Lorazepam combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Cardiomegaly Death Female 1/16/2006 United States
Primary
Concomitant
Cardiomegaly Death 12/1/2005 49 Female 3/7/2006 United States
Primary
Concomitant
Pruritus Generalised Other Serious 12/1/2005 37 Female 160 lb 4/5/2006 Consumer United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 9/1/2001 70 Female 126 lb 4/14/2006 Physician Canada
Primary
Concomitant
Psychotic Disorder Required Intervention 3/31/2006 42 Male 216 lb 6/21/2006 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Other Serious 6/18/2006 46 Female 153 lb 7/26/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 3/13/2006 56 Female 180 lb 5/11/2006 United States
Primary
Concomitant
Granulocytopenia Required Intervention 9/6/2005 19 Female 6/16/2006 United States
Primary
Concomitant
Treatment Noncompliance Other Serious 3/31/2004 56 Female 225 lb 10/12/2006 Physician United States
Primary
Concomitant
Myalgia Required Intervention 7/27/2006 47 Male 265 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Suicide Attempt Hospitalization 28 Male 11/27/2006 Other Health Professional Spain
Primary
Secondary
Therapeutic Agent Toxicity Hospitalization 28 Male 11/27/2006 Other Health Professional Spain
Primary
Secondary
Synovial Cyst Other Serious 1/1/2006 Female 111 lb 1/19/2007 Physician United States
Primary
Concomitant
Myalgia Other Serious 9/1/2006 Male 243 lb 11/9/2006 Pharmacist United States
Primary
Concomitant
Death Death 39 Female 4/6/2007
Primary
Secondary
Thyroid Disorder Death 39 Female 178 lb 4/5/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 2/16/2007 43 Male 4/18/2007 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 39 Female 4/18/2007
Primary
Secondary
Sedation Other Serious 10/29/2006 59 Male 247 lb 4/13/2007 Pharmacist United States
Primary
Secondary
Concomitant
Confusional State Hospitalization 9/29/2006 51 Female 3/14/2007 Consumer United States
Primary
Concomitant
Rhabdomyolysis Death 36 Female 6/18/2007 Other Health Professional United States
Primary
Concomitant
Poisoning Death 39 Female 6/21/2007 Germany
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization 7/2/2007 49 Male 8/9/2007 Pharmacist United States
Primary
Concomitant
Pancreatitis Chronic Other Serious 3/1/2006 33 Female 121 lb 12/10/2007 Physician United States
Primary
Concomitant
Atrial Fibrillation Other Serious 10/25/2007 Female 148 lb 2/29/2008 Physician Germany
Primary
Concomitant
Tooth Loss Other Serious 1/1/2007 Female 135 lb 4/18/2008 Physician United States
Primary
Secondary
Concomitant
Tooth Loss Other Serious 1/1/2007 Female 135 lb 4/29/2008 Physician United States
Primary
Secondary
Concomitant
Drug Eruption Hospitalization 12/1/2007 36 Male 187 lb 6/3/2008 Physician Switzerland
Primary
Concomitant
Muscle Spasms Female 8/29/2008 United States
Primary
Concomitant
Serotonin Syndrome Other Serious 46 Female 12/4/2008
Primary
Secondary
Concomitant
Overdose Death 36 Female 12/29/2008 Pharmacist United States
Primary
Secondary
Completed Suicide Death 1/1/2007 36 Female 12/29/2008 Physician United States
Primary
Secondary
Completed Suicide Death 36 Female 1/15/2009 Physician United States
Primary
Secondary
Intentional Drug Misuse Death 1/1/2007 36 Female 1/19/2009 Physician United States
Primary
Secondary
Completed Suicide Death 1/30/2009 Other Health Professional United States
Primary
Secondary
Nephrolithiasis Other Serious 2/23/2009 Female 3/1/2009 Consumer Canada
Primary
Concomitant
Pulmonary Embolism Other Serious 1/1/2003 36 Female 4/6/2009 United States
Primary
Concomitant
Weight Fluctuation Other Serious 1/1/2004 20 Male 160 lb 4/14/2009 United States
Primary
Concomitant
