Lorazepam combined with Valproate Sodium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Schizophrenia Hospitalization 3/18/2004 Female 1/16/2006 Physician Japan
Primary
Concomitant
Necrosis Other Serious 1/1/2003 38 Female 1/25/2006 Other Health Professional Singapore
Primary
Concomitant
Death Death 12/1/2005 50 Male 2/6/2006 United States
Primary
Concomitant
Schizophrenia Hospitalization 3/18/2004 Female 2/14/2006 Physician Japan
Primary
Concomitant
Catatonia Hospitalization 3/6/2006 Male 181 lb 3/17/2006 Physician India
Primary
Concomitant
Renal Disorder Other Serious 12/1/2005 37 Female 160 lb 3/14/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Tremor Hospitalization 1/31/2006 73 Female 3/20/2006 Switzerland
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 14 Male 3/27/2006 Pharmacist United Kingdom
Primary
Concomitant
Hypokinesia Hospitalization 3/6/2006 Male 181 lb 4/7/2006 Physician India
Primary
Concomitant
Treatment Noncompliance Hospitalization 1/31/2006 Male 4/10/2006 Physician France
Primary
Secondary
Concomitant
Speech Disorder Hospitalization 38 Female 4/7/2006 Physician Thailand
Primary
Concomitant
Psychotic Disorder Other Serious 3/14/2006 14 Male 80 lb 4/10/2006 Pharmacist United Kingdom
Primary
Concomitant
Mucosal Erosion Other Serious 12/1/2004 38 Female 5/19/2006 Other Health Professional United States
Primary
Concomitant
Granulocytopenia Required Intervention 12/1/2005 26 Female 3/6/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/13/2006 50 Female 5/12/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 10/17/2005 30 Female 153 lb 2/8/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 11/14/2005 29 Male 150 lb 3/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/8/2006 49 Male 4/3/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 8/29/2005 14 Male 1/11/2006 Consumer United States
Primary
Concomitant
Leukopenia Required Intervention 3/9/2006 59 Female 100 lb 5/16/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 1/30/2006 43 Male 118 lb 5/15/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 3/10/2006 52 Female 5/22/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/13/2006 38 Female 143 lb 6/1/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 2/16/2006 38 Male 5/19/2006 Consumer United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 19 Female 6/16/2006 United States
Primary
Concomitant
Granulocytopenia Death 1/1/2006 56 Male 9/18/2006 United States
Primary
Concomitant
Septic Shock Death 9/9/2006 28 Male 11/3/2006 United States
Primary
Concomitant
Tremor Hospitalization 6/5/2006 30 Female 11/17/2006 Other Health Professional Switzerland
Primary
Concomitant
Prothrombin Time Shortened Hospitalization 9/28/2006 43 Male 205 lb 12/6/2006 Other Health Professional France
Primary
Concomitant
Tongue Ulceration Other Serious 4/1/2006 47 Female 1/8/2007 Consumer United Kingdom
Primary
Concomitant
Septic Shock Death 9/9/2006 28 Male 1/2/2007 United States
Primary
Concomitant
Tearfulness Other Serious Female 2/6/2007 Physician United Kingdom
Primary
Concomitant
Neuroleptic Malignant Syndrome 10/3/2006 22 Male 2/6/2007 Other Health Professional Denmark
Primary
Secondary
Concomitant
Polydipsia Death 4/18/2004 Female 220 lb 2/12/2007 Physician Japan
Primary
Concomitant
Neutropenia Other Serious 12/14/2006 60 Female 128 lb 2/15/2007 Other Health Professional United Kingdom
Primary
Concomitant
Major Depression Hospitalization 1/14/2007 41 Female 165 lb 2/21/2007 Other Health Professional South Africa
Primary
Secondary
Concomitant
Thirst Death 4/18/2004 Female 220 lb 2/23/2007 Physician Japan
Primary
Concomitant
