Lorazepam combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Mental Status Changes Hospitalization 10/25/2005 Male 1/19/2006 Pharmacist United States
Primary
Concomitant
Suicide Attempt Hospitalization 58 Female 2/7/2006 Pharmacist United States
Primary
Secondary
Completed Suicide Death 28 3/9/2006 United States
Primary
Secondary
Pyrexia Other Serious 17 Female 3/28/2006 Physician Chile
Primary
Secondary
Concomitant
Multiple Drug Overdose Intentional Death 30 Female 6/15/2006 Other Health Professional United States
Primary
Secondary
Anticonvulsant Drug Level Below Therapeutic Other Serious 8/1/2005 Female 179 lb 5/1/2006 Pharmacist United States
Primary
Concomitant
Rash Macular Other Serious 2/2/2006 7/6/2006 Physician Colombia
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 9/26/2005 53 Female 132 lb 2/8/2006 United States
Primary
Concomitant
Hypertension Hospitalization 3/25/2006 76 Female 170 lb 7/21/2006 Physician Switzerland
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 9/8/2005 33 Male 153 lb 3/14/2006 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 8/10/2006 Other Health Professional United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/13/2006 56 Female 180 lb 5/11/2006 United States
Primary
Concomitant
Ventricular Extrasystoles Other Serious 3/24/2006 57 Male 8/28/2006 United Kingdom
Primary
Secondary
Concomitant
Pulmonary Oedema Death 30 Female 9/22/2006 United States
Primary
Secondary
Neuroleptic Malignant Syndrome 8/15/2006 79 Male 138 lb 9/27/2006 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 10/4/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 6/18/2006 60 Female 10/5/2006 Other Health Professional United States
Primary
Concomitant
Hyponatraemia Hospitalization 3/25/2006 76 Female 170 lb 10/27/2006 Physician Switzerland
Primary
Secondary
Concomitant
Salivary Hypersecretion Other Serious 48 Male 172 lb 1/15/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 3/23/2006 76 Female 2/23/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Gait Disturbance Hospitalization 2/14/2007 7 Male 3/1/2007 Physician Germany
Primary
Secondary
Death Death 1/1/2004 58 Unknown 3/22/2007 Pharmacist United States
Primary
Secondary
Rash Other Serious 9/20/2006 10 Male 61 lb 12/22/2006 Other Health Professional United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Life Threatening 1/15/2007 44 Male 4/11/2007 Pharmacist United States
Primary
Secondary
Concomitant
Arrhythmia Other Serious Male 4/30/2007 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
Vasculitis Hospitalization 30 Male 5/23/2007 United Kingdom
Primary
Concomitant
Rash Other Serious 9/20/2006 10 Male 61 lb 3/5/2007 Other Health Professional United States
Primary
Concomitant
Confusional State Hospitalization 9/29/2006 51 Female 3/14/2007 Consumer United States
Primary
Concomitant
Priapism Other Serious 4/21/2007 50 Male 138 lb 6/6/2007 Pharmacist United States
Primary
Secondary
Concomitant
Rhabdomyolysis Death 36 Female 6/18/2007 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 42 Male 6/20/2007 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 191 lb Physician United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 63 Female 7/11/2007
Primary
Secondary
Swollen Tongue Required Intervention 7/11/2007 29 Female 178 lb 7/18/2007 Pharmacist United States
Primary
Concomitant
Hypophosphataemia Other Serious 7/23/2007 45 Male 194 lb 8/27/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 1/10/2003 11 Male 9/17/2007 Other Health Professional United States
Primary
Concomitant
Overdose Other Serious 1/1/2007 Male 9/21/2007 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 8/1/2006 Female 185 lb 10/10/2007 Physician France
Primary
Concomitant
Tardive Dyskinesia Hospitalization 10/16/2002 11 Male 11/2/2007 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 11/1/2007 Female 12/10/2007 Consumer Germany
Primary
Secondary
Concomitant
Overdose Other Serious 1/1/2007 Male 154 lb 12/19/2007 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 1/1/2007 Female 126 lb 12/31/2007 Consumer United States
Primary
Secondary
Concomitant
Poisoning Death 25 Female 1/21/2008 Physician United States
Primary
Secondary
Tardive Dyskinesia Hospitalization 10/16/2002 11 Male 1/29/2008 Other Health Professional United States
Primary
Concomitant
Poisoning Death 25 Female 2/1/2008 Physician United States
Primary
Secondary
Completed Suicide Death 25 Female 2/8/2008 United States
Primary
Secondary
Poisoning Death 25 Female 2/6/2008 Physician United States
Primary
Secondary
Death Death 1/1/2006 25 Female 2/11/2008 Physician United States
Primary
Secondary
Vomiting Hospitalization 11/1/2007 Female 2/12/2008 Consumer Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 10/27/2004 76 Female 2/29/2008 Physician Germany
Primary
Secondary
Concomitant