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 8/7/2009 Physician Germany
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 6/20/2009 Male 154 lb 8/7/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Sedation Hospitalization 8/4/2009 Male 212 lb 8/21/2009 Pharmacist United States
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 42 Female 8/28/2009
Primary
Secondary
Concomitant
Thinking Abnormal Other Serious Female 7/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Chronic Other Serious 10/10/2005 32 Female 134 lb 9/11/2009 United States
Primary
Concomitant
Thinking Abnormal Hospitalization 42 Female 9/10/2009 Physician United States
Primary
Concomitant
Refusal Of Treatment By Patient Other Serious 42 Female 9/15/2009 Physician United States
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 6/1/2009 32 Male 154 lb 9/15/2009 Germany
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 42 Female 9/24/2009 Physician United States
Primary
Concomitant
Tachycardia Other Serious 1/1/2009 33 Female 9/30/2009 Pharmacist United States
Primary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/2/2009 Physician United States
Primary
Concomitant
Status Asthmaticus Hospitalization 7/13/2009 Male 10/30/2009 Physician United States
Primary
Concomitant
Weight Increased Other Serious 16 Male 11/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Weight Increased Hospitalization 16 Male 12/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Nephrolithiasis Other Serious 2/23/2009 Female 12/1/2009 Consumer Canada
Primary
Concomitant
Weight Increased Other Serious 16 Male 12/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 12/1/2009 Female 140 lb 1/8/2010 United States
Primary
Concomitant
Drug Administered At Inappropriate Site 1/7/2010 Female 1/18/2010 Consumer United States
Primary
Concomitant
Drug Toxicity Other Serious 34 Female 1/25/2010 Physician United States
Primary
Secondary
Completed Suicide Death 34 Female 1/25/2010 Physician United States
Primary
Secondary
Poisoning Death 1/1/2008 34 Female 1/28/2010 Physician United States
Primary
Secondary
Epistaxis Other Serious 36 Female 2/11/2010
Primary
Secondary
Poisoning Death 1/1/2008 34 Female 2/1/2010 Physician United States
Primary
Secondary
Completed Suicide Death 2/26/2010 Physician United States
Primary
Secondary
Renal Failure Acute Other Serious 2/16/2010 71 Male 6/21/2010 Physician United States
Primary
Secondary
Concomitant
Leukopenia Other Serious 1/5/2010 52 Female 160 lb 6/24/2010 Pharmacist United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 2/16/2010 71 Male 7/5/2010 Physician United States
Primary
Concomitant
Social Avoidant Behaviour Other Serious 29 Female 160 lb 7/15/2010 Pharmacist United States
Primary
Concomitant
Vitamin D Decreased 8/1/2008 55 Female 240 lb 8/3/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 1/1/2007 51 Female 106 lb 8/20/2010 United States
Primary
Secondary
Concomitant
Nystagmus Other Serious 31 Female 8/30/2010 Other Health Professional United States
Primary
Secondary
Suicide Attempt Other Serious 21 Male 238 lb 8/31/2010
Primary
Secondary
Pyrexia Other Serious 29 Female 160 lb 9/7/2010 Pharmacist United States
Primary
Concomitant
Weight Increased Other Serious 18 Female 9/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 16 Male 9/29/2010 Physician United States
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 37 Female 10/21/2010
Primary
Secondary
Oropharyngeal Pain 8/1/2010 75 Female 11/3/2010 Consumer
Primary
Concomitant
Tardive Dyskinesia Hospitalization 29 Female 161 lb 10/26/2010 United States
Primary
Concomitant
Joint Injury Hospitalization 1/1/2009 52 Female 267 lb 11/9/2010 Other Health Professional United States
Primary
Concomitant
