Primary
Secondary
Concomitant
Upper Respiratory Tract Inflammation Other Serious 5/20/2009 42 Female 12/19/2012 Physician Jp
Primary
Concomitant
Intraocular Pressure Increased Other Serious 1/2013 38 Female 2/12/2013 Consumer Jp
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/26/2012 85 Female 3/6/2013 Physician Jp
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 2/28/2013 71 Female 4/16/2013 Consumer Jp
Primary
Concomitant
Sepsis Life Threatening 3/11/2013 79 Female 64 lb 6/20/2013 Physician Jp
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 1/10/2013 77 Female 121 lb 8/5/2013 Physician Jp
Primary
Secondary
Concomitant

Drug Data