Type 1 Diabetes Mellitus Hospitalization 1/1/2002 27 Female 299 lb 3/24/2008 Physician United States
Primary
Concomitant
Swollen Tongue Hospitalization 3/23/2008 Female 143 lb 4/30/2008 Pharmacist United States
Primary
Concomitant
Lactic Acidosis Other Serious 6/13/2006 43 Female 6/18/2008 Physician Chile
Primary
Concomitant
Tachycardia Hospitalization 5/14/2008 Female 7/3/2008 Other Health Professional Germany
Primary
Secondary
Sleep Apnoea Syndrome Other Serious 59 Female 284 lb 8/6/2008
Primary
Secondary
Concomitant
Violence-related Symptom Other Serious 35 Female 8/12/2008 United States
Primary
Secondary
Cardiac Arrest Death 39 Male 9/16/2008 United Kingdom
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 4 9/23/2008 Consumer United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 9/1/2008 Male 9/19/2008 Other Health Professional Germany
Primary
Secondary
Cardiac Arrest Death 39 Male 9/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/24/2008 Other Health Professional United Kingdom
Primary
Concomitant
Tachycardia Hospitalization 9/24/2008 Male 10/28/2008 Other Health Professional Germany
Primary
Secondary
Orchitis Noninfective Other Serious 1/21/2008 Male 11/12/2008 Physician Canada
Primary
Concomitant
Tardive Dyskinesia Other Serious 10/8/2002 10 Male 11/19/2008 United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 46 Male 12/26/2008 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 46 Male 12/26/2008 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Hyperammonaemia Other Serious 33 Female 12/26/2008 Italy
Primary
Concomitant
Rhabdomyolysis Other Serious 46 Male 12/31/2008 Other Health Professional Netherlands
Primary
Secondary
Interacting
Rhabdomyolysis Hospitalization 46 Male 12/31/2008 Netherlands
Primary
Concomitant
Interacting
Lactic Acidosis Other Serious 6/13/2006 43 Female 1/6/2009 Other Health Professional Chile
Primary
Concomitant
Quadriparesis Other Serious 33 Female 1/12/2009 Italy
Primary
Concomitant
Postpartum Depression Other Serious 35 Female 1/14/2009
Primary
Secondary
Rhabdomyolysis Hospitalization 46 Male 1/12/2009 Physician Netherlands
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 46 Male 1/20/2009 Other Health Professional Netherlands
Primary
Concomitant
Interacting
Therapeutic Agent Toxicity Required Intervention 19 Male 1/19/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 46 Male 1/28/2009 Consumer Netherlands
Primary
Secondary
Concomitant
Urosepsis Hospitalization 46 Male 2/11/2009 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Pleurothotonus Disability 67 Male 2/5/2009 Physician Argentina
Primary
Secondary
Concomitant
Metabolic Acidosis Other Serious 9 Male 2/26/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Death 10/4/2008 44 Female 225 lb 2/9/2009 Pharmacist United States
Primary
Concomitant
Suicidal Ideation Other Serious 4/6/2009 Other Health Professional United States
Primary
Secondary
Urinary Incontinence Other Serious 58 Female 4/9/2009 Other Health Professional Australia
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 7/11/2001 63 Male 220 lb 4/20/2009 United States
Primary
Concomitant
Hepatomegaly Other Serious 13 Female 110 lb 5/11/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Quadriparesis Hospitalization 33 Female 5/8/2009 Other Health Professional Italy
Primary
Concomitant
Pancytopenia Life Threatening 4/7/2009 58 Female 4/29/2009 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Pneumonia Other Serious 26 Female 5/13/2009 Physician United States
Primary
Secondary
Concomitant
Brief Psychotic Disorder, With Postpartum Onset Hospitalization 35 Female 5/15/2009 Physician United States
Primary
Secondary
Quadriplegia Hospitalization 33 Female 5/18/2009 Other Health Professional Italy
Primary
Concomitant
Sjogren's Syndrome Hospitalization 33 Female 5/18/2009 Other Health Professional Italy
Primary
Concomitant
Sjogren's Syndrome Hospitalization 33 Female 5/26/2009 Other Health Professional Italy
Primary
Concomitant
Hepatomegaly Other Serious 13 Female 6/18/2009 Physician United States
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 46 Male 6/23/2009 Netherlands
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/8/2002 11 Male 70 lb 7/21/2009 United States
Primary
Concomitant
Tachycardia Other Serious 7/15/2009 29 Female 198 lb 7/24/2009 Germany
Primary
Secondary
Tachycardia Other Serious 7/15/2009 29 Female 198 lb 8/13/2009 Germany
Primary
Secondary
Psychotic Disorder Other Serious 42 Female 8/28/2009
Primary
Secondary
Concomitant
Completed Suicide Death 25 Female 9/7/2009 Physician United States
Primary
Secondary
Thinking Abnormal Hospitalization 42 Female 9/10/2009 Physician United States
Primary
Concomitant
Electrocardiogram Qt Prolonged Other Serious 34 Male 9/18/2009 Physician United States
Primary
Concomitant