Tardive Dyskinesia Hospitalization 29 Female 160 lb 10/25/2010 Pharmacist United States
Primary
Concomitant
Pyrexia Hospitalization 29 Female 161 lb 11/11/2010 Pharmacist United States
Primary
Concomitant
Weight Decreased Hospitalization 2/1/2009 30 Female 11/12/2010 Physician Portugal
Primary
Secondary
Vaginal Haemorrhage Other Serious 1/1/2009 11/15/2010 Physician United States
Primary
Concomitant
Restless Legs Syndrome Other Serious 6/1/2010 64 Male 10/29/2010 Consumer United States
Primary
Concomitant
Pyrexia Other Serious 29 Female 161 lb 11/22/2010
Primary
Secondary
Vaginal Haemorrhage Other Serious 1/1/2009 11/29/2010 Physician United States
Primary
Concomitant
Sepsis Death 1/1/2007 39 Female 11/30/2010
Primary
Secondary
Weight Decreased Hospitalization 2/1/2009 30 Female 12/8/2010 Physician Portugal
Primary
Secondary
Psychotic Disorder Other Serious 6/20/2009 32 Male 12/1/2010 Germany
Primary
Secondary
Concomitant
Screaming Other Serious 29 Female 160 lb 12/2/2010 Physician United States
Primary
Concomitant
Toxicity To Various Agents Death 32 Female 1/12/2011 Physician United States
Primary
Secondary
Anticonvulsant Drug Level Decreased Other Serious 12/1/2010 44 Male 1/13/2011 Pharmacist Canada
Primary
Concomitant
Restless Legs Syndrome Other Serious Male 1/7/2011 Lawyer United States
Primary
Concomitant
Convulsion Other Serious 12/1/2010 44 Male 1/21/2011 Pharmacist Canada
Primary
Concomitant
No Adverse Event 1/12/2009 48 Male 196 lb 1/21/2011 Other Health Professional Germany
Primary
Concomitant
Respiratory Arrest Death 1/1/2009 32 Female 1/26/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2009 32 Female 1/26/2011 Other Health Professional United States
Primary
Secondary
Cardio-respiratory Arrest Death 32 Female 2/2/2011 United States
Primary
Secondary
Anticonvulsant Drug Level Decreased Other Serious 12/1/2010 44 Male 2/16/2011 Pharmacist Canada
Primary
Concomitant
Cardio-respiratory Arrest Death 32 Female 3/6/2011 Other Health Professional United States
Primary
Secondary
Quadriparesis Other Serious 74 Female 3/14/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Physical Assault Other Serious 52 Female 3/18/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 38 Female 3/24/2011 Physician United States
Primary
Secondary
Anxiety Disorder Other Serious 1/1/2007 48 Female 124 lb 3/24/2011 Physician United States
Primary
Concomitant
Interacting
Feeling Abnormal Hospitalization 2/1/2011 40 Female 205 lb 3/4/2011 Consumer United States
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 71 Male 3/23/2011 Physician Germany
Primary
Secondary
Concomitant
Restless Legs Syndrome Other Serious 1/1/2007 49 Female 124 lb 4/6/2011 United States
Primary
Secondary
Concomitant
Amnestic Disorder Other Serious 71 Male 5/3/2011 Physician Germany
Primary
Secondary
Concomitant
Intracranial Venous Sinus Thrombosis Hospitalization 2/1/2010 21 Female 199 lb 5/31/2011 Lawyer United States
Primary
Concomitant
Heat Illness Death 6/29/2005 54 Male 6/3/2011 Physician Canada
Primary
Concomitant
Blood Pressure Diastolic Increased Other Serious 4/27/2011 55 Female 123 lb 6/29/2011 Physician United States
Primary
Concomitant
Rash Hospitalization 76 Female 7/14/2011 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Influenza Like Illness Other Serious 1/1/1997 41 Female 154 lb 8/3/2011 Physician United States
Primary
Concomitant
Hot Flush Other Serious 1/1/2010 45 Male 160 lb 8/29/2011 Consumer United States
Primary
Secondary
Concomitant
Drug Dose Omission 5/6/2011 35 Female 9/22/2011 United States
Primary
Secondary
Concomitant
Somnolence 9/22/2011 Consumer United States
Primary
Concomitant
Leukopenia Other Serious 19 Male 9/28/2011 Other Health Professional Australia
