Lorazepam combined with Voriconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Thrombotic Stroke Death 10/27/2005 45 Female 1/25/2006 Physician United States
Primary
Secondary
Concomitant
Cardiac Failure Congestive Hospitalization 2/8/2005 18 Female 128 lb 1/10/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/3/2006 37 Male 4/22/2006 United States
Primary
Secondary
Concomitant
Respiratory Syncytial Virus Infection Other Serious 12/13/2006 49 Female 1/20/2007 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/13/2006 49 Female 1/27/2007 Physician United States
Primary
Secondary
Concomitant
Vessel Puncture Site Haematoma Other Serious 12/13/2006 49 Female 1/31/2007 Physician United States
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 1/8/2007 81 Male 3/26/2007 Pharmacist United States
Primary
Concomitant
Zygomycosis Hospitalization 2/27/2007 Male 132 lb 3/29/2007 Physician Canada
Primary
Concomitant
Serotonin Syndrome Other Serious 23 Male 6/5/2007 Pharmacist United States
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 10/24/2006 41 Male 151 lb 10/24/2006 United States
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 4/22/2007 Female 158 lb 7/11/2007 Physician United States
Primary
Secondary
Concomitant
Serotonin Syndrome Other Serious 23 Male 9/29/2007 Pharmacist United States
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Life Threatening 10/7/2007 14 Male 203 lb 11/8/2007 Physician United States
Primary
Secondary
Concomitant
Pseudomonas Infection Required Intervention 9/27/2007 39 Male 154 lb 11/1/2007 Pharmacist United States
Primary
Concomitant
Ventricular Fibrillation Other Serious 10/5/2007 36 Male 1/16/2008 Netherlands
Primary
Concomitant
Renal Failure Hospitalization 5/7/2004 Male 2/8/2008 Physician United States
Primary
Secondary
Concomitant
Tremor Hospitalization 23 Male 3/18/2008 Pharmacist United States
Primary
Concomitant
Ventricular Hypokinesia Other Serious 6/3/2008 33 Male 134 lb 8/4/2008 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 6/3/2008 33 Male 134 lb 8/8/2008 United States
Primary
Secondary
Concomitant
Metabolic Acidosis Life Threatening 7/31/2008 Female 8/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Life Threatening 7/31/2008 Female 8/29/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Life Threatening 7/31/2008 Female 9/16/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 6/3/2008 33 Male 134 lb 10/14/2008 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/6/2008 Male 10/28/2008 Australia
Primary
Secondary
Concomitant
Hypoxia Required Intervention 8/21/2008 49 Female 124 lb 10/1/2008 United States
Primary
Concomitant
Pneumonia Hospitalization 9/30/2008 Male 163 lb 11/24/2008 Australia
Primary
Secondary
Concomitant
Ventricular Hypokinesia Other Serious 6/3/2008 33 Male 134 lb 12/5/2008 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 6/3/2008 33 Male 134 lb 12/11/2008 United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 6/9/2008 60 Male 249 lb 12/22/2008 Physician United States
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 12/9/2008 Male 96 lb 1/15/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Urticaria Hospitalization 15 Male 101 lb 1/23/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 10/5/2007 36 Male 2/13/2009 Netherlands
Primary
Concomitant
Hepatitis Life Threatening 1/20/2009 4/1/2009 Spain
Primary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 4/23/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 4/29/2009 Other Health Professional United States
Primary
Concomitant
Blood Bilirubin Increased Required Intervention 2/22/2009 30 Female 235 lb 2/24/2009 Pharmacist United States
Primary
Concomitant
Respiratory Rate Decreased Required Intervention 3/7/2009 32 Male 159 lb 3/23/2009 Pharmacist United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/5/2009 Male 183 lb 5/13/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Other Serious 4/5/2009 Male 183 lb 5/25/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Other Serious 4/5/2009 Male 183 lb 6/8/2009 Other Health Professional United States