Neuroleptic Malignant Syndrome Life Threatening 34 Male 9/24/2009 Pharmacist United States
Primary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 42 Female 9/24/2009 Physician United States
Primary
Concomitant
Psychotic Disorder Other Serious 16 Male 11/6/2009 Physician United States
Primary
Secondary
Encephalopathy Hospitalization 5/6/2009 57 Female 11/20/2009 Consumer Germany
Primary
Secondary
Concomitant
Hyperreflexia Other Serious 57 Female 11/16/2009 Physician Germany
Primary
Secondary
Concomitant
Overdose Other Serious 19 Male 12/11/2009 Switzerland
Primary
Concomitant
Tachycardia Other Serious 7/15/2009 Female 198 lb 12/7/2009 Physician Germany
Primary
Secondary
Unresponsive To Stimuli Hospitalization 3 Male 42 lb 12/18/2009 Other Health Professional United States
Primary
Concomitant
Overdose Other Serious 19 Male 1/12/2010 Switzerland
Primary
Concomitant
No Therapeutic Response Hospitalization 9 Male 1/21/2010 Physician United States
Primary
Concomitant
Thrombocytopenia Other Serious 9/30/2009 43 Male 2/18/2010 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 55 Female 2/17/2010 Physician Switzerland
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 3 Female 3/22/2010 Other Health Professional United States
Primary
Concomitant
No Adverse Event Hospitalization 50 Male 3/31/2010 Physician United Kingdom
Primary
Concomitant
Adverse Event Hospitalization 50 Male 4/12/2010 Physician United Kingdom
Primary
Concomitant
Somnolence Hospitalization 50 Male 4/16/2010 Physician United Kingdom
Primary
Concomitant
Brief Psychotic Disorder, With Postpartum Onset Hospitalization 35 Female 5/13/2010 Physician United States
Primary
Secondary
Hypocalcaemia Hospitalization 57 Male 5/17/2010 Physician United States
Primary
Concomitant
Leukocytosis Required Intervention 57 Male 5/17/2010 Physician United States
Primary
Concomitant
Nervous System Disorder Other Serious 11 Female 6/1/2010 Other Health Professional United States
Primary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 49 Female 5/27/2010 Physician United States
Primary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 51 Female 5/27/2010 Physician United States
Primary
Secondary
Concomitant
Posture Abnormal Hospitalization 6/4/2010 24 Female 150 lb 6/4/2010 Physician United States
Primary
Concomitant
Somnolence 2/1/2008 22 Male 180 lb 6/23/2010 Other Health Professional United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Female 6/23/2010 Consumer United States
Primary
Concomitant
Status Epilepticus Hospitalization 11/1/2009 73 Male 8/16/2010 Austria
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 51 Male 8/24/2010 Physician Taiwan, Province Of China
Primary
Concomitant
Sick Sinus Syndrome Other Serious 51 Male 10/4/2010 Physician Taiwan, Province Of China
Primary
Concomitant
Sedation Hospitalization 8/17/2010 55 Male 111 lb 11/3/2010 Pharmacist United States
Primary
Concomitant
Somnolence Hospitalization 10/8/2010 38 Male 141 lb 11/3/2010 Pharmacist United States
Primary
Concomitant
Cardio-respiratory Arrest Death 10 Male 1/4/2011 Other Health Professional United States
Primary
Secondary
Injury Death 1/1/2009 10 Male 1/6/2011 Physician United States
Primary
Secondary
Wrong Technique In Drug Usage Process Death 10 Male 1/10/2011 Physician United States
Primary
Secondary
Intentional Drug Misuse Hospitalization 10 Male 1/12/2011 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 10 Male 1/21/2011 Physician United States
Primary
Secondary
Intentional Drug Misuse Death 31 Female 1/21/2011 Physician United States
Primary
Secondary
Poisoning Hospitalization 53 Male 1/27/2011 Other Health Professional Netherlands
Primary
Concomitant
Cardio-respiratory Arrest Other Serious 10 Male 2/7/2011 Other Health Professional United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 10 Male 1/26/2011 Physician United States
Primary
Secondary
Cardiac Arrest Death 1/1/2009 10 Male 1/26/2011 Physician United States
Primary
Secondary
Completed Suicide Death 1/1/2009 31 Female 1/26/2011 Physician United States
Primary
Secondary
Cardiac Arrest Death 10 Male 1/20/2011 United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 10 Male 1/26/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 31 Female 2/8/2011 Physician United States
Primary
Secondary
Cardiac Failure Congestive Hospitalization 1/1/2002 27 Female 298 lb 2/25/2011 United States
Primary
Concomitant
Completed Suicide Death 31 Female 3/6/2011 Other Health Professional United States
Primary
Secondary
Cardio-respiratory Arrest Death 10 Male 3/7/2011 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 31 Female 3/7/2011 Physician United States
Primary
Secondary
Death Death 10 Male 2/25/2011 Physician United States
Primary
Concomitant
Child Abuse Death 10 Male 3/14/2011 Physician United States
Primary
Secondary

Drug Data