Suicide Attempt Required Intervention 23 Female 128 lb 2/16/2007 Physician Japan
Primary
Secondary
Concomitant
Wrong Drug Administered 12/30/2005 66 Female 300 lb 2/28/2007 Pharmacist United States
Primary
Secondary
Concomitant
Sedation Hospitalization 12/21/2006 63 Female 146 lb 3/6/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 1/24/2007 44 Male 4/6/2007 United Kingdom
Primary
Secondary
Agranulocytosis Hospitalization 1/24/2007 44 Male 4/6/2007 United Kingdom
Primary
Secondary
Oedema Peripheral Other Serious 3/22/2007 Female 169 lb 4/23/2007 Physician Australia
Primary
Concomitant
Splenomegaly Hospitalization 1/24/2007 44 Male 4/16/2007 United Kingdom
Primary
Secondary
White Blood Cell Count Increased Hospitalization 1/24/2007 44 Male 4/16/2007 United Kingdom
Primary
Secondary
Somnolence Hospitalization 9/4/2006 22 Female 5/2/2007 Physician Japan
Primary
Concomitant
Vasculitis Hospitalization 7/7/2006 30 Male 6/1/2007 Other Health Professional France
Primary
Secondary
Concomitant
Gait Disturbance Hospitalization 9/19/2006 52 Female 6/6/2007 Other Health Professional Switzerland
Primary
Concomitant
Interacting
Ventricular Dysfunction Death 36 Female 6/14/2007 Physician United States
Primary
Concomitant
Status Epilepticus Life Threatening 7/15/2007 51 Female 8/7/2007 Physician Germany
Primary
Secondary
Neck Pain Hospitalization 6/29/2007 58 Female 8/10/2007 Canada
Primary
Concomitant
Electroencephalogram Abnormal Other Serious 15 Male 9/6/2007 Belgium
Primary
Concomitant
Interacting
Pleurothotonus Hospitalization 6/7/2007 90 Female 10/9/2007 Physician Switzerland
Primary
Concomitant
Neck Pain Hospitalization 6/29/2007 58 Female 10/17/2007 Canada
Primary
Concomitant
Somnolence Other Serious 9/19/2006 50 Female 10/25/2007 Physician Germany
Primary
Secondary
Concomitant
Somnolence Other Serious 7/23/2007 56 Male 11/5/2007 Physician Japan
Primary
Concomitant
Interacting
White Blood Cell Count Increased Other Serious 6/22/2007 16 Female 234 lb 11/27/2007 Pharmacist United Kingdom
Primary
Concomitant
Somnolence Other Serious 9/19/2006 50 Female 173 lb 11/26/2007 Germany
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Hospitalization 11/13/2007 39 Male 12/7/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Suicide Attempt Other Serious 11/19/2007 47 Female 12/4/2007 Physician Germany
Primary
Secondary
Poriomania Other Serious 4/20/2007 34 Female 12/21/2007 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 12/4/2007 72 Female 191 lb 12/24/2007 United States
Primary
Secondary
Concomitant
Poriomania Other Serious 4/20/2007 34 Female 1/14/2008 Other Health Professional Japan
Primary
Concomitant
Restlessness Hospitalization 12/28/2007 21 Male 1/23/2008 Other Health Professional Japan
Primary
Concomitant
Sinus Tachycardia Other Serious 8/1/2003 19 Female 1/30/2008 Physician Australia
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 35 Male 1/28/2008 Physician Germany
Primary
Secondary
Concomitant
Ovarian Cancer Metastatic Other Serious 4/6/2000 Female 150 lb 2/14/2008 Lawyer United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 10/14/2004 33 Female 2/21/2008 Germany
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 9/1/2004 33 Female 2/28/2008 Consumer United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 10/24/2004 76 Female 2/29/2008 Germany
Primary
Secondary
Concomitant
Screaming Other Serious 6/11/2007 17 Male 88 lb 2/26/2008 Physician Austria
Primary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 10/24/2004 Female 3/6/2008 Physician Germany
Primary
Secondary
Concomitant
Pallor Hospitalization 1/4/2008 Female 189 lb 3/14/2008 Pharmacist United States