Primary
Concomitant
Respiratory Distress Other Serious 1/29/2009 Male 186 lb 6/26/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hallucination Life Threatening 3/7/2009 30 Male 174 lb 4/3/2009 Pharmacist United States
Primary
Secondary
Concomitant
Urinary Retention Other Serious 10/14/2004 Male 7/2/2009 Physician Germany
Primary
Secondary
Concomitant
Sudden Death Other Serious 7/6/2009 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 5/1/2009 61 Male 8/10/2009 Other Health Professional United States
Primary
Concomitant
Somnolence Hospitalization 8/11/2009 Male 39 lb 8/18/2009 United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 8/11/2009 Male 39 lb 8/24/2009 United States
Primary
Secondary
Concomitant
Small Intestine Ulcer Other Serious 5/1/2009 61 Male 8/19/2009 Physician United States
Primary
Concomitant
Sepsis Other Serious 5/1/2009 61 Male 9/14/2009 Physician United States
Primary
Concomitant
Venoocclusive Disease Hospitalization 8/11/2009 Male 39 lb 9/16/2009 United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 7/24/2009 60 Male 9/24/2009 Physician United States
Primary
Secondary
Concomitant
Urinary Hesitation Hospitalization 7/28/2008 65 Male 207 lb 10/6/2009 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 7/24/2009 60 Male 223 lb 10/21/2009 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 8/23/2008 24 10/28/2009 Physician Korea, Republic Of
Primary
Concomitant
Renal Failure Acute Life Threatening 8/23/2008 24 Male 148 lb 11/9/2009 Physician Korea, Republic Of
Primary
Concomitant
Unresponsive To Stimuli Other Serious 7/24/2009 60 Male 223 lb 11/5/2009 Physician United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1/20/2009 45 Male 174 lb 11/12/2009 Spain
Primary
Concomitant
Rhonchi Other Serious 10/21/2009 Male 187 lb 11/20/2009 United States
Primary
Concomitant
Thrombocytopenia Life Threatening 2/19/2009 7 Female 63 lb 11/30/2009 Physician United States
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 12/9/2008 Male 96 lb 12/16/2009 Other Health Professional United States
Primary
Concomitant
Tachypnoea Life Threatening 11/7/2009 50 Female 143 lb 11/17/2009 Pharmacist United States
Primary
Concomitant
Infection Death 4/21/2010 64 Male 6/21/2010 Other Health Professional United States
Primary
Concomitant
Prothrombin Time Prolonged 1/26/2007 76 Female 204 lb 6/24/2010 Other Health Professional United States
Primary
Concomitant
Infection Death 4/21/2010 64 Male 6/28/2010 Other Health Professional United States
Primary
Concomitant
Syncope Other Serious 10/6/2007 50 Male 194 lb 6/30/2010 Lawyer United States
Primary
Concomitant
Renal Failure Acute Life Threatening 8/23/2008 24 Male 148 lb 8/16/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2000 51 Male 237 lb 8/27/2010 United States
Primary
Secondary
Concomitant
Tachycardia Other Serious 9/20/2007 50 Male 194 lb 8/27/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/1/2010 61 Female 9/27/2010 Other Health Professional Netherlands
Primary
Concomitant
Vomiting Other Serious 1/1/2000 51 Male 237 lb 10/12/2010 United States
Primary
Secondary
Concomitant
Infection Other Serious 7/5/2010 15 Female 113 lb 10/13/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2000 51 Male 237 lb 10/22/2010 United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 4/28/2010 19 Female 115 lb 11/8/2010 Physician Japan
Primary
Concomitant
Hypertension Hospitalization 1/1/2000 51 Male 237 lb 1/12/2011 Lawyer United States
Primary
Secondary
Concomitant
Headache Other Serious 9/1/2007 50 Male 194 lb 1/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 1/1/2000 51 Male 237 lb 1/21/2011 United States
Primary
Secondary
Concomitant