Primary
Secondary
Concomitant
Myoclonus Other Serious Male 5 lb 10/4/2011 Physician United States
Primary
Secondary
Intracranial Venous Sinus Thrombosis Hospitalization 2/1/2010 21 Female 199 lb 10/7/2011 Other Health Professional United States
Primary
Concomitant
Anxiety Hospitalization 11/10/2006 46 Female 186 lb 10/19/2011 Lawyer United States
Primary
Concomitant
Fall Hospitalization 9/6/2011 5 Female 168 lb 10/19/2011 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Increased Other Serious Female 11/10/2011 Consumer United States
Primary
Concomitant
Chest Discomfort Hospitalization 10/31/2011 64 Male 285 lb 11/28/2011 Physician United States
Primary
Secondary
Concomitant
Chest Discomfort Hospitalization 10/31/2011 64 Male 285 lb 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 10/31/2011 64 Male 285 lb 12/19/2011 Physician United States
Primary
Secondary
Concomitant
Prostatic Specific Antigen Increased Life Threatening 9/30/2011 61 Male 124 lb 12/29/2011 Physician United States
Primary
Secondary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Other Serious 8 Male 1/3/2012 United States
Primary
Secondary
Concomitant
Pulmonary Embolism Death 9/26/2011 52 Female 123 lb 1/4/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Fatigue 1/10/2011 36 Female 1/27/2012 Consumer United States
Primary
Concomitant
Erythema Other Serious 7/1/2010 51 Female 185 lb 1/27/2012 Consumer United States
Primary
Concomitant
Subdural Haematoma Hospitalization Female 1/28/2012 Consumer United States
Primary
Concomitant
Therapeutic Product Ineffective Required Intervention 8/30/2010 80 Male 260 lb 2/9/2012 Other Health Professional United States
Primary
Concomitant
Multiple Drug Overdose Intentional Hospitalization 2/9/2012 41 Female 2/23/2012 Physician Italy
Primary
Secondary
Fibromyalgia Hospitalization 4/1/2009 56 Female 2/23/2012 Consumer United States
Primary
Concomitant
Drug Abuse Death 52 Female 121 lb 2/22/2012 Physician United States
Primary
Secondary
Concomitant
Cystitis Interstitial Hospitalization 1/1/2004 56 Female 3/5/2012 Consumer United States
Primary
Concomitant
Pallidotomy Hospitalization 38 Female 4/12/2012 Other Health Professional Japan
Primary
Concomitant
Visual Acuity Reduced Hospitalization 1/1/2011 45 Female 4/17/2012 Consumer United States
Primary
Concomitant
Oedema Peripheral Other Serious 11/1/2011 67 Female 4/13/2012 Physician United States
Primary
Concomitant
Depression Other Serious 4/30/2012 42 Female 162 lb 5/3/2012 Other Health Professional United States
Primary
Concomitant
Acidosis Hospitalization 38 Female 5/10/2012 Other Health Professional Japan
Primary
Concomitant
Fatigue Death 5/2/2012 50 Male 5/18/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Fatigue Other Serious 5/2/2012 50 Male 5/21/2012 Other Health Professional Germany
Primary
Secondary
Concomitant
Blindness Unilateral Hospitalization 1/1/2011 45 Female 140 lb 5/22/2012 Physician United States
Primary
Concomitant
Multiple Drug Overdose Intentional Hospitalization 5/2/2012 50 Male 5/23/2012 Other Health Professional Germany
Primary
Secondary
Weight Decreased Other Serious 11/1/2011 67 Female 119 lb 5/24/2012 Physician United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 5/1/2011 37 Female 155 lb 5/28/2012 Lawyer United States
Primary
Concomitant
Dizziness Hospitalization 4/21/2012 53 Female 5/30/2012 Consumer United States
Primary
Concomitant
Fatigue Death 5/2/2012 50 Male 6/1/2012 Other Health Professional Germany
Primary
Secondary
Suicide Attempt Hospitalization 5/2/2012 50 Male 6/1/2012 Other Health Professional Germany
Primary
Secondary
Fatigue Hospitalization 5/2/2012 50 Male 6/5/2012 Other Health Professional Germany
Primary
Secondary

Drug Data