Primary
Concomitant
Anticonvulsant Drug Level Increased Other Serious 58 Male 3/20/2008 Belgium
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Other Serious 10/14/2004 Female 3/25/2008 France
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 2/1/2008 Female 160 lb 3/28/2008 Canada
Primary
Concomitant
Pulmonary Embolism Hospitalization 24 Female 3/27/2008 Physician Germany
Primary
Secondary
Concomitant
Prolonged Labour Other Serious Female 4/11/2008 Physician Ireland
Primary
Concomitant
White Blood Cell Count Increased Other Serious 10/17/2006 78 Male 199 lb 6/12/2008 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 2/1/2008 Female 160 lb 6/19/2008 Canada
Primary
Concomitant
Haemorrhage Intracranial Death 6/27/2008 Other Health Professional United Kingdom
Primary
Concomitant
Hospitalisation Hospitalization 1/1/2008 Female 165 lb 7/8/2008 Physician Romania
Primary
Concomitant
Serotonin Syndrome Other Serious 44 Male 7/9/2008 Physician United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 6/16/2008 49 Male 7/30/2008 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 6/13/2008 49 Male 168 lb 7/31/2008 Physician Japan
Primary
Concomitant
Hypoaesthesia Other Serious 4/6/2008 Female 97 lb 8/8/2008 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 6/16/2008 49 Male 168 lb 8/12/2008 Physician Japan
Primary
Concomitant
Mania Hospitalization 7/20/2008 48 Male 8/13/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Tachycardia Hospitalization 8/4/2008 Female 8/13/2008 Other Health Professional Germany
Primary
Secondary
Tachycardia Other Serious 7/7/2008 Male 8/28/2008 Other Health Professional Germany
Primary
Secondary
Overdose Death 6/12/2008 Female 8/27/2008 Physician United States
Primary
Concomitant
Hypophagia Death 74 Female 9/11/2008 Other Health Professional United Kingdom
Primary
Concomitant
Starvation Death 74 Female 9/12/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased 6/1/2008 Male 193 lb 9/13/2008 Consumer United States
Primary
Concomitant
Cardiac Arrest Death 39 Male 9/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/23/2008 United Kingdom
Primary
Secondary
Concomitant
Cardiac Arrest Death 39 Male 9/23/2008 United Kingdom
Primary
Secondary
Concomitant
Tremor Hospitalization 7/1/2008 Female 130 lb 10/3/2008 United States
Primary
Concomitant
Tremor Hospitalization 7/1/2008 Female 130 lb 10/6/2008 United States
Primary
Concomitant
Overdose Death 6/12/2008 Female 11/3/2008 Physician United States
Primary
Concomitant
Confusional State Other Serious 10/24/2008 75 Female 11/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Confusional State Other Serious 10/24/2008 75 Female 11/17/2008 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased 6/1/2008 Male 193 lb 12/12/2008 Consumer United States
Primary
Concomitant
Weight Increased Other Serious Male 12/29/2008 Other Health Professional Ireland
Primary
Concomitant
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Accidental Exposure Other Serious 51 Male 12/29/2008 Other Health Professional Germany
Primary
Secondary
Periorbital Oedema Other Serious 43 Female 2/20/2009 Canada
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Hospitalization 11/17/2008 74 Female 2/25/2009 Physician Italy
Primary
Secondary
Concomitant
Somnolence 3/4/2009 Pharmacist United States
Primary
Concomitant
Rash Papular Other Serious 7/16/2008 Male 141 lb 3/9/2009 Physician Belgium
Primary
Secondary
Concomitant
Hallucination Other Serious 5/1/2006 60 Male 3/11/2009 France
Primary
Interacting
Myelodysplastic Syndrome Hospitalization 11/17/2008 74 Female 3/11/2009 Italy