Chills Death 1/21/2011 62 Female 110 lb 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Death 10/14/2010 49 Male 2/23/2011 Physician United States
Primary
Concomitant
Deep Vein Thrombosis Death 1/1/2010 61 Female 3/11/2011 Physician Netherlands
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 209 lb 3/22/2011 Physician United States
Primary
Concomitant
Abdominal Distension Other Serious 10/7/2010 49 Male 3/10/2011 Other Health Professional United States
Primary
Concomitant
Circulatory Collapse Hospitalization 1/21/2011 62 Female 110 lb 3/27/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Fungal Infection Other Serious 10/13/2009 36 Male 143 lb 4/27/2011 Physician Japan
Primary
Concomitant
Acute Graft Versus Host Disease In Intestine Hospitalization 4/9/2011 42 Female 197 lb 4/28/2011 Consumer United States
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Intestine Hospitalization 4/9/2011 42 Female 197 lb 5/15/2011 Physician United States
Primary
Secondary
Concomitant
Clostridium Difficile Colitis Death 4/29/2011 75 Male 157 lb 6/3/2011 Other Health Professional Canada
Primary
Concomitant
Dehydration Hospitalization 4/7/2010 61 Female 6/10/2011 Physician Netherlands
Primary
Secondary
Concomitant
Facial Pain Other Serious 1/1/2000 51 Male 237 lb 6/27/2011 Lawyer United States
Primary
Secondary
Concomitant
Renal Failure Acute Death 4/29/2011 75 Male 157 lb 7/8/2011 Other Health Professional Canada
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/7/2010 49 Male 6/29/2011 Other Health Professional United States
Primary
Concomitant
Hepatic Failure Death 6/8/2011 62 Male 159 lb 7/20/2011 Consumer Netherlands
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 2/1/2010 68 Male 241 lb 12/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Tubular Necrosis Hospitalization 4/29/2011 75 Male 157 lb 8/15/2011 Other Health Professional Canada
Primary
Concomitant
Hepatic Failure Death 6/8/2011 62 Male 159 lb 8/24/2011 Consumer Netherlands
Primary
Secondary
Concomitant
Death Death 5/28/2009 71 Female 161 lb 9/13/2011 Pharmacist United States
Primary
Concomitant
Sepsis Hospitalization 3/5/2011 65 Female 185 lb 9/16/2011 Physician United States
Primary
Concomitant
Lung Infection Hospitalization Male 148 lb 10/13/2011 Physician Saudi Arabia
Primary
Concomitant
Haematocrit Decreased Hospitalization 3/5/2011 65 Female 185 lb 11/15/2011 Physician United States
Primary
Concomitant
Infection Disability 4/28/2010 19 Female 115 lb 11/29/2011 Physician Japan
Primary
Concomitant
Treatment Noncompliance Hospitalization 12/13/2011 45 Female 129 lb 12/23/2011 Physician United States
Primary
Concomitant
Off Label Use Death 8/15/2011 55 Female 12/30/2011 Other Health Professional United States
Primary
Concomitant
Leukoencephalopathy Other Serious 6/1/2009 71 Female 123 lb 1/6/2012 Pharmacist United States
Primary
Concomitant
Hepatorenal Syndrome Hospitalization 12/8/2011 33 Female 1/26/2012 Physician Netherlands
Primary
Secondary
Concomitant
Eating Disorder Other Serious 1/1/2000 51 Male 237 lb 1/31/2012 United States
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 11/19/2011 33 Female 2/6/2012 Physician Netherlands
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 6/1/2009 71 Female 123 lb 2/7/2012 Pharmacist United States
Primary
Concomitant
Hepatic Enzyme Increased Other Serious Male 1 lb 3/2/2012 Physician United States
Primary
Concomitant
Interacting
Mental Status Changes Death 9/2/2011 74 Male 177 lb 3/2/2012 Physician United States
Primary
Concomitant
Sepsis Death 9/3/2011 60 Female 166 lb 3/12/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Cystitis Haemorrhagic Disability 4/28/2010 19 Female 115 lb 3/21/2012 Physician Japan
Primary
Concomitant
Transaminases Increased Other Serious 2/11/2012 33 Male 3/27/2012 Pharmacist Spain
Primary
Secondary
Concomitant
Graft Versus Host Disease In Liver Other Serious 3/27/2012 46 Female 132 lb 4/6/2012 Physician United States
Primary
Concomitant
Lung Disorder Death 4/24/2012 43 Female 166 lb 5/10/2012 Other Health Professional United States
Primary
Concomitant
Nausea Hospitalization 2/6/2011 64 Female 205 lb 4/27/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Chronic Lymphocytic Leukaemia Hospitalization 1/1/2011 60 Male 195 lb 8/31/2011 Physician United States
Primary
Concomitant
Eating Disorder Other Serious 1/1/2000 51 Male 237 lb 5/24/2012 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Hospitalization 5/29/2012 Male 6/4/2012 Physician Germany
Primary
Concomitant
Febrile Neutropenia Hospitalization 5/14/2012 53 Male 6/5/2012 Physician United States
Primary
Secondary
Concomitant
Haemorrhagic Diathesis Death 5/29/2012 66 Male 176 lb 6/20/2012 Physician Germany
Primary
Concomitant
Abscess Hospitalization 5/14/2012 53 Male 165 lb 6/28/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Haemorrhagic Diathesis Life Threatening 5/29/2012 66 Male 176 lb 7/2/2012 Physician Germany
Primary
Concomitant
Pulmonary Cavitation Hospitalization 7/5/2012 51 Male 144 lb 8/10/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Base Excess Decreased Other Serious 4/25/2012 33 Male 205 lb 7/31/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Pseudomonas Infection Hospitalization 7/5/2012 51 Male 144 lb 8/16/2012 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 10/7/2010 49 Male 5/10/2013 Other Health Professional Us
Primary
Concomitant
Treatment Failure Hospitalization 4/25/2012 33 Male 205 lb 9/21/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 4/25/2012 33 Male 205 lb 8/29/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Multi-organ Failure Death 2012 Female 171 lb 11/12/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 7/15/2012 17 Female 101 lb 11/9/2012 Consumer Us
Primary
Secondary
Concomitant
Hypotension Hospitalization 9/28/2012 17 Female 101 lb 11/2/2012 Physician Us
Primary
Secondary
Vasodilatation Hospitalization 9/28/2012 17 Female 101 lb 11/12/2012 Physician Us
Primary
Secondary
Leukaemia Recurrent Other Serious 8/15/2012 42 Female 131 lb 10/23/2012 Registered Nurse Us
Primary
Secondary
Concomitant
Muscular Weakness Hospitalization 11/19/2012 56 Male 223 lb 3/19/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Urinary Retention Other Serious 10/14/2004 46 Male 188 lb 2/4/2013 Physician De
Primary
Secondary
Concomitant
Pneumonia Other Serious 10/21/2012 58 Female 198 lb 7/8/2013 Physician Us
Primary
Secondary
Concomitant
Pulmonary Toxicity Hospitalization 2/6/2013 45 Male 171 lb 8/2/2013 Consumer Us
Primary
Secondary
Concomitant
Sepsis Hospitalization 11/6/2012 70 Male 191 lb 12/5/2012 Pharmacist Us
Primary
Concomitant
Urinary Glycosaminoglycans Increased Hospitalization 8/2012 0 Male 13 lb 5/2/2013 Consumer Us
Primary
Concomitant
Pneumonia Hospitalization 6/21/2013 71 Male 8/1/2013 Consumer Us
Primary
Concomitant
Septic Shock Death 12/16/2012 58 Female 198 lb 10/4/2013 Physician Us
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 3/29/2013 60 Female 199 lb 7/30/2013 Physician Us
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 4/24/2013 55 Male 238 lb 8/27/2013 Physician Us
Primary
Secondary
Concomitant
Venous Thrombosis Other Serious 2013 12 Male 159 lb 7/23/2013 Us
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 7/13/2013 57 Male 215 lb 7/22/2013 Registered Nurse Us
Primary
Concomitant
Swollen Tongue Hospitalization 7/30/2013 70 Female 193 lb 8/1/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Prophylaxis Hospitalization 7/30/2013 70 Female 193 lb 8/7/2013 Physician Us
Primary
Secondary
Concomitant
No Adverse Event 4/10/2013 55 Male 238 lb 11/1/2013 Physician Us
Primary
Secondary
Concomitant
Haemorrhage Intracranial Death 6/6/2013 33 Female 180 lb 10/3/2013 Physician Us
Primary
Secondary
Concomitant
Vomiting Other Serious 2000 61 Male 237 lb 8/8/2013 Consumer Us
Primary
Secondary
Concomitant

Drug Data