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/1/2003 Male 3/24/2009 Physician United Kingdom
Primary
Concomitant
Hallucination Other Serious 5/1/2006 60 Male 3/26/2009 France
Primary
Interacting
Panic Reaction Other Serious 5/1/2006 Male 3/27/2009 Consumer Germany
Primary
Concomitant
Restless Legs Syndrome Other Serious 59 Male 3/31/2009 Physician Korea, Republic Of
Primary
Concomitant
Weight Increased Other Serious 11/27/2008 Male 4/8/2009 Other Health Professional Ireland
Primary
Concomitant
Urinary Incontinence Other Serious 58 Female 4/24/2009 Australia
Primary
Concomitant
Subdural Haematoma Other Serious 7/1/2005 59 Male 5/14/2009
Primary
Secondary
Urinary Tract Infection Other Serious 1/1/1997 23 Male 150 lb 5/21/2009 United States
Primary
Concomitant
Rectal Fissure Hospitalization 3/19/2009 Female 6/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Emotional Distress Other Serious Female 6/18/2009 Physician Ireland
Primary
Concomitant
Muscle Rigidity Other Serious 58 Male 6/24/2009 Belgium
Primary
Secondary
Concomitant
Mental Impairment Hospitalization Female 6/25/2009 Physician United Kingdom
Primary
Concomitant
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 8/7/2009 Physician Germany
Primary
Secondary
Concomitant
Weight Increased Female 8/20/2009 Consumer United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 44 Female 8/20/2009 Germany
Primary
Concomitant
Psychotic Disorder Life Threatening 6/18/2009 32 Male 163 lb 8/31/2009 Physician Germany
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 9/15/2009 Germany
Primary
Secondary
Concomitant
Thrombosis Other Serious 44 Female 9/17/2009 Germany
Primary
Secondary
Concomitant
Psychotic Disorder Life Threatening 6/18/2009 32 Male 163 lb 9/15/2009 Physician Germany
Primary
Secondary
Concomitant
Vasoconstriction Death 73 Male 143 lb 10/6/2009 Other Health Professional Switzerland
Primary
Concomitant
Tachycardia Other Serious Male 10/26/2009 Consumer Japan
Primary
Concomitant
Muscle Rigidity Hospitalization 58 Male 10/21/2009 Other Health Professional Belgium
Primary
Secondary
Concomitant
Mental Disorder Other Serious 10/24/2008 75 Female 10/23/2009 United Kingdom
Primary
Concomitant
Tachycardia Other Serious 7/10/2008 60 Male 10/30/2009 Physician Japan
Primary
Secondary
Concomitant
Upper Respiratory Tract Infection Hospitalization 9/22/2009 29 Male 11/10/2009 Other Health Professional Switzerland
Primary
Concomitant
Nasopharyngitis Other Serious 55 Male 205 lb 11/11/2009 Physician United Kingdom
Primary
Concomitant
Schizophrenia Death 9/17/2009 Male 11/13/2009 Pharmacist United Kingdom
Primary
Concomitant
Schizophrenia Death 9/17/2009 Male 11/16/2009 Pharmacist United Kingdom
Primary
Concomitant
Encephalopathy Hospitalization 5/6/2009 57 Female 11/17/2009 Consumer Germany
Primary
Secondary
Concomitant
Mania Hospitalization 19 Female 11/24/2009 Other Health Professional Turkey
Primary
Concomitant
Somnolence 10/17/2009 33 Male 11/19/2009 Physician Japan
Primary
Concomitant
Mania Hospitalization 19 Female 11/26/2009 Other Health Professional Turkey
Primary
Concomitant
Delirium Other Serious 55 Male 12/4/2009 Physician Australia
Primary
Concomitant
Tachycardia Other Serious 7/10/2008 60 Male 12/15/2009 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 6/22/2007 16 Female 12/18/2009 Other Health Professional United Kingdom
Primary
Concomitant
Starvation Other Serious 74 Female 1/18/2010 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Tract Infection Other Serious Male 1/22/2010 Physician Ireland
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/1/2001 Male 2/3/2010 Other Health Professional United Kingdom
Primary
Concomitant

Drug Data